N Gleicher

..To describe a case of dramatically improved ovarian reserve in a 42.7-year-old woman who was using the dietary supplement dehydroepiandrosterone (DHEA) as well as acupuncture...

..A better understanding of etiology and pathophysiology would greatly advance the, currently still inaccurate, diagnosis of the condition, and improve approaches towards prevention and treatment...

..LI-IVF should, therefore, as of this point not be offered as routine IVF treatment but only as an experimental procedure...

..Further investigations must not ignore patient stratification, based on ovarian FMR1 genotypes. Genetic definition of high-risk patients should lead to development of successful therapeutic interventions...

..Known associated with low FOR at young age, het-norm/high, thus, appears to preserve FOR into older age, and both het sub-genotypes appear to expand female reproductive lifespan into opposite directions...

..Both, however, reflect distinctively different stages of folliculogenesis...

..However, AMH declines with age and age-specific cut-offs remain to be established in women with proven fertility. This study aims to determine age-specific ranges of AMH in women with proven fertility...

..In an attempt to understand better how fetal gender may affect gestational length in twin gestations after in vitro fertilization, same-sex twins and opposite twins were compared for pregnancy duration...

..Whether characteristics of ART cycles, resulting in twin gestations, can predict prematurity risks was the subject of this study...

..Since CGG counts on FMR1 are associated with ovarian reserve, these findings may reflect potential differences between races/ethnicities in ovarian function and female fertility reported in the literature...

..This function of potential evolutionary importance may explain the preservation of the FMR1 gene despite its, at times, severe neuropsychiatric risks...

..The association of premature (and possibly also term) labor with autoimmune function may, therefore, be the consequence of abnormalities in normal fetal-placental tolerance, leading to uterine activation and labor...

..001). Approximately 29-30 CGG repeats appear reflective of normal ovarian reserve, with higher and lower counts denoting similar risks towards premature ovarian senescence...

..To determine to what degree the number of triple Cytosine/Guanine/Guanine (CGG) repeats on the FMR1 (fragile X) gene correlate with specific ovarian reserve parameters, and potentially facilitate infertility diagnosis...

..To what degree milder forms of premature ovarian aging are also associated with these two etiologies is, however, unknown...

..03). This supports FMR1 testing as useful in fertility practice and suggests why response rates to increasing stimulation with gonadotropins may vary...

..Treatment of PPCM with therapies, proven successful in graft versus host disease and organ rejection, may, therefore, be successful. Their success would also be confirmatory of such a concept...

..To determine whether the worldwide consensus that twin pregnancy after fertility treatment represents an adverse outcome to be avoided is correct...

..To assess whether abnormal autoimmune function and number of triple CGG repeats on the FMR1 (fragile X) gene, both historically associated with risk toward premature ovarian senescence, represent independent risk factors...

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..Because specific PGS indications have remained undefined, PGS should be considered an experimental procedure...

..This study determined the clinical significance of their concordance and discordance in female infertility patients...

..04 ng/mL but significantly increased at AMH 0.41-1.05 ng/mL, resulting in similarly low live-birth rates at all AMH levels ?1.05 ng/mL and significantly improved live-birth rates at AMH ?1.06 ng/mL...

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..Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature...

..In the absence of properly controlled studies, all forms of LI-IVF should be considered experimental and be offered only in well-controlled research settings and with appropriate informed consent...

..Tolerance abnormalities often involve skin reactions. Abnormalities in tolerance of the fetal graft may do the same...

..5-times the odds of being associated with autoimmune positivity (OR 2.5, 1.34-4.55; P?=?0.004). FMR1 genotypes offer a possible explanation for differences in IVF outcomes between races/ethnicities...

..Data generated in DHEA-supplemented women, indeed, suggest a new ovarian aging concept, based on aging of ovarian environments and not, as currently is believed, aging oocytes...

..Current clinical dogma in rheumatology as well as obstetrics/gynecology holds that evidence of aneuploidy in products of conception establishes the cause of miscarriage and rules out other potential causes, including autoimmunity...

..3) for autoimmunity, ovarian function and, likely, pregnancy chance with IVF...

