Research Topics
Species | A ValujskikhSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
The challenge of inhibiting alloreactive T-cell memoryA Valujskikh
Cleveland Clinic Foundation, Immunology, NB30, 9500 Euclid Ave, Cleveland, Ohio, USA
Am J Transplant 6:647-51. 2006..The purpose of this review is to summarize the effects of existing immunosuppressive drugs and costimulatory blockade on functions of alloreactive memory T cells that undermine allograft survival...- Recent progress and new perspectives in studying T cell responses to allograftsA Valujskikh
Department of Immunology and the Glickman Urological and Kidney Disease Institute, Cleveland Clinic, Cleveland, OH, USA
Am J Transplant 10:1117-25. 2010.... - Memory T cells in allograft rejectionAnna Valujskikh
The Cleveland Clinic Foundation, Department of Immunology, Cleveland, OH, USA
Adv Exp Med Biol 601:247-56. 2007..This review discusses several aspects of memory T cell immunobiology pertinent to their role in transplantation... - Targeting T-cell memory: where do we stand?Anna Valujskikh
Department of Immunology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Curr Opin Organ Transplant 13:344-9. 2008..This review brings together recent advances in various fields of immunology that are potentially applicable for targeting memory T cells in sensitized transplant patients... - In remembrance of things past: memory T cells and transplant rejectionAnna Valujskikh
Department of Immunology, The Cleveland Clinic Foundation, 9500 Euclid Avenue NB30, Cleveland, OH 44195, USA
Immunol Rev 196:65-74. 2003..We review here the immunobiology of memory T cells and describe their role in the rejection of solid organ allografts... - Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac graftsA D Schenk
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Am J Transplant 9:64-73. 2009.... - Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipientsA D Schenk
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Am J Transplant 8:1652-61. 2008..These results suggest that strategies for optimal inhibition of alloimmunity should include neutralization of infiltrating CD8 memory T cells within a very narrow window after transplantation... - In vivo blockade of macrophage migration inhibitory factor prevents skin graft destruction after indirect allorecognitionG Hou
Department of Medicine, Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, OH, USA
Transplantation 72:1890-7. 2001..CONCLUSIONS: The results strongly implicate MIF as an active participant in skin graft destruction after indirect recognition and suggest that this effect is mediated through an inhibition of macrophage migration and/or function... - Antibody-mediated rejection: emergence of animal models to answer clinical questionsWilliam M Baldwin
Department of Immunology and the Glickman Urological and Kidney Disease Institute, The Cleveland Clinic, Cleveland, OH, USA
Am J Transplant 10:1135-42. 2010..As small animal models become better defined, it is anticipated that they will be more widely used to answer further questions concerning mechanisms of antibody-mediated tissue injury as well as to design therapeutic interventions... - Frontiers in nephrology: T cell memory as a barrier to transplant toleranceAnna Valujskikh
Department of Immunology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Am Soc Nephrol 18:2252-61. 2007 - Emerging roles of endothelial cells in transplant rejectionAnna Valujskikh
The Department of Immunology and The Glickman Urologic Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Curr Opin Immunol 15:493-8. 2003..Progress made in deciphering the cellular and molecular basis of endothelial cell-mediated inflammation has the potential to help with the identification of novel therapeutic targets for prolonging graft survival... - Effects of T cell frequency and graft size on transplant outcome in miceChunshui He
Department of Immunology and Glickman Urologic Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Immunol 172:240-7. 2004.... - ICOS-Dependent and -independent functions of memory CD4 T cells in allograft rejectionQ W Zhang
Department of Immunology, The Cleveland Clinic Foundation, Cleveland, OH, USA
Am J Transplant 8:497-506. 2008..These results demonstrate the potential efficacy of ICOS blockade in sensitized transplant patients and provide the foundation for rational use of ICOS blockade in combination with other graft-prolonging strategies... - Evaluation of alloreactivity in kidney transplant recipients treated with antithymocyte globulin versus IL-2 receptor blockerL Cherkassky
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA
Am J Transplant 11:1388-96. 2011..In contrast, induction with the IL-2 receptor blocker is less effective at diminishing donor T-cell reactivity... - Interleukin-17 promotes early allograft inflammationVictoria Gorbacheva
Department of Immunology, The Cleveland Clinic, Cleveland, OH 44195, USA
Am J Pathol 177:1265-73. 2010..Targeting the IL-17 signaling network in conjunction with other graft-prolonging therapies may decrease this injury and improve the survival of transplanted organs... - In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapyYifa Chen
Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 172:5456-66. 2004.... - Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in miceAnna Valujskikh
Department of Medicine and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Transplant 2:501-9. 2002..The findings have important implications for ongoing, costimulatory blockade-based trials in humans, whose T-cell repertoires are known to contain memory alloreactive T cells... - CD8 T cells specific for a donor-derived, self-restricted transplant antigen are nonpathogenic bystanders after vascularized heart transplantation in miceAnna Valujskikh
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
J Immunol 176:2190-6. 2006..The results support the contention that CD8 T cells reactive to host-restricted, but donor-derived, Ags are highly specific and are nonpathogenic bystanders during rejection of MHC-disparate cardiac allografts... - Development of autoimmunity after skin graft rejection via an indirect alloresponseAnna Valujskikh
Department of Medicine and the Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Transplantation 73:1130-7. 2002..Although the direct alloresponse is likely to be the driving force in acute graft rejection, posttransplantation induced autoimmune responses may be important elements of delayed or chronic rejection... - Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathwayAnna Valujskikh
Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Nat Immunol 3:844-51. 2002..The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H-Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease... - Antigen location contributes to the pathological features of a transplanted heart graftYifa Chen
Department of Immunology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Pathol 164:1407-15. 2004..This unique result, that target antigen location can influence pathological outcome, has significant implications for understanding the pathogenesis of chronic allograft injury in humans... - Decay-accelerating factor modulates induction of T cell immunityPeter S Heeger
Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Exp Med 201:1523-30. 2005..The results could have broad therapeutic implications for disorders in which T cell immunity is important... - Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survivalQiwei Zhang
Department of Immunology, The Cleveland Clinic Foundation, Cleveland OH 44195, USA
J Immunol 176:770-7. 2006..The data have important implications for guiding FTY720 therapy and for designing combinatorial strategies aimed at prolonging allograft survival in sensitized transplant patients with donor-specific memory T cells... - T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejectionBirte Pantenburg
, Leipzig, Germany
J Immunol 169:3686-93. 2002..The results have important implications for human transplant recipients whose immune repertoires may contain cross-reactively primed allospecific T cells... - Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplantsEugenia V Fedoseyeva
Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
J Immunol 169:1168-74. 2002.... - The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplantBen M Illigens
Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
Hum Immunol 63:912-25. 2002..The implications of this finding for understanding the cellular mechanisms by which rejection is mediated in different transplant models are discussed...
Research Grants
- CD4 Memory T Cells and Allograft RejectionAnna Valujskikh; Fiscal Year: 2007..This information should contribute to the development of combinatorial therapies to improve allograft function and survival in sensitized patients. ..
- CD4 Memory T Cells and Allograft RejectionAnna Valujskikh; Fiscal Year: 2010..This information should contribute to the development of combinatorial therapies to improve allograft function and survival in sensitized patients. ..