Research Topics
| A L WaldoSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Mechanisms of atrial flutter and atrial fibrillation: distinct entities or two sides of a coin?Albert L Waldo
Division of Cardiology, Department of Medicine, MS 5038, University Hospitals of Cleveland/Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5038, USA
Cardiovasc Res 54:217-29. 2002- The interrelationship between atrial fibrillation and atrial flutterAlbert L Waldo
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
Prog Cardiovasc Dis 48:41-56. 2005..In sum, atrial fibrillation and atrial flutter have an important interrelationship... - A perspective on rate control in the treatment of atrial fibrillationAlbert L Waldo
Department of Medicine, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio 44106 5038, USA
Clin Cardiol 27:121-4. 2004..Pursuit of rate or rhythm control should be decided on a case-by-case basis... - Mechanisms of atrial fibrillationAlbert L Waldo
Department of Medicine, Division of Cardiology, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Cardiovasc Electrophysiol 14:S267-74. 2003..However, a precise understanding of the mechanism(s) of AF in patients is not yet available... - Should we control rate or rhythm in atrial fibrillation?Albert L Waldo
Department of Medicine, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio, USA
J Cardiovasc Electrophysiol 14:1122-3. 2003 - From bedside to bench: entrainment and other storiesAlbert L Waldo
Department of Medicine, Division of Cardiology, Case Western Reserve University University Hospitals of Cleveland, Ohio 44106, USA
Heart Rhythm 1:94-106. 2004..Moreover, the principles of entrainment have also been applied clinically to assist in effective application of antitachycardia pacing and catheter ablation techniques... - Inter-relationships between atrial flutter and atrial fibrillationAlbert L Waldo
Department of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106 50388, USA
Pacing Clin Electrophysiol 26:1583-96. 2003..Unstable reentrant circuits can also do the same thing. In short, it appears that there are several mechanisms of atrial fibrillation, one of which is due to a form of very rapid atrial flutter... - Long-term pharmacologic management of atrial fibrillation in the elderlyAlbert L Waldo
Department of Medicine, Division of Cardiology, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106, USA
Am J Geriatr Cardiol 11:233-44; quiz 244-6. 2002..A clinically reasoned approach is suggested in the presence of coronary artery disease, left ventricular dysfunction /congestive heart failure, or hypertension based largely on the risk/benefit profile of the drugs... - Role of functional block extension in lesion-related atrial flutterY Tomita
Department of Medicine, Division of Cardiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio
Circulation 103:1025-30. 2001..These data provide an explanation for the chronic AFL that occurs in some patients after surgical repair of congenital heart lesions... - Imaging dispersion of myocardial repolarization, II: noninvasive reconstruction of epicardial measuresR N Ghanem
Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio, USA
Circulation 104:1306-12. 2001..Its clinical significance lies in the possibility of noninvasive risk stratification and in guidance and evaluation of therapy... - Conduction left-to-right and right-to-left across the crista terminalisK Matsuo
Division of Cardiology, Department of Medicine, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 41106, USA
Am J Physiol Heart Circ Physiol 280:H1683-91. 2001..In these models, there is no fixed conduction block across the CT, and when block in the CT region occurs, as during AFL, it is functional... - Mechanism of interruption of atrial flutter by moricizine. Electrophysiological and multiplexing studies in the canine sterile pericarditis model of atrial flutterJ Ortiz
Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106
Circulation 89:2860-9. 1994..Moricizine is said to have potent effects on cardiac conduction but little or no effect on cardiac refractoriness... - Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmiasKyungmoo Ryu
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
Am J Physiol Heart Circ Physiol 293:H1231-41. 2007..The transmural gradient in the volume fraction of Cx40 and Cx43 in SP is associated with markedly abnormal atrial conduction and is likely an important factor in the vulnerability to induction and maintenance of AFL/AF in SP... - Fixed intercaval block in the setting of atrial fibrillation promotes the development of atrial flutterHanh M Bui
Department of Medicine, Division of Cardiology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Heart Rhythm 5:1745-52. 2008..In the canine sterile pericarditis model, typically only atrial fibrillation (AF) is inducible on postoperative day 2... - Azd7009: a new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis modelRobert N Goldstein
Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Cardiovasc Electrophysiol 15:1444-50. 2004..CONCLUSION: AZD7009 is highly efficacious in terminating AF/AFL and preventing reinduction in this model. It exhibits marked effects on atrial electrophysiology but has only modest effects on the ventricle... - Efficacy and safety of moricizine in the maintenance of sinus rhythm in patients with recurrent atrial fibrillationJ C Geller
Department of Medicine, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Ohio 44106, USA
Am J Cardiol 87:172-7. 2001..During a follow-up (21 +/- 2 months), there were neither deaths nor adverse effects requiring discontinuation of therapy. Thus, moricizine was effective, safe, and well tolerated in our patient cohort with AF... - Typical counterclockwise atrial flutter occurring despite absence of the inferior vena cavaNiraj Varma
Department of Cardiac Electrophysiology, Cleveland, Ohio 44118, USA
Heart Rhythm 1:82-7. 2004..The implications of this congenital abnormality on posterior barriers maintaining the atrial flutter circuit are discussed... - Use of fast fourier transform analysis of atrial electrograms for rapid characterization of atrial activation-implications for delineating possible mechanisms of atrial tachyarrhythmiasKyungmoo Ryu
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
J Cardiovasc Electrophysiol 17:198-206. 2006..Computation time for all FFT analyses took <5 minutes. CONCLUSION: FFT analysis accurately and rapidly identifies global atrial activation patterns during AFL, AT, and AF, thereby assisting in determining arrhythmia mechanisms... - A perspective on antiarrhythmic drug therapy to treat atrial fibrillation: there remains an unmet needAlbert L Waldo
Division of Cardiology, Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
Am Heart J 151:771-8. 2006..Therein lie an important clinical dilemma and an unmet need. Sinus rhythm is good, but we need better ways to maintain it effectively and safely... - Epicardial mapping of chronic atrial fibrillation in patients: preliminary observationsJayakumar Sahadevan
Department of Medicine, Division of Cardiology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, The Louis B. Stokes Veterans' Administration Medical Center, Cleveland, Ohio 44106, USA
Circulation 110:3293-9. 2004.... - Frequency analysis of atrial electrograms identifies conduction pathways from the left to the right atrium during atrial fibrillation-studies in two canine modelsKyungmoo Ryu
Department of Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
J Cardiovasc Electrophysiol 20:667-74. 2009..Computation time for FFT analysis for each AF episode took less than 5 minutes. CONCLUSION: FFT analysis allowed rapid and reliable detection of the LA-to-RA conduction pathways in AF generated by a stable and rapid LA driver... - Vanoxerine, a new drug for terminating atrial fibrillation and flutterNaomichi Matsumoto
Department of Medicine, Division of Cardiology, Case Western Reserve University, School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Cardiovasc Electrophysiol 21:311-9. 2010..Therefore, we proposed that vanoxerine might be antiarrhythmic. In these studies, we tested the hypothesis that vanoxerine would terminate induced atrial fibrillation (AF) and atrial flutter (AFL) in dogs with sterile pericarditis (SP)... - Imaging dispersion of myocardial repolarization, I: comparison of body-surface and epicardial measuresJ E Burnes
Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Cleveland, Ohio, USA
Circulation 104:1299-305. 2001..In contrast, measures based on epicardial electrograms (ARI or epicardial QRST integral maps) provide physiologically relevant information about myocardial repolarization and can locate regions of increased dispersion... - Hospitalized patients with atrial fibrillation and a high risk of stroke are not being provided with adequate anticoagulationAlbert L Waldo
