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Genomes and Genes | Tadahiro KitamuraSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Insulin receptor knockout miceTadahiro Kitamura
Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Annu Rev Physiol 65:313-32. 2003....- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthTadahiro Kitamura
Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
J Clin Invest 110:1839-47. 2002..We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts... - Mosaic analysis of insulin receptor functionTadahiro Kitamura
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Clin Invest 113:209-19. 2004..These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action... - The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cellsMasayuki Adachi
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Gastroenterology 132:1434-46. 2007..Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. A fibrotic stimulus causes HSCs to transdifferentiate from a quiescent phenotype to a collagen-producing myofibroblast-like phenotype and to proliferate... - Transgenic rescue of insulin receptor-deficient miceHaruka Okamoto
Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 114:214-23. 2004..These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes... - The forkhead transcription factor Foxo1 regulates adipocyte differentiationJun Nakae
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Dev Cell 4:119-29. 2003..We propose that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation... - FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA inductionYukari Ido Kitamura
Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
Cell Metab 2:153-63. 2005..The findings provide a mechanism linking glucose- and growth factor receptor-activated pathways to protect beta cells against oxidative damage via FoxO proteins... - Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1Tadahiro Kitamura
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 100321, USA
Mol Cell Biol 29:4417-30. 2009..We conclude that FoxO1+ Ins(-) juxtaductal cells represent a hitherto-unrecognized pancreatic cell population with in vitro capability of endocrine differentiation... - A Foxo/Notch pathway controls myogenic differentiation and fiber type specificationTadahiro Kitamura
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Clin Invest 117:2477-85. 2007..Notch/Foxo1 cooperation may integrate environmental cues through Notch with metabolic cues through Foxo1 to regulate progenitor cell maintenance and differentiation... - Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cellsJun Tanaka
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Diabetes 58:2344-54. 2009..Biochemical mechanism leading from hyperglycemia to oxLDL formation and eNOS dysfunction is unknown... - Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolismMichihiro Matsumoto
Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
J Clin Invest 116:2464-72. 2006.... - Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factorsMarta L Hribal
Russ Berrie Research Pavilion, Rm. 238, 1150 St. Nicholas Avenue, New York, NY 10032, USA
J Cell Biol 162:535-41. 2003..Inhibition of Foxo expression by siRNA resulted in more efficient differentiation, associated with increased myosin expression. These observations indicate that Foxo proteins are key effectors of Akt-dependent myogenesis... - Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intakeTadahiro Kitamura
Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
Nat Med 12:534-40. 2006..Thus, FoxO1 represents a shared component of pathways integrating food intake and peripheral metabolism... - Generation of functional insulin-producing cells in the gut by Foxo1 ablationChutima Talchai
1 Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA 2 Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA 3 Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
Nat Genet 44:406-12. 2012..The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes... - Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptorShouhong Xuan
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 110:1011-9. 2002..These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion... - Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1Jun Nakae
Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nat Genet 32:245-53. 2002..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version... - Role of FoxO Proteins in Pancreatic beta CellsTadahiro Kitamura
Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
Endocr J 54:507-15. 2007..Genetic or pharmacological manipulation of FoxO can be used to prevent beta cell failure or aid in the differentiation of uncommitted endocrine progenitors into beta cells for transplantation... - Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivoKinh Tung T Nguyen
Department of Medicine, Medical Biophysics, Institute of Medical Science, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Mol Cell Biol 26:4511-8. 2006..Parallel enhancement in PI3K signaling was found in PTEN-deficient hypothalamus and beta cells. Together, we have shown that PTEN in insulin-transcribing cells may play an integrative role in regulating growth and metabolism in vivo... - The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathwaysAnaïs Perilhou
Department of Endocrinology, Metabolism, and Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Mol Cell Biol 28:6568-79. 2008..We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism...