Research Topics
| Stephen GoffSummaryAffiliation: Columbia University Country: USA Publications
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Publications
HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8Susana T Valente
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA
Mol Cell 36:279-89. 2009..eIF3f affects HIV-1 3' end processing by modulating the sequence-specific recognition of the HIV-1 pre-mRNA by 9G8...- Isolation of suppressor genes that restore retrovirus susceptibility to a virus-resistant cell lineGuangxia Gao
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Retrovirology 1:30. 2004..These selections have been used to recover lines that block early postentry stages of infection, either before reverse transcription or before nuclear entry. The mechanisms of action of these blocks remain unknown... - Endophilins interact with Moloney murine leukemia virus Gag and modulate virion productionMargaret Q Wang
Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Biol 3:4. 2003..The findings imply that endophilin is another component of the large complex that is hijacked by retroviruses to promote virion production... - Genetic reprogramming by retroviruses: enhanced suppression of translational terminationStephen P Goff
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Cell Cycle 3:123-5. 2004..The observations suggest that retroviruses manipulate the translational machinery in sophisticated ways to fine-tune their own gene expression... - Genetic control of retrovirus susceptibility in mammalian cellsStephen P Goff
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
Annu Rev Genet 38:61-85. 2004..The major host factors involved in the early phase of the viral life cycle are discussed... - Retrovirus restriction factorsStephen P Goff
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Mol Cell 16:849-59. 2004..It may someday be possible to enhance or activate these systems to induce antiviral states... - Host factors exploited by retrovirusesStephen P Goff
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute HHSC 1310c, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, New York 10032, USA
Nat Rev Microbiol 5:253-63. 2007..Ongoing efforts are identifying an enormous array of cellular proteins that are used by the viruses in the course of their travels. These host factors are potential new targets for therapeutic intervention... - Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathwaysS P Goff
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
J Gene Med 3:517-28. 2001..This knowledge in turn should enable the development of better and more efficient retroviral vectors for use in gene therapy protocols in vivo... - Death by deamination: a novel host restriction system for HIV-1Stephen P Goff
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
Cell 114:281-3. 2003..The enzyme attacks viral DNA as it is synthesized in infected cells and prevents the formation of functional proviruses. The Vif gene of HIV-1 blocks this host restriction and so allows virus replication... - Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational terminationMarianna Orlova
Department of Biochemistry and Molecular Biophysics, Integrated Program in Cell and Molecular Biology, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Cell 115:319-31. 2003..These results suggest that RT enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough... - Inhibition of HIV-1 gene expression by a fragment of hnRNP USusana T Valente
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, New York 10032, USA
Mol Cell 23:597-605. 2006..The results suggest that HIV-1 requires machinery for the nuclear export of viral mRNAs that can be specifically blocked by an interfering gene... - Embryonic stem cells use ZFP809 to silence retroviral DNAsDaniel Wolf
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, HHSC 1310, 701 West 168th Street, New York, New York 10032, USA
Nature 458:1201-4. 2009..We propose that ZFP809 evolved as a stem-cell-specific retroviral restriction factor, and therefore constitutes a new component of the intrinsic immune system of stem cells... - Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger proteinGuangxia Gao
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
Science 297:1703-6. 2002..The finding suggests the existence of a previously unknown machinery for the inhibition of virus replication, targeting a step in viral gene expression... - The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle productionFadila Bouamr
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Virol 81:2909-22. 2007..Together, these data indicate that fragments of Hrs containing the C-terminal portion of the protein can potently inhibit HIV-1 particle release by efficiently sequestering Tsg101 away from the Gag polyprotein... - Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognitionDavid Lim
Integrated Program in Cellular, Molecular and Biophysical Studies, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 76:8360-73. 2002..The data also suggest that the C helix may play an important role in polypurine tract recognition and proper formation of the plus-strand DNA's 5' end... - TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cellsDaniel Wolf
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell 131:46-57. 2007..The identification of TRIM28 as a retroviral silencer adds to the growing body of evidence that many TRIM family proteins are involved in retroviral restriction... - Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindnessStephen H Tsang
Brown Glaucoma Laboratory, Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
Hum Mutat 28:243-54. 2007..Nevertheless, such animals should be of considerable value in further studies of the molecular pathology of CSNB... - TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cellsDaniel Wolf
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:12521-6. 2008..These results generalize the role of TRIM28 in retroviral restriction and suggest that this system has evolved to restrict multiple retroviruses... - Inhibition of HIV-1 replication by eIF3fSusana T Valente
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 106:4071-8. 2009..Our results suggest a role of eIF3f in mRNA maturation and that it can specifically interfere with the 3' end processing of HIV-1 mRNAs... - Knockdown screens to knockout HIV-1Stephen P Goff
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1310c, New York, NY 10032, USA
Cell 135:417-20. 2008..Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration... - Dynamic instability of genomic methylation patterns in pluripotent stem cellsSteen Kt Ooi
Department of Genetics and Development, Columbia University, New York, USA
Epigenetics Chromatin 3:17. 2010.... - Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factorsBarbara Studamire
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, Hammer Health Sciences Center, Room 1310c, New York 10032, USA
Retrovirology 5:48. 2008..Significant questions remain regarding the influence of host proteins on the selection of target sites, on the repair of integration intermediates, and on the efficiency of integration... - Upf1 senses 3'UTR length to potentiate mRNA decayJ Robert Hogg
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Cell 143:379-89. 2010..We propose a model for 3'UTR length surveillance in which equilibrium binding of Upf1 to mRNAs precedes a kinetically distinct commitment to RNA decay... - Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infectionAndrew Yueh
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Virol 80:342-52. 2006..The results suggest that the SUMOylation of CA mediated by an interaction with Ubc9 and PIASy is required for early events of infection, after reverse transcription and before nuclear entry and viral DNA integration... - Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factorsGreg J Towers
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nat Med 9:1138-43. 2003..Manipulation of HIV-1 CA recognition by restriction factors promises to advance animal models and new therapeutic strategies for HIV-1 and AIDS... - Characterization of Moloney murine leukemia virus p12 mutants blocked during early events of infectionBing Yuan
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 76:10801-10. 2002.... - Moesin regulates stable microtubule formation and limits retroviral infection in cultured cellsMojgan H Naghavi
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
EMBO J 26:41-52. 2007..Together, these results suggest that moesin negatively regulates stable microtubule networks and is a natural determinant of cellular sensitivity to retroviral infection... - Restriction of multiple divergent retroviruses by Lv1 and Ref1Theodora Hatziioannou
Aaron Diamond AIDS Research Center and The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
EMBO J 22:385-94. 2003..These data suggest that restriction factors in human and non-human primate cells are able to recognize and block infection by multiple, widely divergent retroviruses and that the factors themselves may be related... - Expression of the zinc-finger antiviral protein inhibits alphavirus replicationMatthew J Bick
Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, New York 10021, USA
J Virol 77:11555-62. 2003..Elucidation of the antiviral mechanism by which ZAP inhibits Sindbis virus translation may lead to the development of agents with broad activity against alphaviruses... - Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28Daniel Wolf
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, HHSC 1310, 701 West 168th Street, New York, NY 10032, USA
J Virol 82:4675-9. 2008..Here we show, using a cell line with a point mutation in the HP1 binding domain of TRIM28, that interaction with HP1 is absolutely required for the PBS-dependent restriction of MLV in the F9 EC cell line... - Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infectionYi Jun Zhang
Aaron Diamond AIDS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Virol 76:6332-43. 2002..Overall, these data exclude a major role for GAGs in mediating the attachment of many HIV-1 strains to target cells via interactions with virion-associated gp120 or CypA... - Host restriction factors blocking retroviral replicationDaniel Wolf
HHMI, Department of Biochemistry, Columbia University, New York, NY 10032, USA
Annu Rev Genet 42:143-63. 2008..This review is a survey of the best-characterized restriction factors capable of inhibiting retroviral replication and aims to highlight the diversity of strategies used for this task... - Interaction of Moloney murine leukemia virus matrix protein with IQGAPJuliana Leung
Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
EMBO J 25:2155-66. 2006..Virus replication was potently inhibited by a C-terminal fragment of IQGAP1, and impaired by RNAi knockdown of IQGAP1 and 2. We suggest that the IQGAPs link the virus to the cytoskeleton for trafficking both into and out of the cell... - Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infectionAndrew Yueh
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 77:1820-9. 2003..The restored function of S(61,65)A mutant virus by second or third site mutations may result from a structural change or the addition of positively charged residues in the arginine-rich region... - Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinaseFeng Cong
