Dawn S Chandler

Summary

Affiliation: Columbus Children's Research Institute
Country: USA

Publications

  1. ncbi Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    Dawn S Chandler
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Cancer Res 66:9502-8. 2006
  2. ncbi Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress
    Ravi K Singh
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Exp Cell Res 315:3419-32. 2009
  3. ncbi Intron 7 conserved sequence elements regulate the splicing of the SMN genes
    Jordan T Gladman
    The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Hum Genet 126:833-41. 2009
  4. ncbi Splicing regulation of the survival motor neuron genes and implications for treatment of spinal muscular atrophy
    Thomas W Bebee
    The Molecular, Cellular, and Developmental Biology MCDB Graduate Program, The Ohio State University, Columbus, Ohio, USA
    Front Biosci 15:1191-204. 2010
  5. ncbi MDM2 and MDM4 splicing: an integral part of the cancer spliceome
    Selvi Jeyaraj
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Front Biosci 14:2647-56. 2009
  6. ncbi A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype
    Jordan T Gladman
    Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Hum Mol Genet 19:4239-52. 2010
  7. ncbi Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement
    Thomas W Bebee
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, and the Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Genesis 49:927-34. 2011
  8. ncbi High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis
    Steven T Lott
    Department of Molecular Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Cancer Res 62:1952-5. 2002
  9. ncbi Direct repression of splicing by transformer-2
    Dawn S Chandler
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cell Biol 23:5174-85. 2003

Collaborators

  • Jordan T Gladman
  • Guillermina Lozano
  • Thomas W Bebee
  • Selvi Jeyaraj
  • Ravi K Singh
  • Steven T Lott
  • Dennis M O'Brien
  • Aixa Tapia-Santos
  • Mercedes Lovell
  • Carolyn J Foster
  • Marsha Frazier
  • Adel El-Naggar
  • Ann McNeill Killary
  • Louise C Strong
  • Steven A Curley

Detail Information

Publications9

  1. ncbi Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    Dawn S Chandler
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Cancer Res 66:9502-8. 2006
    ..A stepwise model for malignant conversion by which alternate forms of MDM2 and MDM4 place selective pressure on the cells to acquire additional alterations in the p53 pathway is herein proposed...
  2. ncbi Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress
    Ravi K Singh
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Exp Cell Res 315:3419-32. 2009
    ..This study has implications for identification of novel intervention points for development of future therapeutics for rhabdomyosarcoma...
  3. ncbi Intron 7 conserved sequence elements regulate the splicing of the SMN genes
    Jordan T Gladman
    The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Hum Genet 126:833-41. 2009
    ..A better understanding of the way SMN premRNA is spliced can lead to the development of new therapies...
  4. ncbi Splicing regulation of the survival motor neuron genes and implications for treatment of spinal muscular atrophy
    Thomas W Bebee
    The Molecular, Cellular, and Developmental Biology MCDB Graduate Program, The Ohio State University, Columbus, Ohio, USA
    Front Biosci 15:1191-204. 2010
    ..As therapeutics targeted toward correction of SMN2 splicing continue to be developed available SMA mouse models can be utilized in validating their potential in disease treatment...
  5. ncbi MDM2 and MDM4 splicing: an integral part of the cancer spliceome
    Selvi Jeyaraj
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Front Biosci 14:2647-56. 2009
    ..Although various transcripts have been described for both proteins, here we provide a precise catalog of the alternatively spliced transcripts of both genes and the cancers with which they are associated...
  6. ncbi A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype
    Jordan T Gladman
    Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Hum Mol Genet 19:4239-52. 2010
    ..This Smn C>T mouse represents a new model for an adult onset form of SMA (type III/IV) also know as the Kugelberg-Welander disease...
  7. ncbi Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement
    Thomas W Bebee
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, and the Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Genesis 49:927-34. 2011
    ..Our temporally inducible SMN transgene is able to express SMN in embryonic, neonatal, and weanling mice and as such can be utilized in severe and mild SMA mouse models to identify the therapeutic window for SMN replacement...
  8. ncbi High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis
    Steven T Lott
    Department of Molecular Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Cancer Res 62:1952-5. 2002
    ..A stepwise model for malignant conversion in VHL disease is herein proposed...
  9. ncbi Direct repression of splicing by transformer-2
    Dawn S Chandler
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cell Biol 23:5174-85. 2003
    ..Although required for repression, the element also enhances M1 splicing in the absence of Tra2. We propose that Tra2 represses M1 splicing by interacting with multiple sequences in the pre-mRNA and interfering with enhancer function...