Research Topics
Species | Chandy C JohnSummaryAffiliation: Case Western Reserve University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of KenyaChandy C John
Rainbow Babies and Children s Hospital, RCICH, RBC 487, MS6008, Cleveland, OH 44106, USA
Trans R Soc Trop Med Hyg 99:780-6. 2005..3%. In this epidemic-prone highland area, inter-epidemic periods are characterized by low frequencies of asymptomatically infected individuals. Increases in gametocyte prevalence may be an early indicator of impending outbreaks...- Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infectionChandy C John
Center for Global Health and Diseases, Rainbow Center for International Child Health, Division of Pediatric Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA
Am J Trop Med Hyg 73:222-8. 2005..High levels of IgG antibodies to CSP, LSA-1, and TRAP may be useful immune correlates of protection against P. falciparum infection in malaria-endemic populations... - Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malariaChandy C John
Center for Global Health and Diseases, Case Western Researve University, Cleveland, OH, USA
Infect Immun 72:5135-42. 2004..IFN-gamma responses to LSA-1 appear to require repeated P. falciparum exposure and/or increased age and, as measured by ELISA, are associated with protection against clinical malaria and anemia... - Risk of Plasmodium falciparum infection during a malaria epidemic in highland Kenya, 1997Chandy C John
Rainbow Center for International Child Health, Rainbow Babies and Children s Hospital, Case Western Reserve University, RBC 487, 11100 Euclid Avenue, MS6008, Cleveland, OH 44106, USA
Acta Trop 92:55-61. 2004.... - Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western KenyaAnn M Moormann
Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
Am J Trop Med Hyg 81:489-95. 2009.... - Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic areaAnn M Moormann
Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
Am J Trop Med Hyg 74:585-90. 2006..This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions... - Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of AfricaChandy C John
Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
J Immunol 173:666-72. 2004..falciparum infection, and suggest that the measurement of MSP-1(19) specific inhibitory Abs may serve as an accurate correlate of protection in clinical trials of MSP-1-based vaccines... - Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1 vary by ages of subjects and by season in a highland area of KenyaChandy C John
Center for Global Health and Disease and Division of Pediatric Infectious Disease, Case Western Reserve University School of Medicine and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
Infect Immun 71:4320-5. 2003..falciparum antigens vary in subjects by age and season, and the protective effects of these antibodies against infection may be different in adults and children... - Antibodies to Plasmodium falciparum Erythrocyte-binding Antigen-175 are Associated With Protection From Clinical MalariaMatthew B McCarra
From the Division of Global Pediatrics, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN Centre for Global Health Research, Kenya Medical Research Institute, Kisian, Kenya Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH Department of Pediatrics, University of Massachusetts, Worscester, MA and Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, Bethesda, MD
Pediatr Infect Dis J 30:1037-42. 2011..Many of these studies have not assessed whether high-titer antibodies are associated with protection and have not adjusted for differences in malaria exposure... - Toll-like receptor polymorphisms and cerebral malaria: TLR2 ?22 polymorphism is associated with protection from cerebral malaria in a case control studyJennifer A Greene
Case Western Reserve University, Wolstein Research Building, 2103 Cornell Rd, Cleveland, OH 44106, USA
Malar J 11:47. 2012..There are two common polymorphisms in the 5' un-translated region (UTR) of TLR2, a 22 base pair deletion in the first unstranslated exon (?22), and a GT dinucleotide repeat in the second intron (GTn)... - Drug treatment of malaria in childrenChandy C John
Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA
Pediatr Infect Dis J 22:649-51. 2003 - A family cluster of five cases of group A streptococcal pneumoniaSumita Roy
Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Pediatrics 112:e61-5. 2003..7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease... - Antibodies to Plasmodium falciparum antigens vary by age and antigen in children in a malaria-holoendemic area of KenyaKiprotich Chelimo
Kenya Medical Research Institute, Kisian, Kenya
Pediatr Infect Dis J 24:680-4. 2005..falciparum antigens is infrequent in the first 4 months of life but increases with age and increased exposure. The pattern of age-related IgG response frequencies to P. falciparum antigens varies significantly by antigen... - Microscopy underestimates the frequency of Plasmodium falciparum infection in symptomatic individuals in a low transmission highland areaDavid M Menge
Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Trop Med Hyg 79:173-7. 2008..P. falciparum infection appears to resolve without treatment in most LDR-FMA-positive, microscopy-negative individuals, but is persistent in a subset of these individuals and requires treatment... - Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlandsJustin M Cohen
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Malar J 7:40. 2008..Understanding these local topographic effects may permit prediction of regions at high risk of malaria within the highlands at small spatial scales... - Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan childrenChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
J Infect Dis 197:519-26. 2008..IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria... - Lymphocyte proliferation and antibody responses to Plasmodium falciparum liver-stage antigen-1 in a highland area of Kenya with seasonal variation in malaria transmissionChandy C John
Division of Geographic Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106 4983, USA
Am J Trop Med Hyg 66:372-8. 2002..These data indicate that age and transmission intensity independently affect IgG antibody responses to LSA-1 but do not influence lymphocyte proliferation in this highland area where malaria transmission is highly variable... - Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of diseaseChandy C John
Global Pediatrics Program and Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street, SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
Cytokine 41:204-8. 2008..216, P=0.03) but not IL-8 (76 vs. 62, P=NS). Elevated IL-1ra levels are associated with increased disease severity in children with malaria, and very elevated levels of IL-1ra, G-CSF and MCP-1 are seen in children who die of CM... - Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malariaRobert O Opoka
Department of Paediatrics and Child Health, Mulago Hospital Makerere University Medical School, Kampala, Uganda
Pediatr Infect Dis J 27:319-24. 2008..Differences in mortality in children who are tested by microscopy for Plasmodium falciparum infection as compared with those not tested are not well characterized... - Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factorsKacey C Ernst
University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Malar J 5:78. 2006.... - Low levels of RANTES are associated with mortality in children with cerebral malariaChandy C John
University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Infect Dis 194:837-45. 2006..In children with cerebral malaria (CM), serum chemokine levels and associated morbidity and mortality have not been characterized... - Clinical manifestations of severe malaria in the highlands of southwestern UgandaRichard Idro
Department of Pediatrics and Child Health, Makerere University Medical School/Mulago Hospital, Kampala, Uganda
Am J Trop Med Hyg 72:561-7. 2005..quot;Typical" signs like splenomegaly are frequently absent, prostration is the major manifestation, and other manifestations vary in frequency according to age...