N Altorki

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..This proof-of-concept study examined safety and efficacy of short-term, preoperative pazopanib monotherapy in patients with operable stage I/II NSCLC...

..In this retrospective study, the impact of total nodal count on overall survival in esophageal cancer was examined using a single institution surgical database...

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..To determine the impact of radical node dissection on the recurrence patterns and survival rates of patients with carcinoma of the esophagus...

..End points were toxicity, response rates, and measurement of intratumoral levels of prostaglandin E2 (PGE2)...

..This article examines the rationale,technique, and results of radical esophagectomy, including two-field and three-field lymph node dissection...

..Only in this way will we be able to determine the clinical and molecular characteristics of these lesions and thus hopefully gain insight into their clinical relevance...

..As the US population ages, clinicians are increasingly confronted with octogenarians with resectable non-small cell lung cancer. Earlier reports documented substantial risk for surgical resection in this age group...

..The primary objective of this study was to determine the rate of pathological response after preoperative celecoxib and concurrent taxane-based chemotherapy in patients with cancer of the esophagus and gastroesophageal junction...

..The predominantly focal expression of MAGE-1 suggests that this antigen might not be sufficient as a sole target for immunotherapeutic approaches...

..With the baseline results having been reported previously, the focus of the current study was on the early results of the repeat screenings...

..This regimen may be especially suitable for patients with epidermoid cancer, who had a 25% pathological complete response in this report...

..CONCLUSION: Baseline CT screening for lung cancer provides for detecting the disease at earlier and presumably more commonly curable stages in a cost-effective manner...

..These data suggest that computed tomographic screening may be of value in improving the survival of patients with non-small cell lung cancer...

..These observations will lead to a better understanding of the pathogenesis of esophageal adenocarcinoma and might contribute to enhancing the diagnostic accuracy when presented with dysplastic lesions...

..Consistent with prior observations for COX-2, these data suggest that both cellular transformation and cytokines contribute to the up-regulation of mPGES in NSCLC...

..In cases without p53 mutation, overexpression of mdm-2 occurred in 50% of cases and might be responsible for stabilization of p53 protein and possible loss of tumor suppressor function...

..Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors...

..The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low-radiation-dose computed tomography (low-dose CT) in people at high risk of lung cancer. We report the baseline experience...

..However, the optimal treatment for traumatic patients is unclear. We wanted to examine the outcomes of patients with high output or recurrent chylothorax who were treated by surgical means...

..Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway...

..A discussion follows of the meaning of the results and possible future screening protocols...

..The data also underscore the important role of fibroblast growth factors in tumorigenesis...

..The coexpression pattern of these antigens provides a foundation for developing a polyvalent lung cancer vaccine...

..There is great variability in NY-ESO-1 expression in individual tumors, ranging from an infrequent homogeneous pattern of staining to highly heterogeneous antigen expression...

..CONCLUSIONS: Reflux of duodenal contents into the esophagus led to increased COX-2 expression and mucosal thickening. Bile acids are likely to contribute to these effects...

..Although paraneoplastic neurological syndromes have been associated with several SCLC antigens, neurological symptoms have not been observed in patients with anti-SOX or anti-ZIC2 antibodies...

..Considering the high frequency of 3p21 alterations in lung cancer and the fact that the tumor suppressor gene or genes in this locus have not been identified, additional studies on the NY-LU-12 gene and its product are warranted...

..This refinement may help to better clarify which patients might benefit from novel adjuvant or neoadjuvant therapeutic interventions...

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..The purpose of this study was to determine the incidence and clinical significance of intrathoracic manifestations of cervical anastomotic leaks after transthoracic esophagectomy...

..CONCLUSIONS: Surveillance with postoperative CT may be a cost-effective intervention to detect SPLC in selected patients with previously resected stage IA NSCLC...

..To determine the frequency and natural course of mediastinal masses in asymptomatic people at high risk for lung cancer who were undergoing computed tomographic (CT) screening...

..CONCLUSION: Positron emission tomographic scanning has no demonstrable benefit in the diagnosis, staging, or prognosis of patients with tumors of 2 cm or less in size...

