Research Topics
| Chengpeng BiSummaryAffiliation: Children's Mercy Hospital Country: USA Publications
|
Detail Information
Publications
SEAM: a Stochastic EM-type Algorithm for Motif-finding in biopolymer sequencesChengpeng Bi
Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Pediatrics Research Building, Third Floor, Kansas City, Missouri 64108, USA
J Bioinform Comput Biol 5:47-77. 2007..The convergence of the new algorithm is shown by simulation. The in silico experiments using simulated and biological examples illustrate the power and robustness of the new algorithm SEAM in de novo motif discovery...
A Monte Carlo EM algorithm for de novo motif discovery in biomolecular sequencesChengpeng Bi
Bioinformatics and Intelligent Computing Laboratory, Division of Clinical Pharmacology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
IEEE/ACM Trans Comput Biol Bioinform 6:370-86. 2009..Finally, MCEMDA is applied to detect large blocks of conserved domains using protein benchmarks and exhibits its excellent capacity while compared with other multiple sequence alignment methods...
BIPAD: a web server for modeling bipartite sequence elementsChengpeng Bi
Laboratory of Human Molecular Genetics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
BMC Bioinformatics 7:76. 2006..Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences separated by intervening distances that vary among individual sites...
DNA motif alignment by evolving a population of Markov chainsChengpeng Bi
Bioinformatics and Intelligent Computing Lab, Division of Clinical Pharmacology, Children s Mercy Hospitals, Kansas City, Missouri, USA
BMC Bioinformatics 10:S13. 2009..Hence it would be worth a new algorithm design enabling such information exchange...
A comparative study on computational two-block motif detection: algorithms and applicationsChengpeng Bi
Bioinformatics and Intelligent Computing, Division of Clinical Pharmacology and Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, Missouri 64108, USA
Mol Pharm 5:3-16. 2008..We demonstrate how to use this suite of methods and apply them to human nuclear receptor response elements (i.e., protein binding sites of several relevant nuclear receptors, HNF4alpha, CAR/RXR, and PXR/RXR)...
Bipartite pattern discovery by entropy minimization-based multiple local alignmentChengpeng Bi
Laboratory of Human Molecular Genetics, Children's Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
Nucleic Acids Res 32:4979-91. 2004..Finally, a new bipartite information weight matrix for vitamin D3 receptor/retinoid X receptor alpha (VDR/RXRalpha) binding sites was derived that comprehensively models the natural variability inherent in these sequence elements...
Data augmentation algorithms for detecting conserved domains in protein sequences: a comparative studyChengpeng Bi
Bioinformatics and Intelligent Computing Lab, Children s Mercy Hospitals and Clinics Schools of Medicine, Computing and Engineering University of Missouri, Kansas City, Missouri 64108, USA
J Proteome Res 7:192-201. 2008..As a result, four DA motif discovery algorithms are described, evaluated, and compared by aligning real and simulated protein sequences...
Allele drop-out in the MECP2 gene due to G-quadruplex and i-motif sequences when using polymerase chain reaction-based diagnosis for Rett syndromeCarol J Saunders
Department of Pathology and Laboratory Medicine, The Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
Genet Test Mol Biomarkers 14:241-7. 2010..We identify factors in both the polymerase chain reaction amplification and the sequencing steps that help overcome ADO...
WebSIDD: server for predicting stress-induced duplex destabilized (SIDD) sites in superhelical DNAChengpeng Bi
UC Davis Genome Center, University of California, One Shields Avenue, Davis, CA 95616, USA
Bioinformatics 20:1477-9. 2004..AVAILABILITY: http://orange.genomecenter.ucdavis.edu/benham/sidd/index.html..
Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energyJürgen Bode
German Research Center for Biotechnology, RDIF Epigenetic Regulation, D 38124 Braunschweig, Mascheroder Weg 1, Germany
J Mol Biol 358:597-613. 2006....
The analysis of stress-induced duplex destabilization in long genomic DNA sequencesCraig J Benham
UC Davis Genome Center, University of California, One Shields Avenue, Davis, CA 95616, USA
J Comput Biol 11:519-43. 2004....