Division of Cardiology, Case Western University University Hospitals of Cleveland, Cleveland, Ohio 44106 5038, USA
J Am Coll Cardiol 46:1729-36. 2005..The purpose of this study was to determine both treatment gaps and predictors of warfarin use in atrial fibrillation (AF) patients enrolled in a national multicenter study... - Termination of a tachyarrhythmia by flunarizine is not a specific marker for a triggered mechanismSERGEY A VITEBSKIY
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Heart Rhythm 4:1544-52. 2007..Prior studies have indicated that tachyarrhythmia termination by flunarizine demonstrates a triggered mechanism. This concept was not confirmed in atrial tachyarrhythmias... - Anticoagulation: stroke prevention in patients with atrial fibrillationAlbert L Waldo
Department of Medicine, Case Western Reserve University University Hospitals of Cleveland Case Medical Center, 11100 Euclid Avenue, MS LKS 5038, Cleveland, OH 44106 5038, USA
Cardiol Clin 27:125-35, ix. 2009..The presence of AF confers a fivefold increased risk for stroke. AF is the most common and important cause of stroke. This article considers the risks for and anticoagulation prophylaxis against embolic stroke in patients who have AF... - Comparative effects of single- and linear triple-site rapid bipolar pacing on atrial activation in canine modelsKyungmoo Ryu
Departments of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
Am J Physiol Heart Circ Physiol 289:H374-84. 2005..LTSBRP created a more uniform wave-front propagation with less or no conduction block and/or delay compared with SSBRP... - New possibilities in anticoagulant management of atrial fibrillationAlbert L Waldo
Department of Medicine, Division of Cardiology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio, USA
Rev Cardiovasc Med 5:S30-8. 2004..5%) with elevation of both alanine aminotransferase (ALT) and bilirubin levels can be managed safely, thereby making ximelagatran a promising option for preventing thromboembolism in patients with atrial fibrillation at risk for stroke... - Anticoagulation: stroke prevention in patients with atrial fibrillationAlbert L Waldo
Department of Medicine, Division of Cardiovascular Medicine, Case Western Reserve University University Hospitals of Cleveland Case Medical Center, Cleveland, OH, USA
Med Clin North Am 92:143-59, xi. 2008..AF is the most common and important cause of stroke resulting from any cause. This article considers the risks for and anticoagulation prophylaxis against embolic stroke in patients with AF... - Inter-relationships of atrial fibrillation and atrial flutter mechanisms and clinical implicationsAlbert L Waldo
Department of Medicine, Division of Cardiovascular Medicine, Case Western Reserve University University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio 44106 5038, USA
J Am Coll Cardiol 51:779-86. 2008..In short, there are probably several mechanisms of AF, 1 of which is due to a very rapid AFL causing fibrillatory conduction. All of these interactions of AF and AFL have important clinical implications... - Electrocardiographic imaging (ECGI), a novel diagnostic modality used for mapping of focal left ventricular tachycardia in a young athleteAnselma Intini
Department of Medicine (Cardiology, Case Western Reserve University/University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Heart Rhythm 2:1250-2. 2005..This correlated with subsequent maps obtained using standard techniques. We describe the first case that used ECGI to guide diagnosis and therapy of a clinical tachyarrhythmia... - Vanoxerine: cellular mechanism of a new antiarrhythmicAntonio E Lacerda
ChanTest Corporation, Cleveland, Ohio 44128, USA
J Cardiovasc Electrophysiol 21:301-10. 2010..1) cardiac potassium channel. Consequently,we hypothesized that vanoxerine might also be a potent blocker of cardiac calcium (Ca) and sodium (Na) currents, and would not affect transmural dispersion of repolarization... - Sinus rhythm and ventricular tachycardia coexisting simultaneously in the same heartWilliam R Lewis
MetroHealth Campus, Case Western Reserve University, Cleveland, OH 44109-1998, USA
Heart Rhythm 4:986. 2007 - Prednisone prevents inducible atrial flutter in the canine sterile pericarditis modelRobert N Goldstein
