Research Topics
Species | John A MorrisonSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up StudyJohn A Morrison
Division of Cardiology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Pediatrics 120:340-5. 2007..The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later...- Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohortJohn A Morrison
Cincinnati Children s Hospital Medial Center, Cincinnati, Ohio, USA
J Pediatr 142:637-42. 2003..To determine the role of increasing free testosterone and estradiol in pubertal changes in male lipids... - Development of the metabolic syndrome in black and white adolescent girls: a longitudinal assessmentJohn A Morrison
Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
Pediatrics 116:1178-82. 2005..The metabolic syndrome, associated with increased risk of type 2 diabetes mellitus and cardiovascular disease, begins to develop during adolescence... - Pre-teen insulin resistance predicts weight gain, impaired fasting glucose, and type 2 diabetes at age 18-19 y: a 10-y prospective study of black and white girlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 88:778-88. 2008..Identifying early pre-teen predictors of adolescent weight gain and the development of impaired fasting glucose (IFG) and type 2 diabetes (T2DM) at age 18-19 y could provide avenues for prevention... - Pediatric triglycerides predict cardiovascular disease events in the fourth to fifth decade of lifeJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Metabolism 58:1277-84. 2009..4; 95% confidence interval, 4.24-114.2). Pediatric hypertriglyceridemia appears to be a significant, independent, potentially reversible correlate of young adult CVD... - Paradoxically high adiponectin in obese 16-year-old girls protects against appearance of the metabolic syndrome and its components seven years laterJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr 158:208-14.e1. 2011..To evaluate the relationships of adiponectin levels at age 16 years in obese schoolgirls to metabolic syndrome and its components at age 23 years... - Adolescent oligomenorrhea in a biracial schoolgirl cohort: a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus, insulin, glucose, insulin resistance, and centripetal obesity from age 19 to 25 yearsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Metabolism 60:1285-93. 2011.... - Obesity and the development of insulin resistance and impaired fasting glucose in black and white adolescent girls: a longitudinal studyDavid J Klein
Division of Endocrinology and Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Diabetes Care 27:378-83. 2004..The development of IFG appears to be a function of the rate of increase of BMI in white girls and early obesity in black girls... - A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescentsDavid J Klein
Division of Endocrinology, Cincinnati Children s Hospital Medical Center, ML 7012, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Psychiatry 163:2072-9. 2006..Second-generation, or atypical, antipsychotics effectively treat psychiatric illness in children and adolescents. However, weight gain and abnormalities in insulin sensitivity, including diabetes, complicate this therapy... - Coenzyme Q10 changes are associated with metabolic syndromeMichael V Miles
Division of Cardiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 344:173-9. 2004..The purpose of this study was to determine whether coenzyme Q10 (CoQ) concentrations and redox status are associated with components of the metabolic syndrome... - Homeostasis model assessment of insulin resistance*body mass index interactions at ages 9 to 10 years predict metabolic syndrome risk factor aggregate score at ages 18 to 19 years: a 10-year prospective study of black and white girlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Metabolism 58:290-5. 2009.... - Determinants of persistent obesity and hyperinsulinemia in a biracial cohort: a 15-year prospective study of schoolgirlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr 157:559-65. 2010..To identify childhood-adolescent determinants of persistent hyperinsulinemia and obesity... - Preteen insulin levels interact with caloric intake to predict increases in obesity at ages 18 to 19 years: a 10-year prospective study of black and white girlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 42559, USA
Metabolism 59:718-27. 2010..Evaluating BMI and insulin at ages 9 to 10 years could identify girls (particularly black) who would optimally benefit from dietary and exercise interventions to avoid obesity... - Ramifications of adolescent menstrual cycles ?42 days in young adultsJohn A Morrison
Division Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Fertil Steril 96:236-240.e1. 2011.... - Childhood predictors of adult type 2 diabetes at 9- and 26-year follow-upsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Arch Pediatr Adolesc Med 164:53-60. 2010.... - Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female populationCharles J Glueck
Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
