F Xavier Pi-Sunyer

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus
    F Xavier Pi-Sunyer
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Postgrad Med 121:94-107. 2009
  2. ncbi Improving health outcomes: future directions in the field
    Xavier Pi-Sunyer
    Department of Medicine, Obesity Research Center, Columbia University, St. Luke's-Roosevely Hospital Center, New York, NY 10025, USA
    J Am Diet Assoc 105:S14-6. 2005
  3. ncbi Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    F Xavier Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    JAMA 295:761-75. 2006
  4. ncbi The medical risks of obesity
    Xavier Pi-Sunyer
    Division of Endocrinology Diabetes and Nutrition, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Postgrad Med 121:21-33. 2009
  5. ncbi Use of lifestyle changes treatment plans and drug therapy in controlling cardiovascular and metabolic risk factors
    F Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Obesity (Silver Spring) 14:135S-142S. 2006
  6. ncbi The relation of adipose tissue to cardiometabolic risk
    F Xavier Pi-Sunyer
    Obesity Research Center, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Clin Cornerstone 8:S14-23. 2006
  7. ncbi How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
    F Xavier Pi-Sunyer
    Columbia University, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Nutr Rev 65:101-10. 2007
  8. ncbi The obesity epidemic
    Xavier Pi-Sunyer
    New York Obesity Research Center, New York City 10025, USA
    Manag Care Interface 20:21-2, 37. 2007
  9. ncbi The metabolic syndrome: how to approach differing definitions
    Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, St Luke s Roosevelt Hospital, 1111 Amsterdam Avenue, Room 1020, New York, NY 10025, USA
    Med Clin North Am 91:1025-40, vii. 2007
  10. ncbi Glycemic index in early type 2 diabetes
    Xavier Pi-Sunyer
    Department of Endocrinology, Diabetes, and Nutrition, St Luke's-Roosevelt Hospital, and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 87:3-4. 2008

Research Grants

  1. Diabetes Prevention Program Long-Term Follow-up Study
    F Pi Sunyer; Fiscal Year: 2007
  2. Look AHEAD: Action for Health Diabetes
    F Pi Sunyer; Fiscal Year: 2007
  3. OBESITY RESEARCH CENTER TRAINING PROGRAM
    F Pi Sunyer; Fiscal Year: 2007

Detail Information

Publications81

  1. ncbi The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus
    F Xavier Pi-Sunyer
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Postgrad Med 121:94-107. 2009
    ..The selection of antidiabetes agents that not only improve glucose control but reduce or have a neutral effect on weight with beneficial effects on lipids are ideal options for managing patients with type 2 diabetes...
  2. ncbi Improving health outcomes: future directions in the field
    Xavier Pi-Sunyer
    Department of Medicine, Obesity Research Center, Columbia University, St. Luke's-Roosevely Hospital Center, New York, NY 10025, USA
    J Am Diet Assoc 105:S14-6. 2005
  3. ncbi Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    F Xavier Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    JAMA 295:761-75. 2006
    ..Rimonabant, a selective cannabinoid-1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese...
  4. ncbi The medical risks of obesity
    Xavier Pi-Sunyer
    Division of Endocrinology Diabetes and Nutrition, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Postgrad Med 121:21-33. 2009
    ..This article will review evidence for significant associations of obesity with comorbidities to provide information useful for optimal patient management...
  5. ncbi Use of lifestyle changes treatment plans and drug therapy in controlling cardiovascular and metabolic risk factors
    F Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Obesity (Silver Spring) 14:135S-142S. 2006
    ..To date, the U.S. Food and Drug Administration has approved three weight loss agents: sibutramine, orlistat, and phentermine...
  6. ncbi The relation of adipose tissue to cardiometabolic risk
    F Xavier Pi-Sunyer
    Obesity Research Center, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Clin Cornerstone 8:S14-23. 2006
    ..These agents may play a role in the regulation of adipocytokines, which may directly affect the risk for cardiometabolic disease...
  7. ncbi How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
    F Xavier Pi-Sunyer
    Columbia University, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Nutr Rev 65:101-10. 2007
    ..The risks improve with weight loss and increased physical activity. A decrease of 7% to 10% or more from baseline weight can have a significant effect. This has now been documented in a number of randomized, controlled studies...
