Research Topics
Genomes and GenesSpecies | C J MalemudSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosusCharles W Denko
Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5076, USA
BMC Musculoskelet Disord 5:37. 2004..This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects...- Matrix metalloproteinases (MMPs) in health and disease: an overviewCharles J Malemud
Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Front Biosci 11:1696-701. 2006.... - Cytokines as therapeutic targets for osteoarthritisCharles J Malemud
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
BioDrugs 18:23-35. 2004.... - Matrix metalloproteinases: role in skeletal development and growth plate disordersCharles J Malemud
Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
Front Biosci 11:1702-15. 2006..Genetic manipulation to correct defective or dysfunctional MMP genes or MMP activity found in certain human chondrodysplasias may provide a novel strategy for treating medical disorders characterized by skeletal anomalies... - Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinasesC J Malemud
Division of Rheumatic Diseases Department of Medicine and Department of Anatomy, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
Mini Rev Med Chem 6:689-98. 2006..The efficacy of SAPK/MAPK inhibitors in animal models of inflammation, arthritis, heart failure, cancer and neurological degeneration has provided the impetus for using them in human studies of inflammation and in clinical trials... - Growth hormone, VEGF and FGF: involvement in rheumatoid arthritisCharles J Malemud
Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 2061 Cornell Road, Room 207 Cleveland, OH 44106 5076, USA
Clin Chim Acta 375:10-9. 2007..Acidic FGF (FGF-1) and basic FGF (FGF-2) have also been implicated in aberrant synoviocyte proliferation (i.e. synovial hyperplasia) and apoptosis resistance in adult RA... - Inhibitors of stress-activated protein/mitogen-activated protein kinase pathwaysCharles J Malemud
Medicine and Anatomy, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland OH 44106 5076, USA
Curr Opin Pharmacol 7:339-43. 2007..Several of these compounds are already being tested in human subjects to assess their oral bioavailability, pharmacokinetics and toxicity... - Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugsCharles J Malemud
Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Department of Medicine, Division of Rheumatic Diseases, 2061 Cornell Road, Cleveland, Ohio 44106 5076, USA
Expert Opin Ther Targets 12:171-83. 2008..Peripheral inflammation in RA may influence neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, as well as growth factor production, which can modify neural circuitry and contribute to depression... - Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndromeC J Malemud
Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
Clin Exp Rheumatol 27:S86-91. 2009..To critically evaluate the role of several notable 'pain pathways' in the fibromyalgia syndrome (FMS)... - Anticytokine therapy for osteoarthritis: evidence to dateCharles J Malemud
Department of Medicine, Division of Rheumatic Diseases, Department of Anatomy, Case Western Reserve University, School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
Drugs Aging 27:95-115. 2010..Since the prevalence of OA is high in the elderly population, future development of DMOADs must also take into account potential differences in the way DMOADs would be metabolized in the older individual compared with younger people... - Cardiovascular disease complications in systemic lupus erythematosusAlexander Torres
Department of Medicine, Division of Rheumatic Diseases, University Hospitals Case Medical Center, 2061 Cornell Road, Cleveland, OH 44106 5076, USA
Biomark Med 3:239-52. 2009.... - Future directions for research and treatment of osteoarthritisC J Malemud
Departments of Medicine and Anatomy, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 4946, USA
Front Biosci 4:D762-71. 1999.... - Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytesS Islam
Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Osteoarthritis Cartilage 9:684-93. 2001.... - Proteoglycans synthesized by chondrocytes of human nonarthritic and osteoarthritic cartilageR Shuckett
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
Proc Soc Exp Biol Med 190:275-81. 1989..The findings are noteworthy in that these differences were not previously apparent when organ-cultured cartilage was used to assess putative alterations in proteoglycans between the two groups... - Suppression of proteoglycan synthesis in chondrocyte cultures derived from canine intervertebral discJ U Yoo
Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio
Spine (Phila Pa 1976) 17:221-4. 1992.... - Human cartilage from late stage familial osteoarthritis transcribes type II collagen mRNA encoding a cysteine in position 519D Holderbaum
