Research Topics
Genomes and Genes
| Graham CaseySummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activationRajeev S Samant
Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
Mol Cancer 6:6. 2007..BRMS1 is a member of mSin3-HDAC transcription co-repressor complex and has been shown to suppress the metastasis of breast cancer and melanoma cells in animal models. Hence we hypothesized that BRMS1 regulates OPN expression...- Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomasYosuke Hashimoto
Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
BMC Cancer 6:241. 2006..Here, we report on the prevalence and potential clinical significance of fascin expression in relation to the progression of colorectal adenocarcinoma and to tumor cell proliferation as measured by Ki67 index... - Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancerGraham Casey
Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
JAMA 293:799-809. 2005..Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used... - Podocalyxin variants and risk of prostate cancer and tumor aggressivenessGraham Casey
Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Hum Mol Genet 15:735-41. 2006..48, 95%CI=1.02-2.14, P=0.04). These results implicate PODXL as a candidate prostate cancer tumor aggressiveness gene mapping to chromosome 7q32-q33... - RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer casesGraham Casey
Department of Cancer Biology, ND50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Nat Genet 32:581-3. 2002..Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk... - Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patientsDavid G Hicks
Department of Clinical and Anatomic Pathology, General Surgery-Breast Center, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Clin Cancer Res 12:6702-8. 2006..BRMS1 staining could potentially be used in patient stratification in conjunction with other prognostic markers. Further, mechanisms other than genomic deletion account for loss of BRMS1 gene expression in breast tumors... - Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer riskNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
Carcinogenesis 27:1842-8. 2006.... - Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activityMuzaffer Cicek
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
Cancer Res 65:3586-95. 2005.... - Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressivenessMine S Cicek
Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA
Cancer Epidemiol Biomarkers Prev 13:1331-6. 2004..47, 95% CI 0.29-0.76; P = 0.002). Our findings suggest that 677T and 1298A, or another variant on their haplotype, may be associated with a reduced risk of progression to more advanced prostate cancer... - Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressivenessMine S Cicek
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Ohio, USA
Cancer Epidemiol Biomarkers Prev 14:2173-7. 2005..71; 95% CI, 1.06-6.94; P = 0.04). Our findings suggest that CYP1B1 and PSA variants may affect the risk of prostate cancer and tumor aggressiveness... - Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer riskNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Cancer Epidemiol Biomarkers Prev 15:756-61. 2006..95; 95% CI, 0.53-1.71). Our results highlight the importance of considering genetic modifiers of carcinogens when evaluating smoking in prostate cancer... - Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studiesPhillippa J Neville
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Genes Chromosomes Cancer 36:332-9. 2003..06). These data provide strong evidence that we have mapped a prostate tumor aggressiveness locus to chromosome segments 19q12-q13.11 that may play a role in both familial and non-familial forms of prostate cancer... - FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-AmericansNora L Nock
Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 7281, USA
Carcinogenesis 32:748-56. 2011..Our results are consistent with prior studies and show for the first time that FTO polymorphisms are associated with colorectal adenomas in African-Americans... - Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrinSteven Sizemore
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Cancer Res 67:6183-91. 2007.... - A common 8q24 variant and the risk of colon cancer: a population-based case-control studyLi Li
Department of Family Medicine Research Division, Case Western Reserve University, 11001 Cedar Avenue, Suite 306, Cleveland, OH 44106 7136, USA
Cancer Epidemiol Biomarkers Prev 17:339-42. 2008..These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer... - Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the ARMine S Cicek
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Prostate 59:69-76. 2004..CONCLUSIONS: These findings suggest that the SRD5A2 V89L variant may influence risk of developing prostate cancer, especially among men with a younger age of diagnosis or more aggressive disease... - Vitamin D receptor genotypes/haplotypes and prostate cancer riskMine S Cicek
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio, USA
Cancer Epidemiol Biomarkers Prev 15:2549-52. 2006..This would help explain the somewhat equivocal results for VDR genotype-level associations with prostate cancer... - SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancersHui Li
