Research Topics
Species | Regina I JakackiSummaryAffiliation: Children's Hospital of Pittsburgh Country: USA Publications
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Detail Information
Publications
A pilot study of preirradiation chemotherapy and 1800 cGy craniospinal irradiation in young children with medulloblastomaRegina I Jakacki
Division of Pediatric Hematology Oncology, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 60:531-6. 2004..We prospectively evaluated the feasibility of giving preirradiation chemotherapy followed by 1800 cGy CSI to young children with localized medulloblastoma...- Treatment strategies for high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors. Review of the literatureRegina I Jakacki
Division of Pediatric Hematology Oncology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 102:44-52. 2005..The author reviews the literature, describes currently available treatment options for patients with high-risk PNETs, and discusses strategies aimed at improving outcome and refining prognosis that are currently being explored... - A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium studyRegina I Jakacki
Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
Neuro Oncol 13:910-5. 2011..The recommended phase 2 dose and schedule is carboplatin, 400 mg/m(2)/dose on day 1, and vinblastine, 4 mg/m(2)/dose, weekly × 3, repeated every 4 weeks. Further study of this regimen in patients with low-grade glioma is warranted... - A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhoodRegina I Jakacki
Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Neuro Oncol 10:569-76. 2008..Radiographic changes following RT make determination of early tumor progression difficult. Metastatic disease is common prior to death... - Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium StudyRegina I Jakacki
Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Oncol 26:4921-7. 2008..We conducted a phase I and pharmacokinetic study of the epidermal growth factor receptor (EGFR) inhibitor erlotinib as a single agent and in combination with temozolomide in children with refractory solid tumors... - Phase I trial of pegylated interferon-alpha-2b in young patients with plexiform neurofibromasR I Jakacki
Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Neurology 76:265-72. 2011..We sought to evaluate preliminary efficacy and determine the recommended phase II dose (RP2D) for pegylated interferon-?-2b (PI) in patients with unresectable progressive or symptomatic plexiform neurofibromas (PN)... - IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Childs Nerv Syst 27:87-94. 2011..Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations... - Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Pediatr Blood Cancer 55:1066-71. 2010..However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized... - Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium reportIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Neuro Oncol 9:145-60. 2007..Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern... - Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
J Neurooncol 99:155-63. 2010..In view of the frequency of Akt activation, the evaluation of molecularly targeted therapies that inhibit this pathway warrants consideration for these tumors... - A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samplesAlex Lisovich
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
BMC Med Genomics 4:14. 2011.... - Childhood brain tumors: epidemiology, current management and future directionsIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Nat Rev Neurol 7:495-506. 2011..The latest insights from molecular correlative studies that hold potential for future refinements in therapy will also be discussed... - Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patientsHideyuki Kano
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Suite B 400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Neurooncol 95:219-29. 2009..Stereotactic radiosurgery for pediatric pilocytic astrocytomas should be considered when resection is not feasible, or if there is an early recurrence. The best response was observed in small volume residual solid tumors... - Extraventricular neurocytoma in neurofibromatosis Type 1: case reportAli I Raja
Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurosurg Pediatr 2:63-7. 2008..The importance of obtaining a biopsy in lesions that have atypical imaging features is highlighted... - Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinomaRobert D Timmerman
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
Med Pediatr Oncol 41:564-6. 2003