Research Topics
| Paul J WeidleSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
HIV/AIDS treatment and HIV vaccines for AfricaPaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 359:2261-7. 2002..In this review, we discuss the prospects for use of treatment and vaccines in resource-poor settings...- Adherence to antiretroviral therapy in a home-based AIDS care programme in rural UgandaPaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 368:1587-94. 2006..We assessed adherence to antiretroviral therapy in a cohort of HIV-infected people in a home-based AIDS care programme that provides the therapy and other AIDS care, prevention, and support services in rural Uganda... - Liver enzymes improve over twenty-four months of first-line non-nucleoside reverse transcriptase inhibitor-based therapy in rural UgandaPaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS Patient Care STDS 22:787-95. 2008..The prevalence of hepatic transaminase elevations decreased during non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in this cohort of HIV-infected persons in rural Uganda... - A simplified weight-based method for pediatric drug dosing for zidovudine and didanosine in resource-limited settingsPaul J Weidle
Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pediatr Infect Dis J 25:59-64. 2006..Although weight and height can both be measured, it may be impractical to expect providers in resource-limited settings to estimate accurately body surface area... - Development of phenotypic and genotypic resistance to antiretroviral therapy in the UNAIDS HIV Drug Access Initiative--UgandaPaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention NCHSTP, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
AIDS 17:S39-48. 2003..We describe phenotypic drug resistance, response to therapy, and genotypic mutations among HIV-infected patients in Uganda taking antiretroviral medications for > or = 90 days who had a viral load > or = 1000 copies/ml... - HIV drug resistance and mother-to-child transmission of HIVPaul J Weidle
Epidemiology Branch, Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Clin Perinatol 37:825-42, x. 2010..The magnitude and implications of antiretroviral resistance among HIV-infected pregnant women and HIV-infected infants are summarized... - Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavirPaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 55:5168-71. 2011..Nelfinavir-based antiretroviral regimens given to mothers as prevention of mother-to-child HIV transmission (PMTCT) do not expose the breast-feeding infant to biologically significant concentrations of nelfinavir or M8... - Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistancePaul J Weidle
Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 360:34-40. 2002..We assessed the UNAIDS/Uganda Ministry of Health HIV Drug Access Initiative--one of the first pilot antiretroviral programmes in Africa--in which patients paid for their medications at negotiated reduced prices... - Changes in lipid profile over 24 months among adults on first-line highly active antiretroviral therapy in the home-based AIDS care program in rural UgandaKate Buchacz
Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Acquir Immune Defic Syndr 47:304-11. 2008..The effects of HAART on lipid metabolism among sub-Saharan Africans, for whom access to antiretroviral therapy is expanding, remain largely unknown... - Hematologic changes associated with Zidovudine following single-drug substitution from stavudine in a home-based AIDS care program in rural UgandaFatu Forna
Global AIDS Program, National Center for HIV, Hepatitis, STD, and TB Prevention NCHHSTP, CDC, Atlanta, Georgia, USA
J Int Assoc Physicians AIDS Care (Chic) 8:128-38. 2009..The authors evaluated hematologic changes associated with zidovudine (ZDV) following single-drug substitution from stavudine (D4T) in HIV-infected persons in Uganda... - Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural UgandaFatu Forna
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Acquir Immune Defic Syndr 44:456-62. 2007..We evaluated clinical toxicity in HIV-infected persons receiving antiretroviral therapy (ART) in Uganda... - Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan womenChristine N Dao
Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
AIDS Res Hum Retroviruses 27:1149-55. 2011..Assessment of serum sodium, chloride, and albumin can identify HIV-infected patients at highest risk for mortality who may benefit from more intensive medical management during the first year of ART... - Antiretroviral therapy improves renal function among HIV-infected UgandansPhilip J Peters
Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Kidney Int 74:925-9. 2008..Our study shows that renal dysfunction was common with advanced HIV disease in Uganda but this improved following 2 years of HAART... - Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: implications for resource-limited settingsFatu Forna
Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, CDC, Atlanta, GA 30333, USA
AIDS Rev 8:24-36. 2006.... - HIV antiretroviral drug resistance in AfricaJohn N Nkengasong
Division of HIV AIDS, STD, TB Laboratory Research, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
AIDS Rev 6:4-12. 2004.... - Nevirapine-Associated Hepatotoxicity and Rash among HIV-Infected Pregnant Women in KenyaPhilip J Peters
1Centers for Disease Control and Prevention, Atlanta, GA, USA
J Int Assoc Physicians AIDS Care (Chic) 11:142-9. 2012..Background: Few studies have evaluated the risk of nevirapine (NVP)-associated hepatotoxicity among HIV-infected pregnant women with a CD4 count ?250 cells/mm(3)... - HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysisClement Zeh
Division of HIV AIDS Prevention, US Centers for Disease Control and Prevention, Kisumu, Kenya
PLoS Med 8:e1000430. 2011..Here, we present findings from a KiBS trial secondary analysis that evaluated the emergence of maternal ARV-associated resistance among 32 HIV-infected breastfed infants... - Use of single-dose nevirapine for the prevention of mother-to-child transmission of HIV-1: does development of resistance matter?Michelle S McConnell
Thailand US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
Am J Obstet Gynecol 197:S56-63. 2007..Further research in the optimization of perinatal prevention regimens is needed... - Adverse Events in HIV-Infected Persons Receiving Antiretroviral Drug Regimens in a Large Urban Slum in Nairobi, Kenya, 2003-2005Andrea A Kim
Global AIDS Program, Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
J Int Assoc Physicians AIDS Care (Chic) 6:206-9. 2007..62, 0.42, and 0.21, respectively, and 0.99 at 6, 12, and 18 months. Conclusions: ART toxicities were frequent, but severe toxicities were less common. In resource-limited settings, ART toxicity should not represent a barrier to care... - Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe, CameroonJembia J Mosoko
Division of Global HIV AIDS, Centers for Disease Control and Prevention, Mutengene, Cameroon
J Int AIDS Soc 14:32. 2011.... - A program to provide antiretroviral therapy to residents of an urban slum in nairobi, kenyaBarbara J Marston
Global AIDS Program, Centers for Disease Control and Prevention CDC Kenya
J Int Assoc Physicians AIDS Care (Chic) 6:106-12. 2007..With government commitment, donor support, and community involvement, it is feasible to implement successful ART programs in extremely challenging social and environmental conditions... - The costs of HIV antiretroviral therapy adherence programs and impact on health care utilizationStephanie L Sansom
US Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS Patient Care STDS 22:131-8. 2008..IACM was associated with a significant decrease in hospital days compared to SOC and was cost saving when program costs were compared to savings in health care utilization... - HIV testing and HIV/AIDS treatment services in rural counties in 10 southern states: service provider perspectivesMadeline Sutton
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Rural Health 26:240-7. 2010..Data are limited regarding provider perspectives of the accessibility and availability of HIV testing and treatment services in southern rural counties... - Molecular analysis in support of an investigation of a cluster of HIV-1-infected womenKenneth E Robbins
Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS Res Hum Retroviruses 18:1157-61. 2002..In conclusion, phylogenetic analysis of HIV strains in an epidemiologic investigation is highly useful in support of cluster identification, even without sampling from the putative index patient... - How late is too late? Timeliness to scheduled visits as an antiretroviral therapy adherence measure in Nairobi, Kenya and Lusaka, ZambiaRachel J Blacher
Centers for Disease Control and Prevention, Atlanta, GA, USA
AIDS Care 22:1323-31. 2010..Timeliness to scheduled clinic visits can be used as an objective proxy for self-reported adherence and ultimately for risk of virologic failure... - Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapineBenjamin H Chi
Centre for Infectious Disease Research in Zambia, Zambia
AIDS 21:957-64. 2007.... - Nevirapine-induced Stevens-Johnson syndrome in a mother and sonCheryl A Liechty
AIDS 19:993-4. 2005 - Short-term safety and tolerability of didanosine combined with high- versus low-dose tenofovir disproxil fumarate in ambulatory HIV-1-infected personsBenjamin Young
Rose Medical Center, Denver, Colorado, USA
AIDS Patient Care STDS 20:238-44. 2006.... - A randomized trial of directly administered antiretroviral therapy and adherence case management interventionAmy Rock Wohl
HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
Clin Infect Dis 42:1619-27. 2006.... - Antiretroviral therapy in the private sector of Nairobi, Kenya: a review of the experience of five physiciansDoris K Macharia
AIDS 17:938-40. 2003 - Combination antiretroviral therapy in african nursing mothers and drug exposure in their infants: new pharmacokinetic and virologic findingsMarc Bulterys
J Infect Dis 192:709-12. 2005 - The feasibility of a community-based directly administered antiretroviral therapy programAmy Rock Wohl
HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
Clin Infect Dis 38:S388-92. 2004..Effective communication between the DAART staff, the medical providers, and the pharmacy is essential for the successful implementation of this program... - Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groupsGregory M Lucas
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Clin Infect Dis 42:1628-35. 2006..Directly administered antiretroviral therapy (DAART) in methadone clinics has the potential to improve treatment outcomes for human immunodeficiency virus (HIV)-infected injection drug users (IDUs)... - Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative studyGregory M Lucas
Johns Hopkins University, Baltimore, MD 21287, USA
Clin Infect Dis 38:S409-13. 2004..008). The preliminary results of this study both suggest that DAART can be feasible and acceptable to patients in a methadone clinic setting and provide impetus for further study of this treatment strategy in randomized controlled trials... - Increased body mass index does not alter response to initial highly active antiretroviral therapy in HIV-1-infected patientsEllen M Tedaldi
Temple University School of Medicine, Philadelphia, PA 19140, USA
J Acquir Immune Defic Syndr 43:35-41. 2006.... - Adherence, drug use, and treatment failure in a methadone-clinic-based program of directly administered antiretroviral therapyGregory M Lucas
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS Patient Care STDS 21:564-74. 2007..Given that a relatively small proportion of the total ART doses were supervised in many patients, future studies should assess how DAART affects adherence with nonsupervised doses and retention to ART... - Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in rural UgandaCheryl A Liechty
Centers for Disease Control and Prevention CDC Uganda, Entebbe, Uganda
Trop Med Int Health 12:929-35. 2007..Cryptococcal meningitis is a leading cause of HIV-related mortality in Africa, but current guidelines do not advocate CRAG testing as a screening tool... - Long-term experience providing antiretroviral drugs in a fee-for-service HIV clinic in Uganda: evidence of extended virologic and CD4+ cell count responsesCharles Kabugo
St. Francis Hospital, Nsambya, Kampala, Uganda
J Acquir Immune Defic Syndr 38:578-83. 2005..Strategies to reduce the financial burden and other barriers to uninterrupted care as well as incentives to increase such practice models should be further explored in the African context... - Risk behavior for transmission of human immunodeficiency virus (HIV) among HIV-seropositive individuals in an urban settingJoseph P McGowan
Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA
Clin Infect Dis 38:122-7. 2004..2-7.0) and use of highly active antiretroviral therapy (AOR, 1.8; 95% CI, 1.1-3.1). Ongoing risk-reduction counseling and substance abuse treatment for HIV-infected persons are needed to reduce behaviors associated with HIV transmission...