R Azziz

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160 W, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4650-8. 2005
  2. ncbi How prevalent is metabolic syndrome in women with polycystic ovary syndrome?
    Ricardo Azziz
    Center for Androgen-Related Disorders, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
    Nat Clin Pract Endocrinol Metab 2:132-3. 2006
  3. ncbi The prevalence and features of the polycystic ovary syndrome in an unselected population
    Ricardo Azziz
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233, USA
    J Clin Endocrinol Metab 89:2745-9. 2004
  4. ncbi We should avoid the indiscriminate use of insulin sensitizers in women with polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, California, Los Angeles 92248, USA
    Fertil Steril 80:264-5. 2003
  5. ncbi PCOS: a diagnostic challenge
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Centre and David Geffen School of Medicine at UCLA, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    Reprod Biomed Online 8:644-8. 2004
  6. ncbi Androgen excess is the key element in polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90048, USA
    Fertil Steril 80:252-4. 2003
  7. ncbi Androgen excess in women: experience with over 1000 consecutive patients
    R Azziz
    Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Clin Endocrinol Metab 89:453-62. 2004
  8. ncbi Diagnostic criteria for polycystic ovary syndrome: a reappraisal
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 83:1343-6. 2005
  9. ncbi Role of reproductive surgeons and the Society of Reproductive Surgeons
    Ricardo Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 78:916-7. 2002
  10. ncbi Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature
    Ricardo Azziz
    Department of Obstetrics and Gynecology and Center for Androgen Related Disorders, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 91:781-5. 2006

Research Grants

  1. Adrenal Androgen Excess in PCOS: Role of Genetics
    Ricardo Azziz; Fiscal Year: 2009
  2. ADRENAL ANDROGEN EXCESS IN THE POLYCYSTIC OVARY SYNDROME
    Ricardo Azziz; Fiscal Year: 2002
  3. Adrenal Androgen Excess in PCOS: Role of Genetics
    Ricardo Azziz; Fiscal Year: 2007
  4. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2007
  5. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2009
  6. Annual Meeting of the Androgen Excess Society
    Ricardo Azziz; Fiscal Year: 2007
  7. ANDROGEN EXCESS DISORDER
    Ricardo Azziz; Fiscal Year: 2004
  8. Molecular Defects of Insulin Signaling in PCOS
    Ricardo Azziz; Fiscal Year: 2004
  9. ADRENAL ANDROGEN EXCESS IN THE POLYCYSTIC OVARY SYNDROME
    Ricardo Azziz; Fiscal Year: 2002
  10. ADRENAL ANDROGEN EXCESS--HYPERANDROGENIC OLIGO-OVULATION
    Ricardo Azziz; Fiscal Year: 1993

Collaborators

Detail Information

Publications87

  1. ncbi Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160 W, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4650-8. 2005
    ..6% of unselected reproductive-aged women (approximately 4 million women in the United States) (1990 National Institutes of Health criteria), and potentially represents a significant financial burden to our health care...
  2. ncbi How prevalent is metabolic syndrome in women with polycystic ovary syndrome?
    Ricardo Azziz
    Center for Androgen-Related Disorders, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
    Nat Clin Pract Endocrinol Metab 2:132-3. 2006
  3. ncbi The prevalence and features of the polycystic ovary syndrome in an unselected population
    Ricardo Azziz
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233, USA
    J Clin Endocrinol Metab 89:2745-9. 2004
    ..0 and 4.8%, respectively, not significantly different. These data from a large representative unselected population support the concept that PCOS is the most common endocrine abnormality of reproductive-aged women in the United States...
  4. ncbi We should avoid the indiscriminate use of insulin sensitizers in women with polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, California, Los Angeles 92248, USA
    Fertil Steril 80:264-5. 2003
  5. ncbi PCOS: a diagnostic challenge
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Centre and David Geffen School of Medicine at UCLA, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    Reprod Biomed Online 8:644-8. 2004
    ..Nonetheless, the trend towards the use of uniform diagnostic criteria in studies of PCOS will increase the comparability and potentially the value of published research...
