Research Topics
| David T LodowskiSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Comparative analysis of GPCR crystal structuresDavid T Lodowski
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
Photochem Photobiol 85:425-30. 2009..In this review we summarize recent progress on the structure and activation of rhodopsin in the context of other GPCR structures...- Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchangeDavid T Lodowski
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4965, United States
Biochemistry 49:9425-7. 2010..These results indicate the utility of His-HDX in examining structural rearrangements in native source and membrane proteins without requiring structural modification... - Chemokine receptors and other G protein-coupled receptorsDavid T Lodowski
Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
Curr Opin HIV AIDS 4:88-95. 2009..CXCR4 and CCR5 are utilized as co-receptors during HIV viral entry and, therefore, crystal structures of GPCRs aid in the understanding of their function in viral entry... - Importance of membrane structural integrity for RPE65 retinoid isomerization activityMarcin Golczak
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 285:9667-82. 2010..Thus, our results indicate that the enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment... - Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatasesScott Becka
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
Cell Commun Adhes 17:34-47. 2010..The authors conclude from these experiments that PCP-2 is likely to have a distinct biological function other than cell-cell aggregation... - Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterizationBeata Jastrzebska
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
J Struct Biol 176:387-94. 2011..The molecular envelope thus determined accommodated two Rho molecules together with one G(t) heterotrimer, corroborating the heteropentameric structure of the Rho(?)·G(t) complex... - Crystal structure of native RPE65, the retinoid isomerase of the visual cyclePhilip D Kiser
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
Proc Natl Acad Sci U S A 106:17325-30. 2009.... - Crystal packing analysis of Rhodopsin crystalsDavid T Lodowski
Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
J Struct Biol 158:455-62. 2007..The inter-monomer surface contacts are different for each model, but several of these models coincide in implicating helix I, II, and H-8 as contributors to the main contact surface stabilizing the dimers... - Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changesPaul S H Park
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
Annu Rev Pharmacol Toxicol 48:107-41. 2008..More recent studies indicate a need to move beyond these classical paradigms and to consider additional aspects of the molecular character of GPCRs, such as the oligomerization and dynamics of the receptor... - Structural characterization of the rod cGMP phosphodiesterase 6Anna Goc
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
J Mol Biol 401:363-73. 2010.... - Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ionsPhilip D Kiser
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:457-61. 2007..In general, the structure is similar to the previously determined wild-type GroEL crystal structure with some differences in regard to temperature-factor distribution... - Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1Natalia Mast
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 286:5607-13. 2011.... - Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregationPeng Zhang
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Cell Commun Adhes 16:146-53. 2009..These results further support the hypothesis that mutational inactivation of PTPrho may lead to cancer progression by disrupting cell-cell adhesion... - A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase muSusan M Burden-Gulley
Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
Neoplasia 12:305-16. 2010..Such a tool has clear translational applications and may lead to improved surgical resections and prognosis for patients with this devastating disease... - Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluationsWenyu Sun
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
Vision Res 47:2055-66. 2007..Thus, impairment of retinal structure and function for patients carrying these mutations correlated with the biochemical properties of the mutants...