Jianyuan Chai

Summary

Country: USA

Publications

  1. ncbi Epithelial or mesenchymal: Where to draw the line?
    J Y Chai
    VA Long Beach Healthcare System, CA 90822, USA
    Biosci Trends 4:130-42. 2010
  2. ncbi CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells
    Jianyuan Chai
    Laboratory of GI Injury and Cancer, VA Long Beach Healthcare System, Long Beach, CA 90822, USA
    Lab Invest 90:1140-51. 2010
  3. ncbi Serum response factor: look into the gut
    Cristina Modak
    Department of Research 09 151, VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, United States
    World J Gastroenterol 16:2195-201. 2010
  4. ncbi A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats
    Jianyuan Chai
    Department of Research 151, VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, USA
    Gut 56:621-30. 2007
  5. ncbi Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing
    Jianyuan Chai
    Department of Medicine/Gastroenterology, VA Medical Center, 5901 East Seventh Street, Long Beach, CA 90822, USA
    Gastroenterology 126:1809-18. 2004
  6. ncbi CCN1 is critical for acid-induced esophageal epithelial cell transformation
    Cristina Modak
    VA Long Beach Healthcare System, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Biochem Biophys Res Commun 392:533-7. 2010
  7. ncbi Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner
    Tom Nguyen
    VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, USA
    Am J Pathol 170:1219-28. 2007
  8. ncbi TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new "hot" cancer treatment
    Justine Chow
    VA Long Beach Healthcare System, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Biochim Biophys Acta 1773:565-76. 2007
  9. ncbi Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis
    Jianyuan Chai
    Department of Medicine Gastroenterology, VA Medical Center, Long Beach, California 90822, USA
    FASEB J 18:1264-6. 2004
  10. ncbi Potential of casein kinase I in digestive cancer screening
    Cristina Modak
    Cristina Modak, Jianyuan Chai, Department Research 09 151, VA Long Beach Healthcare System, Long Beach, 90822 and the University of California, Irvine, CA 92697, United States
    World J Gastrointest Oncol 1:26-33. 2009

Collaborators

  • Kevin M Reavis
  • Jing Zhang
  • Cristina Modak
  • Justine Chow
  • Tom Nguyen
  • Reinier Narvaez
  • Wasim Mouazzen
  • Tetsuya Tanigawa
  • Andrzej S Tarnawski
  • Manith Norng
  • Aihua Li
  • Tomohiko Akahoshi

Detail Information

Publications10

  1. ncbi Epithelial or mesenchymal: Where to draw the line?
    J Y Chai
    VA Long Beach Healthcare System, CA 90822, USA
    Biosci Trends 4:130-42. 2010
    ..The information provided here is expected to serve as a reference for both basic and clinical researchers in the fields of epithelial-mesenchymal transition, molecular cell typing and cancer diagnosis...
  2. ncbi CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells
    Jianyuan Chai
    Laboratory of GI Injury and Cancer, VA Long Beach Healthcare System, Long Beach, CA 90822, USA
    Lab Invest 90:1140-51. 2010
    ..In conclusion, our study indicates that CCN1 can induce reversible epithelial-mesenchymal transition, and this feature may have great value for clinical wound healing...
  3. ncbi Serum response factor: look into the gut
    Cristina Modak
    Department of Research 09 151, VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, United States
    World J Gastroenterol 16:2195-201. 2010
    ..This review will summarize what we have learned about SRF in the gastrointestinal tract and provide insights into possible future directions in this area...
  4. ncbi A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats
    Jianyuan Chai
    Department of Research 151, VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, USA
    Gut 56:621-30. 2007
    ..Injection of SRF expression plasmid into rat gastric ulcers significantly accelerated restoration of epithelium and smooth muscle structures...
  5. ncbi Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing
    Jianyuan Chai
    Department of Medicine/Gastroenterology, VA Medical Center, 5901 East Seventh Street, Long Beach, CA 90822, USA
    Gastroenterology 126:1809-18. 2004
    ..SRF promotes migration and proliferation of gastric epithelial and smooth muscle cells, which are essential for re-epithelialization and restoration of muscular structures...
  6. ncbi CCN1 is critical for acid-induced esophageal epithelial cell transformation
    Cristina Modak
    VA Long Beach Healthcare System, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Biochem Biophys Res Commun 392:533-7. 2010
    ..Given the pivotal role of low pH in gastro-esophageal reflux disease and its progression towards esophageal adenocarcinoma, our study identified CCN1 as a key molecule mediating this process...
  7. ncbi Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner
    Tom Nguyen
    VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, USA
    Am J Pathol 170:1219-28. 2007
    ..The up-regulation of IGF-1 in gastric ulcer margin accelerates gastric ulcer healing by promoting cell re-epithelization, proliferation, and COX-2 expression via the phosphatidylinositol 3-kinase pathway...
  8. ncbi TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new "hot" cancer treatment
    Justine Chow
    VA Long Beach Healthcare System, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Biochim Biophys Acta 1773:565-76. 2007
    ..Together, our data suggest that capsaicin may be a promising dietary candidate for cancer chemoprevention...
  9. ncbi Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis
    Jianyuan Chai
    Department of Medicine Gastroenterology, VA Medical Center, Long Beach, California 90822, USA
    FASEB J 18:1264-6. 2004
    ..These findings have potential therapeutic implications, e.g., local anti-SRF treatment may inhibit angiogenesis crucial for tumor growth...
  10. ncbi Potential of casein kinase I in digestive cancer screening
    Cristina Modak
    Cristina Modak, Jianyuan Chai, Department Research 09 151, VA Long Beach Healthcare System, Long Beach, 90822 and the University of California, Irvine, CA 92697, United States
    World J Gastrointest Oncol 1:26-33. 2009
    ..Our emphasis is on their implications in digestive cancers and their potential for cancer screening and therapy...