Ireland Cancer Center, Department of Medicine, and Research Institute, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 100:8412-7. 2003..Structural homology and functional testing demonstrated that SLC5A8 is a member of the family of sodium solute symporters, which are now added as a class of candidate colon cancer suppressor genes... - CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancerSarah J Plummer
Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Cancer Epidemiol Biomarkers Prev 12:928-32. 2003..07; 95% CI, 0.01-0.51; P=0.009). These findings suggest that the CYP3A4 and CYP3A5 variants, or other alleles on the haplotypes they help distinguish, are associated with prostate cancer risk and aggressiveness... - Association of common genetic variants in SMAD7 and risk of colon cancerCheryl L Thompson
Department of Family Medicine, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Carcinogenesis 30:982-6. 2009..015 for rs4939827 and P = 0.061 for rs12953717). Similar effect modification was found in haplotype analyses. Our data add evidence supporting these genetic variants as markers predisposing to colon cancer, specifically in women... - Interleukin-22 genetic polymorphisms and risk of colon cancerCheryl L Thompson
Department of Family Medicine Research Division, Case Western Reserve University University Hospitals of Cleveland, 11001 Cedar Ave, Suite 306, Cleveland, OH 44106 7136, USA
Cancer Causes Control 21:1165-70. 2010..52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer... - The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-cateninAnju Agarwal
Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Oncogene 24:1021-31. 2005..These results indicate a role of this pathway in controlling gene expression important in tumor progression and metastasis... - Characterization of the human polymeric immunoglobulin receptor (PIGR) 3'UTR and differential expression of PIGR mRNA during colon tumorigenesisJune L Traicoff
Department of Molecular Biology and Microbiology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
J Biomed Sci 10:792-804. 2003..We hypothesize that differential regulation of PIGR mRNA stability may contribute to its downregulation in colon cancer... - Fluorescence in situ hybridization of cytologic specimens from Barrett's esophagus: a pilot feasibility studyGary W Falk
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Gastrointest Endosc 60:280-4. 2004..Differences in genomic makeup can be detected in cells from patients negative for dysplasia and in those with adenocarcinoma... - No association between genetic polymorphisms in IGF-I and IGFBP-3 and prostate cancerLi Li
Department of Family Medicine and Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
Cancer Epidemiol Biomarkers Prev 13:497-8. 2004 - Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studiesPhillippa J Neville
Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Neoplasia 4:424-31. 2002..05). These data imply that we have localized a prostate cancer tumor aggressiveness loci to chromosome 7q32-q33 that is involved in familial and nonfamilial forms of prostate cancer... - Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylatesYing Xiang
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer Res 63:6795-801. 2003..Our findings support the notion that RNASEL mutations and some variants allow tumor cells to escape a potent apoptotic pathway... - Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variantsBenjamin T Larson
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA
J Urol 179:1344-8. 2008..We assessed a series of men undergoing radical prostatectomy for clinical and pathological measures of tumor aggressiveness according to the RNASEL R462Q genotype... - Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer riskLi Li
Department of Family Medicine Research Division, Case Western Reserve University, Cleveland, OH 44106 7136, USA
Clin Cancer Res 14:633-7. 2008..The phosphatidylinositol 3-kinase signaling pathway is frequently activated in cancer. Emerging evidence supports the p85alpha regulatory subunit gene, PIK3R1, as a novel oncogene... - Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomasMatthew F Kalady
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
Dis Colon Rectum 52:1039-45. 2009..This study evaluated the disparity in neoplastic changes between colon and rectal cancers... - Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cellsRyuichi Fukuyama
Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195, and School of Biomedical Sciences, Kent State University, USA
Mol Carcinog 46:402-13. 2007.... - Reduced expression of autotaxin predicts survival in uveal melanomaArun D Singh
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Br J Ophthalmol 91:1385-92. 2007..In an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality... - Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cellsMuzaffer Cicek
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Clin Exp Metastasis 21:149-57. 2004..Our results suggest that annexin I and alpha B-crystallin are important cellular proteins that are down regulated through BRMS1 mediated metastasis suppression... - Novel enhanced lung-colonizing variant of murine MBT-2 bladder cancer cellsMinoru Horinaga