Division of Cardiology, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Cardiovasc Electrophysiol 19:74-81. 2008..We tested the hypothesis that suppression of the inflammatory response with steroids would significantly modify the inducibility of postoperative AF/AFL in the canine sterile pericarditis model... - ACC/AHA/Physician Consortium 2008 clinical performance measures for adults with nonvalvular atrial fibrillation or atrial flutter: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and the PhysiciN A Mark Estes
Circulation 117:1101-20. 2008 - Rhythm control versus rate control for atrial fibrillation and heart failureDenis Roy
Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
N Engl J Med 358:2667-77. 2008..However, the benefits and risks of this approach have not been adequately studied... - Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) studyJohn P Dimarco
Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908, USA
Am Heart J 149:650-6. 2005..Bleeding is the major complication of anticoagulant treatment, and the relative risks for bleeding vs stroke must be considered when starting anticoagulation... - Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) studyDavid G Sherman
University of Texas Health Science Center, San Antonio, USA
Arch Intern Med 165:1185-91. 2005..The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study was a multicenter comparison of high-risk patients with AF who were randomized to either a sinus rhythm control or a rate control strategy... - Stroke prevention in atrial fibrillationAlbert L Waldo
JAMA 290:1093-5. 2003 - Atrial fibrillation-atrial flutter interactions: clinical implications for ablationAlbert L Waldo
Circulation 116:2774-5. 2007 - Clinical factors that influence response to treatment strategies in atrial fibrillation: the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) studyAnne B Curtis
University of Florida, Box 100277, 1600 SW Archer Rd, Gainesville, FL 32610, USA
Am Heart J 149:645-9. 2005..The primary outcome of the trial showed no overall difference in survival between strategies. However, there may be important patient subgroups for which there are identifiable differences in outcome with 1 of the 2 strategies... - Treatment of venous thromboembolism: adherence to guidelines and impact of physician knowledge, attitudes, and beliefsJoseph A Caprini
Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
J Vasc Surg 42:726-33. 2005..To assess the treatment of venous thromboembolism (VTE) in hospitalized patients enrolled in a national, multicenter database... - Role of permanent pacing to prevent atrial fibrillation: science advisory from the American Heart Association Council on Clinical Cardiology (Subcommittee on Electrocardiography and Arrhythmias) and the Quality of Care and Outcomes Research InterdisciplinBradley P Knight
Circulation 111:240-3. 2005..At present, permanent pacing to prevent AF is not indicated; however, additional studies are ongoing, which will help to clarify the role of permanent pacing for AF... - Localization of focal atrial tachycardias--back to the future...when (old) electrophysiologic first principles complement sophisticated technologyJonathan M Kalman
J Cardiovasc Electrophysiol 18:7-8. 2007 - Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) StudyScott D Corley
Axio Research Corporation, Seattle, Wash, USA
Circulation 109:1509-13. 2004..If an effective method for maintaining SR with fewer adverse effects were available, it might be beneficial... - The impact of asymptomatic atrial fibrillationElizabeth S Kaufman
J Am Coll Cardiol 43:53-4. 2004 - Catheter ablation of atrial fibrillation: a treatment frontierMichael Domanski
J Interv Card Electrophysiol 15:141-3. 2006 - Antithrombotic therapy practices in US hospitals in an era of practice guidelinesVictor F Tapson
Division of Pulmonary Medicine, Duke University Medical Center, Durham, NC 27710, USA
Arch Intern Med 165:1458-64. 2005..Antithrombotic therapy is efficacious for the prevention of thromboembolic disease, but it necessitates careful risk-benefit assessment... - ACC/AHA/Physician Consortium 2008 Clinical Performance Measures for Adults with Nonvalvular Atrial Fibrillation or Atrial Flutter: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and the PhysiciN A Mark Estes
J Am Coll Cardiol 51:865-84. 2008