Research Topics
Species | Erik van LunterenSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Contrast between cardiac left ventricle and diaphragm muscle in expression of genes involved in carbohydrate and lipid metabolismErik van Lunteren
Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 161:41-53. 2008....- Oxidoreductase, morphogenesis, extracellular matrix, and calcium ion-binding gene expression in streptozotocin-induced diabetic rat heartErik van Lunteren
Pulmonary, Critical Care and Sleep Division, Department of Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Am J Physiol Endocrinol Metab 293:E759-68. 2007.... - Isotonic contractile impairment due to genetic CLC-1 chloride channel deficiency in myotonic mouse diaphragm muscleErik van Lunteren
Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA
Exp Physiol 92:717-29. 2007..These data indicate that genetic CLC-1 chloride channel deficiency in mice not only produces myotonia but also substantially worsens the isotonic contractile performance of diaphragm muscle... - Long-lasting in vivo inotropic effects of the K(+) channel blocker 3,4-diaminopyridine during fatigue-inducing stimulationErik van Lunteren
Department of Pulmonary Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Muscle Nerve 38:1616-22. 2008..These data provide support for a potential role for aminopyridines as inotropic agents in applications such as functional electrical stimulation, in which low to medium stimulation frequencies are typically utilized... - Gene expression microarrays and respiratory musclesErik van Lunteren
Division of Pulmonary, Critical Care and Sleep Medicine, Cleveland VA Medical Center and Case Western Reserve University, Cleveland, OH 44106, United States
Respir Physiol Neurobiol 156:103-15. 2007.... - Genetic CLC-1 chloride channel deficiency modifies diaphragm muscle isometric contractile propertiesErik van Lunteren
Pulmonary and Critical Care Medicine, Case Western Reserve University, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 155:220-6. 2007..These findings indicate that genetic CLC-1 deficiency not only affects muscle relaxation (myotonia) but also modulates diaphragm performance during the contractile phase of the contraction-relaxation cycle... - Gene expression profiling of diaphragm muscle in alpha2-laminin (merosin)-deficient dy/dy dystrophic miceErik van Lunteren
Pulmonary and Critical Care Division, Department of Medicine, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Physiol Genomics 25:85-95. 2006.... - Altered diaphragm muscle action potentials in Zucker diabetic fatty (ZDF) ratsErik van Lunteren
Department of Medicine Pulmonary and Critical Care Division, Cleveland VA Medical Center and Case Western Reserve University, 10701 East Boulevard, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 153:157-65. 2006..These findings in ZDF rats contrast with type 1 diabetic rats, suggesting that isolated hyperglycemia differs from hyperglycemia combined with other metabolic perturbations with respect to diaphragm electrophysiological derangements... - Gene expression profiling in the type 1 diabetes rat diaphragmErik van Lunteren
Pulmonary, Critical Care and Sleep Division, Department of Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, OH, USA
PLoS ONE 4:e7832. 2009..The present study examined to what extent these cellular perturbations involve changes in gene expression... - Reduced amount and disrupted temporal pattern of spontaneous exercise in diabetic ratsErik van Lunteren
Department of Medicine Pulmonary, Cleveland Department of Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, OH, USA
Med Sci Sports Exerc 36:1856-62. 2004..Studies tested the hypothesis that Type I diabetes causes similar changes in spontaneous exercise performance... - Combination of variable frequency train stimulation and K+ channel blockade to augment skeletal muscle forceErik van Lunteren
Department of Medicine Pulmonary, Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
IEEE Trans Neural Syst Rehabil Eng 12:288-94. 2004..The utility of the combined intervention for functional electrical stimulation may be greatest for mechanical tasks requiring high force levels early during the contraction... - Improvement of diaphragm and limb muscle isotonic contractile performance by K+ channel blockadeErik van Lunteren
Division of Pulmonary and Critical Care Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
J Neuroeng Rehabil 7:1. 2010.... - Fatigue-inducing stimulation resolves myotonia in a drug-induced modelErik van Lunteren
Pulmonary and Critical Care Medicine, Case Western Reserve University and Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, OH 44106, USA
BMC Physiol 11:5. 2011..Diaphragm, EDL, and soleus muscles were examined in vitro during repetitive 20 Hz and 50 Hz train stimulation in a drug-induced (9-AC) rat myotonia model... - Differential expression of lipid and carbohydrate metabolism genes in upper airway versus diaphragm muscleErik van Lunteren
Pulmonary, Critical Care and Sleep Division, Department of Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Sleep 33:363-70. 2010..We tested the hypothesis that sternohyoid has lower expression of genes related to lipid and carbohydrate energetic pathways than the diaphragm... - Inotropic effects of the K+ channel blocker 3,4-diaminopyridine on fatigued diaphragm muscleMichele Ionno
