Research Topics
| T B CasaleSummaryAffiliation: Creighton University Country: USA Publications
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Publications
Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophilsHenry Lin
Division of Allergy/Immunology, Department of Medicine, Creighton University, Omaha, Neb, USA
J Allergy Clin Immunol 113:297-302. 2004....- Clinical implications of the allergic rhinitis-asthma linkThomas B Casale
Department of Medicine, Creighton University, Omaha, Nebraska, USA
Am J Med Sci 327:127-38. 2004..The roles of various therapies for dually afflicted patients are evaluated, including topical corticosteroids, antihistamines, leukotriene modifiers, anti-immunoglobulin E monoclonal antibody, theophylline, and immunotherapy... - Asthma: imaging of the smaller airwaysThomas B Casale
Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
Postgrad Med 113:13-4. 2003..Assessment of air trapping in small airways may have diagnostic value, distinguishing those patients who are likely to experience frequent asthmatic exacerbations... - The pathophysiology of small airway inflammation in asthmaThomas B Casale
Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
Postgrad Med 113:7-12. 2003..Inflammatory activity in the distal lung of patients may actually exceed that of the large airways. Anatomic changes in small airways are prominent in cases of fatal asthma... - IntroductionThomas B Casale
Creighton University, Omaha, NE 68131, USA
Postgrad Med 113:5-6. 2003..Corticosteroids delivered by the inhaled route have fulfilled that purpose, and they continue as the mainstay of controller therapy for persistent asthma.1... - Nasal carbon dioxide for the symptomatic treatment of perennial allergic rhinitisThomas B Casale
Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA
Ann Allergy Asthma Immunol 107:364-70. 2011..Brief nasal carbon dioxide insufflation has previously been shown to provide rapid relief of the symptoms of allergic rhinitis... - Immunomodulators for allergic respiratory disordersThomas B Casale
Department of Medicine, Division of Allergy Immunology, Creighton University, Omaha, NE 68131, USA
J Allergy Clin Immunol 121:288-96; quiz 297-8. 2008..The goal of this review is to summarize the data from human clinical trials with immunomodulators, discussing the rationale for their use, efficacy results, and putative adverse events associated with them... - Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitisThomas B Casale
Creighton University School of Medicine, Omaha, NE 68131, USA
J Allergy Clin Immunol 117:134-40. 2006..Rush immunotherapy (RIT) presents an attractive alternative to standard immunotherapy. However, RIT carries a much greater risk of acute allergic reactions, including anaphylaxis... - Intranasal noninhaled carbon dioxide for the symptomatic treatment of seasonal allergic rhinitisThomas B Casale
Division of Allergy and Immunology, Department of Medicine, Creighton University, Omaha, NE 68131, USA
J Allergy Clin Immunol 121:105-9. 2008..Intranasal CO2 might inhibit trigeminal neuronal activation and suppress the release of calcitonin gene-related peptide... - Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitisThomas B Casale
Division of Allergy and Immunology, Department of Internal Medicine, Creighton University, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 97:454-6. 2006..CRX-675 is an aqueous formulation of a toll-like receptor 4 agonist and an inducer of TH1 responses. Studies in allergic dogs showed that pretreatment with CRX-675 reduced nasal congestion induced by allergen challenge... - Small airway asthma therapy, challenges, and the futureThomas B Casale
Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
Postgrad Med 113:15-20. 2003..By extending the delivery of this medication to the peripheral lung and by increasing the efficiency of lung targeting, these new corticosteroid formulations provide more effective treatment at reduced drug doses... - Budesonide Turbuhaler delivered once daily improves health-related quality of life and maintains improvements with a stepped-down dose in adults with mild to moderate asthmaThomas B Casale
Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 90:323-30. 2003..Budesonide inhalation powder administered via Turbuhaler (budesonide Turbuhaler, AstraZeneca LP, Wilmington, DE) is proven efficacious and safe in the treatment of mild to severe asthma... - Recommendations for appropriate sublingual immunotherapy clinical trialsThomas B Casale
Creighton University, Omaha, Neb 68131, USA
J Allergy Clin Immunol 124:665-70. 2009.... - Clinical importance of identifying immunoglobulin E-mediated disease in patients with asthmaThomas B Casale
Allergy Immunology, Creighton University, Omaha, Nebraska, USA
Clin Cornerstone 9:20-9. 2009..These data also suggest that when clinicians participate in education about the role of IgE in asthma and begin testing their patients for allergy, the recognition of allergies among patients with asthma dramatically increases... - Anti-immunoglobulin E (omalizumab) therapy in seasonal allergic rhinitisT B Casale
Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
Am J Respir Crit Care Med 164:S18-21. 2001..With adequate dosing, nasal and ocular symptoms are significantly reduced, and quality of life is significantly improved. Omalizumab is safe and well tolerated and can be safely readministered in subsequent pollen seasons... - Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patientsT B Casale
Department of Medicine Creighton University, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 87:379-85. 2001..Suppression of the hypothalamic-pituitary-adrenal (HPA) axis, a potential systemic effect of inhaled corticosteroid therapy, can be quantified by monitoring serum, urinary, and salivary cortisol levels... - Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trialT B Casale