  8. ncbi The obesity epidemic
    Xavier Pi-Sunyer
    New York Obesity Research Center, New York City 10025, USA
    Manag Care Interface 20:21-2, 37. 2007
  9. ncbi The metabolic syndrome: how to approach differing definitions
    Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, St Luke s Roosevelt Hospital, 1111 Amsterdam Avenue, Room 1020, New York, NY 10025, USA
    Med Clin North Am 91:1025-40, vii. 2007
    ....
  10. ncbi Glycemic index in early type 2 diabetes
    Xavier Pi-Sunyer
    Department of Endocrinology, Diabetes, and Nutrition, St Luke's-Roosevelt Hospital, and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 87:3-4. 2008
  11. ncbi The effects of pharmacologic agents for type 2 diabetes mellitus on body weight
    F Xavier Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Postgrad Med 120:5-17. 2008
    ..Evidence on the clinical utility of antiobesity drugs is more equivocal, and more data are needed to evaluate the safety and tolerability of these agents...
  12. ncbi Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    F Xavier Pi-Sunyer
    Department of Medicine, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue Room 1020, New York, NY 10025, USA
    Diabetes Res Clin Pract 76:132-8. 2007
    ..No confirmed hypoglycemia was reported. Conclusion: Vildagliptin is effective and well-tolerated in drug-naïve patients with T2DM and 100 mg vildagliptin provides similar clinical benefit whether given as single or in divided doses...
  13. ncbi The medical risks of obesity
    F Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes and Nutrition, New York Obesity Research Center, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 111 Amsterdam Ave, New York, NY 10025, USA
    Obes Surg 12:6S-11S. 2002
    ..These are discussed below...
  14. ncbi Obesity: criteria and classification
    F X Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Proc Nutr Soc 59:505-9. 2000
    ..Eventually, classification of obesity may be done by genetic means, but this approach will require more knowledge...
  15. ncbi Comorbidities of overweight and obesity: current evidence and research issues
    F X Pi-Sunyer
    St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Med Sci Sports Exerc 31:S602-8. 1999
    ..The evidence with regard to the relationship of obesity with medical comorbidities was assessed and priority research issues identified...
  16. ncbi Energy balance: role of genetics and activity
    F X Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Ann N Y Acad Sci 819:29-36. 1997
    ....
  17. ncbi The obesity epidemic: pathophysiology and consequences of obesity
    F Xavier Pi-Sunyer
    Division of Endocrinology, Diabetes, and Nutrition, New York Obesity Research Center, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York 10025, USA
    Obes Res 10:97S-104S. 2002
    ..This underscores the importance of identifying people at risk for obesity and its related disease states...
  18. ncbi Type 2 diabetes outcomes
    F Xavier Pi-Sunyer
    Obesity Research, St. Luke's-Roosevelt Hospital Center, Columbia University, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Obes Res 10:22S-26S. 2002
  19. ncbi Glycemic index and disease
    F Xavier Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 76:290S-8S. 2002
    ..Presented herein are the reasons why it is premature to recommend that the general population avoid foods with a high glycemic index...
  20. ncbi Overnutrition and undernutrition as modifiers of metabolic processes in disease states
    F X Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University, New York, NY 10025, USA
    Am J Clin Nutr 72:533S-7S. 2000
    ..Acute conditions such as burns and trauma significantly raise energy expenditure, primarily by increasing sympathetic response and the release of catecholamines, which are powerful stimulators of energy expenditure...
  21. ncbi Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes
    Jeanine B Albu
    Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York, USA
    Diabetes 59:627-33. 2010
    ....
  22. ncbi Serum iron and body fat distribution in a multiethnic cohort of adults living in New York City
    Earle C Chambers
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Am Diet Assoc 106:680-4. 2006
    ..To examine the relationship between serum iron and body composition in a multiracial adult cohort...
  23. ncbi Regional subcutaneous-fat loss induced by caloric restriction in obese women
    Jack Wang
    Body Composition Unit, Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital, Columbia University, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Obes Res 10:885-90. 2002
    ....
  24. ncbi Comparisons of waist circumferences measured at 4 sites
    Jack Wang
    Body Composition Unit and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York 10025, USA
    Am J Clin Nutr 77:379-84. 2003
    ....
