M Febbraio

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein
    R Simantov
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Matrix Biol 24:27-34. 2005
  2. ncbi A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    M Febbraio
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 274:19055-62. 1999
  3. ncbi Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
  4. ncbi Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis
    A C Nicholson
    Center of Vascular Biology, Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 947:224-8. 2001
  5. ncbi The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36
    M Febbraio
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021 4896, USA
    Mol Cell Biochem 239:193-7. 2002
  6. ncbi Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1
    R Simantov
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 107:45-52. 2001
  7. ncbi CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL
    J Husemann
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 21:1301-5. 2001
  8. ncbi Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation
    L Teboul
    INSERM U470, Centre de Biochimie, Parc Valrose, UFR Sciences, Universite de Nice Sophia Antipolis, 06108 Nice, France
    Biochem J 360:305-12. 2001
  9. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000
  10. ncbi CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart
    V Bodart
    Faculty of Pharmacy and Department of Pharmacology, Universite de Montreal, Montreal, Canada
    Circ Res 90:844-9. 2002

Collaborators

  • K Sharma
  • R Simantov
  • J D Smith
  • J Han
  • T Kodama
  • Stanley Hazen
  • L Teboul
  • R L Silverstein
  • V Bodart
  • J Husemann
  • A C Nicholson
  • C T Coburn
  • B Jimenez
  • E Escher
  • P Pohankova
  • H Ong
  • T Sejlitz
  • A Perreault
  • D Lamontagne
  • A Demers
  • N McNicoll
  • D P Hajjar
  • A Obstfeld
  • R L Silversterin
  • S C Silverstein
  • A L Beets
  • N Bouck
  • O V Volpert
  • S E Crawford
  • F F Knapp
  • N A Abumrad

Detail Information

Publications11

  1. ncbi The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein
    R Simantov
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Matrix Biol 24:27-34. 2005
    ..These data suggest that modulation of the TSR/CD36 system may play an important role in the regulation of the angiogenic "switch," and may provide a target for therapeutic interventions...
  2. ncbi A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    M Febbraio
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 274:19055-62. 1999
    ..The data provide evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated...
  3. ncbi Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  4. ncbi Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis
    A C Nicholson
    Center of Vascular Biology, Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 947:224-8. 2001
    ..The mechanism by which OxLDL upregulates CD36 involves activation of the transcription factor, PPAR-gamma...
  5. ncbi The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36
    M Febbraio
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021 4896, USA
    Mol Cell Biochem 239:193-7. 2002
    ..As these in vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36...
  6. ncbi Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1
    R Simantov
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 107:45-52. 2001
    ..These studies suggest that HRGP can modulate the antiangiogenic activity of TSP-1, and identify a potential mechanism of resistance to the antiangiogenic effect of TSP-1...
  7. ncbi CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL
    J Husemann
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 21:1301-5. 2001
    ..It may play a hitherto-unsuspected role in regulating macrophage signaling pathways involved in inflammation and atherogenesis...
  8. ncbi Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation
    L Teboul
    INSERM U470, Centre de Biochimie, Parc Valrose, UFR Sciences, Universite de Nice Sophia Antipolis, 06108 Nice, France
    Biochem J 360:305-12. 2001
    ..We conclude that murine FAT/CD36 expression in adipose tissue is dependent upon transcriptional activation via PPARs through binding to two PPREs located at -245 to -233 bp and -120 to -108 bp from the transcription start site...
  9. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000
    ..The membrane transport step may represent an important control site for fatty acid metabolism in vivo...
  10. ncbi CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart
    V Bodart
    Faculty of Pharmacy and Department of Pharmacology, Universite de Montreal, Montreal, Canada
    Circ Res 90:844-9. 2002
    ..These data suggest that CD36 may mediate the coronary vasospasm seen in hypercholesterolemia and atherosclerosis...
  11. ncbi Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    B Jimenez
    Department of Microbiology, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
    Nat Med 6:41-8. 2000
    ..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells...