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Genomes and Genes | G S MarkowitzSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody seropositivitySamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
Clin J Am Soc Nephrol 3:682-90. 2008..We report 10 cases of necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody seropositivity...
Toxic acute tubular necrosis following treatment with zoledronate (Zometa)Glen S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 64:281-9. 2003..Zoledronate (Zometa) is a new, highly potent bisphosphonate used in the treatment of hypercalcemia of malignancy. We report the first clinical-pathologic study of nephrotoxicity associated with this agent...
Dysproteinemia and the kidneyGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Adv Anat Pathol 11:49-63. 2004..This review emphasizes the pathologic, clinical, and prognostic differences among the patterns of renal parenchymal disease related to dysproteinemia...
An overlapping etiology of rapidly progressive glomerulonephritisGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 43:388-93. 2004
Drug-induced renal failure: a focus on tubulointerstitial diseaseGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Clin Chim Acta 351:31-47. 2005..This review focuses on the multitude of patterns of drug-induced renal failure due to tubulointerstitial disease...
An 18-year-old male with hematuria, renal insufficiency, and defective synthesis of type IV collagenG S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 69:2278-82. 2006
The ISN/RPS 2003 classification of lupus nephritis: an assessment at 3 yearsG S Markowitz
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Kidney Int 71:491-5. 2007..As it gains widespread acceptance, the ISN/RPS classification is already providing a standardized approach to renal biopsy interpretation needed to compare outcome data across centers...
Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failureGlen S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, 630 West 168th Street, Room VC14 224, New York, NY 10032, USA
J Am Soc Nephrol 16:3389-96. 2005..Potential etiologic factors include inadequate hydration (while receiving OSPS), increased patient age, a history of hypertension, and concurrent use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker...
Classification of lupus nephritisGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Curr Opin Nephrol Hypertens 18:220-5. 2009....
Membranous glomerulopathy: emphasis on secondary forms and disease variantsG S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Adv Anat Pathol 8:119-25. 2001..This review emphasizes the detection of secondary forms and variants of MGN...
Acute phosphate nephropathyGlen S Markowitz
Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
Kidney Int 76:1027-34. 2009....
Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosisGlen S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, 630 West 168th Street, VC 14 224, New York, NY 10032, USA
Clin J Am Soc Nephrol 5:607-15. 2010..Treatment with IFN is rarely associated with nephrotic syndrome and renal biopsy findings of minimal-change disease or FSGS...
Primary renal allograft dysfunctionKirk Foster
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 44:376-81. 2004
Multiple myeloma, nephrotic syndrome and crystalloid inclusions in podocytesS H Nasr
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Kidney Int 69:616-20. 2006
Membranous glomerulopathy associated with graft-versus-host disease following allogeneic stem cell transplantation. Report of 2 cases and review of the literatureJ Lin
Division of Nephrology, Department of Medicine, Columbia University, New York Presbyterian Hospital, New York, N Y, USA
Am J Nephrol 21:351-6. 2001..The close temporal association as well as evidence from murine models of GVHD support a pathogenetic association between GVHD and the development of MG...
Idiopathic hypocomplementemic interstitial nephritis with extensive tubulointerstitial depositsN Kambham
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Am J Kidney Dis 37:388-99. 2001..The preferential tubulointerstitial immune deposition and significant interstitial plasma cell component suggest pathomechanisms that involve local immune complex formation...
C1q nephropathy: a variant of focal segmental glomerulosclerosisGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 64:1232-40. 2003..Although further studies are needed to determine the pathomechanism of C1q deposition, we hypothesize that it may be a non-specific marker of increased mesangial trafficking in the setting of glomerular proteinuria...
Polycystin-2 expression is developmentally regulatedG S Markowitz
Department of Pathology, Renal Pathology Laboratory, Columbia Presbyterian Medical Center, New York 10032, USA
Am J Physiol 277:F17-25. 1999..The persistent strong expression in adult kidney is consistent with a more organ-specific function in the maintenance of the mature metanephric tubule...
Heavy chain deposition disease: the disease spectrumN Kambham
Department of Pathology, Renal Pathology Laboratory, New York, NY, USA
Am J Kidney Dis 33:954-62. 1999..There is no effective treatment for this condition, and virtually all patients progress to chronic renal failure...