  25. ncbi Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the look AHEAD study
    L Maria Belalcazar
    Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    Arterioscler Thromb Vasc Biol 31:1689-95. 2011
    ....
  26. ncbi Serum magnesium and type-2 diabetes in African Americans and Hispanics: a New York cohort
    Earle C Chambers
    Obesity Research Center, New York, NY 10025, USA
    J Am Coll Nutr 25:509-13. 2006
    ..The aim of this study was to examine the relationship of serum Mg with stage of diabetes measured by fasting serum glucose in a cohort of 485 African American and Hispanic adults...
  27. ncbi Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?
    Jose R Fernandez
    Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 77:71-5. 2003
    ....
  28. ncbi Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery
    Mousumi Bose
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Diabetes 2:47-55. 2010
    ..The aim of the present study was to determine the mechanisms underlying Type 2 diabetes remission after gastric bypass (GBP) surgery by characterizing the short- and long-term changes in hormonal determinants of blood glucose...
  29. ncbi Multicomponent methods: evaluation of new and traditional soft tissue mineral models by in vivo neutron activation analysis
    ZiMian Wang
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 76:968-74. 2002
    ..Practical and accurate methods for quantifying the soft tissue mineral component of multicomponent fat-estimation models are needed...
  30. ncbi Weight loss with self-help compared with a structured commercial program: a randomized trial
    Stanley Heshka
    New York Obesity Research Center, St Luke s Roosevelt Hospital and Columbia University, New York, NY, USA
    JAMA 289:1792-8. 2003
    ..Although commercial weight loss programs provide treatment to millions of clients, their efficacy has not been evaluated in rigorous long-term trials...
  31. ncbi Higher post-absorptive skeletal muscle LPL activity in African American vs. non-Hispanic White pre-menopausal women
    Evan S Berk
    New York Obesity Research Center, St Luke s Hospital, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 16:199-201. 2008
    ..Higher post-absorptive post-heparin plasma lipoprotein lipase (LPL) activity has been reported in African Americans as compared to non-Hispanic whites but differences in tissue-specific LPL activity are unclear...
  32. ncbi Prevalence of co-morbidities in obese patients before bariatric surgery: effect of race
    Luigi Residori
    Obesity Research Center and Department of Medicine, St Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Obes Surg 13:333-40. 2003
    ..Age, ethnicity and gender influence the type of co-morbid conditions. More research is needed to understand why diabetes and other metabolic complications remain undiagnosed and untreated in a large number of these high risk patients...
  33. ncbi Menopause and risk of diabetes in the Diabetes Prevention Program
    Catherine Kim
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Menopause 18:857-68. 2011
    ..The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions...
  34. ncbi Body size and shape changes and the risk of diabetes in the diabetes prevention program
    Wilfred Y Fujimoto
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 56:1680-5. 2007
    ..Reduced diabetes risk with lifestyle intervention may have been through effects upon both overall body fat and central body fat but with metformin appeared to be independent of body fat...
  35. ncbi Race, menopause, health-related quality of life, and psychological well-being in obese women
    BLANDINE LAFERRERE
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York 10025, USA
    Obes Res 10:1270-5. 2002
    ..To investigate the health-related quality of life (HR-QOL) in African-American (AA) and white (W) obese women...
  36. ncbi A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change: from the Look AHEAD (Action for Health in Diabetes) study
    L Maria Belalcazar
    Department of Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes Care 33:2297-303. 2010
    ....
  37. ncbi Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women
    Evan S Berk
    New York Obesity Research Center, St. Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue, Department of Medicine, Babcock Building Room 1031, New York, NY 10025, USA
    J Clin Endocrinol Metab 91:4099-106. 2006
    ..CONCLUSION: The impaired substrate use observed in African-American women during these three studies demonstrates the existence of MI and may contribute to their greater prevalence of obesity and insulin resistance...
  38. ncbi Measurement of human daily physical activity
    Kuan Zhang
    New York Obesity Research Center, St Luke s Roosevelt Hospital New York, New York 10025, USA
    Obes Res 11:33-40. 2003
    ..To validate a new device, Intelligent Device for Energy Expenditure and Activity (IDEEA), for the measurement of duration, frequency, and intensity of various types of human physical activity (PA)...
