Run Yu

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi Cardiac abnormalities associated with pheochromocytoma and other adrenal tumors
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:10-6. 2009
  2. ncbi Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Cente, Los Angeles, CA 90048, USA
    Pancreas 36:428-31. 2008
  3. ncbi Diagnosis and treatment of pheochromocytoma in an academic hospital from 1997 to 2007
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90084, USA
    Am J Med 122:85-95. 2009
  4. ncbi Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells
    Run Yu
    UCLA School of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room D3066, Los Angeles, California 90048, USA
    J Endocrinol 191:45-53. 2006
  5. ncbi Pheochromocytoma in patients suspected of harboring adrenal metastasis: management and clinical predictors
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Endocr Pract 14:967-72. 2008
  6. ncbi Ordering pattern and performance of biochemical tests for diagnosing pheochromocytoma between 2000 and 2008
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:313-21. 2009
  7. ncbi False positive test results for pheochromocytoma from 2000 to 2008
    R Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Exp Clin Endocrinol Diabetes 118:577-85. 2010
  8. ncbi Diagnosis and management of pheochromocytoma in an academic hospital 3 years after formation of a pheochromocytoma interest group
    Run Yu
    Cedars Sinai Medical Center, Los Angeles, CA, USA
    Endocr Pract 17:356-62. 2011
  9. ncbi A natural inactivating mutant of human glucagon receptor exhibits multiple abnormalities in processing and signaling
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocrinol Nutr 58:258-66. 2011
  10. ncbi Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 6:e23397. 2011

