Ganesh K Kumar

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Analysis of expression and posttranslational modification of proteins during hypoxia
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol 96:1178-86; discussion 1170-2. 2004
  2. ncbi Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    J Physiol 575:229-39. 2006
  3. ncbi Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44109, USA
    J Physiol 577:705-16. 2006
  4. ncbi Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells
    Guoxiang Yuan
    Department of Physiology, Case Western Reserve, University, Cleveland, OH 44106, USA
    J Physiol 557:773-83. 2004
  5. ncbi 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase
    Ying-Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44019, USA
    J Physiol 576:289-95. 2006
  6. ncbi Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body
    Dong-Kyu Kim
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:291-6. 2003
  7. ncbi Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44109, USA
    Exp Physiol 92:39-44. 2007
  8. ncbi Detection of oxygen sensing during intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Methods Enzymol 381:107-20. 2004
  9. ncbi Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction
    Yingjie Peng
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:559-64. 2003
  10. ncbi Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Exp Pharmacol Physiol 32:447-9. 2005

Collaborators

Detail Information

Publications19

  1. ncbi Analysis of expression and posttranslational modification of proteins during hypoxia
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol 96:1178-86; discussion 1170-2. 2004
    ....
  2. ncbi Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    J Physiol 575:229-39. 2006
    ....
  3. ncbi Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44109, USA
    J Physiol 577:705-16. 2006
    ....
  4. ncbi Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells
    Guoxiang Yuan
    Department of Physiology, Case Western Reserve, University, Cleveland, OH 44106, USA
    J Physiol 557:773-83. 2004
    ..These results suggest IH-induced c-fos-mediated transcriptional activation involves oxidative stress...
  5. ncbi 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase
    Ying-Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44019, USA
    J Physiol 576:289-95. 2006
    ....
  6. ncbi Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body
    Dong-Kyu Kim
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:291-6. 2003
  7. ncbi Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44109, USA
    Exp Physiol 92:39-44. 2007
    ....
  8. ncbi Detection of oxygen sensing during intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Methods Enzymol 381:107-20. 2004
  9. ncbi Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction
    Yingjie Peng
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:559-64. 2003
  10. ncbi Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Exp Pharmacol Physiol 32:447-9. 2005
    ..Bilateral sectioning of the sinus nerves abolished these responses, suggesting chronic IH-induced alterations in carotid body sensitivity contribute to LTF in SNA and the subsequent cardiovascular alterations...
  11. ncbi Reactive oxygen species facilitate oxygen sensing
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Novartis Found Symp 272:95-9; discussion 100-5, 131-40. 2006
    ..These observations suggest that chronic IH facilitates O2 sensing in the CB by mechanisms involving increased generation of ROS in the chemoreceptor tissue...
  12. ncbi Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors
    Dong Kyu Kim
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol 96:376-83. 2004
    ..These results demonstrate that glomus cells of the rabbit carotid body express ACh and that hypoxia overall inhibits ACh release via activation of muscarinic and dopaminergic autoinhibitory receptors in the carotid body...
  13. ncbi Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species
    Dong-Kyu Kim
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106-4935, USA
    J Appl Physiol 96:1206-15; discussion 1196. 2004
    ..Our findings also suggest that oxidative stress plays a central role in IH-induced augmentation of transmitter release from PC12 cells during acute hypoxia...
  14. ncbi Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 157:148-53. 2007
    ....
  15. ncbi Oxidative stress in the systemic and cellular responses to intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Biol Chem 385:217-21. 2004
    ....
  16. ncbi Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas
    Ying-Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:10073-8. 2003
    ..The sensory LTF may contribute to persistent reflex activation of sympathetic nerve activity and blood pressure in recurrent apnea patients experiencing CIH...
  17. ncbi Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation
    Ganesh K Kumar
    Department of Biochemistry, Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol 95:536-44. 2003
    ..Our results also suggest that IH-induced phosphorylation of TH facilitates the removal of endogenous inhibition of TH, leading to increased synthesis of dopamine...
  18. ncbi Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 135:145-54. 2003
    ..The combined observations from the pre- and post-genomic era strongly support the involvement of SP and also other tachykinins in the control of respiration during hypoxia...
  19. ncbi ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
    ....