MICHAEL NOBUAKI ODASummaryAffiliation: Children's Hospital Oakland Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteinsMichael N Oda
Life Sciences Division MS 1 220, Lawrence Berkeley National Laboratory, One Cylotron Road, Berkeley, California 94720, USA
Biochem Biophys Res Commun 290:921-7. 2002..Excess mPON1 also inhibited lipid hydroperoxide formation on HDL. These data strongly suggest that overexpression of mPON1 protects HDL integrity and function...- The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational triggerMichael N Oda
Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
Nat Struct Biol 10:455-60. 2003..This conformational switch is analogous to triggered events in viral fusion proteins and may serve as a means to overcome the energy barriers of lipid sequestration, a critical step in cholesterol efflux and HDL assembly... - Reconstituted high density lipoprotein enriched with the polyene antibiotic amphotericin BMichael N Oda
Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Lipid Res 47:260-7. 2006..25 mg/kg. These results indicate that AMB-rHDLs constitute a novel formulation that effectively solubilizes the antibiotic and elicits strong in vitro and in vivo antifungal activity with no observed toxicity at therapeutic doses... - Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solutionJens O Lagerstedt
Department of Biochemistry, University of California, Davis, California 95616, USA
J Biol Chem 282:9143-9. 2007..Based on intermolecular dipolar coupling at positions 26, 44, and 64, these secondary structural elements were arranged into a tertiary fold to generate a structural model for lipid-free apoA-I in solution... - Apolipoprotein A-I assumes a "looped belt" conformation on reconstituted high density lipoproteinDale D O Martin
Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
J Biol Chem 281:20418-26. 2006..Specifically, in the looped belt model, with the exception of amino acids 134-145, apoA-I aligns with its counterpart in a helix 5-helix 5 registry, centered at position 139... - Combined N- and C-terminal truncation of human apolipoprotein A-I yields a folded, functional central domainJennifer A Beckstead
Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
Biochemistry 44:4591-9. 2005..Lipid association likely results in a conformational adaptation wherein helix-helix contacts are substituted for helix-lipid interactions... - Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteinsGiorgio Cavigiolio
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
J Biol Chem 285:18847-57. 2010..This impairment of apoA-I exchange reaction may be a trait of dysfunctional HDL contributing to reduced ATP-binding cassette A1-mediated cholesterol efflux and atherosclerosis... - Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasisJennifer A Beckstead
Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Biochemistry 42:9416-23. 2003..Taken together, the results demonstrate recombinant apoA-V possesses unique structural and functional characteristics, in keeping with its proposed role in the modulation of plasma lipid levels... - The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclassesGiorgio Cavigiolio
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Biochemistry 47:4770-9. 2008..8 nm particles, concomitant with the dissociation of lipid-free/lipid-poor apoA-I. Thus, lipid-free/lipid-poor apoA-I generated by the remodeling of HDL may be an essential intermediate in RCT and HDL's in vivo maturation... - Optimized bacterial expression of human apolipoprotein A-IRobert O Ryan
Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA
Protein Expr Purif 27:98-103. 2003..Together, these changes in apoA-I cDNA and bacterial expression protocol significantly improve the yield of apoA-I protein without compromising the relative ease of purification... - Mapping the structural transition in an amyloidogenic apolipoprotein A-IJens O Lagerstedt
Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
Biochemistry 46:9693-9. 2007.... - Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transportBaohai Shao
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Biol Chem 280:5983-93. 2005..This impaired biological activity of chlorinated apoA-I suggests that MPO-mediated oxidation of HDL might contribute to the link between inflammation and cardiovascular disease... - Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-IBaohai Shao
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:12224-9. 2008..These observations implicate oxidation of a single Met in apoA-I in impaired LCAT activation, a critical early step in reverse cholesterol transport... - Apolipoprotein A-I(Milano) and apolipoprotein A-I(Paris) exhibit an antioxidant activity distinct from that of wild-type apolipoprotein A-IJohn K Bielicki
Genome Sciences Department, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Biochemistry 41:2089-96. 2002..These studies are the first to relate gain of function to rare cysteine mutations in the apoA-I primary sequence... - Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humansTomas Vaisar
Department of Medicine, HSB BB512, Box 356426, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Curr Atheroscler Rep 9:417-24. 2007..Thus, oxidative modifications to HDL and changes in its protein composition might be useful biomarkers-and perhaps mediators-of CVD... - Pathways for oxidation of high-density lipoprotein in human cardiovascular diseaseBaohai Shao
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Curr Opin Mol Ther 8:198-205. 2006..Collectively, these observations indicate that MPO oxidatively damages HDL in humans and suggest that oxidation of specific amino acid residues in apoA-I may contribute to atherogenesis by impairing cholesterol efflux from macrophages... - Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoproteinBaohai Shao
Department of Medicine, University of Washington, Seattle, 98195, USA
Curr Opin Cardiol 21:322-8. 2006..Moreover, oxidized HDL might prove useful as a blood marker for clinically significant cardiovascular disease in humans... - Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-IBaohai Shao
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 281:9001-4. 2006.... - ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-IJonathan D Smith
Department of Cell Biology NC10, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Lipid Res 45:635-44. 2004..Finally, we could not reproduce a two-step effect on lipid efflux using conditioned medium from ABCA1-expressing cells pretreated with cyclodextrin... - Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible miceTrudy M Forte
Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
J Lipid Res 43:477-85. 2002..We conclude that impairment of LCAT activity and accumulation of oxidized phospholipids are part of an early atherogenic phenotype in these models...
Research Grants
- Structure-function relations in apoA-I's central domainMICHAEL ODA; Fiscal Year: 2007..This information will allow us to generate a structural context for apoA-I function and outline the molecular mechanism for the conformational adaptations that occur during lipid-association, its regulation and function. ..
- Structure of apolipoprotein A-I on defined states of HDLMICHAEL NOBUAKI ODA; Fiscal Year: 2010..Additionally, an enhanced understanding of apoA-I structure and HDL function will illuminate the cause of disease through dysfunction of HDL or apoA-I. ..