Research Topics
| P RobertsonSummaryAffiliation: Cephalon Inc Country: USA Publications
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Detail Information
Publications
Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteersE T Hellriegel
Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
J Clin Pharmacol 41:895-904. 2001..The results indicate that administration of low-dose methylphenidate 8 hours after treatment with modafinil does not appear to alter the steady-state pharmacokinetics of modafinil in healthy volunteers...- In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinilP Robertson
Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
Drug Metab Dispos 28:664-71. 2000..Although effects obtained in vitro are not always predictive of effects in vivo, such results provide a rational basis for understanding drug-drug interactions that are observed clinically and for planning subsequent investigations... - Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteersPhilmore Robertson
Department of Drug Disposition, Cephalon, Inc, West Chester, PA 19380, USA
Clin Pharmacol Ther 71:46-56. 2002..Modafinil has been reported to produce a concentration-related induction of CYP3A4/5 activity in vitro in primary cultures of human hepatocytes... - Clinical pharmacokinetic profile of modafinilPhilmore Robertson
Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
Clin Pharmacokinet 42:123-37. 2003..In summary, the results show that modafinil is a moderately long-lived drug that is well absorbed and extensively metabolised... - Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjectsMona Darwish
Clinical Pharmacology, Cephalon Inc, Frazer, PA 19355, USA
Clin Pharmacokinet 47:61-74. 2008..Study 3 evaluated the potential for armodafinil to inhibit the activity of CYP2C19 using oral omeprazole as the probe substrate... - Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot studyMona Darwish
Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
Clin Drug Investig 27:605-11. 2007.... - Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrateMona Darwish
Cephalon Inc, 41 Moores Road, Frazer, PA 19355, USA
J Clin Pharmacol 47:343-50. 2007..The rate and extent of fentanyl absorption were greater following administration of FBT compared to OTFC. An approximately 30% smaller dose of FBT achieved systemic exposures comparable to OTFC... - Single-dose and steady-state pharmacokinetics of fentanyl buccal tablet in healthy volunteersMona Darwish
Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania, USA
J Clin Pharmacol 47:56-63. 2007..This was attributed to the redistribution of fentanyl from a deep tissue compartment into the plasma. This study indicates that fentanyl buccal tablet has predictable pharmacokinetics following multiple-dose administration... - Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokineticsMona Darwish
Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
Clin Pharmacokinet 45:843-50. 2006..The fentanyl buccal tablet (FBT) is designed to enhance the rate and extent of fentanyl absorption through the buccal mucosa... - Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteersMona Darwish
Department of Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
Clin Ther 28:707-14. 2006..The fentanyl effervescent buccal tablet (FEBT) is designed to enhance the rate and extent of the absorption of fentanyl, an opioid, through the buccal mucosa... - Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjectsMona Darwish
Clinical Pharmacology, Cephalon Inc, Frazer, PA 19355, USA
Clin Drug Investig 28:1-7. 2008..e. above a molar tooth between the upper gum and cheek) and sublingual (i.e. placed under the tongue) placement in order to provide an alternative option to patients... - Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytesAjay Madan
XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
Drug Metab Dispos 31:421-31. 2003.... - Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteersEdward T Hellriegel
Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
J Clin Pharmacol 42:450-60. 2002..The results indicate that administration of low-dose dextroamphetamine in this dosing regimen does not alter the steady-state pharmacokinetics of modafinil. The combination has a similar tolerability profile as modafinil alone... - Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteersPhilmore Robertson
Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
J Clin Pharmacol 42:205-14. 2002..However, limitations arising from investigation of single doses of warfarin preclude global conclusions about the potential for more subtle interactions after chronic warfarin administration... - Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitorJohn L Marshall
Georgetown University Medical Center-Lombardi Cancer Center, Washington, DC 20007, USA
Invest New Drugs 23:31-7. 2005..Further study is necessary to determine the clinical efficacy of this novel new chemotherapeutic agent...