Irving Kushner

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk?
    Irving Kushner
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Arch Intern Med 162:867-9. 2002
  2. ncbi The trivialization of diagnosis
    Irving Kushner
    Department of Medicine, Case Western Reserve University, Metro Health Campus, Cleveland, Ohio 44109 1998, USA
    J Hosp Med 5:116-9. 2010
  3. ncbi What does minor elevation of C-reactive protein signify?
    Irving Kushner
    Department of Medicine, Case Western Reserve University, MetroHealth Medical Center Campus, Cleveland, Ohio, USA
    Am J Med 119:166.e17-28. 2006
  4. ncbi The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive protein gene promoter
    Hyunjoo Cha-Molstad
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Immunol 44:2933-42. 2007
  5. ncbi Binding of C/EBPbeta to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA
    Duprane Pedaci Young
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 181:2420-7. 2008
  6. ncbi Improving albumin levels among hemodialysis patients: a community-based randomized controlled trial
    Janeen B Leon
    Division of Nephrology, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Kidney Dis 48:28-36. 2006
  7. ncbi C-reactive Protein
    Steven Black
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:48487-90. 2004
  8. ncbi Do acute-phase reactants predict response to glucocorticoid therapy in retroperitoneal fibrosis?
    Marina N Magrey
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Arthritis Rheum 61:674-9. 2009
  9. ncbi Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury
    Frederick Frost
    Cleveland Clinic Foundation, MetroHealth Medical Center, Cleveland, OH 44195, USA
    Arch Phys Med Rehabil 86:312-7. 2005
  10. ncbi Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3
    Alok Agrawal
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    Immunology 108:539-47. 2003

Collaborators

  • Alok Agrawal
  • Steven B Black
  • Mazen Elyan
  • Duprane Pedaci Young
  • Marina N Magrey
  • David Samols
  • Hyunjoo Cha-Molstad
  • Janeen B Leon
  • Frederick Frost
  • Leonard H Calabrese
  • M Elaine Husni
  • Edith Lerner
  • Jennifer Zimmerer
  • Laurine Sperry
  • Jeffrey M Albert
  • Suzanne Mach
  • Ashwini R Sehgal
  • Gina Gilchrist
  • Edmond Ricanati
  • Catherine Sullivan
  • Angela Majerle
  • David Porter
  • Mary Jo Roach
  • Peter Schreiber

Detail Information

Publications14

  1. ncbi Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk?
    Irving Kushner
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Arch Intern Med 162:867-9. 2002
    ..We conclude that at present, none of the 3 major criteria--accuracy, reliability, and likelihood of beneficial intervention--are satisfied...
  2. ncbi The trivialization of diagnosis
    Irving Kushner
    Department of Medicine, Case Western Reserve University, Metro Health Campus, Cleveland, Ohio 44109 1998, USA
    J Hosp Med 5:116-9. 2010
    ..Nonetheless, it is clear that diagnosis must continue to play a central role in clinical medicine. We propose several ways by which we can resist these forces and assure that diagnosis retains its appropriate position of primacy...
  3. ncbi What does minor elevation of C-reactive protein signify?
    Irving Kushner
    Department of Medicine, Case Western Reserve University, MetroHealth Medical Center Campus, Cleveland, Ohio, USA
    Am J Med 119:166.e17-28. 2006
    ....
  4. ncbi The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive protein gene promoter
    Hyunjoo Cha-Molstad
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Immunol 44:2933-42. 2007
    ....
  5. ncbi Binding of C/EBPbeta to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA
    Duprane Pedaci Young
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 181:2420-7. 2008
    ..We conclude that the CRP promoter has a low level of transcription factor occupancy in the absence of cytokines and induction occurs with binding of C/EBP, and that c-Rel and TBP are important for modulating CRP expression...
  6. ncbi Improving albumin levels among hemodialysis patients: a community-based randomized controlled trial
    Janeen B Leon
    Division of Nephrology, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Kidney Dis 48:28-36. 2006
    ..CONCLUSION: A nutrition intervention tailored to patient-specific barriers resulted in modest improvements in albumin levels regardless of levels of inflammatory markers...
  7. ncbi C-reactive Protein
    Steven Black
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:48487-90. 2004
    ..This review will largely focus on our current understanding of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions...
  8. ncbi Do acute-phase reactants predict response to glucocorticoid therapy in retroperitoneal fibrosis?
    Marina N Magrey
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Arthritis Rheum 61:674-9. 2009
    ....
  9. ncbi Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury
    Frederick Frost
    Cleveland Clinic Foundation, MetroHealth Medical Center, Cleveland, OH 44195, USA
    Arch Phys Med Rehabil 86:312-7. 2005
    ..To determine the relation between serologic markers of information and clinical characteristics of people with chronic spinal cord injury (SCI)...
  10. ncbi Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3
    Alok Agrawal
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    Immunology 108:539-47. 2003
    ..They raise the possibility, not as yet established, that NF-kappaB activation may be responsible for the synergistic effect of IL-1beta on IL-6-induced CRP expression...
  11. ncbi Why does C-reactive protein predict coronary events?
    Irving Kushner
    Am J Med 121:e11. 2008
  12. ncbi CRP can play both pro-inflammatory and anti-inflammatory roles
    Irving Kushner
    Mol Immunol 44:670-1. 2007
  13. ncbi C-reactive protein and atherosclerosis
    Irving Kushner
    Science 297:520-1. 2002
  14. ncbi Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Immunol 40:373-80. 2003
    ..We conclude that c-Rel regulates CRP expression without the requirement of binding to a kappaB site, and binds directly to C/EBPbeta to facilitate the binding of C/EBPbeta to the CRP promoter...