Immunofluorescence on pronase-digested paraffin sections: a valuable salvage technique for renal biopsiesS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 70:2148-51. 2006..We conclude that IF-P is a valuable salvage immunohistochemical technique for renal biopsies lacking adequate cortical sampling for IF-F, and is superior to IF-F for the diagnosis of LCFS...
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletionN Tanji
Departments of Pathology and Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Hum Pathol 32:734-40. 2001..This novel form of nephrotoxicity may serve as a prototype for other forms of renal toxicity caused by reverse transcriptase inhibitors...
Effect of tissue processing on the ability to recover nucleic acid from specific renal tissue compartments by laser capture microdissectionN Tanji
Department of Pathology of Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Exp Nephrol 9:229-34. 2001..The specificity of LCM coupled with the sensitivity of RT-PCR should prove a powerful tool for the analysis of gene expression in specific renal compartments from archival human renal biopsies...
Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantationE K Ho
Department of Pathology, Columbia University, New York, NY 10032, USA
Transpl Immunol 20:61-7. 2008..SPA and FC, however, are of great importance for identifying patients which require close monitoring by biopsy and serology for early diagnosis and treatment of acute antibody mediated rejection (AAMR)...
Hepatitis C virus-associated glomerular disease in patients with human immunodeficiency virus coinfectionJ T Cheng
Department of Medicine at Harlem Hospital Center, New York, New York 10037, USA
J Am Soc Nephrol 10:1566-74. 1999..Although hypocomplementemia, cryoglobulinemia, and more prominent hypertension and microscopic hematuria may provide clues to the presence of HCV-GD, renal biopsy is essential to differentiate HCV-GD from HIV-associated nephropathy...
Obesity-related glomerulopathy: an emerging epidemicN Kambham
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 59:1498-509. 2001..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy...
Microscopic intrarenal particles after pulsatile machine preservation do not adversely affect outcomes after renal transplantationJ V Guarrera
Division of Abdominal Organ Transplantation, New York Presbyterian Hospital, New York, New York, USA
Transplant Proc 38:3384-7. 2006..These FPs likely originate from surgical gloves. FPs are too small to be captured by standard filters but clear spontaneously and do not have deleterious effects on renal function or outcomes...
A dual pattern of immunofluorescence positivitySamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 42:419-26. 2003
Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smokingGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Hum Pathol 33:826-35. 2002..0007), degree of tubular atrophy and interstitial fibrosis (P =.0517), and degree of arteriosclerosis (P =.0096). In conclusion, ING is a progressive vasculopathic lesion linked to hypertension and cigarette smoking...
Plasmapheresis treatment of recurrent FSGS in adult renal transplant recipientsA Matalon
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, 10032, USA
Clin Nephrol 56:271-8. 2001..Predictors of response to PP include early initiation of treatment after recurrence and possibly an early recurrence of disease...
Cellular focal segmental glomerulosclerosis: Clinical and pathologic featuresM B Stokes
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Kidney Int 70:1783-92. 2006..Our data support the view that CELL and COLL FSGS are not equivalent and validates an approach to pathologic classification that distinguishes between COLL, CELL, and tip lesion variants of FSGS...
Renal monoclonal immunoglobulin deposition disease: the disease spectrumJ Lin
Division of Nephrology, Department of Medicine, Columbia University, New York-Presbyterian Hospital, 630 W. 168th Street, New York, NY 10032, USA
J Am Soc Nephrol 12:1482-92. 2001..0 mg/dl, emphasizing the importance of early detection. On multivariate analysis, initial creatinine was the only predictor of renal and patient survival in pure MIDD, underscoring the prognostic significance of the renal involvement...
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritisSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 65:85-96. 2004..Proper recognition of this entity requires confirmation of monoclonality by staining for the gamma heavy chain subclasses...
Fibrillary and immunotactoid glomerulonephritis: Distinct entities with different clinical and pathologic featuresJordan L Rosenstock
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Kidney Int 63:1450-61. 2003..Differentiation of FGN from the much more rare entity IT appears justified on immunopathologic, ultrastructural, and clinical grounds...
Membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxibG S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Clin Nephrol 59:137-42. 2003..These cases enlarge the spectrum of potential renal toxicities of the COX-2-specific non-steroidal anti-inflammatory drugs...
