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Genomes and Genes | Suzy A A ComhairSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Antioxidant responses to oxidant-mediated lung diseasesSuzy A A Comhair
Department of Pulmonary and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Physiol Lung Cell Mol Physiol 283:L246-55. 2002..In this paper, we review how antioxidants in the lung respond to oxidative stress in several lung diseases and focus on the mechanisms that upregulate extracellular glutathione peroxidase...- Redox control of asthma: molecular mechanisms and therapeutic opportunitiesSuzy A A Comhair
Pathobiology, Lerner Research Institute, and the Respiratory Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Antioxid Redox Signal 12:93-124. 2010..Novel therapeutic strategies that target correction of redox abnormalities show promise for the treatment of asthma... - Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthmaSuzy A A Comhair
Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA
Am J Respir Crit Care Med 172:306-13. 2005.... - The regulation and role of extracellular glutathione peroxidaseSuzy A A Comhair
Department of Pulmonary and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
Antioxid Redox Signal 7:72-9. 2005..Induction of extracellular glutathione peroxidase occurs in airway inflammation and undoubtedly plays an important defense against oxidative injury to the airway surface... - Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivationSudakshina Ghosh
Department of Pathobiology, Cleveland Clinic Foundation, 9500 Euclid Avenue NC22, Cleveland, OH 44195, USA
J Immunol 176:5587-97. 2006..Loss of catalase activity likely amplifies oxidative stress, contributing to the chronic inflammatory state of the asthmatic airway... - Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivitySuzy A A Comhair
Department of Pathobiology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Pathol 166:663-74. 2005..These findings link oxidative and nitrative stress to loss of SOD activity and downstream events that typify asthma, including apoptosis and shedding of the airway epithelium and hyperresponsiveness... - Oxidative and nitrosative events in asthmaAthena A Andreadis
Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Free Radic Biol Med 35:213-25. 2003..This review discusses the rapidly accruing data linking oxidative and nitrosative events as critical participants in the acute and chronic inflammation of asthmatic airways... - Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cellsIwona Fijalkowska
Department of Pathology, Johns Hopkins Univesity School of Medicine, Baltimore, MD, USA
Am J Pathol 176:1130-8. 2010..These findings indicate that alterations of nitric oxide and MnSOD contribute to pathological HIF-1alpha expression and account for lower numbers of mitochondria in IPAH-ECs... - Deficiency of lung antioxidants in idiopathic pulmonary arterial hypertensionFares A Masri
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio, USA
Clin Transl Sci 1:99-106. 2008..04). Pulmonary artery pressure (PAP) could be predicted by a regression model incorporating SOD, GPx, and NO(3) values (R(2)= 0.96, p= 0.01). These findings suggest that SOD and GPx are associated with alterations in NO and PAP in IPAH... - Alterations of the arginine metabolome in asthmaAbigail Lara
Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 178:673-81. 2008..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation... - Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthmaRaed A Dweik
Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 181:1033-41. 2010..Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more reactive, at-risk asthma phenotype... - Circulating angiogenic precursors in idiopathic pulmonary arterial hypertensionKewal Asosingh
Cleveland Clinic, Department of Pathobiology, NC22, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Pathol 172:615-27. 2008..Thus, mobilization of high levels of proliferative bone marrow-derived proangiogenic precursors is a characteristic of IPAH and may participate in the pulmonary vascular remodeling process... - Detrimental effects of environmental tobacco smoke in relation to asthma severitySuzy A A Comhair
Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America
PLoS ONE 6:e18574. 2011..Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown... - Abnormalities in nitric oxide and its derivatives in lung cancerFares A Masri
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Respir Crit Care Med 172:597-605. 2005..CONCLUSIONS: This study provides evidence in favor of a role for reactive nitrogen and oxygen species in lung cancer... - Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in childrenSamuel H Wedes
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
J Pediatr 159:248-55.e1. 2011..To determine the usefulness of urinary bromotyrosine, a noninvasive marker of eosinophil-catalyzed protein oxidation, in tracking with indexes of asthma control and in predicting future asthma exacerbations in children... - High levels of hyaluronan in idiopathic pulmonary arterial hypertensionMetin Aytekin
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Physiol Lung Cell Mol Physiol 295:L789-99. 2008..This is associated with increased tissue levels and increased binding of inflammatory cells suggesting a role for HA in remodeling and inflammation in IPAH... - Noninvasive markers of airway inflammation in asthmaSamuel H Wedes
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA
Clin Transl Sci 2:112-7. 2009..Although airway inflammation plays a major role in the pathophysiology of asthma, quantitative markers of airway inflammation are limited in clinical practice... - Signal transduction and oxidative processes in sinonasal polyposisSteven B Cannady
Head and Neck Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
J Allergy Clin Immunol 120:1346-53. 2007..Based on its critical role in mediating cell growth and antimicrobial function, decrease of NO levels has been implicated in the pathogenesis of nasal polyposis... - Cystic fibrosis and normal human airway epithelial cell response to influenza a viral infectionWeiling Xu
Department of Pathobiology and Pulmonary Allergy and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Interferon Cytokine Res 26:609-27. 2006..Taken together, the lesser antiviral and greater early inflammatory response likely contribute to the severe respiratory illness of CF patients with viral infections... - Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertensionFares A Masri
Department of Pathobiology, Allergy and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Am J Physiol Lung Cell Mol Physiol 293:L548-54. 2007..Phosphorylated STAT3 was detected in endothelial cells of IPAH lesions in vivo, suggesting that STAT3 activation plays a role in the proliferative pulmonary vascular lesions in IPAH lungs... - Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertensionWeiling Xu
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 18:1746-8. 2004..Thus, substrate availability affects NOS activity and vasodilation, implicating arginase II and alterations in arginine metabolic pathways in the pathophysiology of PAH... - STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activationWeiling Xu
Pulmonary and Critical Care Medicine and Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Physiol Lung Cell Mol Physiol 285:L137-48. 2003..9 kb upstream of the transcription start site. Taken together, our findings support a model in which a physical interaction between c-Fos and STAT-1 participates in NOS2 gene transcriptional activation... - Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component... - Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimeticEmanuela Masini
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Free Radic Biol Med 39:520-31. 2005..In summary, our findings support the potential therapeutic use of SOD mimetics in asthma and anaphylactic reactions and account for a critical role for superoxide in acute allergic asthma-like reaction in actively sensitized guinea pig... - Gene expression profile of human airway epithelium induced by hyperoxia in vivoArnaud Chambellan
Institut du Thorax, INSERM U533, , Nantes, France
Am J Respir Cell Mol Biol 35:424-35. 2006..Thus, the human airway early response to hyperoxia relies predominantly upon induction of cytoprotective chaperones and the ubiquitin-proteasome-dependent protein degradation system to maintain airway homeostatic integrity... - Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammationEmanuela Masini
Dept Preclinical and Clinical Pharmacology, University of Florence Viale G Pieraccini 6, I 50139 Florence, Italy
J Pharmacol Exp Ther 324:548-57. 2008..These results implicate ceramide in the development of allergic asthmatic response and airway inflammation. Strategies aimed at reducing the levels of ceramide and downstream events should yield promising novel anti-asthmatic agents...