Samuel Rahbar

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
  2. ncbi The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems
    Samuel Rahbar
    City of Hope National Medical Center and Beckman Research Institute, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:9-19. 2005
  3. ncbi Novel inhibitors of glycation and AGE formation
    Samuel Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA
    Cell Biochem Biophys 48:147-57. 2007
  4. ncbi Novel inhibitors of advanced glycation endproducts (part II)
    S Rahbar
    Department of Diabetes, City of Hope National Medical Center, Duarte, California, 91010, USA
    Mol Cell Biol Res Commun 3:360-6. 2000
  5. ncbi Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, The Leslie and Susan Gonda Goldschmied Diabetes and Genetic Research Building, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 301:65-77. 2000
  6. ncbi A new rapid method to detect inhibition of Amadori product generated by delta-gluconolactone
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Gonda Diabetes Center, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 287:123-30. 1999
  7. ncbi Novel inhibitors of advanced glycation endproducts
    S Rahbar
    Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, California, 91010 0269, USA
    Biochem Biophys Res Commun 262:651-6. 1999
  8. ncbi Renoprotective and lipid-lowering effects of LR compounds, novel advanced glycation end product inhibitors, in streptozotocin-induced diabetic rats
    James Lester Figarola
    Department of Diabetes, Endocrinology, and Metabolism, Gonda Building, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:767-76. 2005
  9. ncbi Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors
    James Lester Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA
    Diabetes Metab Res Rev 21:533-44. 2005
  10. ncbi Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes
    James L Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Diabetes 56:647-55. 2007

Collaborators

  • R Natarajan
  • Timothy Synold
  • James Lester Figarola
  • James L Figarola
  • Bixin Xi
  • Steven Scott
  • Sofia Loera
  • J L Figarola
  • John Termini
  • Daniel Tamae
  • Gerald E Wuenschell
  • Narkunaraja Shanmugam
  • Lawrence Weiss
  • L Weiss
  • C Tessler
  • S Scott
  • S Loera
  • P Chu
  • J Hardy

Detail Information

Publications13

  1. ncbi Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
    ....
  2. ncbi The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems
    Samuel Rahbar
    City of Hope National Medical Center and Beckman Research Institute, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:9-19. 2005
    ....
  3. ncbi Novel inhibitors of glycation and AGE formation
    Samuel Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA
    Cell Biochem Biophys 48:147-57. 2007
    ....
  4. ncbi Novel inhibitors of advanced glycation endproducts (part II)
    S Rahbar
    Department of Diabetes, City of Hope National Medical Center, Duarte, California, 91010, USA
    Mol Cell Biol Res Commun 3:360-6. 2000
    ..All 29 compounds show some degrees of inhibitory activities as detected by the four assay methods, 9 compounds demonstrated high percent inhibition (PI) in all tests, 30 to 40 times stronger than aminoguanidine...
  5. ncbi Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, The Leslie and Susan Gonda Goldschmied Diabetes and Genetic Research Building, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 301:65-77. 2000
    ..We show that that three compounds; pioglitazone, metformin and pentoxifylline are also inhibitors of glycation...
  6. ncbi A new rapid method to detect inhibition of Amadori product generated by delta-gluconolactone
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Gonda Diabetes Center, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 287:123-30. 1999
    ....
  7. ncbi Novel inhibitors of advanced glycation endproducts
    S Rahbar
    Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, California, 91010 0269, USA
    Biochem Biophys Res Commun 262:651-6. 1999
    ....
  8. ncbi Renoprotective and lipid-lowering effects of LR compounds, novel advanced glycation end product inhibitors, in streptozotocin-induced diabetic rats
    James Lester Figarola
    Department of Diabetes, Endocrinology, and Metabolism, Gonda Building, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:767-76. 2005
    ..These compounds may have an additional beneficial effect as an antioxidant against lipid peroxidation, and thus may provide alternative therapeutic options for the treatment of various diabetic macrovascular complications...
  9. ncbi Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors
    James Lester Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA
    Diabetes Metab Res Rev 21:533-44. 2005
    ..These compounds may have an additional beneficial effect as an antioxidant against lipid peroxidation, and thus may provide alternative therapeutic options for the treatment of various diabetic macrovascular complications...
  10. ncbi Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes
    James L Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Diabetes 56:647-55. 2007
    ..These new data show that, in addition to its AGE inhibitory effects, LR-90 has novel anti-inflammatory properties and might therefore have additional protective effects against diabetic vascular complications...
  11. ncbi Advanced glycation end products of DNA: quantification of N2-(1-Carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    Timothy Synold
    Division of Clinical and Molecular Pharmacology, City of Hope Medical Center, 1500 East Duarte Road, Duarte, California 91010, USA
    Chem Res Toxicol 21:2148-55. 2008
    ..Strategies for dealing with artifactual adduct formation due to oxoaldehyde generation during DNA isolation and enzymatic workup procedures are described...
  12. ncbi LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats
    J L Figarola
    Department of Diabetes and Endocrinology, City of Hope National Medical Center, Duarte, California 91010, USA
    Diabetologia 46:1140-52. 2003
    ..The AGE inhibitory and therapeutic effects of LR-90 could be attributed, at least in part, to its ability to react with reactive carbonyl species and/or potent metal chelating activity that inhibits glycoxidative-AGE formation...
  13. ncbi Association of hemoglobin H disease with Hb J-Iran (beta 77 His----Asp): impact on subunit assembly
    S Rahbar
    Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010 0269
    Blood 70:1790-1. 1987
    ..This observation provides further support for an electrostatic model of Hb subunit assembly...