ADAM JONATHAN RATNERSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Arcanolysin is a cholesterol-dependent cytolysin of the human pathogen Arcanobacterium haemolyticumB Helen Jost
Department of Veterinary Science and Microbiology, The University of Arizona, 1117 E Lowell Street, Tucson, AZ 85721, USA
BMC Microbiol 11:239. 2011..A. haemolyticum also displays variable hemolytic activity on laboratory blood agar that is dependent upon which species the blood is derived...- Nod1 mediates cytoplasmic sensing of combinations of extracellular bacteriaAdam J Ratner
Departments of Microbiology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell Microbiol 9:1343-51. 2007..We conclude that combinations of extracellular organisms can activate innate immune pathways previously considered to be reserved for the detection of intracellular microorganisms... - Epithelial cells are sensitive detectors of bacterial pore-forming toxinsAdam J Ratner
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 281:12994-8. 2006..Osmosensing may thus represent a novel innate immune response to a common bacterial virulence strategy... - Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane poresJorge L Aguilar
Department of Pediatrics, Columbia University, New York, New York, United States of America
PLoS ONE 4:e8076. 2009..Epithelial regulation of MAPK signaling in response to membrane disruption involves distinct pathways and may require different strategies for therapeutic interventions... - Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfacesAdam J Ratner
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:3429-34. 2005..These synergistic responses, demonstrated both in vitro and in vivo, may contribute to inflammation of heavily colonized mucosal barriers... - Cigarette smoke inhibits airway epithelial cell innate immune responses to bacteriaRitwij Kulkarni
Department of Pediatrics, Columbia University, 650 West 168th Street BB 443, New York, NY 10032, USA
Infect Immun 78:2146-52. 2010..05 compared to cells without CSC treatment). These results identify a novel oxidant-mediated immunosuppressive role for CS in epithelial cells... - Antibody-based detection and inhibition of vaginolysin, the Gardnerella vaginalis cytolysinTara M Randis
Department of Pediatrics, Columbia University, New York, NY, USA
PLoS ONE 4:e5207. 2009..Furthermore, VLY antiserum functions as an inhibitor of VLY-CD59 interaction, mitigating cell lysis. These strategies may have a potential role in the diagnosis and treatment of BV... - The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formationDane Parker
Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Infect Immun 77:3722-30. 2009..This work highlights the role played by the neuraminidase in pathogenesis and represents an important step in drug development for prevention of colonization of the respiratory tract by this important pathogen... - Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalisShari E Gelber
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Bacteriol 190:3896-903. 2008..Further investigation of the mechanism of action of VLY may improve understanding of the functions of the CDC family as well as diagnosis and therapy for BV... - Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killingElena S Lysenko
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS Pathog 3:e118. 2007..These observations offer insight into mechanisms of microbial competition and demonstrate the importance of Nod1 in neutrophil-mediated clearance of bacteria in vivo... - Interleukin-8 secretion in response to aferric enterobactin is potentiated by siderocalinAaron L Nelson
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104 6076, USA
Infect Immun 75:3160-8. 2007..This may be a novel mechanism for the mucosa to respond to metabolic signals of expanding microbial communities... - Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus inersRyan Rampersaud
Columbia University, New York, NY 10032, USA
J Bacteriol 193:1034-41. 2011..INY represents a new target for studies directed at understanding the role of L. iners in states of health and disease at the vaginal mucosal surface... - Crystal structures of respiratory pathogen neuraminidasesYu Shan Hsiao
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Biochem Biophys Res Commun 380:467-71. 2009..This work represents an important step in the development of drugs to prevent respiratory tract colonization by these two pathogens... - Capsule enhances pneumococcal colonization by limiting mucus-mediated clearanceAaron L Nelson
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076, USA
Infect Immun 75:83-90. 2007..In conclusion, our findings demonstrate that capsule confers an advantage to mucosal pathogens distinct from its role in inhibition of opsonophagocytosis--escape from entrapment in lumenal mucus... - Emergence of vaccine-related pneumococcal serotypes as a cause of bacteremiaAndrew P Steenhoff
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Clin Infect Dis 42:907-14. 2006..In the postlicensure period, the impact of non-PCV7 serotypes against pediatric pneumococcal bacteremia is unknown... - Antibody-enhanced pneumococcal adherence requires IgA1 proteaseJeffrey N Weiser
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 100:4215-20. 2003..These enzymes may enable pathogens to subvert the antigen specificity of the humoral immune response to facilitate adhesive interactions and persistence on the mucosal surface...
Research Grants
- Polymicrobial induction of epithelial inflammationAdam Ratner; Fiscal Year: 2006..Ratner to a wide variety of techniques in the areas of cell biology, biochemistry, physiology, and molecular biology, thus providing a solid foundation for beginning an independent research career. ..
- Gardnerella vaginalis: toxin production and pathogenesisADAM JONATHAN RATNER; Fiscal Year: 2011....