Henry Lynch

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
  2. ncbi Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
  3. ncbi Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies
    Anna Gonzalez-Neira
    Genotyping Unit, CeGen, Human Cancer Genetics Programme, Spanish National Cancer Centre, Spain
    BMC Genomics 8:299. 2007
  4. ncbi BRCA1 and pancreatic cancer: pedigree findings and their causal relationships
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 158:119-25. 2005
  5. ncbi Cancer in Jews: introduction and overview
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68131, USA
    Fam Cancer 3:177-92. 2004
  6. ncbi Challenging pedigrees seen in a hereditary cancer consultation center
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 153:91-101. 2004
  7. ncbi Inherited predisposition to cancer: a historical overview
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Am J Med Genet C Semin Med Genet 129:5-22. 2004
  8. ncbi Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Fam Cancer 7:27-39. 2008
  9. ncbi A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Neb 68178, USA
    JAMA 291:718-24. 2004
  10. ncbi Lynch syndrome and the role of the registered nurse: commentary on "hereditary nonpolyposis colorectal cancer (Lynch syndrome): molecular pathogenesis and clinical approaches ti diagnosis and management for nurses"
    Henry T Lynch
    Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Biol Res Nurs 9:200-2; discussion 203-4. 2008

Research Grants

  1. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
  2. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2007

Detail Information

Publications96

  1. ncbi Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  2. ncbi Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  3. ncbi Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies
    Anna Gonzalez-Neira
    Genotyping Unit, CeGen, Human Cancer Genetics Programme, Spanish National Cancer Centre, Spain
    BMC Genomics 8:299. 2007
    ....
  4. ncbi BRCA1 and pancreatic cancer: pedigree findings and their causal relationships
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 158:119-25. 2005
    ....
  5. ncbi Cancer in Jews: introduction and overview
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68131, USA
    Fam Cancer 3:177-92. 2004
    ..We urge our colleagues to continue to probe further into these statistical differences in cancer's incidence and prevalence in order to garner a better understanding of cancer's etiology and pathogenesis...
  6. ncbi Challenging pedigrees seen in a hereditary cancer consultation center
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 153:91-101. 2004
    ....
  7. ncbi Inherited predisposition to cancer: a historical overview
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Am J Med Genet C Semin Med Genet 129:5-22. 2004
    ..Emphasis has been placed upon the manner in which improved cancer control will emanate from these discoveries...
  8. ncbi Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Fam Cancer 7:27-39. 2008
    ....
  9. ncbi A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Neb 68178, USA
    JAMA 291:718-24. 2004
    ..However, while carriers of these mutations should be identified, counseled, and offered clinical surveillance, at present the mutations are not tested for in mutation analyses...
  10. ncbi Lynch syndrome and the role of the registered nurse: commentary on "hereditary nonpolyposis colorectal cancer (Lynch syndrome): molecular pathogenesis and clinical approaches ti diagnosis and management for nurses"
    Henry T Lynch
    Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Biol Res Nurs 9:200-2; discussion 203-4. 2008
  11. ncbi Challenging colonic polyposis pedigrees: differential diagnosis, surveillance, and management concerns
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 148:104-17. 2004
    ....
  12. ncbi Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer 100:53-64. 2004
    ..S each year. Its diagnosis is wholly dependent on a meticulously obtained family history of cancer of all anatomic sites, with particular attention to the pattern of cancer distribution within the family...
  13. ncbi Familial sarcoma: challenging pedigrees
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer 98:1947-57. 2003
    ....
  14. ncbi Hereditary breast cancer: part I. Diagnosing hereditary breast cancer syndromes
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Breast J 14:3-13. 2008
    ..We postulate that increasing knowledge about the genetics of BC may have partially contributed to the identification of high-risk patients who thereby may have benefited significantly from early diagnosis...
  15. ncbi Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer 112:2655-63. 2008
    ..Management options for unaffected mutation carriers include prophylactic total gastrectomy...
