Hehuang Xie

Summary

Affiliation: Children's Memorial Hospital
Country: USA

Publications

  1. ncbi High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum
    Hehuang Xie
    Department of Pediatrics, Division of Anatomic Pathology, Falk Brain Tumor Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Nucleic Acids Res 37:4331-40. 2009
  2. ncbi Genetic and epigenetic variations contributed by Alu retrotransposition
    Alexandre de Andrade
    Falk Brain Tumor Center, Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Chicago, IL 60614 3394, USA
    BMC Genomics 12:617. 2011
  3. ncbi Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
    Christopher A Hamm
    Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA
    BMC Cancer 10:471. 2010
  4. ncbi Epigenomic analysis of Alu repeats in human ependymomas
    Hehuang Xie
    Falk Brain Tumor Center, Cancer Biology and Epigenomics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Proc Natl Acad Sci U S A 107:6952-7. 2010
  5. ncbi Genome-wide quantitative assessment of variation in DNA methylation patterns
    Hehuang Xie
    Falk Brain Tumor Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago IL 60614 3394, USA
    Nucleic Acids Res 39:4099-108. 2011
  6. ncbi BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors
    Min Wang
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Box 220, Chicago, IL 60614 3394, USA
    Neuroinformatics 9:59-67. 2011
  7. ncbi Recent patents on the identification and clinical application of microRNAs and target genes
    Min Wang
    Children s Memorial Research Center, Chicago, Illinois 60614, USA
    Recent Pat DNA Gene Seq 1:116-24. 2007
  8. ncbi SNP-based prediction of the human germ cell methylation landscape
    Hehuang Xie
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Genomics 93:434-40. 2009
  9. ncbi Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas
    Ajay K Yadav
    Department of Neurological Surgery, Northwestern Brain Tumor Institute, Lurie Center for Cancer Genetics Research, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3015, USA
    JAMA 302:276-89. 2009

Collaborators

  • Min Wang
  • Marcelo B Soares
  • Markus Bredel
  • Sunit Das
  • Jianjun Chen
  • Arnab Chakravarti
  • Alexandre de Andrade
  • Christopher A Hamm
  • Ajay K Yadav
  • Maria F Bonaldo
  • Simone T Sredni
  • Maria de Fatima Bonaldo
  • Jose A Morcuende
  • Thomas L Casavant
  • Jeff W Stevens
  • Hakeem Abdulkawy
  • Mary J C Hendrix
  • Deli Wang
  • Elisabeth A Seftor
  • Sergey Malchenko
  • Elio F Vanin
  • Jared M Bischof
  • Griffith R Harsh
  • Denise M Scholtens
  • Jaclyn J Renfrow
  • Claudia Bredel
  • James P Chandler
  • George E Duran
  • Hannes Vogel
  • Branimir I Sikic
  • Adrienne C Scheck
  • Pierre A Robe
  • John A Kessler

Detail Information

Publications9

  1. ncbi High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum
    Hehuang Xie
    Department of Pediatrics, Division of Anatomic Pathology, Falk Brain Tumor Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Nucleic Acids Res 37:4331-40. 2009
    ..We anticipate the amplicons herein described to prove invaluable as epigenome representations, to monitor epigenomic alterations during normal development, in aging and in diseases such as cancer...
  2. ncbi Genetic and epigenetic variations contributed by Alu retrotransposition
    Alexandre de Andrade
    Falk Brain Tumor Center, Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Chicago, IL 60614 3394, USA
    BMC Genomics 12:617. 2011
    ..In this study, we exploited Alu-anchored bisulfite PCR libraries to identify evolutionarily recent Alu element insertions, and to investigate their genetic and epigenetic variation...
  3. ncbi Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
    Christopher A Hamm
    Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA
    BMC Cancer 10:471. 2010
    ..Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy...
  4. ncbi Epigenomic analysis of Alu repeats in human ependymomas
    Hehuang Xie
    Falk Brain Tumor Center, Cancer Biology and Epigenomics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Proc Natl Acad Sci U S A 107:6952-7. 2010
    ..Lastly, aberrant methylation of several genomic loci was confirmed to be associated with the aggressive primary tumors and the relapsed ependymomas...
  5. ncbi Genome-wide quantitative assessment of variation in DNA methylation patterns
    Hehuang Xie
    Falk Brain Tumor Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago IL 60614 3394, USA
    Nucleic Acids Res 39:4099-108. 2011
    ..Lastly, using subcloned normal fibroblast cells, we demonstrated the highly variable methylation patterns are resulted from low fidelity of DNA methylation inheritance...
  6. ncbi BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors
    Min Wang
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Box 220, Chicago, IL 60614 3394, USA
    Neuroinformatics 9:59-67. 2011
    ..This integrated platform will facilitate uncovering interactions among genetic and epigenetic factors associated with brain tumor development. BTECH is freely available at http://cmbteg.childrensmemorial.org/...
  7. ncbi Recent patents on the identification and clinical application of microRNAs and target genes
    Min Wang
    Children s Memorial Research Center, Chicago, Illinois 60614, USA
    Recent Pat DNA Gene Seq 1:116-24. 2007
    ....
  8. ncbi SNP-based prediction of the human germ cell methylation landscape
    Hehuang Xie
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Genomics 93:434-40. 2009
    ....
  9. ncbi Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas
    Ajay K Yadav
    Department of Neurological Surgery, Northwestern Brain Tumor Institute, Lurie Center for Cancer Genetics Research, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3015, USA
    JAMA 302:276-89. 2009
    ..Glioblastomas--uniformly fatal brain tumors--often have both monosomy of chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on chromosome 7, an association for which the mechanism is poorly understood...