Research Topics
| Helen LuSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Tissue engineering strategies for the regeneration of orthopedic interfacesHelen H Lu
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace, MC 8904, New York, NY 10027, USA
Ann Biomed Eng 38:2142-54. 2010..It is anticipated that interface tissue engineering will enable integrative soft tissue repair, and will be instrumental for the development of complex musculoskeletal tissue systems with biomimetic complexity and functionality...- Compositional effects on the formation of a calcium phosphate layer and the response of osteoblast-like cells on polymer-bioactive glass compositesHelen H Lu
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
Biomaterials 26:6323-34. 2005..The results of this study suggest that there is a threshold BG content which is optimal for osteoblast growth, and the interactions between PLAGA and BG may modulate the kinetics of Ca-P formation and the overall cellular response... - Controlled delivery of platelet-rich plasma-derived growth factors for bone formationHelen H Lu
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Biomed Mater Res A 86:1128-36. 2008..Future studies will focus on optimizing this system to increase the clinical efficacy of PRP by matching the distribution and temporal sequencing of PRP-derived factors to the bone healing cascade... - Interface tissue engineering and the formulation of multiple-tissue systemsHelen H Lu
Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA
Adv Biochem Eng Biotechnol 102:91-111. 2006..Future directions in the field of interface tissue engineering will also be discussed... - Biomimetic stratified scaffold design for ligament-to-bone interface tissue engineeringHelen H Lu
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
Comb Chem High Throughput Screen 12:589-97. 2009..Finally, potential challenges and future directions in this emerging area of advanced scaffold design will be discussed... - Differential growth factor retention by platelet-rich plasma compositesRick C Tsay
Division of Oral and Maxillofacial Surgery, School of Dental and Oral Surgery, Columbia University, New York, NY 1032, USA
J Oral Maxillofac Surg 63:521-8. 2005..TRAP-BS may prove more efficacious than thrombin in sustaining growth factor levels critical for the cascade of events leading to bone formation... - Osteoblast and chondrocyte interactions during coculture on scaffoldsJeffrey P Spalazzi
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
IEEE Eng Med Biol Mag 22:27-34. 2003 - In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering using polymer-bone morphogenetic protein matricesHelen H Lu
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Biochem Biophys Res Commun 305:882-9. 2003..These results demonstrate the efficacy of a BMP-polymer matrix in inducing the expression of the osteoblastic phenotype by muscle-derived cells and present a new paradigm for bone tissue engineering... - Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repairJie Jiang
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
Ann Biomed Eng 38:2183-96. 2010..These results demonstrate the potential of the stratified scaffold for integrative cartilage repair and future studies will focus on scaffold optimization and in vivo evaluations... - Polymer-ceramic composite scaffold induces osteogenic differentiation of human mesenchymal stem cellsNatalie L Leong
Dept. of Biomed. Eng, Columbia Univ, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:2651-4. 2006..The findings of this study collectively demonstrate the osteoinductivity of the PLGA-BG composite and its potential as a bone tissue engineering scaffold... - In vivo evaluation of a tri-phasic composite scaffold for anterior cruciate ligament-to-bone integrationJeffrey P Spalazzi
Dept. of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:525-8. 2006..The results of this study demonstrate the feasibility of multi-tissue regeneration on a single graft, as well as th- e potential of interface tissue engineering to enable the biological fixation of soft tissue grafts to bone... - Role of cell-cell interactions on the regeneration of soft tissue-to-bone interfaceI-Ning E Wang
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:783-6. 2006..The findings of thi- s study provide new insight into the mechanisms governing the regeneration of soft tissue-to-bone interfaces... - Co-culture of osteoblasts and chondrocytes modulates cellular differentiation in vitroJie Jiang
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Biochem Biophys Res Commun 338:762-70. 2005..These results collectively suggest that interactions between osteoblasts and chondrocytes modulate cell phenotypes, and the importance of these interactions on osteochondral interface regeneration will be explored in future studies... - Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studiesHelen H Lu
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Biomaterials 26:4805-16. 2005..Therefore based on the overall cellular response and its temporal mechanical and degradation properties in vitro, the PLLA braided scaffold pre-coated with Fn was found to be the most suitable substrate for ACL tissue engineering... - Controlled release of PRP-derived growth factors promotes osteogenic differentiation of human mesenchymal stem cellsSylvia S Lin
Coll. of Dental Med, Columbia Univ, New York, NY, USA
Conf Proc IEEE Eng Med Biol Soc 1:4358-61. 2006..Future studies will focus on in vitro and in vivo testing of the efficacy of hydrogel-based PRP release systems... - In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integrationJeffrey P Spalazzi
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Biomed Mater Res A 86:1-12. 2008.... - Development of controlled matrix heterogeneity on a triphasic scaffold for orthopedic interface tissue engineeringJeffrey P Spalazzi
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
Tissue Eng 12:3497-508. 2006..The results of this study demonstrate the feasibility of multi-tissue regeneration on a single scaffold, and the potential of interface tissue engineering to enable the biological fixation of soft tissue grafts to bone... - Anatomically shaped osteochondral constructs for articular cartilage repairClark T Hung
Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
J Biomech 36:1853-64. 2003..Anatomically shaped constructs on a bony substrate may represent a new paradigm in the design of a functional articular cartilage tissue replacement... - Activation of platelet-rich plasma using thrombin receptor agonist peptideRegina Landesberg
Division of Oral and Maxillofacial Surgery, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
J Oral Maxillofac Surg 63:529-35. 2005..This study proposes an alternative preparation method of platelet-rich plasma (PRP). Specifically, we compare the use of thrombin receptor agonist peptide-6 (TRAP) and bovine thrombin as a clotting agent in the preparation of PRP... - Role of osteoblast-fibroblast interactions in the formation of the ligament-to-bone interfaceI Ning E Wang
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace Building, MC 8904, New York, New York 10027, USA
J Orthop Res 25:1609-20. 2007..These results provide new insight into the mechanism of fibrocartilage formation, which are critical for interface tissue engineering and achieving biological fixation of soft tissue grafts to bone... - Mechanoactive scaffold induces tendon remodeling and expression of fibrocartilage markersJeffrey P Spalazzi
Department of Biomedical Engineering, Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
Clin Orthop Relat Res 466:1938-48. 2008..The data suggest the potential of a mechanoactive scaffold to promote the formation of an anatomic fibrocartilage enthesis on tendon-based ACL reconstruction grafts... - Age-dependent changes in matrix composition and organization at the ligament-to-bone insertionI-Ning E Wang
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, 351 Engineering Terrace Bldg, MC8904, New York, New York 10027, USA
J Orthop Res 24:1745-55. 2006..Marked differences in collagen fiber orientation between the femoral and tibial insertions were observed, and these differences became more pronounced with age... - Novel nanofiber-based scaffold for rotator cuff repair and augmentationKristen L Moffat
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
Tissue Eng Part A 15:115-26. 2009..Moreover, nanofiber organization has a profound effect on cellular response and matrix properties, and it is a critical parameter for scaffold design... - Orthopedic interface tissue engineering for the biological fixation of soft tissue graftsKristen L Moffat
Department of Biomedical Engineering, Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace Building, MC 8904, New York, NY 10027, USA
Clin Sports Med 28:157-76. 2009.... - Characterization of the structure-function relationship at the ligament-to-bone interfaceKristen L Moffat
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 105:7947-52. 2008..The interface structure-function relationship elucidated in this study provides critical insight for interface regeneration and the formation of complex tissue systems... - Characterization of the mechanical properties and mineral distribution of the anterior cruciate ligament-to-bone insertion siteKristen L Moffat
Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, New York, NY 10021, USA
Conf Proc IEEE Eng Med Biol Soc 1:2366-9. 2006..The findings of this study suggest that a structure-function relationship exists at the ACL-to-bone interface... - Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament-bone insertionsJeffrey P Spalazzi
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, and St. Luke's/Roosevelt Hospital Center, Department of Orthopaedic Surgery, New York, New York 10027, USA
J Orthop Res 24:2001-10. 2006..Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone... - Effects of applied DC electric field on ligament fibroblast migration and wound healingPen Hsiu Grace Chao
Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
Connect Tissue Res 48:188-97. 2007..Our results demonstrate that applied EFs augment ACL fibroblast migration and biosynthesis and provide potential mechanisms by which EFs may be used for enhancing ligament healing and repair... - Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitroHelen H Lu
Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
J Biomed Mater Res A 64:465-74. 2003..Future work will focus on the optimization of the composite scaffold for bone tissue-engineering applications and the evaluation of the 3-D composite in an in vivo model... - Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineeringGregory H Altman
Tufts University, Department of Chemical and Biological Engineering, Bioengineering Center, 4 Colby Street, Medford, MA 02155, USA
J Biomech Eng 124:742-9. 2002..5%) over 14 days in culture. The system supported cell spreading and growth on the silk fiber matrices based on SEM characterization, as well as the differentiation of the cells into ligament-like cells and tissue (Altman et al., 2001)... - Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered boneSaadiq F El-Amin
Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
J Orthop Res 20:20-8. 2002.... - Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluationJames A Cooper
Department of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
Biomaterials 26:1523-32. 2005..The resultant micro-porous scaffold exhibited optimal pore diameters (175-233 microm) for ligament tissue ingrowth, and initial mechanical properties of the construct approximate those of the native ligament... - Silk matrix for tissue engineered anterior cruciate ligamentsGregory H Altman
Bioengineering Center, Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
Biomaterials 23:4131-41. 2002..These results point toward this matrix as a new option for ACL repair to overcome current limitations with synthetic and other degradable materials... - Engineering complex tissuesAntonios G Mikos
Department of Bioengineering, Rice University, Houston, Texas, USA
Tissue Eng 12:3307-39. 2006..b>Helen Lu discussed engineering of tissue interfaces, a problem critical for biological fixation of tendons and ligaments, ..
Research Grants
- Interface Tissue Engineering for Soft Tissue-to-Bone IntegrationHelen H Lu; Fiscal Year: 2010....
- Development of a Multi-phased Scaffold for Soft Tissue to Bone IntegrationHelen Lu; Fiscal Year: 2006..abstract_text> ..