Research Topics
Genomes and Genes | Alessandra B PernisSummaryAffiliation: Columbia University Country: USA Publications
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Publications
The role of IRF-4 in B and T cell activation and differentiationAlessandra B Pernis
Department of Medicine, Columbia University, New York, NY 10032, USA
J Interferon Cytokine Res 22:111-20. 2002..Genetic studies have indicated that IRF-4 is critical for the function of mature T and B cells. Here we review the role of IRF-4 as a downstream effector and potentially an integrator of lymphocyte responses...- Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4S Gupta
Department of Medicine, Columbia University, New York, New York 10032, USA
J Exp Med 190:1837-48. 1999..Since expression of IRF-4 is mostly confined to lymphoid cells, these data provide a potential mechanism by which IL-4-inducible genes can be regulated in a lineage-specific manner... - Th17 cells in rheumatoid arthritis and systemic lupus erythematosusA B Pernis
Department of Medicine, Columbia University, New York, NY 10032, USA
J Intern Med 265:644-52. 2009..In this review, we will discuss recent studies that have begun elucidating the factors that regulate the development of Th17 cells and provide a brief overview of the role of Th17 cells in RA and SLE... - Rho GTPase-mediated pathways in mature CD4+ T cellsAlessandra B Pernis
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Autoimmun Rev 8:199-203. 2009.... - Estrogen and CD4+ T cellsAlessandra B Pernis
Department of Medicine, Columbia University, New York, New York 10032, USA
Curr Opin Rheumatol 19:414-20. 2007..We highlight recent studies that begin to provide insights into the mechanisms by which estrogen modulates CD4 T-cell development and function, and thus potentially contribute to disease pathogenesis... - JAK-STAT signaling in asthmaAlessandra B Pernis
Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 109:1279-83. 2002 - Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in micePartha S Biswas
Department of Medicine, Columbia University, New York, New York, USA
J Clin Invest 120:3280-95. 2010.... - Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)Jessica C Fanzo
Department of Molecular Medicine, Columbia University, New York, NY 10032, USA
J Exp Med 197:303-14. 2003..These data suggest that IRF-4, by modulating the efficiency of the Fas-mediated death signal, is a novel participant in the regulation of lymphoid cell apoptosis... - T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapseSanjay Gupta
Departments of Medicine and Medicine and Pharmacology, Columbia University, New York, New York 10032, USA
J Biol Chem 278:43541-9. 2003..The recruitment and activation of distinct classes of GEFs may allow for precise control of Rho GTPase function at the crucial interface between T cells and antigen presenting cells... - IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factorQinzhong Chen
Department of Medicine, Columbia University, New York, NY 10032, USA
Immunity 29:899-911. 2008..Thus, IBP appears to be important in preventing T cell-mediated autoimmunity by ensuring that the production of IL-17 and IL-21 does not occur in response to self-antigens... - Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunityJessica C Fanzo
Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 116:703-14. 2006..Collectively, these findings indicate that IBP, a novel regulator of Rho GTPases, is required for optimal T cell effector function, lymphocyte homeostasis, and the prevention of systemic autoimmunity... - Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunityPartha S Biswas
Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA
J Exp Med 209:581-96. 2012..Collectively, these data provide novel insights into the mechanisms that normally couple and coordinately regulate T and B cell responses to ensure tight control of productive T-B cell interactions... - IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?Partha S Biswas
Department of Medicine, Columbia University, New York, NY 10032, USA
Immunol Rev 233:79-96. 2010..A better understanding of these novel pathways will hopefully provide new insights into mechanisms responsible for the development of inflammatory arthritis and potentially guide the design of novel therapeutic approaches... - Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune systemSanjay Gupta
Department of Pathology, Columbia University, New York, NY 10032, USA
Hum Immunol 64:389-401. 2003..Taken together these findings indicate that IBP is a novel type of GEF, which participates in the activation of Rho GTPases in lymphoid tissues... - Modulation of T cell cytokine production by interferon regulatory factor-4Chuan Min Hu
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
J Biol Chem 277:49238-46. 2002..These studies thus support the notion that IRF-4 represents one of the lymphoid-specific components that control the ability of T lymphocytes to produce a distinctive array of cytokines... - Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPasesQinzhong Chen
Columbia University, 630 West 168th Street, New York, NY 10032, USA
J Leukoc Biol 85:539-43. 2009..Our results thus identify IBP/Def6 as a novel component of the TLR4-induced signaling cascade that controls the production of proinflammatory cytokines... - Aberrant ROCK activation promotes the development of type I diabetes in NOD micePartha S Biswas
Department of Medicine, Columbia University, NY 10032, USA
Cell Immunol 266:111-5. 2011..These studies thus support the idea that ROCK2 is inappropriately activated in NOD T cells and that ROCK kinases could represent important therapeutic targets for the treatment of T1D...