Metabolism 58:714-21. 2009..Identification of women with clinical features of PCOS should alert the clinician to potentially increased risk for CHD and prompt CHD risk factor testing... - Sex hormone-binding globulin, oligomenorrhea, polycystic ovary syndrome, and childhood insulin at age 14 years predict metabolic syndrome and class III obesity at age 24 yearsCharles J Glueck
Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
J Pediatr 159:308-13.e2. 2011.... - Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adultsMichael V Miles
Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 347:139-44. 2004.... - Serum testosterone associates with lower high-density lipoprotein cholesterol in black and white males, 10 to 15 years of age, through lowered apolipoprotein AI and AII concentrationsJohn A Morrison
Division of Cardiology, Department of Pediatrics, University of Cincinnati College of Medicine and Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Metabolism 51:432-7. 2002..Thus, increased F-T appears to explain decreased HDL-C via decreased apoAI and apoAII, not decreases in the amount of cholesterol associated with these proteins... - Paradoxically high adiponectin and the healthy obese phenotype in obese black and white 16-year-old girlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Transl Res 156:302-8. 2010..20, 95% confidence intervals 0.04-0.95, P = 0.043). We conclude that paradoxically high adiponectin is associated with the healthy obese phenotype in obese adolescent black and white girls... - Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescentsLawrence M Dolan
Division of Endocrinology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Pediatr 146:751-8. 2005..To document the frequency of glucose intolerance in adolescents in a population-based study of primarily African-American/Non-Hispanic whites in an urban-suburban school district... - Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white childrenJohn A Morrison
Division of Cardiology, Children s Hospital Medical Center, Cincinnati, OH, USA
Metabolism 53:465-8. 2004..However, the QQ genotype was population-specific, encompassing most black children versus 1% to 3% of white children. As such, K121Q genotyping should be useful in epidemiology, population genetics, and forensic anthropology... - Body mass index and waist-to-height changes during teen years in girls are influenced by childhood body mass indexFrank M Biro
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Adolescent Medicine ML 4000, Cincinnati, Ohio 45229, USA
J Adolesc Health 46:245-50. 2010..This study examined longitudinal changes in waist-to-height ratio and components of body mass index (BMI) among young and adolescent girls of black and white race/ethnicity... - Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescentsCharles J Glueck
Cholesterol Center, Alliance Hospitals, Cincinnati, OH 45229, USA
Metabolism 55:508-14. 2006.... - Hyperinsulinemia and metabolic syndrome at mean age of 10 years in black and white schoolgirls and development of impaired fasting glucose and type 2 diabetes mellitus by mean age of 24 yearsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Metabolism 60:24-31. 2011..30, P < .0001. Insulin and MS at a mean age of 10 years plus change in body mass index over 15 years, and 15-year average insulin rank independently predict IFG + T2DM by mean age of 24 years, suggesting avenues for primary prevention... - Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years laterJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Pediatr 152:201-6. 2008..To prospectively assess the association of the metabolic syndrome in childhood with adult metabolic syndrome and type 2 diabetes mellitus (T2DM) 25 to 30 years later... - Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndromeCharles J Glueck
Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
J Pediatr Endocrinol Metab 21:973-84. 2008..Pre-peri-menarchal diagnosis of polycystic ovary syndrome (PCOS) is important, because intervention with metformin-diet may prevent progression to full blown PCOS... - Body mass indexes and lipid profiles in hospitalized children and adolescents exposed to atypical antipsychoticsNick C Patel
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, and Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Ohio 45267 0004, USA
J Child Adolesc Psychopharmacol 17:303-11. 2007..The purpose of this study was to examine body mass indexes (BMI) and lipid profiles of children and adolescents hospitalized for a psychiatric illness and exposed to an atypical antipsychotic... - Insulin resistance and triglyceridesCharles J Glueck
Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
J Investig Med 57:874-81. 2009..Homeostasis model assessment IR is a significant, potentially reversible explanatory variable for TG in patients referred because of hyperlipidemia and in population subjects... - Evidence of shared genetic effects between pre- and postobesity epidemic BMI levelsLisa J Martin
Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Obesity (Silver Spring) 18:1378-82. 2010..Furthermore, shared genetic effects survive the period of the transition from adolescence to adulthood... - Pubertal maturation in girls and the relationship to anthropometric changes: pathways through pubertyFrank M Biro