  39. ncbi Korean and Caucasian overweight premenopausal women have different relationship of body mass index to percent body fat with age
    Sochung Chung
    Department of Medicine, Obesity Research Center, St. Luke's-Roosevelt Hospital and College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    J Appl Physiol 99:103-7. 2005
    ..Investigators who use BMI as an index of fatness should be aware of the well documented differences in the relationship of BMI and fatness across race/ethnic groups...
  40. ncbi Validation of a 3-dimensional photonic scanner for the measurement of body volumes, dimensions, and percentage body fat
    Jack Wang
    Body Composition Unit, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Am J Clin Nutr 83:809-16. 2006
    ..The 3-dimensional photonic scan (3DPS) technique has been used during the past decade in the fashion industry and for epidemiologic surveys to estimate human body sizes...
  41. ncbi Obesity and type 2 diabetes
    Carol A Maggio
    Division of Endocrinology, Diabetes, and Nutrition, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, Room 1020, New York, NY 10025, USA
    Endocrinol Metab Clin North Am 32:805-22, viii. 2003
    ..In addition, the article reviews the results of lifestyle intervention trials designed to reduce conversion to type 2 diabetes in at-risk individuals...
  42. ncbi Regional body volumes, BMI, waist circumference, and percentage fat in severely obese adults
    Jack Wang
    Body Composition Unit, New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York 10025, USA
    Obesity (Silver Spring) 15:2688-98. 2007
    ....
  43. ncbi Depression score predicts weight loss following Roux-en-Y gastric bypass
    Yelena Averbukh
    Department of Medicine, St.Luke's-Roosevelt Hospital, New York, USA
    Obes Surg 13:833-6. 2003
    ..Future prospective studies should examine possible mechanisms and effects of depression and other psychiatric disturbances on long-term weight loss after RYGBP...
  44. ncbi Does ghrelin really matter after bariatric surgery?
    Hongchan Lee
    Division of Bariatric Surgery, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Surg Obes Relat Dis 2:538-48. 2006
  45. ncbi Cholecystokinin and stomach distension combine to reduce food intake in humans
    Harry R Kissileff
    St Luke s Roosevelt Hospital, 1111 Amsterdam Ave, New York, NY 10025, USA
    Am J Physiol Regul Integr Comp Physiol 285:R992-8. 2003
    ..These results are consistent with the hypothesis that CCK's suppression of food intake is enhanced when the stomach is distended...
  46. ncbi Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  47. ncbi Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?
    Mousumi Bose
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Obes Surg 19:217-29. 2009
    ..Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated...
  48. ncbi Amylin, food intake, and obesity
    Tarek K Reda
    New York Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, USA
    Obes Res 10:1087-91. 2002
    ..Amylin administration may overcome resistance at target tissues, delay gastric emptying, and have potential for inducing weight loss in obese individuals...
  49. ncbi Physical disability and obesity
    Tsan-Hon Liou
    New York Obesity Research Center, St. Luke's-Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Nutr Rev 63:321-31. 2005
    ..Health professionals should identify disabled patients at risk and provide early prevention guidance. Research is needed to help generate detailed clinical guidelines to promote weight control among people with physical disabilities...
  50. ncbi Incretins, diabetes, and bariatric surgery: a review
    Rachel Fetner
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Surg Obes Relat Dis 1:589-97; discussion 597-8. 2005
  51. ncbi Marine omega-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study
    L Maria Belalcazar
    Department of Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes Care 33:197-9. 2010
    ..To examine usual marine omega-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss...
  52. ncbi Pathophysiology and long-term management of the metabolic syndrome
    F Xavier Pi-Sunyer
    Department of Medicine, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, Room 1020, New York, NY 10025, USA
    Obes Res 12:174S-80S. 2004
    ..Successful treatment requires the introduction of lifestyle changes initially and pharmacotherapy subsequently if lifestyle changes are not sufficient...
  53. ncbi Adipose tissue distribution is different in type 2 diabetes
    Dympna Gallagher
    Body Composition Unit New York Obesity Research Center, St Luke s Roosevelt Hospital, 1111 Amsterdam Avenue, Scrymser Basement, New York, NY 10025, USA
    Am J Clin Nutr 89:807-14. 2009
    ..The extent to which adipose tissue (AT) distribution is different between persons with type 2 diabetes (T2DM) and nondiabetic control subjects remains unclear...
  54. ncbi The epidemiology of central fat distribution in relation to disease
    F Xavier Pi-Sunyer
    Obesity Research Center, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY 10025, USA
    Nutr Rev 62:S120-6. 2004
    ..These include Asian populations. It is likely that with better differentiation of abdominal fat into visceral and subcutaneous depots, clearer data will accrue on their impact on disease risk...
  55. ncbi Association of BMI and cardiovascular risk stratification in the elderly African-American females
    Fahad Javed
    New York Obesity Research Center, Division of Endocrinology, Diabetes, and Nutrition, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:1182-6. 2011
    ..Weight reduction to a greater extent than previously indicated could play an integral role in prevention and control of high blood pressure in this particular population...
  56. ncbi Body cell mass: model development and validation at the cellular level of body composition
    ZiMian Wang
    Weight Control Unit, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 286:E123-8. 2004
    ..0083 x TBK) formulated on rough tissue composition estimates. The present analyses provide a physiologically based, improved, and validated TBK-BCM prediction formula that should prove useful in body composition and metabolism research...
  57. ncbi Intentional weight loss reduces mortality rate in a rodent model of dietary obesity
    Joseph R Vasselli
    New York Obesity Research Center, Columbia University, New York, NY, USA
    Obes Res 13:693-702. 2005
    ..002). Diet composition had no effect on life span (p = 0.52). DISCUSSION: Weight loss after the onset of obesity during adulthood leads to a substantial increase in longevity in rats...
  58. ncbi Improving energy expenditure estimation for physical activity
    Kuan Zhang
    NY Obesity Research Center, St Lukes Roosevelt Hospital and Institute of Human Nutrition, Department of Medicine, Columbia University, New York, NY 10025, USA
    Med Sci Sports Exerc 36:883-9. 2004
    ..An additional aim was to improve the accuracy of the estimation of energy expenditure of physical activity based on second-by-second information of type, onset, and duration of activity...
  59. ncbi Neighborhood and weight-related health behaviors in the Look AHEAD (Action for Health in Diabetes) study
    Tiffany L Gary-Webb
    Department of Epidemiology, Columbia Mailman School of Public Health, New York, NY, USA
    BMC Public Health 10:312. 2010
    ..This study aims to conduct a multi-level analysis to examine the relationship between neighborhood SES and weight-related health behaviors...
  60. ncbi Waist circumference correlates with metabolic syndrome indicators better than percentage fat
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Obesity (Silver Spring) 14:727-36. 2006
    ....
  61. ncbi The bariatric surgery patient: lost to follow-up; from morbid obesity to severe malnutrition
    Gregory B Dodell
    Division of Endocrinology, Diabetes and Nutrition, St Luke s Roosevelt Hospital Center, New York, New York
    Endocr Pract 18:e21-5. 2012
    ..Malnutrition needs to be recognized and aggressively treated. Nutritional markers should be followed closely in this population of bariatric patients in an effort to avert the onset of severe malnutrition...
  62. ncbi Neighborhood socioeconomic status, depression, and health status in the Look AHEAD (Action for Health in Diabetes) study
    Tiffany L Gary-Webb
    Department of Epidemiology, Columbia Mailman School of Public Health, New York, NY, USA
    BMC Public Health 11:349. 2011
    ..The objective of this manuscript was to evaluate the relationship between neighborhood-level SES and health status and depression...
  63. ncbi Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study
    Richard R Rubin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:2549-51. 2010
    ..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)...
  64. ncbi Obesity and endocrine disease
    Panagiotis Kokkoris
    Division of Endocrinology, Diabetes, and Metabolism, Hellenic Air Force General Hospital, 3 P Kanelopoulou Street, Athens 11525, Greece
    Endocrinol Metab Clin North Am 32:895-914. 2003
    ..In addition, the fat cell has been found to be an endocrine organ that produces several peptides that are bioactive and participate in the regulation of adipocyte function...
  65. ncbi Obesity-related leptin regulates Alzheimer's Abeta
    Darius C Fewlass
    Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    FASEB J 18:1870-8. 2004
    ..Thus, leptin can modulate bidirectional Abeta kinesis, reducing its levels extracellularly. Most strikingly, chronic administration of leptin to AD-transgenic animals reduced the brain Abeta load, underlying its therapeutic potential...
