Kannan Sivaprakasam

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation
    Kannan Sivaprakasam
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, 14853 2703, USA
    Curr Med Chem 13:2179-88. 2006
  2. ncbi Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors
    ONE R PAGAN
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Neurosci Res 85:2943-9. 2007
  3. ncbi Minimal RNA aptamer sequences that can inhibit or alleviate noncompetitive inhibition of the muscle-type nicotinic acetylcholine receptor
    Kannan Sivaprakasam
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    J Membr Biol 233:1-12. 2010

Collaborators

  • ONE R PAGAN
  • Robert E Oswald

Detail Information

Publications3

  1. ncbi Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation
    Kannan Sivaprakasam
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, 14853 2703, USA
    Curr Med Chem 13:2179-88. 2006
    ..For the first time, a coherent view of amyloid aggregation is presented in this review. The possible role of neuroinflammatory response in the events leading to the degeneration of cholinergic neurons is also discussed...
  2. ncbi Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors
    ONE R PAGAN
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Neurosci Res 85:2943-9. 2007
    ..The predicted values of IC(50) correlated well with the published results both for neuronal and for electroplaque-desensitized nAChR, suggesting that the results can be generalized to include neuronal nAChRs...
  3. ncbi Minimal RNA aptamer sequences that can inhibit or alleviate noncompetitive inhibition of the muscle-type nicotinic acetylcholine receptor
    Kannan Sivaprakasam
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    J Membr Biol 233:1-12. 2010
    ..We demonstrate that a truncated class I aptamer containing a sequence of seven nucleotides inhibits the nAChR and that a truncated class II aptamer containing a sequence of only four nucleotides can alleviate MK-801 inhibition...