RODNEY J ROTHSTEIN

..Here we describe ScreenMill, a new software suite that automates image analysis and simplifies data review and analysis for high-throughput biological experiments...

..These processes all contribute to the timing of Rad52 recruitment, its stability and function. Here, we summarize the regulatory events affecting the Rad52 protein and discuss how this regulation impacts DNA repair and cell survival...

..These approaches are general and the insights that we gain and the methods that we develop will not be confined to yeast alone, but will be applicable to many cellular systems. ..

..In addition, the approach outlined here is applicable to other tissue types and it is anticipated that this research will lead to further study of other human tumors. ..

..Expression of the target gene will be knocked down by siRNA to determine the effect on cell viability. ..

..These approaches are general and the insights that we gain and the methods that we develop will not be confined to yeast alone, but will be applicable to many cellular systems. ..

..These combined genetic and cell biological approaches to the many issues related to the recognition and repair of DNA damage in yeast will continue to yield new insights into this important biological process. ..

..All of these are characterized by disruptions in normal chromosome function, which can be readily studied in yeast. ..

..g., Candida or one of many bacterial strains). Successful completion of these aims will greatly expand the methods available in the molecular geneticist's tool kit. ..

..The combination of genetic and biochemical approaches to the many issues related to the repair of double strand breaks in yeast are expected by the researchers to continue to yield new insights into this important biological phenomenon. ..

..These approaches are general and the insights that we gain and the methods that we develop will not be confined to yeast alone, but will be applicable to many cellular systems. ..

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..These approaches are general and the insights that we gain and the methods that we develop will not be confined to yeast alone, but will be applicable to many cellular systems. ..