Raul Perez-Jimenez

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Nat Struct Mol Biol 16:890-6. 2009
  2. ncbi Single-molecule paleoenzymology probes the chemistry of resurrected enzymes
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Nat Struct Mol Biol 18:592-6. 2011
  3. ncbi Probing the chemistry of thioredoxin catalysis with force
    Arun P Wiita
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 450:124-7. 2007
  4. ncbi Single-molecule force spectroscopy approach to enzyme catalysis
    Jorge Alegre-Cebollada
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:18961-6. 2010
  5. ncbi Dwell time analysis of a single-molecule mechanochemical reaction
    Robert Szoszkiewicz
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Langmuir 24:1356-64. 2008
  6. ncbi Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:27121-9. 2008
  7. ncbi Stretching single talin rod molecules activates vinculin binding
    Armando Del Rio
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 323:638-41. 2009

Collaborators

Detail Information

Publications7

  1. ncbi Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Nat Struct Mol Biol 16:890-6. 2009
    ..A computational analysis of Trx structures identifies the evolution of the binding groove as an important factor controlling the chemistry of Trx catalysis...
  2. ncbi Single-molecule paleoenzymology probes the chemistry of resurrected enzymes
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Nat Struct Mol Biol 18:592-6. 2011
    ....
  3. ncbi Probing the chemistry of thioredoxin catalysis with force
    Arun P Wiita
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 450:124-7. 2007
    ....
  4. ncbi Single-molecule force spectroscopy approach to enzyme catalysis
    Jorge Alegre-Cebollada
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:18961-6. 2010
    ..Finally, the specific requirements that must be fulfilled to apply this new methodology to any other enzyme will be discussed...
  5. ncbi Dwell time analysis of a single-molecule mechanochemical reaction
    Robert Szoszkiewicz
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Langmuir 24:1356-64. 2008
    ..These experiments demonstrate that dwell time analysis techniques are a powerful approach to studying chemical reactions at the single-molecule level...
  6. ncbi Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis
    Raul Perez-Jimenez
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:27121-9. 2008
    ..Our results constitute a direct observation of distant residue co-evolution in enzyme catalysis...
  7. ncbi Stretching single talin rod molecules activates vinculin binding
    Armando Del Rio
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 323:638-41. 2009
    ..Such protein stretching may be a more general mechanism for force transduction...