  6. ncbi Androgen excess is the key element in polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90048, USA
    Fertil Steril 80:252-4. 2003
  7. ncbi Androgen excess in women: experience with over 1000 consecutive patients
    R Azziz
    Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Clin Endocrinol Metab 89:453-62. 2004
    ..Hirsutism, menstrual dysfunction, or acne, but not alopecia, improved in the majority of patients treated with a combination suppressive therapy; although more than 60% experienced side effects...
  8. ncbi Diagnostic criteria for polycystic ovary syndrome: a reappraisal
    Ricardo Azziz
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 83:1343-6. 2005
    ....
  9. ncbi Role of reproductive surgeons and the Society of Reproductive Surgeons
    Ricardo Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 78:916-7. 2002
  10. ncbi Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature
    Ricardo Azziz
    Department of Obstetrics and Gynecology and Center for Androgen Related Disorders, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 91:781-5. 2006
    ....
  11. ncbi Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 79:932-7. 2003
    ..To determine whether amelioration of insulin resistance in polycystic ovary syndrome (PCOS) with the insulin sensitizer troglitazone (TGZ) decreases circulating adrenal androgens (AAs), as reflected by DHEAS levels...
  12. ncbi Early adrenarche in normal prepubertal girls: a prospective longitudinal study
    Ricardo Azziz
    Departments of Obstetrics and Gynecology and Medicine, The University ofAlabama at Birmingham, Birmingham, AL, USA
    J Pediatr Endocrinol Metab 17:1231-7. 2004
    ..To study basal and ACTH stimulated levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and cortisol (F) in healthy girls during prepuberty...
  13. ncbi 3 beta-hydroxysteroid dehydrogenase deficiency in hyperandrogenism
    R Azziz
    Department of Obstetrics and Gynecology, University of Alabama, Birmingham
    Am J Obstet Gynecol 168:889-95. 1993
    ....
  14. ncbi Adrenocortical hyperresponsivity to adrenocorticotropic hormone: a mechanism favoring the normal production of cortisol in 21-hydroxylase-deficient nonclassic adrenal hyperplasia
    R Huerta
    Department of Obstetrics and Gynecology, The University of Alabama, Birmingham 35294 7333, USA
    Fertil Steril 74:329-34. 2000
    ..The excess production of S in these NCAH patients may, in part, account for their normal F production...
  15. ncbi FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome
    M O Goodarzi
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:2842-9. 2008
    ..We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion...
  16. ncbi Ovulation after glucocorticoid suppression of adrenal androgens in the polycystic ovary syndrome is not predicted by the basal dehydroepiandrosterone sulfate level
    R Azziz
    Department of Obstetrics Gynecology, The University of Alabama at Birmingham, 35233 7333, USA
    J Clin Endocrinol Metab 84:946-50. 1999
    ..Finally, these data suggest that, while AA may be an important risk factor for PCOS, once the syndrome is established, they play a limited role in the associated ovulatory dysfunction...
  17. ncbi Adrenal androgen production in response to adrenocorticotropin infusions in men
    C R Parker
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA
    Endocr Res 22:717-22. 1996
    ..Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17-OH P...
  18. ncbi Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial
    R Azziz
    Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama 35249, USA
    J Clin Endocrinol Metab 86:1626-32. 2001
    ..Troglitazone improves the ovulatory dysfunction, hirsutism, hyperandrogenemia, and insulin resistance of PCOS in a dose-related fashion, with a minimum of adverse effects...
  19. ncbi Altered autophosphorylation of the insulin receptor in the ovary of a woman with polycystic ovary syndrome
    C Moran
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 75:625-8. 2001
    ..The mechanisms through which insulin acts to produce an excess in ovarian androgen production in the face of a decrease in ovarian IR autophosphorylation remain to be determined...