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Urology 66:676-81. 2005..To develop an enhanced lung-colonizing variant of murine bladder cancer that will allow the mechanism of metastasis to be studied more readily... - Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States)Li Li
Department of Family Medicine, Case Western Reserve University, Cleveland, OH 44106-4945, USA
Cancer Causes Control 14:721-6. 2003..These results lend support to the hypothesis that IGF-I, or the IGF-I to IGFBP-3 molar ratio, is an important risk factor for prostate cancer... - ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancerBon Hun Koo
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Int J Cancer 121:1710-6. 2007.... - Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFRDavid G Hicks
Clinical and Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
Am J Surg Pathol 30:1097-104. 2006.... - Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for preventionEric A Klein
Section of Urologic Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44122, USA
Urology 68:1145-51. 2006 - Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancerZhenwen Zhao
Department of Cancer Biology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
J Clin Oncol 25:2696-701. 2007..Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking... - Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimensMona Fahmy
Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Mod Pathol 17:588-96. 2004..Selected biomarkers from this study merit further investigation to determine their potential to detect genetic changes in patients with Barrett's esophagus prior to the development of high-grade dysplasia... - Diffuse large B-cell lymphoma of the stomach: assessment of microsatellite instability, allelic imbalance, and trisomy of chromosomes 3, 12, and 18Marek Skacel
Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Diagn Mol Pathol 11:75-82. 2002..Because of the relatively low frequency of MSI in the high-grade B-cell lymphomas of the stomach, this feature cannot be used to reliably discriminate between the histologic types of extranodal diffuse large B-cell lymphoma... - Identification of the methylator (serrated) colorectal cancer phenotype through precursor serrated polypsCraig A Messick
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
Dis Colon Rectum 52:1535-41. 2009..This study analyzes characteristics of precursor polyps occurring within different molecular subtypes of sporadic colorectal cancer... - Chromosomal autonomy of hMLH1 methylation in colon cancerHui Li
Department of Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio, OH 44106, USA
Oncogene 21:1443-9. 2002..We posit that hMLH1 methylation is dependent on and maintained by cis chromosomal marks, whose nature remains to be elucidated... - Reconstitution of TGF-beta sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7June L Traicoff
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
J Biomed Sci 10:253-9. 2003..The data suggest that the VACO-411 defect in TGF-beta signaling will be able to be further complemented by microcell-mediated chromosome transfer... - 8q24 and prostate cancer: association with advanced disease and meta-analysisIona Cheng
Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143 0794, USA
Eur J Hum Genet 16:496-505. 2008..Our findings provide the first confirmation that the three 8q24 regions independently influence the risk of prostate cancer and, in particular, advanced disease... - Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family RegistryJenny N Poynter
Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
Cancer Res 67:11128-32. 2007..These data suggest that common variants may play important roles in the risk of CRC... - Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1Benjamin D Hedley
London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
Int J Cancer 123:526-34. 2008..These studies clarify one mechanism by which BRMS1 can suppress metastasis... - Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissueJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer Epidemiol Biomarkers Prev 11:809-14. 2002..We concluded that DNA derived from PET that archived for less than 18 years can be used successfully for detecting BRCA1 gene mutations if quality control is strictly maintained... - Toll-like receptor 4 genetic variation and advanced prostate cancer riskIona Cheng
Department of Epidemiology and Biostatistics and Center of Human Genetics, University of California at San Francisco, 94143 0794, USA
Cancer Epidemiol Biomarkers Prev 16:352-5. 2007..006). We estimated through permutation analysis that a similarly strong result would occur by chance 2.5% of the time. Our findings support previous studies and suggest that inherited differences in TLR4 influence prostate cancer risk... - Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variantAnatoly Urisman
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS Pathog 2:e25. 2006..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals... - DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancerBenjamin A Rybicki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA
Cancer Epidemiol Biomarkers Prev 13:23-9. 2004.... - No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancerLi Li
Department of Epidemiology and Biostatistics, University of California at San Francisco, 500 Parnassus Avenue, MU-420 West, San Francisco, CA 94143-0560
Cancer Epidemiol Biomarkers Prev 13:2280-1. 2004 - Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type XNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA
JAMA 293:1979-85. 2005..Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown... - Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alphaXin Liu
Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
Am J Epidemiol 164:984-9. 2006..30). The authors observed similar associations when examining dose/duration of NSAID use. This suggests that any potential chemoprevention of prostate cancer by NSAIDs may be most appropriate for men with the LTA +80CC genotype... - Prediction of germline mutations and cancer risk in the Lynch syndromeSining Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
JAMA 296:1479-87. 2006..Current clinical guidelines are effective but limited by applicability and cost... - Genome-wide scan of brothers: replication and fine mapping of prostate cancer susceptibility and aggressiveness lociJohn S Witte
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
Prostate 57:298-308. 2003..Here we investigate prostate cancer susceptibility and aggressiveness with genome-wide linkage analyses of affected brothers... - Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family historyEric Jorgenson
Department of Epidemiology and Biostatistics, Center for Human Genetics, University of California, San Francisco, San Francisco, California 94143 0794, USA
Prostate 67:172-7. 2007..To evaluate the effect of PAI-1 expression on cancer development, we examined the association of the 4G/5G polymorphism in a sibling-based case-control study of prostate cancer... - Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2Anu Loukola
Amersham Biosciences, Sunnyvale, CA 94085, USA
Eur J Hum Genet 12:321-32. 2004..02). Undertaking a two-phase study comprising SNP discovery, haplotype tagging, and association analyses allowed us to more fully decipher the relation between CYP17A1, CYP3A4, and SRD5A2 and prostate cancer... - Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variantXin Liu
Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA 94143 0794, USA
Carcinogenesis 28:1232-6. 2007..This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q... - Association of testis derived transcript gene variants and prostate cancer riskXin Liu
Department of Epidemiology and Biostatistics, and Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143 0794, USA
J Urol 177:894-8. 2007..To investigate this concept we evaluated the effects of 7 tagging single nucleotide polymorphisms that comprehensively captured the common genetic variants in TES on aggressive prostate cancer in a case-control study... - Relationship between body size and prostate cancer in a sibling based case-control studyXin Liu
Department of Epidemiology and Biostatistics, University of California-San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143-0560, USA
J Urol 174:2169-73. 2005..14, 0.56), respectively. Similar inverse patterns were observed for weight. No noteworthy associations were observed between PCa and height or body mass index. CONCLUSIONS: These observations suggest that PCa may be affected by LBM... - No association between genetic polymorphisms in insulin and insulin receptor substrate-1 and prostate cancerLi Li
Department of Epidemiology and Biostatistics, University of California, San Francisco, 500 Parnassus Avenue, MU-420 West, San Francisco, CA 94143-0560, USA
Cancer Epidemiol Biomarkers Prev 14:2462-3. 2005 - Association of vitamin D receptor gene variants, adiposity and colon cancerHeather M Ochs-Balcom
Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USA
Carcinogenesis 29:1788-93. 2008..Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity... - Development of a clinically feasible molecular assay to predict recurrence of stage II colon cancerYuqiu Jiang
Veridex LLC, a Johnson and Johnson Company, 33 Technology Drive, Warren, NJ 07059, USA
J Mol Diagn 10:346-54. 2008..The ability to identify colon cancer patients with an unfavorable outcome may help patients at high risk for recurrence to seek more aggressive therapy... - Ascending the learning curve--MSI testing experience of a six-laboratory consortiumNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA
Cancer Biomark 2:5-9. 2006..The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium... - Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435Lalita A Shevde
University of South Alabama Mitchell Cancer Institute, Mobile, AL 36688 0002, USA
Clin Exp Metastasis 23:123-33. 2006..Thus, in addition to the widely reported roles of OPN in late stages of tumor progression, these results provide functional evidence that OPN contributes to breast tumor growth as well... - MIC1 and IL1RN genetic variation and advanced prostate cancer riskIona Cheng
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143-0794, USA
Cancer Epidemiol Biomarkers Prev 16:1309-11. 2007
Research Grants
- Genomic Wide Association Study of Colorectal CancerGraham Casey; Fiscal Year: 2007....