  66. ncbi Assessment of human locomotion by using an insole measurement system and artificial neural networks
    Kuan Zhang
    Obesity Research Center, St Luke s Roosevelt Hospital Center, 1111 Amsterdam Avenue, Room 1017, New York, NY 10025, USA
    J Biomech 38:2276-87. 2005
    ..It provides an alternative tool to the use of a gait lab to quantitatively study locomotion with high accuracy via a small, light and portable device, and to do so under free-living conditions for the clinical applications...
  67. ncbi Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans
    Laurence J Nolan
    New York Obesity Research Center, St. Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Nutrition 19:553-7. 2003
    ..CONCLUSIONS: A large quantity of tomato soup stimulates significant CCK release; therefore, some of the satiating effects of soup preloads could have been mediated by an elevation in endogenous CCK...
  68. ncbi Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    Xavier Pi-Sunyer
    St Luke s Roosevelt Hospital Center, USA
    Diabetes Care 30:1374-83. 2007
    ..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
  69. ncbi Dietary carbohydrate (amount and type) in the prevention and management of diabetes: a statement by the american diabetes association
    Nancy F Sheard
    Department of Family Practice, University of Vermont, Burlington, USA
    Diabetes Care 27:2266-71. 2004
  70. ncbi Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 87:1212-8. 2008
    ..Greater central adiposity is related to the risk of diabetes...
  71. ncbi Weight loss in type 2 diabetic patients
    F Xavier Pi-Sunyer
    Diabetes Care 28:1526-7. 2005
  72. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss
    Paul Poirier
    Quebec Heart and Lung Institute, Sainte Foy, Canada
    Arterioscler Thromb Vasc Biol 26:968-76. 2006
    ..As a whole, overweight/obesity predispose or is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death through its impact on the cardiovascular system...
  73. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical
    Paul Poirier
    Circulation 113:898-918. 2006
    ..In this statement, we review the available evidence of the impact of obesity on CVD with emphasis on the evaluation of cardiac structure and function in obese patients and the effect of weight loss on the cardiovascular system...
  74. ncbi Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial
    David E Kelley
    Montifiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 25:1033-41. 2002
    ....
  75. ncbi Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy
    Richard E Pratley
    Vermont College of Medicine, Burlington, USA
    Diabetes Care 30:3017-22. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of vildagliptin in elderly patients with type 2 diabetes...
  76. ncbi Truncal adiposity and lung function in older black women
    Earle C Chambers
    Department of Family and Social Medicine, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Ave, Mazer 111, Bronx, New York 10461, USA
    Lung 186:13-7. 2008
    ..Results of this study show that truncal fat mass measured by DXA is more strongly associated with lung function than anthropometric indices of truncal adiposity in this sample of women...
  77. ncbi Carbohydrate issues: type and amount
    Madelyn L Wheeler
    Nutritional Computing Concepts, Zionsville, IN 46077, USA
    J Am Diet Assoc 108:S34-9. 2008
    ..Glycemic index/glycemic load concepts are attempts to use these carbohydrate availability and amount issues for controlling postprandial glycemia...
  78. ncbi Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes
    V Lee Grotz
    Medical and Nutritional Affairs, McNeil Nutritionals, New Bruswick, NJ 08903 2400, USA
    J Am Diet Assoc 103:1607-12. 2003
    ..To investigate the effect of 3-months' daily administration of high doses of sucralose, a non-nutritive sweetener, on glycemic control in subjects with type 2 diabetes...
  79. ncbi Dietary guidelines vs beverage guidance system
    Connie Weaver
    Am J Clin Nutr 84:1245-6; author reply 1246-8. 2006
  80. ncbi Stepping down as Editor-in-Chief
    F Xavier Pi-Sunyer
    Obes Res 10:1201-2. 2002

Research Grants8

  1. Diabetes Prevention Program Long-Term Follow-up Study
    F Pi Sunyer; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
  2. Look AHEAD: Action for Health Diabetes
    F Pi Sunyer; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..
  3. OBESITY RESEARCH CENTER TRAINING PROGRAM
    F Pi Sunyer; Fiscal Year: 2007
    ..The program is intended to develop independent investigative skills and a rigorous approach to investigation through regular research and didactic seminars. A broad program of courses is available to the trainees at Columbia University. ..