  20. ncbi Hyperandrogenemia in patients presenting with acne
    S M Slayden
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249-7333, USA
    Fertil Steril 75:889-92. 2001
    ..CONCLUSION(S): Hyperandrogenemia was evident in a majority of nonhirsute acneic patients studied, regardless of age. These data suggest that androgen suppression may be useful in treating acne in many of these patients...
  21. ncbi Idiopathic hirsutism: an uncommon cause of hirsutism in Alabama
    R Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233 7333, USA
    Fertil Steril 70:274-8. 1998
    ..To determine the prevalence of idiopathic hirsutism among a population of consecutive hirsute patients...
  22. ncbi Adrenocortical secretion of dehydroepiandrosterone in healthy women: highly variable response to adrenocorticotropin
    R Azziz
    Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama 35233, USA
    J Clin Endocrinol Metab 86:2513-7. 2001
    ..Whether the AA excess frequently observed in PCOS is due to the greater risk of those women with higher AA levels, basally and after ACTH stimulation, remains to be confirmed...
  23. ncbi Association study of four key folliculogenesis genes in polycystic ovary syndrome
    K Sproul
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    BJOG 117:756-60. 2010
    ..GDF9 may thus serve as a modifier gene. These results suggest that inherited defects in folliculogenesis are not major factors in the genetic susceptibility to PCOS...
  24. ncbi Steroidogenic acute regulatory protein (StAR) in the ovaries of healthy women and those with polycystic ovary syndrome
    M D Kahsar-Miller
    Laboratory of Medical Genetics, The University of Alabama at Birmingham, USA
    Am J Obstet Gynecol 185:1381-7. 2001
    ....
  25. ncbi Idiopathic hirsutism
    R Azziz
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233 7333, USA
    Endocr Rev 21:347-62. 2000
    ..Further investigations into the genetic, molecular, and metabolic aspects of this disorder, including only well defined patients, are needed...
  26. ncbi Influence of insulin and testosterone on adrenocortical steroidogenesis in vitro: preliminary studies
    G A Hines
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama 35233-7333, USA
    Fertil Steril 76:730-5. 2001
    ..Expanded studies are required to confirm these results...
  27. ncbi Family history as a risk factor for the polycystic ovary syndrome
    R Azziz
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35249 7333, USA
    J Pediatr Endocrinol Metab 13:1303-6. 2000
    ..In absence of molecular diagnostic markers, a positive family history appears to be the most informative risk factor for the development PCOS...
  28. ncbi Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:1214-9. 2008
    ..Polymorphisms in the SGTA gene have not been evaluated for a role in PCOS...
  29. ncbi A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome
    M Kahsar-Miller
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Alabama, Birmingham, USA
    Fertil Steril 74:1237-40. 2000
    ..To determine whether the frequency of the N363S variant of the glucocorticoid receptor (GRL) was increased in women with PCOS and adrenal androgen (AA) excess...
  30. ncbi The role of the adrenal cortex in polycystic ovary syndrome
    C Moran
    Department of Obstetrics and Gynecology, Division of Reproductive Biology and Endocrinology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol Clin North Am 28:63-75. 2001
    ..Although glucocorticoid administration may improve the ovulatory function of these patients, the results are modest and cannot be predicted by the circulating androgen levels...
  31. ncbi Repeated freezing and thawing does not generally alter assay results for several commonly studied reproductive hormones
    R Reyna
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama 35233-7333, USA
    Fertil Steril 76:823-5. 2001
    ..CONCLUSION(S): There is no consistent or predictable alteration in the results of SHBG, or the glycoprotein and steroid hormones evaluated, as a function of repeated freeze/thaw or the storage temperature of human serum...
  32. ncbi Reproductive outcome of women with 21-hydroxylase-deficient nonclassic adrenal hyperplasia
    C Moran
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160 W, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 91:3451-6. 2006
    ..0001, for both). CONCLUSIONS: The risk of a mother with 21-OH-deficient NCAH for giving birth to a child affected with CAH is 2.5%; at least 14.8% of children born to these mothers have NCAH...
