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Genomes and Genes | Steven D BillingsSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variantsSteven D Billings
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Dermatopathol 29:437-42. 2007..CD34 was diffusely positive (10/11). A high index of suspicion based on clinical context and identification of other typical features of SCL are key features to the diagnosis of low-fat and fat-free SCL...- Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experienceMunir R Tanas
Department of Pathology, Cleveland Clinic, Ohio, USA
Arch Pathol Lab Med 134:1797-803. 2010..Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH)... - Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damageGopal K Marathe
Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
J Biol Chem 280:35448-57. 2005..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses... - Initial presentation of stasis dermatitis mimicking solitary lesions: a previously unrecognized clinical scenarioJoshua Weaver
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Am Acad Dermatol 61:1028-32. 2009..Early recognition of signs and appropriate diagnosis can lead to timely treatment that can prevent painful complications, such as leg ulcers which are at risk for development of squamous cell carcinoma... - The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimensKaren J Fritchie
Dept of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Clin Pathol 137:229-39. 2012..Awareness of the variety of histologic patterns is critical to avoid misdiagnosis, especially in small biopsy specimens... - Acral soft tissue tumors: a reviewDipti Mahajan
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
Adv Anat Pathol 18:103-19. 2011..Clinical, histologic, and immunohistochemical features are discussed along with prognosis and differential diagnosis... - FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferationsAnthony P Fernandez
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
J Cutan Pathol 39:234-42. 2012.... - Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 casesMunir R Tanas
Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
Mod Pathol 23:93-7. 2010..Finally, we discuss some of the potential pitfalls of this technique, including confusion with other mesenchymal neoplasms containing rearrangement of EWSR1, in particular Ewing's sarcoma/PNET... - Low-fat and fat-free pleomorphic lipomas: a diagnostic challengeMandi P Sachdeva
Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Dermatopathol 31:423-6. 2009..When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas... - Postradiation cutaneous vascular tumors of the breast: a reviewJoshua Weaver
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Semin Diagn Pathol 26:141-9. 2009..Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL... - Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthomaSteven D Billings
Departments of Pathology and Laboratory Medicine and Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Pathol 163:2451-8. 2003..The HaCaT-NIE cells formed thin tumors resembling conventional SCC. The HaCaT-AR cells formed rapidly growing tumors with AR expression similar to KA. HaCaT-AR cells may represent a new system for the further evaluation of KA... - Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermisRaymond L Konger
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Invest Dermatol 124:965-70. 2005..In cultured primary human keratinocytes, we also verified the presence of functional EP(1) receptor coupled to intracellular calcium mobilization and EP(2) receptor coupled to cAMP production... - Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptorQiwei Zhang
Department of Dermatology, H B Wells Center for Pedoatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Invest 115:2855-61. 2005..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis... - Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentationMary F Varsegi
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
J Cutan Pathol 35:591-3. 2008..To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma... - Myeloid leukemia cutis: a histologic and immunohistochemical reviewThomas L Cibull
Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
J Cutan Pathol 35:180-5. 2008..The histologic diagnosis of myeloid leukemia cutis (LC) can be difficult, requiring confirmatory immunohistochemical stains... - Expression of OCT4 transcription factor in cutaneous neoplasiaTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
Appl Immunohistochem Mol Morphol 15:359-62. 2007..In contrast to previous studies, our data indicate that the OCT4 expression is not retained in cutaneous neoplasms derived from basal epidermis or related adnexal neoplasms, including lesions of the scalp... - Leiomyosarcoma of the penis presenting as a cutaneous lesionThomas L Cibull
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
J Cutan Pathol 35:585-7. 2008..This is an important diagnosis in the differential diagnosis of cutaneous spindle cell neoplasms of the male genital tract... - Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progressionTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1552-6. 2007..Further, in this series, several loci associated with the tumor suppressor gene PTEN on chromosome 10 appear to be associated with progression from plaque to tumor stage... - Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma?Terrence M Katona
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46259, USA
J Cutan Pathol 35:174-9. 2008..We investigated whether AR and CK20 immunostains may distinguish between mBCC and DTE... - Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanomaTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1029-37. 2007.... - Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an updateSteven D Billings
Department of Pathology, Indiana University, Indianapolis, IN, USA
Am J Dermatopathol 26:141-55. 2004..The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed... - Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 casesSteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 28:781-8. 2004..The median interval to death was 33.5 months. All 4 patients with disease have documented metastasis. CPRASB differs from Stewart-Treves AS by its shorter latency period and lack of association with lymphedema... - Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyiTricia L Humphreys
Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Infect Immun 73:3896-902. 2005..Soler, T. L. Humphreys, S. M. Spinola, and J. J. Campbell, Blood 101:1677-1683, 2003), these studies led us to propose a model of memory T-cell trafficking to skin in response to experimental H. ducreyi infection... - Langerhans cell histiocytosis associated with myelodysplastic syndrome in adultsSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Cutan Pathol 33:171-4. 2006..Langerhans cell histiocytosis (LCH) is primarily a pediatric disease, and rarely LCH has been described in association with pediatric MDS. We are aware of only a single case report of LCH associated with MDS in an adult... - Spindle cell lipoma of the oral cavitySteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Dermatopathol 28:28-31. 2006..The combination of the histologic features and the immunoreactivity for CD34 confirmed the diagnosis. Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors... - Abdominal plaque in a 10-day-old boyErnest Lee
Indiana University School of Medicine, Indianapolis, USA
Arch Dermatol 142:641-6. 2006 - Fungating forehead plaque: angiosarcomaBenjamin N Lockshin
Case Western Reserve School of Medicine, Silver Spring, MD, USA
Arch Dermatol 142:1059-64. 2006 - Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host diseaseAndrew T Bridge
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Dermatopathol 29:1-6. 2007..Patients with composite skin GVHD may benefit from an earlier, more aggressive immunosuppressive interventional strategy... - Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant?Terrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Dermatopathol 29:7-12. 2007..In small, partial biopsy specimens, coexpression of androgen receptor and cytokeratin 20 may aid in the diagnosis of fibroepithelioma of Pinkus... - CD4+ CD56+ hematodermic neoplasmThomas L Cibull
Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
Am J Dermatopathol 29:59-61. 2007..CD4+CD56+ hematodermic neoplasms are rare and commonly present as cutaneous lesions. This is an important diagnosis in the differential diagnosis of cutaneous hematologic malignancies because of the extremely poor prognosis... - Cutaneous malignant ossifying fibromyxoid tumorThomas L Cibull
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5126, USA
Am J Dermatopathol 29:156-9. 2007..Given the histologic features, this tumor was considered a malignant OFMT. The patient had a wide excision. The patient died secondary to unrelated comorbidities without evidence of recurrence or metastasis... - Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?Torsten Ehrig
Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
Ann Diagn Pathol 11:153-9. 2007..0 years). Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES. These may have a hitherto unrecognized variant genetic abnormality... - Clonal relationships between epidermotropic metastatic melanomas and their primary lesions: a loss of heterozygosity and X-chromosome inactivation-based analysisSoon Bahrami
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Mod Pathol 20:821-7. 2007..Our data also indicated that some cases diagnosed as epidermotropic metastatic melanoma might be divergent clones or new primaries rather than metastatic disease... - Subungual pleomorphic fibromaYa-Ju Hsieh
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan
J Cutan Pathol 30:569-71. 2003..This is only the second case reported of a subungual pleomorphic fibroma. Pleomorphic fibroma should be considered in the differential diagnosis of pleomorphic subungual tumors...