Department of Medicine, Creighton University, Omaha, NE, USA
JAMA 286:2956-67. 2001..A recombinant humanized monoclonal anti-IgE antibody (omalizumab) forms complexes with free IgE, blocking its interaction with mast cells and basophils and lowering free IgE levels in the circulation... - Future forms of immunotherapyThomas B Casale
Division of Allergy Immunology, Creighton University, Omaha, Neb 68131, USA
J Allergy Clin Immunol 127:8-15; quiz 16-7. 2011..One thing is clear: the next century of immunotherapy will be vastly different from today's current standard of care... - First do no harm: managing antihistamine impairment in patients with allergic rhinitisThomas B Casale
Creighton University, School of Medicine, Omaha, NE 68131, USA
J Allergy Clin Immunol 111:S835-42. 2003..In addition, further epidemiologic studies on the effects of antihistamines should be performed... - Allergy immunotherapy for primary care physiciansJeffrey R Stokes
Creighton University, Division of Allergy Immunology, Department of Medicine, Omaha, Neb 68131, USA
Am J Med 119:820-3. 2006..Even with newer therapies on the horizon, allergen immunotherapy will continue to have an important role in the treatment of allergic diseases... - Anti-immunoglobulin E monoclonal antibody administered with immunotherapyKevin W Parks
Division of Allergy and Immunology, Department of Internal Medicine, Creighton University, Omaha, Nebraska 68131, USA
Allergy Asthma Proc 27:S33-6. 2006..Results thus far provide the opportunity to develop strategies using omalizumab pretreatment to enhance the safety and efficacy of allergen-immunotherapy to treat a wide variety of allergic diseases... - The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthmaWilliam W Busse
Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
J Allergy Clin Immunol 121:1167-74. 2008.... - Rationale for new treatments aimed at IgE immunomodulationJeffrey Stokes
Division of Allergy/Immunology, Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 93:212-7; quiz 217-9, 271. 2004..CONCLUSIONS: Newer therapies hold great promise for the future treatment of allergic respiratory diseases, but clinical trials are necessary to accurately evaluate risk-benefit ratios of IgE immunomodulators... - Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadineDouglas H Jones
Division of Allergy, Asthma, and Immunology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 100:452-6. 2008..Second- and third-generation histamine1-antihistamines are generally devoid of these adverse effects but are typically not used because of a perceived slower onset of action... - Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trialLee E Morrow
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Creighton University School of Medicine, Omaha, Nebraska, USA
Am J Respir Crit Care Med 182:1058-64. 2010..It is unknown whether probiotic modification of the upper aerodigestive flora can reduce nosocomial infections... - Omalizumab in asthma: approval and postapproval experienceDean T Chiang
Division of Allergy and Immunology, Creighton University Medical Center, Omaha, NE, USA
Clin Rev Allergy Immunol 29:3-16. 2005..Postmarketing surveillance has shown omalizumab to be a relatively safe and well-tolerated medication... - A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroidsHarold S Nelson
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Clin Pharmacol 42:319-26. 2002..Because it is noninvasive, salivary cortisol measurement offers distinct advantages as a screening method for detecting pronounced HPA axis suppression in asthma patients receiving corticosteroid therapy... - Ragweed skin test responsiveness correlates with specific immunoglobulin E levelsJeffrey Stokes
Division of Allergy/lmmunology, Department of Medicine, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
Allergy Asthma Proc 26:103-7. 2005..Skin test responsiveness to ragweed correlated with in vitro ragweed-specific IgE levels, but these tests are not equivalent indicators of the degree of IgE-mediated sensitivity... - Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivityWilliam W Busse
Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
Ann Allergy Asthma Immunol 96:60-8. 2006..Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluated in the subpopulation of asthmatic patients with seasonal asthma symptoms... - Time-dependent effects of inhaled corticosteroids on lung function, bronchial hyperresponsiveness, and airway inflammation in asthmaVinay Mehta
Allergy, Asthma and Immunology Associates, PC, Lincoln, Nebraska, USA
Ann Allergy Asthma Immunol 103:31-7. 2009..Exhaled nitric oxide (F(ENO)) and exhaled breath condensate (EBC) are noninvasive markers that directly measure airway inflammation and may potentially be useful in assessing asthma control and response to therapy... - Anti-IgE therapyJaine Brownell
Division of Allergy and Immunology, Department of Medicine, Creighton University School of Medicine, 601 North 30th Street Suite 5850 Omaha, NE 68131, USA
Immunol Allergy Clin North Am 24:551-68, v. 2004..The primary mechanism of action of anti-IgE therapy is the reduction in serum levels of IgE and FcepsilonRI expression on mast cells and basophils... - Safety and efficacy of olopatadine hydrochloride nasal spray 0.6% in pediatric subjects with allergic rhinitisWilliam E Berger
Department of Pediatrics, Division of Allergy and Immunology, University of California, Irvine, California, USA