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
J Biol Chem 277:34870-8. 2002..These results suggest that one role of c-Abl may be to negatively regulate UV-DDB activity by phosphorylation of DDB2... - Defects in virion production caused by mutations affecting the C-terminal portion of the Moloney murine leukemia virus capsid proteinMargaret Q Wang
Department of Microbiology, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 77:3339-44. 2003..The results suggest that the unique carboxy terminus of CA in the Mo-MuLV plays an important role in Gag-Gag association during virion production... - Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cellsJason J Rodriguez
Columbia University, Howard Hughes Medical Institute, HHSC 1310c, New York, New York 10032, USA
J Virol 84:2556-62. 2010..These data suggest that XMRV may replicate more efficiently in LNCaP cells in part due to the transcriptional environment in LNCaP cells... - Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase CBaojie Li
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 277:12418-22. 2002.... - RNA sequences in the Moloney murine leukemia virus genome bound by the Gag precursor protein in the yeast three-hybrid systemMatthew J Evans
Department of Biochemistry and Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Virol 78:7677-84. 2004..These finding support the notion that two stem-loops (C and D) are not sufficient to form a core MMLV encapsidation signal... - Somatic cell genetic analyses to identify HIV-1 host restriction factorsSusana T Valente
Department of Biochemistry, Columbia University, Howard Hughes Medical Institute College of Physicians and Surgeons, New York NY, USA
Methods Mol Biol 485:235-55. 2009..Here we report the strategy and techniques to prepare a library and isolate HIV antiviral genes, using the identification of N-86-HnRNPU as an example... - Role of residues in the tryptophan repeat motif for HIV-1 reverse transcriptase dimerizationGilda Tachedjian
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th St, New York, NY 10032, USA
J Mol Biol 326:381-96. 2003..We conclude that mutations at codons 401 and 414 in p66 impair dimerization by altering the proper positioning of structural elements in between these residues that make important contacts with p51... - Transient immunosuppression stops rejection of virus-transduced enhanced green fluorescent protein in rabbit retinaKentaro Doi
Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St, New York, NY 10032, USA
J Virol 78:11327-33. 2004..Detection must depend upon a brief window of time after surgery needed to introduce the vector, perhaps related to a concurrent but transient inflammation. This strategy may be useful in managing other types of rejection in the retina... - Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationMatthew J Evans
Integrated Program in Cellular, Molecular, and Biophysical Studies, Department of Biochemistry and Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 101:13038-43. 2004.... - Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cellsMojgan H Naghavi
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Genes Dev 19:1105-15. 2005..Thus, our data suggest that FEZ1 overexpression is sufficient to explain the resistant phenotype of R3-2 cells and identify FEZ1 as a new gene capable of causing retrovirus resistance... - PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected]Fadila Bouamr
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Virol 77:11882-95. 2003..This result suggests that Nedd4 is involved early in budding of HTLV-1... - c-Abl-deficient mice exhibit reduced numbers of peritoneal B-1 cells and defects in BCR-induced B cell activationRachel A Liberatore
Columbia University, New York, NY, USA
Int Immunol 21:403-14. 2009..Additionally, we show that c-Abl-deficient B cells are defective in their ability to be activated in response to antigen receptor engagement, suggesting a functional role for c-Abl in BCR-dependent activation signaling pathways... - Genetic interactions between hepatitis C virus repliconsMatthew J Evans
Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Virol 78:12085-9. 2004..These results suggest that at least one factor in Huh7 cells required for HCV RNA replication is limiting and saturable... - Pitx3 is required for development of substantia nigra dopaminergic neuronsIrene Nunes
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:4245-50. 2003..These data suggest that Pitx3-dependent gene expression is specifically required for the differentiation of DA progenitors within the mesencephalic DA system... - DDB1 is essential for genomic stability in developing epidermisYong Cang
Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:2733-7. 2007..Our results suggest that DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability... - Homo- and hetero-oligomerization of the c-Abl kinase and Abelson-interactor-1Pang-Dian Fan
Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 63:873-7. 2003..These results suggest the possibility that oligomerization of Abl kinases, perhaps involving regulation by their interaction partners, may play a role in modulation of kinase activity in both normal and oncogenic processes... - Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cellsYong Cang
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Cell 127:929-40. 2006..Our results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells... - Crystal structure of the moloney murine leukemia virus RNase H domainDavid Lim