..Such an effect is mathematically inconceivable without beneficial effects on embryo ploidy. This study, therefore, assesses effects of DHEA on embryo aneuploidy...

..Heterozygous and homozygous genotypes recruit fewer follicles at younger ages, thus preserving OR into advanced age. These observations suggest a direct FMR1 effect on follicular recruitment and OR and, therefore, on women's fecundity...

..This communication argues that overvaluation of RCT and undervaluation of other study formats in establishing best available evidence hurts progress in reproductive medicine and in medicine in general...

..001). DHEA supplementation, thus, significantly improved ovarian reserve in parallel with longer DHEA use and was more pronounced in younger women...

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..We investigated if the prevalence of POA differs between these two ethnic populations...

..According to US guidelines, e-SET, therefore, appears to represent an appropriate transfer option for only a small minority of IVF patients. Argument in favour of indiscriminate SET appears unrealistic and should be reconsidered...

..In view of increased exposure to cell traffic, women, of course, would be expected to pay a higher price, reflected in more autoimmunity...

..To determine whether pregnancy outcome can be positively affected if the ovarian stimulation in women with diminished ovarian reserve (DOR) is changed...

..This risk appears to correlate with mode of delivery and may be the consequence of varying cell traffic dynamics with vaginal and cesarean section deliveries...

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..In follow-up to an earlier study of in vitro fertilization (IVF) outcomes in Europe and the U.S. for the year 2001, the present study reports on 2002 outcomes in an attempt to determine diverging practice trends...

..The better pregnancy and live birth outcomes in the US are not explainable by the transfer of larger embryo numbers alone...

..Recognizing PE-E as a clinical condition that is characterized by autoimmune abnormalities may facilitate earlier and more specific diagnosis, along with preventive and more specific therapies for women at risk...

..Better efforts to reach infertility diagnoses more accurately should improve the diagnostic accuracy of hitherto frequently missed diagnoses, which often falsely have led to a diagnosis of UI...

..To assess whether inadequate, thin endometrium (<7 mm), after failure to expand with standard treatment options, will be responsive to cytokine treatment...

..This study intended to investigate this notion for accuracy...

..It is unknown whether etiologies differ between milder forms of premature ovarian senescence (the acronym given here 'premature ovarian aging, POA'), and premature ovarian failure (POF)...

..To compare how a given level of antimüllerian hormone (AMH) might be used to predict the level of FSH...

..To determine whether women with polycystic ovary syndrome (PCOS) are at increased risk for embryonic aneuploidy...

..Instead, a definition of acceptable minimal pregnancy and life birth rates could be used to define the limits of offered access to IVF, independent of age and/or baseline FSH levels...

..Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage rates...

..The aim of this study was to investigate the effect of treatment with dehydroepiandrosterone (DHEA) on fertility outcomes among women with diminished ovarian reserve...

..The objective of this study was to characterize the continuum of ovarian function based on age-specific categories of baseline FSH...

..We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function...

..In 76 IVF cycles investigated, AMH was clearly superior in predicting IVF outcomes in comparison with FSH...

..Whether women with PDOF demonstrate an increased level of aneuploidy in their embryos, based on increasing aneuploidy rates with advancing female age, is unknown, and was the subject of this study...

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..To compare the performance of a new coaxial catheter system with an echo-dense tip (Cook Echo-Tip catheter) with a Wallace catheter during ultrasound-guided ET...

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..They, however, allow for an improved selectivity of stimulation protocols. The creation of recombinant FSH/LH products and cost adjustments for recombinant products, may affect these conclusions in favour of recombinant products...

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..To determine whether human embryos accept blastomere transplants and integrate them normally into the architecture of the developing embryo...

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..The aim of this study was to evaluate the effect of ovarian stimulation with LH-containing gonadotropins (human menopausal gonadotropin, hMG), on ploidy of human cleavage-stage-embryos...

..This opinion piece is an attempt to reconcile difference of opinion by integrating clinical data from the human experience with well-established experimental models in animals...

..These findings support the assumption that aetiologies other than autoimmune disease lead to POA...

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