  33. ncbi Facial and abdominal hair growth in hirsutism: a computerized evaluation
    G Hines
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham 35233-7333, USA
    J Am Acad Dermatol 45:846-50. 2001
    ..Hence evaluation of either of the body areas, using an objective method of assessing hair growth, should provide equivalent results...
  34. ncbi The Second International Symposium on the Developmental Aspects of Androgen Excess, Toronto, Canada, 20 June 2000
    R Azziz
    Depts of Obstetrics and Gynecology, and Medicine, University of Alabama at Birmingham, USA
    Trends Endocrinol Metab 11:338-40. 2000
    ....
  35. ncbi The effectiveness of the interview for predicting the presence of polycystic ovary syndrome
    M D Kahsar-Miller
    Laboratory of Medical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Endocrinol 17:449-54. 2003
    ..Thus direct interviewing of PCOS patients or their mothers and sisters reliably predicts affected status, but patient interview alone will not predict PCOS in almost 50% of the affected sisters...
  36. ncbi Regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome: role of tumor necrosis factor-{alpha}
    Gregorio Chazenbalk
    Department of Obstetrics and Gynecology and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 95:935-42. 2010
    ..The mechanisms underlying these defects and the role of concurrent obesity remain to be determined...
  37. ncbi Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters
    Bulent O Yildiz
    Hacettepe University Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara, Turkey
    Fertil Steril 86:1688-93. 2006
    ..Our results support the hypothesis that circulating AA levels represent an inherited trait in PCOS...
  38. ncbi Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline
    Ricardo Azziz
    Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, California, USA
    J Clin Endocrinol Metab 91:4237-45. 2006
    ..Finally, the task force recognized, and fully expects, that the definition of this syndrome will evolve over time to incorporate new research findings...
  39. ncbi Degree of facial and body terminal hair growth in unselected black and white women: toward a populational definition of hirsutism
    Catherine Marin DeUgarte
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160 W, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 91:1345-50. 2006
    ....
  40. ncbi Nonreplication of the type 5 17beta-hydroxysteroid dehydrogenase gene association with polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 93:300-3. 2008
    ....
  41. ncbi Role of diet in the treatment of polycystic ovary syndrome
    Crystal C Douglas
    Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama, USA
    Fertil Steril 85:679-88. 2006
    ....
  42. ncbi Family size in women with polycystic ovary syndrome
    Marita Pall
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 85:1837-9. 2006
    ....
  43. ncbi Difference in dietary intake between women with polycystic ovary syndrome and healthy controls
    Crystal C Douglas
    Pittman General Clinical Research Center, University of Alabama at Birmingham, USA
    Fertil Steril 86:411-7. 2006
    ....
  44. ncbi The adrenal and polycystic ovary syndrome
    Bulent O Yildiz
    Department of Internal Medicine, Endocrinology and Metabolism Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Rev Endocr Metab Disord 8:331-42. 2007
    ..Finally, DHEAS levels and the response of AAs to ACTH are relatively constant over time and are closely correlated between PCOS patients and their siblings suggesting that this abnormality is an inherited trait in PCOS...
  45. ncbi Reproducibility of the adrenal androgen response to adrenocorticotropic hormone stimulation
    Shahin Ghadir
    Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Fertil Steril 86:484-6. 2006
    ..When the women were subdivided into either high or low responders to ACTH stimulation (relative to the group median), the relative adrenocortical response within individual subjects was found to be highly constant over time...
  46. ncbi Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Medical Genetics Institute, Los Angeles, CA, USA
    Best Pract Res Clin Endocrinol Metab 20:193-205. 2006
    ..Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive...
  47. ncbi Diagnosis, phenotype, and prevalence of polycystic ovary syndrome
    Enrico Carmina
    Department of Clinical Medicine, University of Palermo, Palermo, Italy
    Fertil Steril 86:S7-8. 2006
    ..However, it is unclear whether the normoandrogenic phenotype actually represents PCOS. Overall, 6% to 8% of reproductive-aged women suffer from PCOS, making this disorder one of the most common endocrine abnormalities...