  16. ncbi Pancreatic cancer and the FAMMM syndrome
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    Fam Cancer 7:103-12. 2008
    ....
  17. ncbi Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine, Creighton University Medical School, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 3:229-32. 2004
    ..Additional biopsies should be taken of any flat lesions, masses, or strictures. Prophylactic colectomy may then be indicated when severe dysplasia is confirmed by knowledgeable pathologists...
  18. ncbi Familial pancreatic carcinoma in Jews
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68131, USA
    Fam Cancer 3:233-40. 2004
    ..Attention should also be given to the search for mutations predisposing to PC in Jews so that opportunities to learn more about the disease's pathogenesis, as well as screening and control, may take place...
  19. ncbi Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Cancer Genet Cytogenet 165:91-7. 2006
    ..Despite these psychological consequences, carriers and noncarriers reported a positive attitude toward genetic testing...
  20. ncbi Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Eur J Hum Genet 14:390-402. 2006
    ....
  21. ncbi American founder mutation for Lynch syndrome. Prevalence estimates and implications
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University, Omaha, Nebraska 68178, USA
    Cancer 106:448-52. 2006
    ..This test might serve as first-line screening for Lynch syndrome mutations, provided AFM was prevalent, which is assessed in the current study...
  22. ncbi Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Invest Dermatol 126:2158-9. 2006
    ..Proof of diagnosis is identification of one of the mismatch repair germline mutations...
  23. ncbi Clinical selection of candidates for mutational testing for cancer susceptibility
    Henry T Lynch
    Department of Preventive Medicine, Creighton University, School of Medicine, Omaha, Nebraska 68178, USA
    Oncology (Williston Park) 20:29-34. 2006
    ..This article is an attempt to crystallize all of these issues in a format that will help physicians-particularly those in the oncology community-to meet this challenge effectively...
  24. ncbi Hereditary cancer syndrome diagnosis: molecular genetic clues and cancer control
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha NE 68178, USA
    Future Oncol 3:169-81. 2007
    ....
  25. ncbi What the physician needs to know about Lynch syndrome: an update
    Henry T Lynch
    Department of Preventive Medicine Creighton University School of Medicine Omaha, Nebraska 68178, USA
    Oncology (Williston Park) 19:455-63; discussion 463-4, 466, 469. 2005
    ..These cancer control strategies have a major impact on at-risk family members once they have been counseled and educated thoroughly about Lynch syndrome's natural history and their own hereditary cancer risk...
  26. ncbi Who should be sent for genetic testing in hereditary colorectal cancer syndromes?
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Clin Oncol 25:3534-42. 2007
    ..Genetic counselors may be extremely helpful to the practicing gastroenterologist, oncologist, or surgeon; when more specialized knowledge is called for, referral can be made to a medical geneticist and/or a medical genetics clinic...
  27. ncbi Gastric cancer: new genetic developments
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Surg Oncol 90:114-33; discussion 133. 2005
    ..This paper reviews the genetics of both intestinal and diffuse types of gastric carcinoma, their differential diagnosis, molecular genetics, pathology, and, when known, their mode of genetic transmission within families...
  28. ncbi Phenotypic heterogeneity in multiple myeloma families
    Henry T Lynch
    Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA
    J Clin Oncol 23:685-93. 2005
    ..Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM...
  29. ncbi Prophylactic surgery prevents endometrial and ovarian cancer in Lynch syndrome
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    Nat Clin Pract Oncol 4:672-3. 2007
  30. ncbi Genetic counseling for DAPK1 mutation in a chronic lymphocytic leukemia family
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 186:95-102. 2008
    ..Their intellectual and emotional reaction to its presence or absence in them was assessed. This family serves as a model for genetic counseling in disorders for which lifesaving intervention is not yet possible...
  31. ncbi Current status of prophylactic surgery for hereditary breast and gynecologic cancers
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Curr Opin Obstet Gynecol 13:25-30. 2001
    ....