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
Biochem Biophys Res Commun 192:1169-74. 1993..The presence of both mutant and normal alleles of Col2A1 in cDNA derived from cartilage obtained from this patient suggests that Cys519-containing type II collagen may continue to be produced even in advanced stages of osteoarthritis... - Fundamental pathways in osteoarthritis: an overviewC J Malemud
Departments of Medicine and Anatomy, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 4946, USA
Front Biosci 4:D659-61. 1999.... - Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseasesCharles W Denko
Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Semin Arthritis Rheum 35:24-34. 2005.... - Hydrostatic pressure increases apoptosis in cartilage-constructs produced from human osteoarthritic chondrocytesReid Wenger
Department of Orthodontics, Case Western Reserve University School of Dentistry, Cleveland, Ohio 44106-4946, USA
Front Biosci 11:1690-5. 2006..02) the proportion of apoptotic cells in the cartilage-constructs (41% +/- 4.2%; mean +/- SD) compared to control cartilage-constructs (28.5 +/- 8.4%)... - The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patientsCharles W Denko
Department of Medicine, Case Western Reserve University School of Medicine and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106-5076, USA
Front Biosci 9:1660-4. 2004..We conclude that the serum growth hormone to somatostatin ratio may be a useful surrogate marker of disease activity in symptomatic RA... - Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategiesCharles J Malemud
Department of Medicine, Case Western Reserve University School of Medicine, and Research Institute of University Hospitals of Cleveland, Ohio 44106 5076, USA
Cells Tissues Organs 174:34-48. 2003..MAPK activity appears critical for regulating chondrocyte and synoviocyte apoptosis and MMP genes... - Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndromeCharles W Denko
Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Rheumatol Int 25:146-51. 2005..e., 27 microU/ml(-1)). Based on these results, basal serum GH and fasting serum insulin levels appear to be valuable surrogate markers in clinically active, normoglycemic fibromyalgia patients... - Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH)Charles W Denko
Department of Medicine, Case Western Reserve University School of Medicine, and the Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 41106-4946, USA
Front Biosci 7:a37-43. 2002..Clinical improvement did not alter serum IGF-I concentration. We conclude that serum GH concentration could be employed to monitor clinical remission in DISH... - Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9Kalpana Gupta
Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Arthritis Rheum 56:3326-35. 2007..Among these bands is an approximately 125-130-kd band for high molecular weight (HMW) gelatinase, which has not been characterized. This study was undertaken to characterize the HMW MMP activity in OA SF... - Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2Najmul Islam
Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4946, USA
J Cell Biochem 87:266-78. 2002..These results indicated that HP is a strong inducer of apoptosis in osteoarthritic human chondrocytes in vitro... - Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytesRashmi Singh
Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106-4946, USA
J Orthop Res 21:102-9. 2003..These are novel findings and indicate that EGCG may be of potential benefit in inhibiting IL-1beta-induced catabolic effects in OA chondrocytes that are dependent on JNK activity... - Intra-erythrocyte deposition of growth hormone in rheumatic diseasesCharles W Denko
Department of Medicine, Case Western Reserve University School of Medicine, Division of Rheumatic Diseases, Foley Building, Room 207, 2061 Cornell Road, Cleveland, OH 44106-5076, USA
Rheumatol Int 23:11-4. 2003..While intra-erythrocyte GH levels exceeded serum GH levels in osteoarthritis and DISH, intra-erythrocyte GH was not a strong predictor of serum GH levels in osteoarthritis, DISH, or in the control group... - Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fracturesAlicia L Bertone
Comparative Orthopedic Research Laboratories, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
Am J Vet Res 66:1881-90. 2005..Thus, tissue in the OC bed may be degenerative cartilage, whereas tissue in the fracture bed may be reparative fibrous callus... - Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH)Charles W Denko
Department of Medicine, Division of Rheumatic Diseases, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 44106-5076, USA
Rheumatol Int 26:292-7. 2006..However, BMI did not correlate with either basal serum GH (adjusted r2 = -0.013) or IGF-1 levels (adjusted r2 = -0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH...