James M Smith

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi Hospital management of mass radiological casualties: reassessing exposures from contaminated victims of an exploded radiological dispersal device
    James M Smith
    Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, MS E 39, 1600 Clifton Road N E, Atlanta, GA 30333, USA
    Health Phys 89:513-20. 2005
  2. ncbi Generation of a dual RT Env SHIV that is infectious in rhesus macaques
    James M Smith
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Med Primatol 39:213-23. 2010
  3. ncbi Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine
    Rama Rao Amara
    Vaccine Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 76:6138-46. 2002
  4. ncbi Repeated rectal SHIVSF162P3 exposures do not consistently induce sustained T cell responses prior to systemic infection in the repeat-low dose preclinical macaque model
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 25:905-17. 2009
  5. ncbi Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    Rama Rao Amara
    Vaccine Research Center, Yerkes Regional Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Vaccine 20:1949-55. 2002
  6. ncbi Multiprotein HIV type 1 clade B DNA/MVA vaccine: construction, safety, and immunogenicity in Macaques
    James M Smith
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    AIDS Res Hum Retroviruses 20:654-65. 2004
  7. ncbi Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challenges
    Yuyang Tang
    Vaccine Research Center, Yerkes National Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    J Virol 76:10147-54. 2002
  8. ncbi DNA/MVA vaccine for HIV type 1: effects of codon-optimization and the expression of aggregates or virus-like particles on the immunogenicity of the DNA prime
    James M Smith
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    AIDS Res Hum Retroviruses 20:1335-47. 2004
  9. ncbi Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primates
    Nattawan Promadej-Lanier
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, TB Prevention, CCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Primatol 38:263-71. 2009
  10. ncbi Studies on the cross-clade and cross-species conservation of HIV-1 Gag-specific CD8 and CD4 T cell responses elicited by a clade B DNA/MVA vaccine in macaques
    Rama Rao Amara
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 334:124-33. 2005

Collaborators

Detail Information

Publications10

  1. ncbi Hospital management of mass radiological casualties: reassessing exposures from contaminated victims of an exploded radiological dispersal device
    James M Smith
    Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, MS E 39, 1600 Clifton Road N E, Atlanta, GA 30333, USA
    Health Phys 89:513-20. 2005
    ..It is demonstrated that exceptional but plausible cases may require special precautions by the healthcare provider, even while managing life-threatening injuries of a contaminated victim from a radiological dispersal device event...
  2. ncbi Generation of a dual RT Env SHIV that is infectious in rhesus macaques
    James M Smith
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Med Primatol 39:213-23. 2010
    ..We describe construction of a dual SHIV containing both HIV RT and a CCR5-specific HIV envelope gene in a simian immunodeficiency virus backbone...
  3. ncbi Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine
    Rama Rao Amara
    Vaccine Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 76:6138-46. 2002
    ..Our results highlight the importance of immune responses to Env, as well as to Gag-Pol, in the control of immunodeficiency virus challenges and the protection of CD4(+) cells...
  4. ncbi Repeated rectal SHIVSF162P3 exposures do not consistently induce sustained T cell responses prior to systemic infection in the repeat-low dose preclinical macaque model
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 25:905-17. 2009
    ..Our results provide further insights into the repeat exposure macaque model. We find that this model can be used for testing biomedical prevention strategies without concern of eliciting a systemic vaccination effect...
  5. ncbi Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    Rama Rao Amara
    Vaccine Research Center, Yerkes Regional Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Vaccine 20:1949-55. 2002
    ..These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic...
  6. ncbi Multiprotein HIV type 1 clade B DNA/MVA vaccine: construction, safety, and immunogenicity in Macaques
    James M Smith
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    AIDS Res Hum Retroviruses 20:654-65. 2004
    ....
  7. ncbi Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challenges
    Yuyang Tang
    Vaccine Research Center, Yerkes National Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    J Virol 76:10147-54. 2002
    ..Thus, to date, control of the challenge infection has appeared to improve with time, with the decay rates for viral DNA being at the lower end of values reported for patients on highly active antiretroviral therapy...
  8. ncbi DNA/MVA vaccine for HIV type 1: effects of codon-optimization and the expression of aggregates or virus-like particles on the immunogenicity of the DNA prime
    James M Smith
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    AIDS Res Hum Retroviruses 20:1335-47. 2004
    ..Based on the breadth of the T cell response and a trend toward higher titers of anti-Env Ab, we are moving forward with human trials of the noncodon-optimized VLP-expressing DNA...
  9. ncbi Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primates
    Nattawan Promadej-Lanier
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, TB Prevention, CCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Primatol 38:263-71. 2009
    ..There is considerable interest in developing coitally independent, sustained release formulations for long-term administration of HIV microbicides. Vaginal ring devices are at the forefront of this formulation strategy...
  10. ncbi Studies on the cross-clade and cross-species conservation of HIV-1 Gag-specific CD8 and CD4 T cell responses elicited by a clade B DNA/MVA vaccine in macaques
    Rama Rao Amara
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 334:124-33. 2005
    ..Our results demonstrate that the clade B DNA/MVA HIV vaccine elicits T cell responses against epitopes that are conserved in multiple clades and recognized by humans and macaques...