  48. ncbi Impact of obesity on the risk for polycystic ovary syndrome
    Bulent O Yildiz
    Department of Internal Medicine, Endocrinology, and Metabolism Unit, Hacettepe University School of Medicine, Hacettepe, 06100 Ankara, Turkey
    J Clin Endocrinol Metab 93:162-8. 2008
    ....
  49. ncbi The age-associated decline of androgens in reproductive age and menopausal Black and White women
    Jessica B Spencer
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:4730-3. 2007
    ..The effect of race and obesity on the age-associated decline of androgens in reproductive-aged and menopausal women has not been well characterized...
  50. ncbi Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 196:398.e1-5; discussion 398.e5-6. 2007
    ..The purpose of this study was to assess the sibling correlation of adrenocorticotropic hormone-stimulated steroid hormone levels between probands with polycystic ovary syndrome and their sisters...
  51. ncbi Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome
    Mark O Goodarzi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 87:1473-6. 2007
    ..In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS...
  52. ncbi Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:48-53. 2006
    ..Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis...
  53. ncbi Polycystic ovary syndrome in Mexican-Americans: prevalence and association with the severity of insulin resistance
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 84:766-9. 2005
    ..Hyperinsulinemic euglycemic clamp studies showed greater insulin resistance in the women with PCOS...
  54. ncbi Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess
    Carlos Moran
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 81:126-31. 2004
    ..CONCLUSION(S): Adrenal androgen excess in PCOS is associated with a greater delta(5)17-OH activity in response to ACTH...
  55. ncbi Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome
    Lisa Farah Eways
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 81:120-5. 2004
    ..A common factor determining both the effectiveness of glucose to control its own production or uptake and adrenocortical biosynthesis may be aberrant in PCOS...
  56. ncbi Minimal response of circulating lipids in women with polycystic ovary syndrome to improvement in insulin sensitivity with troglitazone
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:5137-44. 2003
    ..Treatment with an insulin-sensitizing agent may have minimal impact on circulating lipids. Further surveillance and treatment of abnormal lipid levels may be necessary in these women...
  57. ncbi 21-hydroxylase-deficient nonclassic adrenal hyperplasia: the great pretender
    Carlos Moran
    Health Research Council, Mexican Institute of Social Security, Mexico City, Mexico
    Semin Reprod Med 21:295-300. 2003
    ..However, because the disorders have significant clinical and hormonal similarities, the measurement of 17-HP, preferably basally as a screening method, should be incorporated into the evaluation of all hyperandrogenic patients...
  58. ncbi The evaluation and management of hirsutism
    Ricardo Azziz
    Departments of Obstetrics and Gynecology and Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 101:995-1007. 2003
    ....
  59. ncbi Polycystic ovary syndrome, insulin resistance, and molecular defects of insulin signaling
    Ricardo Azziz
    J Clin Endocrinol Metab 87:4085-7. 2002
  60. ncbi Effect of oral micronized progesterone on androgen levels in women with polycystic ovary syndrome
    Keslie S Woods
    Department of Obstetrics and Gynecology The University of Alabama at Birmingham, Birmingham, Alabama 35233-7333, USA
    Fertil Steril 77:1125-7. 2002
    ....
  61. ncbi Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus
    Fernando Ovalle
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 77:1095-105. 2002
    ....
  62. ncbi Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome
    Melissa Kahsar-Miller
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 82:973-5. 2004
    ..It does not appear that this common variant of CYP17, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal androgen excess of PCOS...
  63. ncbi Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess
    Selma F Witchel
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Fertil Steril 83:371-5. 2005
    ....
  64. ncbi Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
    Catherine Marin DeUgarte
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 83:1454-60. 2005
    ..Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature...