  32. ncbi Familial multiple myeloma: a family study and review of the literature
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Natl Cancer Inst 93:1479-83. 2001
    ..Here we describe the medical histories of members of a family prone to MM...
  33. ncbi Update on familial pancreatic cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Curr Gastroenterol Rep 3:121-8. 2001
    ..A subset of those FAMMM kindred with the CDKN2A (p16) germline mutation that expresses both pancreatic cancer and malignant melanoma may constitute a new hereditary pancreatic cancer-prone syndrome...
  34. ncbi Cigarette smoking and breast cancer risk
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Womens Health (Lond Engl) 7:413-6. 2011
    ..This is the possibly the largest cohort that has demonstrated the hazards of cigarette smoking and its impact on carcinoma of the breast in women...
  35. ncbi FAP, gastric cancer, and genetic counseling featuring children and young adults: a family study and review
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 9:581-8. 2010
    ....
  36. ncbi Making sense of missense in Lynch syndrome: the clinical perspective
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University, Omaha, Nebraska 68131, USA
    Cancer Prev Res (Phila) 3:1371-4. 2010
    ..This affects the clinical features of tumors associated with defective DNA MMR activity. New work reported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR...
  37. ncbi Anticipation in familial Hodgkin's lymphoma
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    Hum Genet 107:290-3. 2000
    ..Anticipation is discussed in relation to Hodgkin's lymphoma, non-Hodgkin's lymphoma, and familial cancer...
  38. ncbi Lynch syndrome: genetics, natural history, genetic counseling, and prevention
    H T Lynch
    Creighton University School of Medicine, Omaha, NE, USA
    J Clin Oncol 18:19S-31S. 2000
    ..A search for chemoprevention agents, such as cyclo-oxygenase 2 inhibitors, as well as for putative environmental effects and how they may interact with the genetic component in CRC etiology should abet this entire cancer control process...
  39. ncbi The identification and management of hereditary diffuse gastric cancer in a large Jordanian family
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 10:667-72. 2011
    ..We are hopeful that this model can be repeated throughout Jordan as well as other emerging countries where knowledge and action about hereditary cancer is lacking...
  40. ncbi Hereditary nonpolyposis colorectal cancer
    H T Lynch
    Creighton University School of Medicine, Omaha, Nebraska, USA
    Semin Surg Oncol 18:305-13. 2000
    ..Physicians must also be aware of clinical nuances of this disorder to provide the necessary care...
  41. ncbi Genetics of colonic cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebr, USA
    Digestion 59:481-92. 1998
    ..These molecular genetic discoveries are providing new insights into the pathogenesis of CRC. Individuals within these kindreds who are harbingers of these germ-line mutations will benefit from screening and, one day, chemoprevention...
  42. ncbi Cancer genetics in the new era of molecular biology
    H T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Ann N Y Acad Sci 833:1-28. 1997
    ..Central to translation of these momentous molecular genetic discoveries into patient care is the necessity of determining who requires DNA testing. The cancer family history is the linchpin in making this decision...
  43. ncbi Molecular genetics and clinical-pathology features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confirmation
    H T Lynch
    Creighton University School of Medicine, Omaha, Nebr 68178, USA
    Oncology 55:103-8. 1998
    ..These discoveries should aid in elucidating its pathogenesis and carcinogenesis and in the next decade we likely will learn more about chemoprevention and surgical prophylaxis of HNPCC...
  44. ncbi Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion
    Henry T Lynch
    Department of Preventive Medicine, Creighton University, Omaha, Nebraska 68178, USA
    Am J Gastroenterol 106:1829-36. 2011
    ..The tumor spectrum of such families appears to differ from classical LS...
  45. ncbi Family information service participation increases the rates of mutation testing among members of families with BRCA1/2 mutations
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Breast J 15:S20-4. 2009
    ..FIS attendance significantly increased the rate of mutation testing among high-risk family members...
  46. ncbi Hereditary cancer: family history, diagnosis, molecular genetics, ecogenetics, and management strategies
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68131, USA
    Biochimie 84:3-17. 2002
    ..We believe very firmly that this knowledge needs to be extended to the individual patient(s), first- and second-degree relatives so that they can benefit from this knowledge...
  47. ncbi Genetic counseling and the advanced practice oncology nursing role in a hereditary cancer prevention clinic: hereditary breast cancer focus (part II)
    Henry T Lynch
    Department of Preventive Medicine, Creighton University, Omaha, Nebraska 68178, USA
    Breast J 15:S11-9. 2009
    ..The role of the oncology nurse-genetic counselor has been described in each of these family reports...
  48. ncbi Hereditary breast-ovarian cancer at the bedside: role of the medical oncologist
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    J Clin Oncol 21:740-53. 2003
    ..To provide practical considerations for diagnosing, counseling, and managing patients at high risk for hereditary breast cancer...
  49. ncbi Hereditary colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebr 68178, USA
    N Engl J Med 348:919-32. 2003
  50. ncbi Hereditary chronic lymphocytic leukemia: an extended family study and literature review
    Henry T Lynch
    Department of Preventive Medicine and Public Health at Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Med Genet 115:113-7. 2002
    ..Given the explosive developments in molecular genetics during the past decade, it is certain that families of this type will provide important clues to the etiology, pathogenesis, and ultimate prevention of CLL...
  51. ncbi Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Mol Oncol 3:97-137. 2009
    ..This paper reviews the subject of hereditary ovarian cancer, with particular attention to its molecular genetic basis, its pathology, and its phenotypic/genotypic heterogeneity...
  52. ncbi Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 137:8-14. 2002
    ..However, two family members affected with AML exhibited abnormal acquired clones in their bone marrow specimens by both G-band studies and interphase FISH, both with a deletion of 5q...
  53. ncbi Hereditary pancreatic cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Pancreatology 1:466-71. 2001
    ..These individuals would benefit greatly from method(s) capable of detecting cancer at an early stage, and such knowledge would also be useful for improving the diagnosis of the much more common 'sporadic' form of PC...
  54. ncbi Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Genet 76:1-18. 2009
    ..LS explains only 10-25% of familial CRC...
  55. ncbi Cancer variation associated with the position of the mutation in the BRCA2 gene
    Jan Lubinski
    Hereditary Cancer Center Department of Genetics and Pathology, Pomeranian Academy of Medicine, Szczecin, Poland
    Fam Cancer 3:1-10. 2004
    ..0; P = 0.03) compared to families of other ethnic origins. In conclusion, both the position of mutation and the ethnic background of the family appear to contribute to the phenotypic variation observed in families with BRCA2 mutations...
  56. ncbi Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene
    Anja Wagner
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 72:1088-100. 2003
    ..Genealogical, molecular, and haplotype studies showed that this deletion represents a North American founder mutation that could be traced back to the 19th century...
  57. ncbi Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay
    Carlos Sarroca
    Uruguayan Collaborative Group Survey of Hereditary Oncologic Disorders, Hospital Central de las Fuerzas Armadas, 11600 Montevideo, Uruguay
    Cancer Genet Cytogenet 142:13-20. 2003
    ....
  58. ncbi Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers
    Carey A Cullinane
    City of Hope National Medical Center, Duarte, CA, USA
    Int J Cancer 117:988-91. 2005
    ..Among BRCA2 carriers, increasing parity was associated with a significant increase in the risk of breast cancer before age 50 and this increase was greatest in the 2-year period following a pregnancy...
  59. ncbi BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes
    Donald A Berry
    Department of Biostatistics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 20:2701-12. 2002
    ....
  60. ncbi BRCA1 and BRCA2 mutations in breast and ovarian cancer syndrome: reflection on the Creighton University historical series of high risk families
    Olga M Sinilnikova
    Plate forme Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon Centre Léon Bérard, Lyon Cedex 08, 69373, France
    Fam Cancer 5:15-20. 2006
    Over the last four decades, Henry Lynch has collected pedigrees and samples from high risk breast and/or ovarian cancer families, generating a unique resource for the study of breast cancer susceptibility...
  61. ncbi Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
    N Engl J Med 354:261-9. 2006
    ..CONCLUSIONS: These findings suggest that prophylactic hysterectomy with bilateral salpingo-oophorectomy is an effective strategy for preventing endometrial and ovarian cancer in women with the Lynch syndrome...
  62. ncbi Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking
    Rhonda M Brand
    Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
    World J Gastroenterol 12:4485-91. 2006
    ..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
  63. ncbi Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Steven A Narod
    The Centre for Research on Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    J Natl Cancer Inst 94:1773-9. 2002
    ..We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2...
  64. ncbi History and molecular genetics of Lynch syndrome in family G: a century later
    Julie A Douglas
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    JAMA 294:2195-202. 2005
    ..stomach, and endometrium in Dr Warthin's family G was later followed up by his colleagues, most recently by Henry Lynch, MD...
  65. ncbi Hereditary diffuse gastric cancer: association with lobular breast cancer
    Kasmintan A Schrader
    Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada
    Fam Cancer 7:73-82. 2008
    ....
  66. ncbi Origins and prevalence of the American Founder Mutation of MSH2
    Mark Clendenning
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 68:2145-53. 2008
    ..The consequences of this finding would be that the AFM is significantly more frequent in the United States than was previously predicted...
  67. ncbi AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
    ..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
  68. ncbi Genotype/phenotype of familial pancreatic cancer
    Randall E Brand
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, and Section of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingsten Road, Glenview, IL 60026, USA
    Endocrinol Metab Clin North Am 35:405-15, xi. 2006
    ..The aim of this article is to review the challenges in identifying pancreatic cancer-prone families and how environmental factors interact with genetic factors in these families...
  69. ncbi Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
    ....
  70. ncbi MYC is amplified in BRCA1-associated breast cancers
    Tatyana A Grushko
    Section of Hematology Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, Chicago, Illinois 60637 1463, USA
    Clin Cancer Res 10:499-507. 2004
    ....
  71. ncbi Genetic factors and colorectal cancer in Ashkenazi Jews
    Gershon Y Locker
    Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Fam Cancer 3:215-21. 2004
    ....
  72. ncbi The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers
    Kelly A Metcalfe
    Faculty of Nursing, University of Toronto, 50 St George Street, Toronto, ON, Canada, M5S 3H4
    Gynecol Oncol 96:222-6. 2005
    ..To estimate the risk of ovarian cancer after a primary diagnosis of breast cancer among women with a BRCA1 or BRCA2 mutation and to identify host and treatment-related factors that might modify the risk...
  73. ncbi Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene
    David J Hughes
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 117:230-3. 2005
    ....
  74. ncbi Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study
    Andrea Eisen
    Toronto Sunnybrook Regional Cancer Center, Toronto, ON, Canada
    J Clin Oncol 23:7491-6. 2005
    ....
  75. ncbi Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Am J Gastroenterol 98:664-70. 2003
    ....
  76. ncbi Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    N Engl J Med 346:1616-22. 2002
    ..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...
  77. ncbi BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations
    Sophie M Ginolhac
    Centre National de la Recherche Scientifique, UMR 5641, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:90-5. 2003
    ..27)...
  78. ncbi Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein
    Tiina E Raevaara
    Division of Genetics, Department of Biosciences, University of Helsinki, Helsinki, Finland
    Gastroenterology 125:501-9. 2003
    ..CONCLUSIONS: Our results suggest that the pathogenicity of hMLH1 del616 is not linked to nonfunctionality, but to shortage of the functional protein...
  79. ncbi Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  80. ncbi Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancer
    Jeremy Z Fields
    CA*TX Inc, Gladwyne, Pennsylvania, USA
    J Lab Clin Med 143:59-66. 2004
    ....