Dysproteinemia, proteinuria, and glomerulonephritisS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 69:772-5. 2006
Methotrexate-associated B-cell lymphoma presenting with acute renal failure and bilateral nephromegalyS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 71:272-5. 2007
Nephrotoxicity of antiretroviral therapy in an HIV-infected patientS M Said
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Kidney Int 71:1071-5. 2007
Uveitis and acute renal failureL C Herlitz
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Kidney Int 72:1554-7. 2007
Uromodulin storage diseaseS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 73:971-6. 2008
Glomerular tip lesion: a distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrumM Barry Stokes
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 65:1690-702. 2004..0054). CONCLUSION: Within the MCD/FSGS spectrum, GTL is a distinctive and prognostically favorable clinical-pathologic entity whose presenting features and outcome more closely approximate those of MCD...
Comparative outcome analysis of ABO-incompatible and positive crossmatch renal transplantation: a single-center experienceAnand Padmanabhan
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
Transplantation 87:1889-96. 2009..It is important to compare outcomes, study resource utilization, and attempt to risk stratify patients in these higher risk transplant settings...
Pathology of thin basement membrane nephropathyKirk Foster
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Semin Nephrol 25:149-58. 2005..Importantly, TBMN must be differentiated from the GBM thinning seen in some renal biopsy specimens from boys and female heterozygotes with X-linked Alport syndrome because of the very different prognoses of these two conditions...
Paraplegia, proteinuria, and renal failureS H Nasr
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Kidney Int 69:412-5. 2006
Sickle cell disease, nephrotic syndrome, and renal failureS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 69:1276-80. 2006
Myeloma cast nephropathy, direct renal infiltration by myeloma, and renal extramedullary hematopoiesisS H Nasr
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York City, New York 10032, USA
Kidney Int 73:517-8. 2008
Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronateG S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
J Am Soc Nephrol 12:1164-72. 2001..These data provide the first association of collapsing FSGS with toxicity to a therapeutic agent...
Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reactionN Tanji
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, USA
Histol Histopathol 21:393-401. 2006..IS-PCR is a powerful technique to detect viral DNA in human tissue sections, but requires proper use of negative controls to set optimal fixation, protein digestion, and amplification conditions...
Acute poststaphylococcal glomerulonephritis superimposed on diabetic glomerulosclerosisS H Nasr
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Kidney Int 71:1317-21. 2007
Secondary oxalosis due to excess vitamin C intakeS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Kidney Int 70:1672. 2006
ANCA-associated glomerulonephritis in the very elderlyAndrew S Bomback
Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 79:757-64. 2011..3). However, when follow-up was extended beyond 2 years, immunosuppression was associated with a lower risk of death (HR 0.33, 95% CI 0.11-0.97) and death or ESRD (HR 0.16, 95% CI 0.06-0.42) in multivariable models...
Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literatureSamih H Nasr
Department of Pathology, Division of Nephrology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Medicine (Baltimore) 87:21-32. 2008..Diabetes and aging have emerged as major risk factors for adult APIGN. Full recovery of renal function can be expected in just over half of patients, and prognosis is dismal in those with underlying diabetic glomerulosclerosis...
Thin basement membrane nephropathy cannot be diagnosed reliably in deparaffinized, formalin-fixed tissueSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
Nephrol Dial Transplant 22:1228-32. 2007..No clear criteria could be established to diagnose TBMN by EM-F. Renal pathologists should be aware that reprocessing of paraffin tissue for EM causes artifactual GBM thinning that precludes accurate diagnosis of TBMN...
Mycophenolate mofetil for the treatment of interstitial nephritisDean C Preddie
Department of Medicine Division of Nephrology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH4 124, New York, NY 10032, USA
Clin J Am Soc Nephrol 1:718-22. 2006..4 mo. MMF was well tolerated by all patients. It is concluded that MMF is a useful therapeutic option for steroid-resistant AIN and may be considered as potential first-line therapy in select populations...
Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalitiesLeal C Herlitz
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 78:1171-7. 2010..Our study shows that tenofovir nephrotoxicity is a largely reversible form of toxic acute tubular necrosis targeting proximal tubules and manifesting distinctive light microscopic and ultrastructural features of mitochondrial injury...
Pauci-immune crescentic glomerulonephritis superimposed on diabetic glomerulosclerosisSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
Clin J Am Soc Nephrol 3:1282-8. 2008..Pauci-immune necrotizing and crescentic glomerulonephritis (PNCGN) superimposed on diabetic glomerulosclerosis (DGS) is a rare occurrence. Only limited data on this dual glomerulopathy are available...