..We asked whether cancer-testis gene expression occurred coordinately, and whether it correlated with variables of disease and clinical outcome of non-small cell lung cancer (NSCLC)...

..This enhanced survival is comparable to survival rates reported in complete pathologic responders after neoadjuvant chemoradiation...

..This multicenter, phase II, randomized trial investigated efficacy and safety of irinotecan and docetaxel and irinotecan and gemcitabine, with or without CBX, in second-line treatment of NSCLC...

..In this study, we sought to determine the impact of multifocal, intralobar non-small cell lung cancer (NSCLC) on patient survival and its potential relevance to stage designation...

..Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship in esophageal cancer...

..These data provide an immunological rationale for vaccine design in light of recently reported favorable clinical responses in NSCLC patients after vaccination with MAGE-A3 protein plus adjuvant AS02B...

..We found by ELISA that PLAC1 is immunogenic in a subset of cancer patients and healthy women. Its physical and expression characteristics render it a potential target for both active and passive cancer immunotherapeutic strategies...

..This study assessed the predictive accuracy of clinical response (CR) and positron emission tomography (PET) scanning in determining pathological downstaging and disease free survival (DFS) after chemotherapy...

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..The goal of this study was to analyze the risk factors for occult mediastinal metastases in this subset of patients...

..CONCLUSION: Eighty-one percent of patients with resected non-small cell lung cancer measuring 1 cm or less had stage IA disease. After surgical resection, recurrence is rare and long-term survival is excellent...

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..VATS or thoracotomy are rarely necessary for a diagnosis of lung cancer in the CT-detected small pulmonary nodule...

..This development provides the framework for further evaluating integrated immune responses in vaccine settings and for optimizing these responses for clinical benefit...

..CONCLUSIONS: Positron emission tomography scanning does not reliably predict pathologic response to preoperative chemotherapy in NSCLC in either the primary tumor or the draining lymph nodes...

..0 cm and 63.4% (95% CI, 49.6 to 77.1%) for patients with tumors > 2.0 cm. CONCLUSIONS: These data suggest that size within stage IA is an important predictor of survival and that further substaging should be considered...

..However, in the setting of a ruptured thoracic aneurysm, one may not have the luxury of complex end-organ support. We analyzed our experience with ruptured thoracic aneurysms to define morbidity and mortality in the present era...

..Recent work on low-dose helical CT, however, has renewed interest in the challenge of detecting early-stage lung cancer...

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..65), as important prognostic variables. CONCLUSIONS: Surgical resection may be a viable option for patients with residual N2 disease after induction chemotherapy, provided an R0 resection can be performed...

..We also sought to determine whether resectable metachronous lung cancer can be detected with surveillance scans...

..Importantly, these results clearly show that levels of a pharmacologic target (i.e., COX-2) can be affected by both the intrinsic molecular properties of a tumor and therapy...

..These findings need to be confirmed in larger studies. More sophisticated technology continues to be developed for imaging carcinoma of the esophagus, which will more than likely affect staging algorithms in the future...

..Patients who have neurologic signs or symptoms should undergo a brain imaging study (CT or MRI). --Screening for extrathoracic disease is not necessary in asymptomatic patients who have clinical stage I or II disease...

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..05). Taken together, these results support a role for CYP1B1 in TS-induced carcinogenesis in the aerodigestive tract...

..For the majority of these early stage patients, standard lobectomy is the treatment of choice. New options to potentially detect and treat early stage lung cancer will increase dramatically in the future...

..To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans...

..A small but carefully selected group of patients may be treated successfully without operation. Esophagectomy should be reserved for patients with carcinoma or extensive necrosis of the esophagus...

..He underwent successful resection using a computer-enhanced robotic surgical system. This case is an example of the continued extension of robotic-assisted thoracic surgery...

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..Moreover, these findings strengthen the rationale for determining whether inhibitors of COX-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract...

..My colleagues and I describe a simple approach for the definitive management of the open pleural space involving split-thickness skin grafts to marsupialize the pleural cavity...

..Typically, the lesion presents in the extremities or the head and neck. We present an unusual case of proliferative myositis with involvement of the anterior chest wall...