  81. ncbi The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers
    Susan Colilla
    Department of Biostatistics and Epidemiology and Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 27:599-605. 2006
    ....
  82. ncbi Molecular screening for the Lynch syndrome--better than family history?
    Henry T Lynch
    N Engl J Med 352:1920-2. 2005
  83. ncbi Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, University of Toronto, Women s College Hospital, 790 Bay Street, 7th Floor, Totonto, Ontario M5G 1N8, Canada
    Cancer Causes Control 16:667-74. 2005
    ..46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation...
  84. ncbi Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Room 750, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada
    Breast Cancer Res Treat 105:221-8. 2007
    ..Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective...
  85. ncbi Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:7804-10. 2005
    ..Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT...
  86. ncbi Clinical implications of advances in the molecular genetics of colorectal cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68179, USA
    Tumori 81:19-29. 1995
    ..It is now important for physicians to take careful cancer family histories so that this disorder can be readily identified, thereby enabling the initiation of highly targeted surveillance and management programs...
  87. ncbi Multicenter experience with upper gastrointestinal polyps in pediatric patients with familial adenomatous polyposis
    Thomas M Attard
    Department of Pediatrics, The University of Nebraska Medical Center, Omaha, NE 68198-5160, USA
    Am J Gastroenterol 99:681-6. 2004
    ..Patients with APC mutation between codon 1225-1694 may be more susceptible to aggressive gastroduodenal involvement in FAP...
  88. ncbi The FAMMM syndrome: epidemiology and surveillance strategies
    R M Fusaro
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, University Nebraska Medical Center, Omaha, USA
    Cancer Invest 18:670-80. 2000
    ....
  89. ncbi Genetic counseling and testing for germline p16 mutations in two pancreatic cancer-prone families
    H T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Gastroenterology 119:1756-60. 2000
    ..Our experience highlights limited options for managing these families and emphasizes the need for better tools to diagnose pancreatic cancer at a curable stage...
  90. ncbi Cancer risk in mismatch repair gene mutation carriers
    P Watson
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 1:57-60. 2001
    ..Prevention strategies depend on estimates of age-specific risk. Clearly, multicenter studies to obtain such estimates are needed...
  91. ncbi Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer
    P Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Med Genet 40:591-6. 2003
    ..In hereditary cancer syndrome families with an identified cancer associated mutation, mutation testing changes the carrier risk status of the tested person and may change the carrier risk status of relatives...
  92. ncbi Familial adenomatous polyposis and extracolonic cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine Omaha, Nebraska 68178, USA
    Dig Dis Sci 46:2325-32. 2001
    ..We conclude that, due in part to improved longevity as a result of being spared CRC, several family members have developed certain FAP integral extracolonic cancers...
  93. ncbi The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer
    P Watson
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Gynecol Oncol 82:223-8. 2001
    ..HNPCC patients with ovarian cancer are more likely to have a synchronous endometrial cancer than other ovarian cancer patients and are more likely to be diagnosed at an early stage...
  94. ncbi Psychological aspects of monitoring high risk women for breast cancer
    H T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178
    Cancer 74:1184-92. 1994
    ..CONCLUSIONS. All accounts agree with the need to devote more research to the special needs--psychological, social, insurance, and general public health measures--of these high risk women...
  95. ncbi E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma
    H T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 122:1-6. 2000
    ..Emotional stress in at-risk patients, the limited knowledge of the mutation's penetrance, and limitations of available screening mandate patient-centered genetic counseling...
  96. ncbi Genetic and immunopathological findings in a lymphoma family
    H T Lynch
    Department of Preventive Medicine Public Health, Creighton University School of Medicine, Omaha, NE 68178
    Br J Cancer 59:622-6. 1989
    ..The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas...

Research Grants6

  1. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  2. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2007
    ..b. a study to evaluate the acceptability of hypothetical biomarkers among high risk and average risk individuals and primary health care providers. ..