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Pediatr 142:643-6. 2003..We examined the relationship of the initial manifestation of puberty in girls with anthropometric measures, as well as age at menarche... - Influence of obesity on timing of pubertyFrank M Biro
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Int J Androl 29:272-7; discussion 286-90. 2006..However, changes in caloric consumption, caloric density and physical activity, combined with greater lifespan, may allow expression of the adverse consequences of these adaptations, such as the metabolic syndrome or cancers... - Race, childhood insulin, childhood caloric intake, and class 3 obesity at age 24: 14-year prospective study of schoolgirlsJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Obesity (Silver Spring) 20:597-604. 2012.... - Dietary trans fatty acid intake is associated with increased fetal lossJohn A Morrison
Children s Hospital Medical Center, Cincinnati, Ohio, USA
Fertil Steril 90:385-90. 2008..of pregnancies - no. of live births). The basis of our inquiry derives from the facts that the PPAR-gamma receptor plays a pivotal role in placental function and that TFAs down-regulate PPAR-gamma gene mRNA expression... - The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up StudyJohn A Morrison
Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr 160:590-597.e3. 2012..To evaluate children's cardiovascular disease (CVD) risk factors as predictors of parents' subsequent CVD, type 2 diabetes mellitus (T2DM), and high blood pressure (HBP)... - Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-lipid research clinics follow-up studyJohn A Morrison
Division of Cardiology, Children s Hospital of Cincinnati, Cincinnati, OH, USA
Metabolism 61:531-41. 2012..Identification of pediatric risk factors for CVD, IFG + T2DM, and HBP facilitates initiation of primary prevention programs to reduce development of adult CVD, IFG + T2DM, and HBP... - Metformin for weight loss in pediatric patients taking psychotropic drugsJohn A Morrison
Division of Cardiology, Children s Hospital Medical Center, Cincinatti, Ohio 45229, USA
Am J Psychiatry 159:655-7. 2002..Metformin was assessed as a treatment for weight gain in children taking olanzapine, risperidone, quetiapine, or valproate... - Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adultsMichael V Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3030, USA
Clin Chim Acta 332:123-32. 2003..The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q(10) for self-reported healthy adults... - Sensitivity, specificity, and predictive values of pediatric metabolic syndrome components in relation to adult metabolic syndrome: the Princeton LRC follow-up studyTerry T K Huang
Endocrinology, Nutrition and Growth Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
J Pediatr 152:185-90. 2008.... - Obesity development during adolescence in a biracial cohort: the NHLBI Growth and Health StudySue Y S Kimm
Department of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 110:e54. 2002..The purpose of this report was to examine changes in the annual prevalence rates of overweight and obesity in the NGHS cohort from ages 9 to 19 years... - Impact of objective and subjective social status on obesity in a biracial cohort of adolescentsElizabeth Goodman
Schneider Institute for Health Policy, Heller School for Social Policy and Management, Brandeis University MS 35, 415 South Street, Waltham, MA 02454 9110, USA
Obes Res 11:1018-26. 2003..To characterize the associations between socioeconomic status (SES), two levels of subjective social status (SSS), and adolescent obesity... - Metabolic risk with second-generation antipsychotic treatment: a double-blind randomized 8-week trial of risperidone and olanzapineDeanna L Kelly
Maryland Psychiatric Research Center, University of Maryland, School of Medicine, Baltimore, Maryland 21228, USA
Ann Clin Psychiatry 20:71-8. 2008..This study examined weight and metabolic changes with two widely used antipsychotics, risperidone and olanzapine; addressing the issue of early monitoring for metabolic side effects... - Factor analysis of clustered cardiovascular risks in adolescence: obesity is the predominant correlate of risk among youthElizabeth Goodman
Heller School for Social Policy and Management, Brandeis University, MS 35, 415 South St, Waltham, MA 02453 9110, USA
Circulation 111:1970-7. 2005..The increasing rates of obesity and type 2 diabetes and the growing importance of metabolic syndrome among adolescents make assessment of CV risk clustering even more urgent in this age group... - Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescentsElizabeth Goodman
Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts 02454, USA
J Pediatr 145:445-51. 2004.... - What's love got to do with it? Family cohesion and healthy eating behaviors in adolescent girlsDebra L Franko
Department of Counseling and Applied Educational Psychology, Northeastern University, Boston, Massachusetts 02115 5000, USA
Int J Eat Disord 41:360-7. 2008..To examine the association between family cohesion and behaviors linked to health or overweight in adolescents...
Research Grants
- LONGITUDINAL LDL-C STUDIES IN BLACK AND WHITE FAMILIESJohn Morrison; Fiscal Year: 2003..They conclude that this information can be used to improve prediction of future CHD risk and to formulate interventions. ..