Research Topics
Genomes and GenesSpecies | S D VernonSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
A method for improving SELDI-TOF mass spectrometry data qualityToni Whistler
Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd, G41, Atlanta, Georgia, 30329, USA
Proteome Sci 5:14. 2007..However, the events that occur between the first and last sample run are likely to introduce technical variation in the results...- Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndromeAngela P Presson
Biostatistics, University of California, Los Angeles, CA, USA
BMC Syst Biol 2:95. 2008..Here we show that the additional inclusion of genetic marker data allows one to characterize network relationships as causal or reactive in a chronic fatigue syndrome (CFS) data set... - Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjectsToni Whistler
Viral Exanthems and Herpesvirus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
BMC Physiol 5:5. 2005..To search for markers of CFS-associated post-exertional fatigue, we measured peripheral blood gene expression profiles of women with CFS and matched controls before and after exercise challenge... - Chronic fatigue syndrome--a clinically empirical approach to its definition and studyWilliam C Reeves
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Med 3:19. 2005..The lack of standardized criteria for defining chronic fatigue syndrome (CFS) has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria... - Comparison of human papillomavirus detection and typing by cycle sequencing, line blotting, and hybrid captureS D Vernon
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 38:651-5. 2000.... - The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndromeSuzanne D Vernon
Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA, USA
Pharmacogenomics 7:345-54. 2006.... - Validation of array-based gene expression profiles by real-time (kinetic) RT-PCRM S Rajeevan
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
J Mol Diagn 3:26-31. 2001..Real-time RT-PCR based on LightCycler technology is well-suited to validate DNA array results because it is quantitative, rapid, and requires 1000-fold less RNA than conventional assays... - Detection of human papillomavirus in archival tissues. Comparison of in situ hybridization and polymerase chain reactionE R Unger
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
J Histochem Cytochem 46:535-40. 1998..This degree of concordance required individual optimization of assay conditions for each block. ISH and PCR assays for HPV yield complementary results, and both can be successfully applied to archival tissues... - Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologiesM S Rajeevan
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Ceners for Disease Control and Prevention, US Department of Health and Public Services, Atlanta, Georgia 30333, USA
Methods 25:443-51. 2001.... - Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndromeM S Rajeevan
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Genes Brain Behav 6:167-76. 2007.... - Bioelectronic DNA detection of human papillomaviruses using eSensor: a model system for detection of multiple pathogensSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
BMC Infect Dis 3:12. 2003..We used human papillomaviruses (HPV) as a model system to evaluate the utility of a nucleic acid, hybridization-based bioelectronic DNA detection platform (eSensor) in identifying multiple pathogens... - Analysis of 16S rRNA gene sequences and circulating cell-free DNA from plasma of chronic fatigue syndrome and non-fatigued subjectsSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
BMC Microbiol 2:39. 2002..Plasma DNA from 34 CFS and 55 non-fatigued subjects was assessed to determine plasma DNA concentration and the presence of bacterial 16S ribosomal DNA (rDNA) sequences... - Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosisSuzanne D Vernon
Viral Exanthems and Herpesvirus Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MSA15, Atlanta, GA 30333, USA
Brain Res 1068:1-6. 2006..Thus, investigation of the PNI response in peripheral blood may provide novel insights into the complex pathophysiology of centrally mediated disease states... - Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virusSuzanne D Vernon
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
BMC Infect Dis 6:15. 2006..The objective of this pilot study was to determine the gene expression correlates of post-infective fatigue following acute Epstein Barr virus (EBV) infection... - Challenges for molecular profiling of chronic fatigue syndromeSuzanne D Vernon
Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, National Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pharmacogenomics 7:211-8. 2006..Successful molecular profiling of CFS will require the integration of genetic, genomic and proteomic data with environmental and behavioral data to define the heterogeneity in order to optimize intervention... - Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort studyIan Hickie
Brain and Mind Research Institute, Sydney University, Sydney, NSW 2050, Australia
BMJ 333:575. 2006..Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome... - Evaluation of RNA markers for early detection of cervical neoplasia in exfoliated cervical cellsMartin Steinau
Division of Viral and Rickettsial Disease, Viral Exanthems and Herpesvirus Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 41, Atlanta, GA 30333, USA
Cancer Epidemiol Biomarkers Prev 16:295-301. 2007.... - Comparison of target labeling methods for use with Affymetrix GeneChipsWilliam Lonergan
Chronic Viral Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