Oxalate nephropathy complicating Roux-en-Y Gastric Bypass: an underrecognized cause of irreversible renal failureSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Clin J Am Soc Nephrol 3:1676-83. 2008..The most common bariatric surgery is Roux-en-Y gastric bypass (RYGB), which has been associated with hyperoxaluria and nephrolithiasis. We report a novel association of RYGB with renal insufficiency as a result of oxalate nephropathy...
Foamy podocytesNeil Renwick
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 41:891-6. 2003
Dense deposit disease: clinicopathologic study of 32 pediatric and adult patientsSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Clin J Am Soc Nephrol 4:22-32. 2009..Dense deposit disease (DDD) is a rare disorder that most commonly affects children. This study reports the largest North American series addressing clinicopathologic and outcome differences in children and adults...
Membranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritisSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
Clin J Am Soc Nephrol 4:299-308. 2009..Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported...
Proliferative glomerulonephritis with monoclonal IgG depositsSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Am Soc Nephrol 20:2055-64. 2009..We conclude that proliferative glomerulonephritis with monoclonal IgG deposits does not seem to be a precursor of myeloma in the vast majority of patients...
Nephrotic syndrome after treatment with pamidronateGlen S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 39:1118-22. 2002
Acute and hyperacute humoral rejection in kidney allograft recipients treated with anti-human thymocyte antibodiesAdriana I Colovai
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Hum Immunol 66:501-12. 2005..Flow cytometry testing of ATG reactivity to endothelial cells may be useful in identifying and discarding the ATG lots containing xenoantibodies that can bind to activated endothelial cells of the transplant...
An unusual finding in the renal medullaLawrence Tsao
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 46:780-6. 2005
Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survivalGeorge Vlad
Department of Pathology, Columbia University, New York, NY 10032, USA
Hum Immunol 70:589-94. 2009..Nevertheless, SPA and FCXM are invaluable tools, assisting clinicians in gauging AMR risk and tailoring immunosuppression of the posttransplantation immunological monitoring accordingly...
A 14-year-old male with asymptomatic proteinuria and hearing lossSamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 41:259-64. 2003
Hereditary nephritis mimicking immune complex-mediated glomerulonephritisSamih H Nasr
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10023, USA
Hum Pathol 37:547-54. 2006..These cases expand the spectrum of unusual pathological findings in hereditary nephritis and emphasize the potential for hereditary nephritis to mimic immune complex glomerulonephritis...
Development of glomerulonephritis during anti-TNF-alpha therapy for rheumatoid arthritisMichael B Stokes
Department of Pathology, Renal Pathology Laboratory, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Nephrol Dial Transplant 20:1400-6. 2005..Treatment of rheumatoid arthritis with anti-tumour necrosis factor alpha (TNFalpha) agents may lead to autoantibody formation and flares of vasculitis, but renal complications are rare...
IgG1 lambda light and heavy chain renal amyloidosisS H Nasr
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 70:7. 2006
Chronic lymphocytic leukemia and cryoglobulinemic glomerulonephritisS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 71:93. 2007
Recurrent hemolytic uremic syndrome in the renal allograftS H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 69:949. 2006
Collapsing glomerulopathyJoshua A Schwimmer
Division of Nephrology, Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
Semin Nephrol 23:209-18. 2003..The role of other immunosuppressive agents such as mycophenolate mofetil in the treatment of collapsing FSGS remains to be defined. Prospective clinical trials are needed to define optimal therapy of this aggressive form of FSGS...
Identification of IgG subclasses and C-reactive protein in lupus nephritis: the relationship between the composition of immune deposits and FCgamma receptor type IIA allelesRicardo Zuniga
Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, New York 10021, USA
Arthritis Rheum 48:460-70. 2003....
Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansingGlen S Markowitz
Department of Pathology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
Hum Pathol 35:675-84. 2004..Greater awareness of this entity is needed to identify potential risk factors...
De novo thrombotic microangiopathy following treatment with sirolimus: report of two casesR John Crew
Division of Nephrology, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Nephrol Dial Transplant 20:203-9. 2005
Development of focal segmental glomerulosclerosis after anabolic steroid abuseLeal C Herlitz
Columbia University College of Physicians and Surgeons, Department of Pathology, New York, NY 10032, USA
J Am Soc Nephrol 21:163-72. 2010..Because of the expected rise in serum creatinine as a result of increased muscle mass in bodybuilders, this complication is likely underrecognized...
