Research Topics
| M P YeagerSummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
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Detail Information
Publications
A novel method for selective delivery of drugs to the pulmonary arteriesMark P Yeager
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Drug Deliv 12:261-5. 2005..This is a first step toward development of first-pass pulmonary clearance as a mechanism to concentrate drugs in pulmonary arteries...- Perioperative beta-blockade and late cardiac outcomes: a complementary hypothesisMark P Yeager
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
J Cardiothorac Vasc Anesth 19:237-41. 2005 - Perioperative fluid management: current consensus and controversiesMark P Yeager
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Semin Dial 19:472-9. 2006..Some of the benefits of this new approach range from relatively ''minor'' outcomes such as diminished nausea after surgery to preventing postoperative complications such as wound breakdown and cardiopulmonary failure... - In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytesMark P Yeager
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA
Anesth Analg 107:1726-34. 2008..Since some GC effects on inflammation are stimulatory, we hypothesized that acute in vivo GC depletion would decrease inflammatory responses of human monocytes... - Glucocorticoid regulation of the inflammatory response to injuryM P Yeager
Department of Anesthesiology, Dartmouth Medical School, Hanover, NH
Acta Anaesthesiol Scand 48:799-813. 2004..Varying doses of GCs do not lead simply to varying degrees of inflammation suppression, but rather GCs can exert a full range of effects from permissive to stimulatory to suppressive... - Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxinMark P Yeager
Department of Anesthesiology and Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Crit Care Med 37:2727-32. 2009.... - Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humansMark P Yeager
Department of Anesthesiology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Anesth Analg 94:94-9, table of contents. 2002..On the basis of these results, the use of fentanyl should not be restricted because of concerns that it may suppress immune function... - Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgeryMary P Fillinger
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
J Cardiothorac Vasc Anesth 16:163-9. 2002..CONCLUSION: This study shows significant effects of glucocorticoids on the production of IL-6 and IL-10 in response to cardiac surgery but only minor effects on clinical recovery... - Cortisol antiinflammatory effects are maximal at postoperative plasma concentrationsMark P Yeager
Department of Anesthesiology, Dartmouth Medical School, Hanover, NH, USA
Crit Care Med 33:1507-12. 2005.... - Stopcock lumen contamination does not reflect the full burden of bacterial intravenous tubing contamination: analysis using a novel injection portMatthew K Muffly
Department of Anesthesiology and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Am J Infect Control 38:734-9. 2010..We also measured the effect of a novel injection port protective device (Port Guide; Matrix Tooling, Inc, Wood Dale, IL) on contamination... - Insulin increases neutrophil count and phagocytic capacity after cardiac surgeryAthos J Rassias
Department of Anesthesiology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Anesth Analg 94:1113-9, table of contents. 2002.... - Epidural anesthesia and analgesia: effects on recovery from cardiac surgeryMary P Fillinger
Departments of Anesthesiology and Surgery, Dartmouth Hitchcock Medical Center, Lebanon and Dartmouth Medical School, Hanover, NH 03756, USA
J Cardiothorac Vasc Anesth 16:15-20. 2002..To measure predefined clinical effects resulting from the use of epidural anesthesia and analgesia during and after cardiac surgery... - Hand contamination of anesthesia providers is an important risk factor for intraoperative bacterial transmissionRandy W Loftus
Department of Anesthesiology and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Anesth Analg 112:98-105. 2011..In this study, we hypothesized that bacterial contamination of anesthesia provider hands before patient contact is a risk factor for direct intraoperative bacterial transmission... - Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgeryRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Anesthesiology 113:639-46. 2010..Little is known regarding its efficacy in opiate-dependent patients with a history of chronic pain. We hypothesized that ketamine would reduce postoperative opiate consumption in this patient population... - Decreased physiologic variability as a generalized response to human endotoxemiaAthos J Rassias
Department of Anesthesiology, Dartmouth Medical School, Hanover, NH, USA
Crit Care Med 33:512-9. 2005..CONCLUSIONS: Increased regularity, or decreased variability, of organ functions is a generalized response to systemic inflammation that occurs in widely divergent systems during endotoxemia... - The in vivo effects of general and epidural anesthesia on human immune functionM A Procopio
Department of Anesthesiology, Dartmouth Medical School, Hanover, New Hampshire, USA
Anesth Analg 93:460-5, 4th contents page. 2001..IMPLICATIONS: General or epidural anesthesia alone, in the absence of surgery, seems to have only transient and minor effects on human immune function... - Increase in plasma and surface CD163 levels in patients undergoing coronary artery bypass graft surgeryJonathan I Goldstein
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755, USA
Atherosclerosis 170:325-32. 2003..The proposed role of CD163 as a Hp-Hb scavenger and anti-inflammatory molecule, in conjunction with the results of this study, make CD163 an intriguing target for potential manipulation of the acute response to inflammation... - Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the ratR W Colburn
Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Neuroimmunol 79:163-75. 1997..The current findings support the use of bupivacaine as a tool to suppress microglial activation and challenge the putative role of microglia in initiating or potentiating pain behaviors which result from nerve injury... - Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163Katharine A Hintz
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA
J Leukoc Biol 72:711-7. 2002..As hemoglobin can bind LPS and enhance its toxicity, it will be important to determine how cell surface and soluble CD163 influence inflammatory processes during sepsis... - Anesthesia and surgical outcomes: an orphean ambitionMark P Yeager
Reg Anesth Pain Med 29:515-9. 2004