Allergy Asthma Proc 30:612-23. 2009..In subjects 6 to <12 years of age, OLO was superior to vehicle in the treatment of SAR. In subjects 2 to <12 years of age, OLO had an overall low rate of AEs and low systemic exposure... - Experience with monoclonal antibodies in allergic mediated disease: seasonal allergic rhinitisT B Casale
Creighton University, Omaha, Nebraska 68231, USA
J Allergy Clin Immunol 108:S84-8. 2001..Furthermore, subcutaneous or intravenous administration of omalizumab does not invoke the generation of anti-omalizumab antibodies. Thus, omalizumab represents a novel agent that should assist in the treatment of allergic rhinitis... - Pediatric allergic rhinitis: treatmentLien Lai
Department of Medicine, Creighton University Medical Center, 601 North 30th Street, Suite 5850, Omaha, NE 68131 USA
Immunol Allergy Clin North Am 25:283-99, vi. 2005..Immunotherapy generally is reserved for patients unresponsive to therapy or unable to take medications... - Omalizumab in the treatment of allergic respiratory diseaseJustin Clark
Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA
J Asthma 43:87-93. 2006 - Expression and function of a novel variant of estrogen receptor-?36 in murine airwaysShuping Jia
Department of Medicine, Creighton University Medical Center, Omaha, NE 68131, USA
Am J Respir Cell Mol Biol 45:1084-9. 2011..The identification and localization of specific estrogen receptor subtypes in the lung could lead to newer therapeutic avenues aimed at addressing sex differences of asthma susceptibility... - The role of vitamin D in asthmaManbir S Sandhu
Creighton University, Department of Medicine, Division of Allergy and Immunology, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 105:191-9; quiz 200-2, 217. 2010..To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency... - Treatment of allergic asthmaHenry Lin
Division of Allergy/Immunology, Department of Medicine, Creighton University, Omaha, Nebraska, USA
Am J Med 113:8S-16S. 2002..In patients with asthma and concomitant allergic rhinitis, antihistamines may be useful as adjunctive therapy... - Managing impairment in patients with allergic rhinitisJeffrey Stokes
Division of Allergy/Immunology, Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
Allergy Asthma Proc 27:12-6. 2006..Second-generation antihistamines are the preferred medication when antihistamines are necessary... - Necrotizing pneumonia with a questionable lung mass in a 59-year-old manJaine Brownell
Department of Medicine, Division of Allergy and Immunology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 96:116-21. 2006 - Omalizumab: an effective anti-IgE treatment for allergic asthma and rhinitisThomas B Casale
Medical Information Department, Prous Science, Provença 388, 08025 Barcelona, Spain
Drugs Today (Barc) 40:367-76. 2004..Omalizumab has a good safety profile, with only mild to intermediate drug-related adverse events... - Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen bindingSven Klunker
Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, United Kingdom
J Allergy Clin Immunol 120:688-95. 2007..One proposed mechanism of immunotherapy is to induce regulatory antibodies that inhibit facilitated antigen presentation... - Omalizumab treatment downregulates dendritic cell FcepsilonRI expressionCalman Prussin
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Allergy Clin Immunol 112:1147-54. 2003..CONCLUSION: These results demonstrate that anti-IgE therapy causes a rapid decrease in DC surface FcepsilonRI expression and establish that IgE is an important regulator of FcepsilonRI expression by DCs... - Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park studyEli O Meltzer
Allergy and Asthma Medical Group and Research Center, San Diego, California, USA
Ann Allergy Asthma Immunol 90:79-86. 2003..Patients with allergic rhinitis have a wide range of symptoms that are often treated with oral combination products that contain antihistamines, decongestants, and analgesics... - Sublingual immunotherapy and subcutaneous immunotherapy: issues in the United StatesPaul A Greenberger
J Allergy Clin Immunol 120:1466-8. 2007 - Guidelines for treatment of pediatric asthmaThomas B Casale
JAMA 299:2855; author reply 2855. 2008 - Next generation antihistamines: therapeutic rationale, accomplishments and advancesJohn J Oppenheimer
University of Medicine and Dentistry, Pulmonary and Allergy Associates, New Jersey Medical School, 101 Madison Avenue, Morristown, NJ 07960-7305 USA
Expert Opin Investig Drugs 11:807-17. 2002..The clinical benefit of these newer oral antihistamines will clearly help improve the quality of life of patients with chronic allergies... - Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normalHisatoshi Sugiura
Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
Am J Respir Cell Mol Biol 37:424-30. 2007..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma... - Identifying and managing rhinitis and its subtypes: allergic and nonallergic components--a consensus report and materials from the Respiratory & Allergic Disease FoundationMervat Nassef
Curr Med Res Opin 22:2541-8. 2006..CONCLUSION: The use of these clinical practice tools may improve the management of rhinitis by helping clinicians to identify both the allergic and nonallergic components of a patient's disease and choose an appropriate treatment... - Asthma quality-of-care measures using administrative data: relationships to subsequent exacerbations in multiple databasesMichael Schatz
American Academy of Allergy, Asthma and Immunology and American College of Allergy, Asthma and Immunology Joint Quality Measures Task Force, USA
Ann Allergy Asthma Immunol 101:235-9. 2008 - Status of immunotherapy: current and futureThomas B Casale
J Allergy Clin Immunol 113:1036-9. 2004