  65. ncbi Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS)
    Ashim Kumar
    Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Clin Endocrinol (Oxf) 62:644-9. 2005
    ..While BMI and fasting insulin had little impact on circulating DHEAS levels in healthy women, among White PCOS patients these parameters were negatively associated with circulating DHEAS levels...
  66. ncbi Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 57:1279-87. 2004
    ..We examined the measurement properties of a questionnaire (PCOSQ) measuring health-related quality of life (HRQOL) in women with the polycystic ovary syndrome (PCOS)...
  67. ncbi The prevalence of androgen excess among patients with minimal unwanted hair growth
    Irene Souter
    Department of Obstetrics/Gynecology, Cedars-Sinai Medical Center, Los Angeles, Calif, USA
    Am J Obstet Gynecol 191:1914-20. 2004
    ..Eumenorrhea does not preclude an underlying AE disorder, and ovulatory function should be assessed in these women...
  68. ncbi Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups
    Wendy Y Chang
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, California, USA
    Fertil Steril 83:1717-23. 2005
    ....
  69. ncbi Stability of adrenocortical steroidogenesis over time in healthy women and women with polycystic ovary syndrome
    Bulent O Yildiz
    Hacettepe University Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara, Turkey
    J Clin Endocrinol Metab 89:5558-62. 2004
    ....
  70. ncbi Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study
    Francesco Orio
    Department of Molecular, Clinical Endocrinology and Oncology, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:6072-6. 2005
    ..Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients...
  71. ncbi Resistin stimulation of 17alpha-hydroxylase activity in ovarian theca cells in vitro: relevance to polycystic ovary syndrome
    Iqbal Munir
    Department of Obstetrics and Gynecology, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4852-7. 2005
    ..A newly discovered hormone resistin has been shown to be increased in women with polycystic ovary syndrome (PCOS)...
  72. ncbi Metformin use in polycystic ovary syndrome: metabolic benefits and diabetes prevention
    Mark O Goodarzi
    Am J Med 121:e9; author reply e11. 2008
  73. ncbi Polycystic ovary syndrome is a family affair
    Ricardo Azziz
    J Clin Endocrinol Metab 93:1579-81. 2008
  74. ncbi Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome
    Mark O Goodarzi
    Department of Obstetrics Gynecology and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 93:2909-12. 2008
    ....
  75. ncbi Laser hair reduction in the hirsute patient: a critical assessment
    Luis A Sanchez
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233-7333, USA
    Hum Reprod Update 8:169-81. 2002
    ..While larger prospective, controlled, blinded and uniform studies are still needed, laser hair removal appears to be a useful adjuvant in the treatment of the hirsute patient...
  76. ncbi Socioeconomic and racial predictors of undergoing laparoscopic hysterectomy for selected benign diseases: analysis of 341487 hysterectomies
    Haim Arie Abenhaim
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    J Minim Invasive Gynecol 15:11-5. 2008
    ..The purpose of our study was to evaluate whether these factors influence use of laparoscopic hysterectomy for management of benign gynecologic diseases...
  77. ncbi Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women
    Mark O Goodarzi
    Department of Ob Gyn and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 91:4085-91. 2006
    ..Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5alpha-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS)...
  78. ncbi Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:2659-64. 2007
    ..Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS). Polymorphisms in these genes have not been evaluated as modulators of DHEAS level in PCOS...
  79. ncbi Laparoscopic evaluation following failure to achieve pregnancy after ovulation induction with clomiphene citrate
    Frank Ochoa Capelo
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 80:1450-3. 2003
    ..Although predictors for intrapelvic disease were isolated, their high prevalence reduced their predictive value...
  80. ncbi Diagnosis of polycystic ovary syndrome
    Bradley Trivax
    Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Clin Obstet Gynecol 50:168-77. 2007
    ..Overall, at least 1 in 15 women of reproductive age will be affected by PCOS, making this disorder the most common endocrine abnormality in this age group, with a health burden of over 4 billion dollars in the United States alone...
