Research Topics
| J S BradleySummaryAffiliation: Children's Hospital and Health Center Country: USA Publications
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Detail Information
Publications
Pharmacokinetics of a fluoronaphthyridone, trovafloxacin (CP 99,219), in infants and children following administration of a single intravenous dose of alatrofloxacinJ S Bradley
Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
Antimicrob Agents Chemother 44:1195-9. 2000..5 +/- 10.1 microg. h/ml and the susceptibility (< or =0.5 microg/ml) of common pediatric bacterial pathogens to trovafloxacin, dosing of 4 mg/kg/day once or twice daily should be appropriate...- Convalescent phase outpatient parenteral antiinfective therapy for children with complicated appendicitisJ S Bradley
Division of Infectious Diseases, Children s Hospital, San Diego, CA, USA
Pediatr Infect Dis J 20:19-24. 2001..This prospective study investigates the outcomes when children who meet specified criteria are discharged to complete parenteral antibiotic therapy at home... - Empiric use of cefepime in the treatment of lower respiratory tract infections in childrenJ S Bradley
Division of Infectious Diseases, Children s Hospital of San Diego, CA 92123, USA
Pediatr Infect Dis J 20:343-9. 2001..These studies were designed to assess the efficacy and safety of cefepime, a fourth generation cephalosporin, for the treatment of serious infections, including lower respiratory tract infections (LRTI) in children... - Anti-infective research and development--problems, challenges, and solutionsJohn S Bradley
Antimicrobial Availability Task Force of the Infectious Diseases Society of America, Alexandria, VA, USA
Lancet Infect Dis 7:68-78. 2007 - Newer antistaphylococcal agentsJohn S Bradley
Division of Infectious Diseases, Children s Hospital San Diego, San Diego, California 92123, USA
Curr Opin Pediatr 17:71-7. 2005.... - Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonateJohn S Bradley
Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
Pediatr Infect Dis J 27:794-9. 2008..Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic... - Antibiotic stewardship in pediatrics: a necessityJohn S Bradley
Children's Hospital San Diego, University of California, San Diego, USA
Pediatr Infect Dis J 26:538-9. 2007 - Pharmacodynamics and the prediction of efficacy in short-course antibiotic therapy: pediatric studies to validate the modelJohn S Bradley
Division of Infectious Diseases, Children s Hospital San Diego, San Diego, California 92123, USA
Pharmacotherapy 25:159S-164S. 2005..By using a mathematic model that integrates all important variables, one may be able to predict the probability of a cure with short-course therapy for each pathogen, antibiotic, site of infection, and host interaction... - Guidelines for the selection of antibacterial therapy in childrenAlice L Pong
Children's Hospital and Health Center, 3020 Children's Way, MC 5041, San Diego, CA 92123, USA
Pediatr Clin North Am 52:869-94, viii. 2005..This article reviews factors important in the selection of antimicrobial agents in infants and children. Recommendations for antibiotic therapy for a wide range of infections occurring in children are provided... - Clinical challenges of nosocomial infections caused by antibiotic-resistant pathogens in pediatricsAlice Pong
Division of Infectious Diseases, Children's Hospital and Health Center, San Diego, CA 92123, USA
Semin Pediatr Infect Dis 15:21-9. 2004..Nosocomial outbreaks caused by resistant organisms are described, and an approach to empiric therapy based on presumed pathogens, site of infection, and local resistance patterns is discussed... - Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory featuresJohn A D Leake
Divisions of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
Pediatr Infect Dis J 23:756-64. 2004..The epidemiology, infectious antecedents and pathogenesis of ADEM are poorly characterized, and some ADEM patients are subsequently diagnosed with multiple sclerosis (MS)... - Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and reviewJohn A D Leake
Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA, 92123, USA
Clin Infect Dis 34:699-703. 2002..Pathologic diagnosis of this condition may be critical to exclude more-common processes and to expedite the decision to administer high-dose corticosteroid therapy, which is potentially lifesaving... - Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USAMichael D Green
Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine. Pittsburgh, PA, USA
J Antimicrob Chemother 57:1240-3. 2006.... - Management of community-acquired pediatric pneumonia in an era of increasing antibiotic resistance and conjugate vaccinesJohn S Bradley
Division of Infectious Diseases, Children's Hospital, San Diego, CA, USA
Pediatr Infect Dis J 21:592-8; discussion 613-4. 2002..pneumoniae. In contrast antibiotic regimens for life-threatening pulmonary infections in which Staphylococcus aureus is a suspected pathogen should include vancomycin... - Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatmentJ T Kanegaye