Integrated Program in Cellular, Molecular and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 80:8379-89. 2006..coli, and HIV-1 revealed that a loop of the HIV-1 connection domain resides within the same region of the Mo-MLV and E. coli C-helix. The HIV-1 connection domain may serve to recognize and bind the RNA/DNA substrate major groove... - Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexesDarius Moradpour
Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
J Virol 78:7400-9. 2004..These findings reveal an unexpected flexibility of the C-terminal domain of NS5A and provide tools for studying the formation and turnover of HCV replication complexes in living cells... - HIV: replication trimmed backStephen P Goff
Nature 427:791-3. 2004 - The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifsXuemin Guo
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
J Virol 78:12781-7. 2004..Disruption of the second and fourth zinc fingers abolished ZAP's activity, whereas disruption of the first and third fingers just slightly lowered its activity... - Post-entry restriction of retroviral infectionsGreg J Towers
Wohl Virion Center, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, 46 Cleveland St, London W1T 4JF, UK
AIDS Rev 5:156-64. 2003..In each case the block to one retrovirus can be saturated by co-infection with a second restricted virus. The possible mechanisms of action, and evolutionary consequences of restriction, are reviewed... - The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infectionJuliane Haedicke
Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
J Virol 82:4665-70. 2008..Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks... - The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivoStephen H Tsang
Jules Stein Eye Institute, UCLA School of Medicine, 100 Stein Plaza, Los Angeles, CA 90095 7000, USA
Vision Res 42:439-45. 2002..In fact, animals carrying the Del7C transgene have low PDE activity as well as reduced PDEalpha and PDEbeta content... - Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activityBaojie Li
Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609
J Biol Chem 277:28870-6. 2002..These results suggest that Aph2 may be involved in ER stress-induced apoptosis in which c-Abl plays an important role... - Retroviral proteins that interact with the host cell cytoskeletonMojgan H Naghavi
School of Medicine and Medical Science, Center for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
Curr Opin Immunol 19:402-7. 2007..Developing studies are discovering several host and viral factors that play important roles in retroviral trafficking... - Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C deltaBaojie Li
Institute of Molecular and Cell Biology, Proteos Singapore 138673
Genes Dev 18:1824-37. 2004..Hence, our results unveiled a previously unrecognized mechanism by which c-Abl and Atm participate in oxidative stress response... - Role of Gas6 in erythropoiesis and anemia in miceAnne Angelillo-Scherrer
Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, University Hospital Center, University of Lausanne, Lausanne, Switzerland
J Clin Invest 118:583-96. 2008..These findings may have implications for the treatment of patients with anemia who fail to adequately respond to Epo... - Characterization of murine leukemia virus restriction in mammalsCaroline Besnier
Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom
J Virol 77:13403-6. 2003..We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked... - The effect of NNRTIs on HIV reverse transcriptase dimerizationGilda Tachedjian
Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Commercial Road, Melbourne, Victoria 3004, Australia
Curr Opin Investig Drugs 4:966-73. 2003..These studies suggest that modulation of subunit interaction by NNRTIs represents a previously unrecognized property of these RT inhibitors that could be exploited to produce more potent inhibitors of HIV-1 RT... - Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formationGilda Tachedjian
Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Melbourne, VIC 3004, Australia
FEBS Lett 579:379-84. 2005..These data suggest that potent mediators of RT dimerization might interfere with the late-stages of viral replication... - Gln(84) of moloney murine leukemia virus reverse transcriptase regulates the incorporation rates of ribonucleotides and deoxyribonucleotidesShufeng Liu
Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
FEBS Lett 580:1497-501. 2006..Kinetic analysis and gel-retardation assays suggested that the substitution increased the enzyme's general affinity for the template-primer... - Small philanthropy and big science: the RETROVIROLOGY prize and Stephen P. GoffKuan Teh Jeang
The National Institutes of Health, Bethesda, MD, USA
Retrovirology 2:43. 2005..Stephen P. Goff wins the 2005 RETROVIROLOGY prize... - Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinasesMasahiro Maruoka
Laboratory of Molecular Oncology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
FEBS Lett 579:2986-90. 2005..These results show that Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions...
Research Grants
- CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTSStephen Goff; Fiscal Year: 2003..In each case, these tests will be applied to existing panels of mutants to help localize the regions needed for these activities. ..
- CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTSStephen Goff; Fiscal Year: 2006..These experiments will significantly extend our understanding of retrovirus replication, and may provide important new targets for antiviral intervention. ..