Research Topics
Species | Benigno RodriguezSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?Keri N Althoff
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
AIDS Res Ther 7:45. 2010..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ?50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...- Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAARTBenigno Rodriguez
University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, OH
J Int Assoc Physicians AIDS Care (Chic) 6:198-202. 2007..Studies with longer follow-up and detailed metabolic and immunologic monitoring are needed to confirm these findings and assess their significance and mechanisms... - In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infectionBenigno Rodriguez
Case Western Reserve University Center for AIDS Research, Cleveland, OH 44106 5083, USA
Clin Immunol 136:400-8. 2010..Our results indicate that naïve T cell proliferation predicts response to neo-, but not recall antigens, and suggest that it may be a meaningful reflection of in vivo immune competence in HIV-infected persons... - Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infectionBenigno Rodriguez
Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, USA
JAMA 296:1498-506. 2006..Plasma human immunodeficiency virus (HIV) RNA level predicts HIV disease progression, but the extent to which it explains the variability in rate of CD4 cell depletion is poorly characterized... - Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell functionSara J Conry
Department of Medicine, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland, OH, USA
J Virol 83:11175-87. 2009.... - TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infectionNicole L Yonkers
Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Veterans Affairs Medical Center, University Hospitals of Cleveland and Cleveland Clinic Foundation, Cleveland, OH 44106, USA
J Immunol 178:4436-44. 2007.... - Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infectionNicole L Yonkers
Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland and VA Medical Center, Cleveland, OH, USA
Clin Immunol 131:288-97. 2009..These data indicate that during viral infection with HIV, accessory cell dependent NK function in the periphery is impaired. This impairment may be related to the identified MDC numerical defect... - Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infectionWei Jiang
Case Western Reserve University, Cleveland, Ohio 44106, USA
J Infect Dis 199:1177-85. 2009..These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection... - Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activationNicholas T Funderburg
Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, OH, USA
Blood 115:161-7. 2010..Thus, drivers of immune activation in HIV disease, such as HIV replication, and potentially, microbial translocation, may activate clotting cascades and contribute to thrombus formation and cardiovascular morbidities in HIV infection... - Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progressionGareth A D Hardy
Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7288, USA
Blood 113:5497-505. 2009..Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression... - Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cellsHua Liang
Department of Medicine, Division of Infectious and Rheumatic Diseases, Case Western Reserve University, Center for AIDS Research and VA Medical Center, Cleveland Ohio 44106, USA
J Virol 83:5693-707. 2009.... - Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV diseaseBenigno Rodriguez
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
J Leukoc Biol 90:621-8. 2011..These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation... - Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesisNicholas Funderburg
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
PLoS ONE 3:e1915. 2008..These events may contribute to the pathogenesis of immune dysfunction and CD4+ T cell losses in chronic infection with the human immunodeficiency virus... - Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cellsMichael M Lederman
Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Infect Dis 204:1217-26. 2011..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection... - Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagementScott F Sieg
Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, Ohio 44106 4984, USA
J Infect Dis 192:62-70. 2005..Thus, in HIV infection, central memory T cells may be highly susceptible to bystander mechanisms of immune activation, leading to S-phase entry... - Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infectionBenigno Rodriguez
Division of Infectious Diseases, Case Western Reserve University, Center foe AIDS Research, University Hospitals of Cleveland, Cleveland, Ohio, USA
AIDS 20:1379-89. 2006.... - Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infectionWei Jiang
Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
J Virol 82:7837-45. 2008..Impaired responsiveness to TLR9 agonists may contribute to defects in humoral immunity in HIV infection... - TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting functionWei Jiang
Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 4984, USA
Eur J Immunol 37:2205-13. 2007..We propose that the activation and expansion of naïve B cells induced by TLR9 agonists could enhance the potential of these cells to interact with cognate antigens and facilitate cell-mediated immune responses... - Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expressionElizabeth Mayne