Research Grants

  1. SECURIN REGULATION OF PANCREATIC beta CELL MASS
    Run Yu; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. ncbi Cardiac abnormalities associated with pheochromocytoma and other adrenal tumors
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:10-6. 2009
    ..To study the specific cardiac abnormalities associated with pheochromocytoma and to suggest a strategy for evaluating cardiac function in patients with pheochromocytoma...
  2. ncbi Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Cente, Los Angeles, CA 90048, USA
    Pancreas 36:428-31. 2008
    ..Nesidioblastosis and hyperplasia of alpha cells should be considered in the differential diagnosis of hyperglucagonemia. Somatostatin analog may be used to suppress glucagon secretion in alpha-cell hyperplasia...
  3. ncbi Diagnosis and treatment of pheochromocytoma in an academic hospital from 1997 to 2007
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90084, USA
    Am J Med 122:85-95. 2009
    ..We aimed to systemically study the diagnostic accuracy and treatment outcomes of pheochromocytoma and to reveal the causes and consequences of misdiagnosis (including both overdiagnosis and underdiagnosis)...
  4. ncbi Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells
    Run Yu
    UCLA School of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room D3066, Los Angeles, California 90048, USA
    J Endocrinol 191:45-53. 2006
    ....
  5. ncbi Pheochromocytoma in patients suspected of harboring adrenal metastasis: management and clinical predictors
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Endocr Pract 14:967-72. 2008
    ..To study clinical management of patients with suspected adrenal metastasis and to assess whether there are clinical predictors of pheochromocytoma in this patient population...
  6. ncbi Ordering pattern and performance of biochemical tests for diagnosing pheochromocytoma between 2000 and 2008
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:313-21. 2009
    ..To examine what tests are ordered by physicians for pheochromocytoma diagnosis and how those tests perform in modern clinical practice...
  7. ncbi False positive test results for pheochromocytoma from 2000 to 2008
    R Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Exp Clin Endocrinol Diabetes 118:577-85. 2010
    ..Pretest risk, physiological variations of catecholamine levels, laboratory errors, and drug interference should be considered in interpreting abnormal test results...
  8. ncbi Diagnosis and management of pheochromocytoma in an academic hospital 3 years after formation of a pheochromocytoma interest group
    Run Yu
    Cedars Sinai Medical Center, Los Angeles, CA, USA
    Endocr Pract 17:356-62. 2011
    ..To examine whether establishment of a pheochromocytoma interest group improves diagnosis and management of pheochromocytoma in an academic hospital...
  9. ncbi A natural inactivating mutant of human glucagon receptor exhibits multiple abnormalities in processing and signaling
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocrinol Nutr 58:258-66. 2011
    ..To elucidate the pathogenetic mechanisms of a mutant P86S glucagon receptor (GCGR) in causing a novel human disease (Mahvash disease)...
  10. ncbi Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 6:e23397. 2011
    ..Our results further suggest that completely inhibiting glucagon signaling may not be a safe approach to treat diabetes...
  11. ncbi Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor
    Cuiqi Zhou
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 38:941-6. 2009
    ..The goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic alpha cell hyperplasia without glucagonoma syndrome...
  12. ncbi Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
    Vera Chesnokova
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Cancer Res 67:10564-72. 2007
    ....
  13. ncbi Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion
    Hongxiang Hui
    Division of Diabetes, Endocrinology, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Endocrinology 143:3529-39. 2002
    ..The present study lays the research foundation to investigate the potential use of GLP-1 for the gene or cell therapy of diabetes...
  14. ncbi Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence
    Vera Chesnokova
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90048, USA
    Endocrinology 150:2603-10. 2009
    ..Our results also suggest that ductal progenitor beta-cells are exhausted by excessive neogenesis induced by apoptosis in PTTG(-/-) mice...
  15. ncbi A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration
    Kozo Akino
    Department of Medicine, Cedars-Sinai Research Institute UCLA School of Medicine, Los Angeles, California, USA
    J Surg Res 129:142-6. 2005
    ....
  16. ncbi Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes
    Zhiyong Wang
    Department of Medicine, Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 100:3428-32. 2003
    ..PTTG-/- beta cells had pleiotropic nuclei, suggesting defects in cell division. The results indicated that securin is indispensable for normal pancreatic beta cell proliferation...
  17. ncbi Pituitary tumor transforming gene: an update
    Run Yu
    Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Front Horm Res 32:175-85. 2004
    ....
  18. ncbi Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 6:360-3. 2008
    ..The nonapproved use of human growth hormone (HGH) for anti-aging has been increasing. Theoretical concerns for neoplastic potentiation by HGH have been raised, but not proven clinically...
  19. ncbi Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas
    Run Yu
    Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 91:5126-9. 2006
    ....
  20. ncbi Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1
    Anna Milanesi
    Division of Endocrinology, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 40:634-7. 2011
    ..Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications...
  21. ncbi Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
    Run Yu
    Cedars Sinai Research Institute, Universityof California Los Angeles School of Medicine, 90048, USA
    Endocrinology 144:4991-8. 2003
    ..These results demonstrate that PTTG induces aneuploidy in single, live, human cancer cells...
  22. ncbi Pathogenesis of pituitary tumors
    Run Yu
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Prog Brain Res 182:207-27. 2010
    ....
  23. ncbi Clinical use and utility of metaiodobenzylguanidine scintigraphy in pheochromocytoma diagnosis
    Irina Lev
    Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocr Pract 16:398-407. 2010
    ..To examine the indications for metaiodobenzylguanidine (MIBG) scintigraphy and to assess its performance in localizing pheochromocytoma in the post-computed tomography and magnetic resonance imaging era...
  24. ncbi Pancreatic neuroendocrine tumors: presentation, management, and outcomes
    Nicholas N Nissen
    Department of Surgery, Center for Liver Diseases and Transplantation, Cedars Sinai Medical Center, 8635 W 3rd Street, Suite 590W, Los Angeles, CA 90048, USA
    Am Surg 75:1025-9. 2009
    ..Pancreatic resection results in greater than 80 per cent 3-year survival in nonmetastatic pNET. In patients presenting with metastatic pNET, excellent survival rates are also achievable using a multidisciplinary multimodal approach...
  25. ncbi Metabolic and receptor imaging in patients with neuroendocrine tumors: comparison of fludeoxyglucose-positron emission tomography and computed tomography with indium in 111 pentetreotide
    Martina L Zalom
    Department of Internal Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocr Pract 15:521-7. 2009
    ..To determine whether positron emission tomography/computed tomography (PET/CT) and indium In 111 pentetreotide, individually or collectively, predict the outcome of patients with neuroendocrine tumors (NETs)...
  26. ncbi Ki-67 proliferative index predicts progression-free survival of patients with well-differentiated ileal neuroendocrine tumors
    Deepti Dhall
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 43:489-95. 2012
    ..In conclusion, the Ki-67 index predicts PFS of patients with ileal wNETs...
  27. ncbi Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism
    Run Yu
    Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Endocrine 29:119-20. 2006
  28. ncbi Small pheochromocytomas: significance, diagnosis, and outcome
    Run Yu
    From the Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 1 and the Cedars Sinai Medical Care Foundation, Beverly Hills, CA2
    J Clin Hypertens (Greenwich) 14:307-15. 2012
    ..Small pheochromocytomas should be removed to prevent hypertensive crisis and future complications of pheochromocytoma...
  29. ncbi Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion
    Song-Guang Ren
    Cedars-Sinai Research Institute, University of California, Los Angeles, School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 88:4239-45. 2003
    ....
  30. ncbi Pathologic pancreatic endocrine cell hyperplasia
    Debra Ouyang
    Debra Ouyang, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States
    World J Gastroenterol 17:137-43. 2011
    ..Further studies of pathologic pancreatic endocrine cell hyperplasia will likely yield insights into the pathogenesis and treatment of diabetes and pancreatic neuroendocrine tumors...
  31. ncbi The cell adhesion molecules N-cadherin and neural cell adhesion molecule regulate human growth hormone: a novel mechanism for regulating pituitary hormone secretion
    Tami Rubinek
    Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
    J Clin Endocrinol Metab 88:3724-30. 2003
    ..05). This study indicates that pituitary cell-cell contact mediated by homophilic interactions between adhesion molecules regulates human GH secretion...

Research Grants2

  1. SECURIN REGULATION OF PANCREATIC beta CELL MASS
    Run Yu; Fiscal Year: 2007
    ..John Adams and Basil Rapoport). Building on my extensive basic and clinical training, I expect to become an independent endocrine researcher upon completion of this K08 grant . ..