Division of Emergency Medicine, Children s Hospital and Health Center and Department of Pediatrics, University of California San Diego, San Diego, California 92123, USA
Pediatrics 108:1169-74. 2001..We conducted a retrospective review of children with bacterial meningitis to describe the rate at which parenteral antibiotic pretreatment sterilizes CSF cultures... - Considerations unique to pediatrics for clinical trial design in hospital-acquired pneumonia and ventilator-associated pneumoniaJohn S Bradley
Rady Children s Hospital San Diego, University of California, San Diego, USA
Clin Infect Dis 51:S136-43. 2010.... - Old and new antibiotics for pediatric pneumoniaJohn S Bradley
University of California San Diego, School of Medicine, San Diego, CA, USA
Semin Respir Infect 17:57-64. 2002.... - Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulationJohn S Bradley
Division of Infectious Diseases, Children's Hospital, San Diego, CA, USA
Pediatr Infect Dis J 22:982-92; quiz 993-5. 2003 - Comparative study of levofloxacin in the treatment of children with community-acquired pneumoniaJohn S Bradley
Children s Hospital and Health Center, San Diego, CA, USA
Pediatr Infect Dis J 26:868-78. 2007..Levofloxacin has established efficacy and safety in the treatment of community-acquired pneumonia (CAP) in adults, and its use as an alternative therapy for children with CAP has been proposed... - Unique considerations in the evaluation of antibacterials in clinical trials for pediatric community-acquired pneumoniaJohn S Bradley
Division of Pediatric Infectious Diseases, Rady Children s Hospital San Diego, San Diego, California 92123, USA
Clin Infect Dis 47:S241-8. 2008..Clinical trials that require invasive techniques for diagnosis and placebo-controlled randomized trials are not acceptable for children, who are considered to be a vulnerable population... - Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse eventsJohn S Bradley
Rady Children s Hospital San Diego, San Diego, California 92123, USA
Pediatrics 123:e609-13. 2009..This report describes and summarizes the reported cases that led to safety concerns regarding the concurrent administration of intravenous ceftriaxone and calcium in this age group... - Prediction of neurologic sequelae in childhood tuberculous meningitis: a review of 20 cases and proposal of a novel scoring systemAkihiko Saitoh
Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, CA, USA
Pediatr Infect Dis J 24:207-12. 2005..CONCLUSIONS: The TBAN score is an objective marker for predicting severe NS in children with TBM... - Antimicrobial agents for complicated skin and skin-structure infections: justification of noninferiority margins in the absence of placebo-controlled trialsBrad Spellberg
Division of Infectious Diseases, Harbor University of California at Los Angeles Medical Center, Torrance, California 90502, USA
Clin Infect Dis 49:383-91. 2009..In the absence of placebo-controlled trials, we sought to define the magnitude of efficacy of antimicrobial agents and resulting noninferiority margins for studies of complicated skin and skin-structure infection (SSSI)... - A comparison of early versus late conversion from intravenous to oral therapy in the treatment of septic arthritisROBERT TRACY BALLOCK
Rady Children s Hospital, San Diego, California, USA
J Pediatr Orthop 29:636-42. 2009.... - New antibiotics for Gram-positive infectionsJohn S Bradley
Division of Infectious Diseases, Children's Hospital, San Diego, CA 92123, USA
Adv Exp Med Biol 582:151-65. 2006 - Aggressive management of shunt infection: combined intravenous and intraventricular antibiotic therapy for twelve or less daysHector E James
Lucy Gooding Pediatric Neurosurgery Center, University of Florida HSC Jacksonville and Wolfson Children s Hospital, Jacksonville, FL 32207, USA
Pediatr Neurosurg 44:104-11. 2008..This report is limited to patients with a single cerebrospinal fluid (CSF) shunt infected by a single organism, and compares two treatment protocols... - Management of complicated shunt infections: a clinical reportHector E James
Lucy Gooding Pediatric Neurosurgery Center, University of Florida Health Sciences Center, Jacksonville, FL 32207, USA
J Neurosurg Pediatr 1:223-8. 2008..The authors present their experience with a protocol for the treatment of patients with complicated shunt infections... - Macrolide resistance among middle ear isolates of Streptococcus pneumoniae observed at eight United States pediatric centers: prevalence of M and MLSB phenotypesEdward O Mason
Baylor College of Medicine, Houston, TX, USA
Pediatr Infect Dis J 22:623-7. 2003..pneumoniae increased during the 6-year study. The proportion of M phenotype remained constant at 75%, meaning that these isolates remain susceptible to clindamycin. Continued surveillance to document potential changes is essential... - Levofloxacin pharmacokinetics in childrenShuchean Chien