National Health Laboratory Services and University of Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 59:340-6. 2012..In this study, we explore the activation state of platelets in HIV disease... - Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic successRajeev K Mehlotra
Center for Global Health and Diseases and Diseases, Wolstein Research Bldg, Room 4204, 2103 Cornell Rd, Cleveland, OH 44106 7286, USA
J Infect Dis 204:291-8. 2011..In patients receiving highly active antiretroviral therapy (HAART), antiretroviral drug-metabolizing enzyme and transporter gene polymorphisms, as well as chemokine receptor gene polymorphisms, may influence response to treatment... - Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infectionJulia M Sugalski
Department of Medicine, Case Western Reserve University Center for AIDS Research and VA Medical Center, Cleveland, OH 44106, USA
J Immunol 185:3019-27. 2010.... - Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138Michael M Lederman
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
J Infect Dis 194:1677-85. 2006..Although the determinants of immune deficiency and immune restoration in chronic human immunodeficiency virus (HIV)-1 infection are not well understood, immune activation has been proposed as being central to the pathogenesis of HIV... - Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and productionWei Jiang
Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
J Virol 79:4109-19. 2005..Application of CpG ODNs in HIV disease for adjuvant or immunoregulatory purposes may be particularly useful for HIV+ donors without high-level viremia... - Plasma levels of B-lymphocyte stimulator increase with HIV disease progressionBenigno Rodriguez
University Hospitals of Cleveland, Cleveland, OH, USA
AIDS 17:1983-5. 2003..Moreover, BLyS levels increased exponentially below 100 CD4 cells/microl. BLyS and globulin levels increase as HIV dis ease progresses, suggesting a role for BLyS in the hypergammaglobulinemia of HIV infection... - A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adultsLANCE T VERNON
Case Western Reserve University School of Dental Medicine, Department of Biological Sciences, Cleveland, Ohio 44106 4905, USA
AIDS Res Hum Retroviruses 27:1157-66. 2011..In the context of HIV infection, PD may contribute to CVD risk. Intervention studies treating PD may help clarify this association... - Determinants of protection among HIV?exposed seronegative persons: an overviewMichael M Lederman
Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
J Infect Dis 202:S333-8. 2010.... - Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patientsBenigno Rodriguez
University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, Ohio 44106, USA
J Infect Dis 187:504-7. 2003..This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART... - Persistent replication of human immunodeficiency virus type 1 despite treatment of pulmonary tuberculosis in dually infected subjectsHarriet Mayanja Kizza
Case Western Reserve University, Department of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44106-4984, USA
Clin Diagn Lab Immunol 12:1298-304. 2005..Concurrent institution of highly active antiretroviral treatment needs to be evaluated in patients dually infected with pulmonary TB and HIV-1... - Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5Michael M Lederman
Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA
Science 306:485-7. 2004..These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention... - HIV coinfection impairs CD28-mediated costimulation of hepatitis C virus-specific CD8 cellsNicole L Yonkers
Department of Medicine, Cleveland Veterans Administration Medical Center, Center for AIDS Research and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
J Infect Dis 194:391-400. 2006..This functional defect has implications for the pathogenesis of HCV/HIV coinfection... - Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229Grace A McComsey
Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
AIDS 24:2507-15. 2010..Lipoatrophy is prevalent on thymidine nucleoside reverse transcriptase inhibitors (tNRTIs). A pilot trial showed that uridine (NucleomaxX) increased limb fat... - Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infectionNicole L Yonkers
Department of Pathology, Division of Infectious and Rheumatic Diseases, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Infect Dis 203:635-45. 2011..In addition, chronically HCV-infected individuals have reduced response to vaccine. Alterations in naive CD4 T cell phenotype or function may contribute to these immune impairments... - Interferon-alpha administration enhances CD8+ T cell activation in HIV infectionMaura Manion
Division of Infectious Diseases, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
PLoS ONE 7:e30306. 2012..In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic immune activation... - Monitoring clinical trials of therapeutic vaccines in HIV infection: role of treatment interruptionMichael M Lederman
Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
Curr Opin HIV AIDS 2:56-61. 2007.... - Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populationsRebekah L Benish
Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
Infect Genet Evol 10:60-7. 2010.... - Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of antiretroJan Weber
Diagnostic Hybrids, Inc, Cleveland, Ohio, USA
Antimicrob Agents Chemother 55:3729-42. 2011....