  81. ncbi A twenty-first century research agenda for polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, M S Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Best Pract Res Clin Endocrinol Metab 20:331-6. 2006
    ..Overall, this disorder is a prototype for the benefits of translational science and a transdisciplinary approach to understanding the pathophysiology and therapy for anovulatory infertility...
  82. ncbi Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement
    William Rosner
    St Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, AJA 403, New York, New York 10019, USA
    J Clin Endocrinol Metab 92:405-13. 2007
    ..The objective of the study was to evaluate the current state of clinical assays for total and free testosterone...
  83. ncbi Report on the Third Annual Meeting of the Androgen Excess Society, San Diego, California, June 3, 2005
    Francesco Orio
    University Federico II, Naples, Italy
    Fertil Steril 86:1318-20. 2006
    ..The experience of the 21-OH-deficient Nonclassical Adrenal Hyperplasia (NCAH) Multicenter Study Group was also discussed, along with a keynote presentation on the molecular aspects of 3beta-HSD-deficient NCAH...
  84. ncbi Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:66-71. 2005
    ..Finally, the fasting glucose concentration was poorly associated with 2-h glucose concentrations among PCOS women with IGT, suggesting that the fasting glucose concentration is inadequate to predict the presence of IGT in PCOS...
  85. ncbi Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndrome
    Heath J Antoine
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 87:862-9. 2007
    ..To investigate the relationship of the peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala and silent exon 6 (His447His) polymorphisms with the clinical features of polycystic ovary syndrome (PCOS)...

Research Grants20

  1. Adrenal Androgen Excess in PCOS: Role of Genetics
    Ricardo Azziz; Fiscal Year: 2009
    ....
  2. ADRENAL ANDROGEN EXCESS IN THE POLYCYSTIC OVARY SYNDROME
    Ricardo Azziz; Fiscal Year: 2002
    ..5 mg/day), and their clinical response correlated with various adrenocortical markers. These studies will shed light on the etiology and role of adrenocortical of HO. ..
  3. Adrenal Androgen Excess in PCOS: Role of Genetics
    Ricardo Azziz; Fiscal Year: 2007
    ....
  4. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2007
    ..Overall, these studies have the potential of elucidating the etioloaic mechanism(s) in PCOS, and guiding our search for therapies and molecular markers. ..
  5. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2009
    ..Overall, these studies have the potential of elucidating the etioloaic mechanism(s) in PCOS, and guiding our search for therapies and molecular markers. ..
  6. Annual Meeting of the Androgen Excess Society
    Ricardo Azziz; Fiscal Year: 2007
    ..abstract_text> ..
  7. ANDROGEN EXCESS DISORDER
    Ricardo Azziz; Fiscal Year: 2004
    ..The institution has committed to releasing the Candidate from other duties in order for him to dedicate at least 50% of his time to the research and mentoring activities. ..
  8. Molecular Defects of Insulin Signaling in PCOS
    Ricardo Azziz; Fiscal Year: 2004
    ..Long term, these studies have the potential of eventually elucidating the etiologic mechanism(s) in some, or most, patients; helping to develop targeted therapies; and guiding the search for molecular markers for PCOS. ..
  9. ADRENAL ANDROGEN EXCESS IN THE POLYCYSTIC OVARY SYNDROME
    Ricardo Azziz; Fiscal Year: 2002
    ..5 mg/day), and their clinical response correlated with various adrenocortical markers. These studies will shed light on the etiology and role of adrenocortical of HO. ..
  10. ADRENAL ANDROGEN EXCESS--HYPERANDROGENIC OLIGO-OVULATION
    Ricardo Azziz; Fiscal Year: 1993
    ..5 mg/day), and their clinical response correlated with various adrenocortical markers. These studies will shed light on the etiology and role of adrenocortical of HO...
  11. ADRENAL ANDROGEN EXCESS IN THE POLYCYSTIC OVARY SYNDROME
    Ricardo Azziz; Fiscal Year: 1999
    ..abstract_text> ..