BMC Biotechnol 7:24. 2007.... - Genetic evaluation of the serotonergic system in chronic fatigue syndromeAlicia K Smith
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
Psychoneuroendocrinology 33:188-97. 2008..These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS... - Microarray technology for use in molecular epidemiologySuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Centers for Infectious Diseases, Center for Disease Control and Prevention, Atlanta, GA, USA
Methods Mol Biol 382:97-113. 2007..This reproducible and reliable approach for using microarrays should be applicable to any biological questions asked... - Gene expression profiling of dysplastic differentiation in cervical epithelial cells harboring human papillomavirus 16Daya G Ranamukhaarachchi
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service/US DHHS, Atlanta, GA 30333, USA
Genomics 85:727-38. 2005..Some of the genes with altered expression identified in this model of dysplastic differentiation may be useful biomarkers for early detection of cervical neoplasia and other HPV-associated oropharyngeal and anogenital cancers... - Gene expression profile of cervical tissue compared to exfoliated cells: impact on biomarker discoveryMartin Steinau
Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Genomics 6:64. 2005..However, because of keratinization and terminal differentiation it is not clear that these cells have an mRNA profile representative of cervical tissue, and that the profile can distinguish the lesions targeted for early detection... - Global amplification of sense RNA: a novel method to replicate and archive mRNA for gene expression analysisMangalathu S Rajeevan
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA
Genomics 82:491-7. 2003..00001-0.1%). This reflects the high fidelity of sRNA synthesis for mRNA as low as 0.3 copies/cell. sRNA is amplified synthetic mRNA in the 5'-->3' direction; the appropriate template for any gene expression analysis... - Impact of RNA extraction from limited samples on microarray resultsHanna Ojaniemi
Karolinska Institutet at Huddinge University Hospital, Royal Institute of Technology, Stockholm, Sweden
Biotechniques 35:968-73. 2003..These experiments illustrate that microarray technology holds great promise for the use of limited clinical samples in the diagnostic setting... - Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolutionWilliam C Reeves
Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
BMC Health Serv Res 3:25. 2003..Difficulties with accurate case ascertainment contribute to this ignorance... - Molecular quality of exfoliated cervical cells: implications for molecular epidemiology and biomarker discoveryAngelique H Habis
Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA
Cancer Epidemiol Biomarkers Prev 13:492-6. 2004..However, with a sensitive gold particle-based detection method, reproducible microarray results were obtained using this RNA... - Epidemiologic and viral factors associated with cervical neoplasia in HPV-16-positive womenMangalathu S Rajeevan
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Int J Cancer 115:114-20. 2005..Cellular proliferation and differentiation pathways affected by HPV should be investigated as biomarkers for cervical cancer screening... - Molecular markers for early detection of cervical neoplasiaElizabeth R Unger
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA
Dis Markers 20:103-16. 2004 - Exploration of neuroendocrine and immune gene expression in peripheral blood mononuclear cellsAinsley C Nicholson
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Brain Res Mol Brain Res 129:193-7. 2004.... - Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndromeMartin Steinau
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MSG-41, Atlanta, GA 30333, USA
J Mol Med 82:750-5. 2004..The real-time reverse-transcription PCR assays that we developed for assay of these biomarkers will facilitate high-throughput testing of these additional samples... - Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndromeSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Dis Markers 18:193-9. 2002..These results successfully demonstrate the utility of the blood for gene expression profiling to distinguish subjects with CFS from healthy controls and for identifying genes that could serve as CFS biomarkers... - Molecular characterization of human papillomaviruses by PCR and in situ hybridizationSuzanne D Vernon
Centers of Disease Control and Prevention, Atlanta, GA, USA
Methods Mol Med 97:159-80. 2004 - Modifying differential display polymerase chain reaction to detect relative changes in gene expression profilesDaya G Ranamukhaarachchi
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA
Anal Biochem 306:343-6. 2002 - Two optimized combination assays to examine apoptosis pathways in clinical samplesMark Hollier
Chronic Viral Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
Cytometry A 71:675-85. 2007..This hinders studies on clinical samples that have limited cell numbers. Our objective was to combine and optimize assays that target specific stages of apoptosis for use in a typical clinical blood sample... - Assessment of normal variability in peripheral blood gene expressionCatherine Campbell
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Dis Markers 18:201-6. 2002..These results suggest that observed variation was due to experimental variability... - Absence of Mycoplasma species DNA in chronic fatigue syndromeSuzanne D Vernon
J Med Microbiol 52:1027-8. 2003 - Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistabilityShakti Gupta
Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Theor Biol Med Model 4:8. 2007..The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related diseases...