Angiotensin converting enzyme inhibition in chronic allograft nephropathyJulie Lin
Department of Medicine, Columbia University, New York, New York 10032, USA
Transplantation 73:783-8. 2002..It is associated with a trend of slowing renal insufficiency as well as a significant survival benefit in the combined endpoint of allograft failure or death...
Osmotic nephrosis in a renal transplant recipientZ Ebcioglu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Kidney Int 70:1873-6. 2006
A destructive nasal lesion and glomerulonephritisF P Wilson
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Kidney Int 69:1699-703. 2006
Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosaN Kambham
Departments of Pathology and Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Kidney Dis 36:190-6. 2000..This is the first demonstration of beta4 integrin expression in human glomeruli. We postulate a role for altered beta4 integrin function in the mediation of the glomerular permeability defect...
Supersized kidneys: Lessons from the preclinical obese kidneyV D D'Agati
Department of Pathology, Columbia University, New York, New York 10032, USA
Kidney Int 73:909-10. 2008..Kidney biopsies and functional studies performed on morbidly obese patients without overt renal disease who presented for bariatric surgery have helped to elucidate the earliest obesity-related structural and functional responses...
Giant cell tubulitis with immune complex deposits in a patient with lupus nephritisJeffrey B Hodgin
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 53:513-7. 2009..The present case suggests there may also be a pathogenetic role for autoimmunity in this condition...
Very low birth weight is a risk factor for secondary focal segmental glomerulosclerosisJeffrey B Hodgin
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Clin J Am Soc Nephrol 4:71-6. 2009..LBW is associated with reduced nephron endowment and increased glomerular volume; however, the development of secondary focal segmental glomerulosclerosis (FSGS) has not been reported previously...
Alloantibodies and the outcome of cadaver kidney allograftsElena Rodica Vasilescu
Department of Pathology, Columbia University, New York, NY, USA
Hum Immunol 67:597-604. 2006..Extensive analysis of patients' sera using a comprehensive set of tests may contribute to early treatment and better understanding of the mechanism underlying humoral rejection...
Granulomatous interstitial nephritisSamih H Nasr
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 41:714-9. 2003
IgA-dominant acute poststaphylococcal glomerulonephritis complicating diabetic nephropathySamih H Nasr
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Hum Pathol 34:1235-41. 2003..Proper recognition of this entity is needed to avoid an erroneous diagnosis of IgA nephropathy, with corresponding therapeutic and prognostic implications...
A rare infectious cause of renal allograft dysfunctionAllison A Hill-Edgar
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 40:1103-7. 2002
Cardiac defects and renal failure in mice with targeted mutations in Pkd2G Wu
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Nat Genet 24:75-8. 2000..Our studies advance our understanding of the function of polycystin-2 in development and our mouse models recapitulate the complex human ADPKD phenotype...
Minimal change disease in systemic lupus erythematosusG K Dube
Department of Pathology, Columbia University, New York Presbyterian Hospital, NY, USA
Clin Nephrol 57:120-6. 2002..Proper recognition of this entity requires careful integration of the renal biopsy immunofluorescence and electron microscopic findings...
RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathyThoralf M Wendt
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Am J Pathol 162:1123-37. 2003....
A rare cause of nephrotic syndromeRita Shaknovich
Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
Am J Kidney Dis 39:892-5. 2002
A rare complication of monoclonal gammopathySamih H Nasr
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 40:867-71. 2002
Renal failure following bowel cleansing with a sodium phosphate purgativeGlen S Markowitz
Nephrol Dial Transplant 20:850-1. 2005
Towards the incidence of acute phosphate nephropathyGlen S Markowitz
J Am Soc Nephrol 18:3020-2. 2007
SLE and rapidly progressive glomerulonephritisNaveed N Masani
Department of Medicine, Division of Nephrology and Hypertension, Winthrop University Hospital, Mineola, NY, USA
Am J Kidney Dis 45:950-5. 2005
Prolonged postpartum proteinuria after early preeclampsiaJohn H C Durham
Department of Medicine, Division of Nephrology and Hypertension, Winthrop University Hospital, Mineola, NY, USA
Am J Kidney Dis 43:186-91. 2004
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney diseaseStephanie J Leuenroth
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 104:4389-94. 2007..We anticipate that small molecule induction of PC2-dependent calcium release is likely to be a valid therapeutic strategy for ADPKD...