Division of Pulmonary and Critical Care Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, United States
Respir Physiol Neurobiol 160:45-53. 2008..Nonetheless DAP-induced force increases were usually sufficient to restore force to values present prior to the onset of fatigue-inducing stimulation... - Sternohyoid muscle fatigue properties of dy/dy dystrophic mice, an animal model of merosin-deficient congenital muscular dystrophyErik van Lunteren
Department of Medicine, Cleveland VA Medical Center, Cleveland, OH 44106, USA
Pediatr Res 54:547-53. 2003.... - Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridineErik van Lunteren
Department of Medicine, Pulmonary Division, Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, Ohio 44106, USA
Muscle Nerve 26:71-8. 2002..It is possible that DAP may be useful for the clinical management of a variety of disorders causing muscle weakness... - Streptozotocin-diabetes alters action potentials in rat diaphragmErik van Lunteren
Department of Medicine Pulmonary, Pulmonary Section 111J W, Cleveland V A Medical Center, Case Western Reserve University, 10701 East Boulevard, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 135:9-16. 2003..These data indicate that diabetes shortens diaphragm action potentials, which appears to be due to altered K(+) channels... - Isotonic fatigue in laminin alpha2-deficient dy/dy dystrophic mouse diaphragmJennifer Pollarine
Department of Medicine, Case Western Reserve University, 10701 East Boulevard, Cleveland, Ohio 44106, USA
Muscle Nerve 36:672-8. 2007..This has important implications for increased susceptibility to respiratory failure in laminin alpha2-deficient muscular dystrophy... - Reduced fatigue in diaphragm muscle of merosin-deficient DY/DY dystrophic miceErik van Lunteren
Department of Medicine Pulmonary, Cleveland VA Medical Center and Case Western Reserve University, Ohio 44106, USA
Respiration 70:636-42. 2003..The effects of dystrophin deficiency on diaphragm contractile function are well delineated, whereas the consequences of merosin (laminin alpha2) deficiency are not well defined... - Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channelsErik van Lunteren
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
J Appl Physiol 95:602-10. 2003..These data indicate that voluntary running slows diaphragm action potential repolarization, most likely by modulating K+ channel number or function... - Inotropic effects of the K+ channel blocker 3,4-diaminopyridine: differential responses of rat soleus and extensor digitorum longusErik van Lunteren
Cleveland Department of Veterans Affairs Medical Center, Cleveland OH, USA
IEEE Trans Neural Syst Rehabil Eng 14:419-26. 2006..Thus, the K+ channel blocker DAP improves contractile performance of limb muscles, but the profile of improvement is distinct between the soleus and EDL muscles... - Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performanceErik van Lunteren
Department of Medicine, Pulmonary, Case Western Reserve University and Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Appl Physiol 97:895-901. 2004.... - Differential susceptibility of muscles to myotonia and force impairment in a mouse model of myotonic dystrophyMichelle Moyer
Department of Medicine, Division of Pulmonary, Critical Care and Sleep, Cleveland VA Medical Center, K201, 10701 East Boulevard, Cleveland, Ohio 44106, USA
Muscle Nerve 43:818-27. 2011..Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation resulting from persistent electrical discharges... - Modulation of biphasic rate of end-plate potential recovery in rat diaphragmErik van Lunteren
Department of Medicine, Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
Muscle Nerve 31:321-30. 2005.... - Slowing of rat diaphragm action potential depolarization by endurance treadmill trainingErik van Lunteren
Department of Medicine Pulmonary 111J W, Case Western Reserve University and Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
Neurosci Lett 339:175-8. 2003..Thus treadmill running endurance exercise training slows rat diaphragm action potential depolarization but not repolarization, suggestive of altered Na+ but not K+ channel function... - Role of K+ channels in L-6 myoblast migrationErik van Lunteren
Department of Medicine Pulmonary Division, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, 10701 East Boulevard, Cleveland OH 44106, USA
J Muscle Res Cell Motil 23:197-204. 2002..These data indicate that in L-6 myoblasts migration is regulated by K+ channels, and that several types of K+ channels appear to participate in cell migration... - Impaired Wheel Running Exercise in CLC-1 Chloride Channel-Deficient Myotonic MiceErik van Lunteren
Cleveland Department of Veterans Affairs Medical Center Cleveland, OH, USA
Front Physiol 2:47. 2011..Conclusion/Significance: These findings indicate that CLC-1 chloride deficient myotonia in mice markedly impairs spontaneous exercise activity, with reductions in both total distance and consecutive running times... - Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtypeDara S Berger
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
PLoS ONE 6:e19274. 2011.... - Beer and the respiratory muscles: the adverse effects of ascitesErik van Lunteren
J Appl Physiol 104:1551-2. 2008
Research Grants
- Transmitter Repletion: Key to Phrenic-Diaphragm FunctionErik van Lunteren; Fiscal Year: 2005..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..