Johnson and Johnson Pharmaceutical Research and Development, LLC, 920 Route 202 South, PO Box 300, Raritan, NJ 08869-0602, USA
J Clin Pharmacol 45:153-60. 2005.... - Best in class: a good principle for antibiotic usage to limit resistance development?Sebastian G B Amyes
Centre for Infectious Diseases, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
J Antimicrob Chemother 59:825-6. 2007.... - Prevention of influenza: recommendations for influenza immunization of children, 2007-2008Joseph A Bocchini
Pediatrics 121:e1016-31. 2008..However, oseltamivir and zanamivir can be prescribed for treatment or chemoprophylaxis, because influenza A and B strains remain susceptible... - Optimizing therapy with antibacterial agents: use of pharmacokinetic-pharmacodynamic principles in pediatricsChristopher M Rubino
Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12206 1072, USA
Paediatr Drugs 9:361-9. 2007..Application of these PK-PD principles allows rational dosage regimen selection, both for serious infections in critically ill children and for non-life-threatening community-acquired infections... - Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniaeTina Q Tan
Pediatric Infectious Diseases Sections of Northwestern University Medical School, Children s Memorial Hospital, Chicago, Illinois 60614, USA
Pediatrics 110:1-6. 2002.... - Recurrent systemic pneumococcal disease in childrenEdward O Mason
Pediatric Infectious Disease Section, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
Pediatr Infect Dis J 26:480-4. 2007..Recurrent systemic pneumococcal infection usually occurs in immunocompromised patients and patients with underlying conditions... - Pneumococcal endocarditis in childrenLaurence B Givner
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Clin Infect Dis 38:1273-8. 2004..Pneumococcal endocarditis in children is unusual but often has serious complications... - Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccineSheldon L Kaplan
Pediatric Infectious Diseases Sections of the Baylor College of Medicine, Houston, Texas, USA
Pediatrics 113:443-9. 2004.... - Defining pneumonia in critically ill infants and childrenJoanne M Langley
Clinical Trials Research Centre, IWK Health Center, and the Department of Pediatrics, Dalhousie University, Halifax, Canada
Pediatr Crit Care Med 6:S9-S13. 2005..Future research should determine the utility of these definitions in the critically ill child and adapt them accordingly... - Streptococcus pneumoniae infections in the neonateJill A Hoffman
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Pediatrics 112:1095-102. 2003..The aim of this study was to review the current epidemiology and clinical course of SPIN... - Six year multicenter surveillance of invasive pneumococcal infections in childrenSheldon L Kaplan
Pediatric Infectious Diseases Sections, Baylor College of Medicine, Houston, TX, USA
Pediatr Infect Dis J 21:141-7. 2002..Monitor clinical and microbiologic features including antimicrobial susceptibility of invasive pneumococcal infections among children... - In vitro activities of cethromycin (ABT-773), a new ketolide, against Streptococcus pneumoniae strains that are not susceptible to penicillin or macrolidesEdward O Mason
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Antimicrob Agents Chemother 47:166-9. 2003..The ketolides appear to be active antimicrobials against penicillin- and macrolide-resistant pneumococci... - Acute otitis media due to penicillin-nonsusceptible Streptococcus pneumoniae before and after the introduction of the pneumococcal conjugate vaccineM Catherine McEllistrem
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
Clin Infect Dis 40:1738-44. 2005..The impact of the 7-valent pneumococcal conjugate vaccine (PCV7 [Prevnar]) on penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) recovered from children with acute otitis media (AOM) is unclear... - Population pharmacokinetic model for gatifloxacin in pediatric patientsChristopher M Rubino
Cognigen Corporation, Buffalo, NY, USA
Antimicrob Agents Chemother 51:1246-52. 2007..The success of this strategy provides a model for future pediatric drug development programs... - Effect of oseltamivir on the risk of pneumonia and use of health care services in children with clinically diagnosed influenzaCharles E Barr
Roche Laboratories, Nutley, NJ 07110 1199, USA
Curr Med Res Opin 23:523-31. 2007..To evaluate the effectiveness of oseltamivir in reducing the rate of complications of influenza in children... - Practice guidelines for outpatient parenteral antimicrobial therapy. IDSA guidelinesAlan D Tice
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Clin Infect Dis 38:1651-72. 2004 - Comparative safety profile of levofloxacin in 2523 children with a focus on four specific musculoskeletal disordersGary J Noel
Johnson and Johnson Pharmaceutical Research and Development LLC, Raritan, NJ 08869, USA
Pediatr Infect Dis J 26:879-91. 2007..A large prospective trial is needed to assess the risks associated with using levofloxacin in children...