B D Hoit

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi New approaches to phenotypic analysis in adult mice
    B D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA
    J Mol Cell Cardiol 33:27-35. 2001
  2. ncbi Echocardiographic characterization of the cardiovascular phenotype in rodent models
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Toxicol Pathol 34:105-10. 2006
  3. ncbi Spectral and color M-mode Doppler in genetically altered mice. Assessment of diastolic function
    B D Hoit
    Division of Cardiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106 5038, USA
    Minerva Cardioangiol 51:609-18. 2003
  4. ncbi Obstructive sleep apnea is a false-negative cause of flow velocity paradoxus in pericardial effusion: case report
    H Paydak
    Division of Cardiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5029, USA
    Echocardiography 18:685-8. 2001
  5. ncbi Murine physiology: measuring the phenotype
    Brian D Hoit
    Department of Medicine, Division of Cardiology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 37:377-87. 2004
  6. ncbi Left ventricular diastolic function
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA
    Crit Care Med 35:S340-7. 2007
  7. ncbi Pericardial disease and pericardial tamponade
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA
    Crit Care Med 35:S355-64. 2007
  8. ncbi Remodeling of the left atrium in pacing-induced atrial cardiomyopathy
    Brian D Hoit
    University Hospitals of Cleveland and Case Western Reserve University, OH, USA
    Mol Cell Biochem 238:145-50. 2002
  9. ncbi Management of effusive and constrictive pericardial heart disease
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio, USA
    Circulation 105:2939-42. 2002
  10. ncbi Phenotype-driven genetic approaches in mice: high-throughput phenotyping for discovering new models of cardiovascular disease
    B D Hoit
    Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Trends Cardiovasc Med 11:82-9. 2001

Research Grants

  1. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003

Collaborators

Detail Information

Publications85

  1. ncbi New approaches to phenotypic analysis in adult mice
    B D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA
    J Mol Cell Cardiol 33:27-35. 2001
    ....
  2. ncbi Echocardiographic characterization of the cardiovascular phenotype in rodent models
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Toxicol Pathol 34:105-10. 2006
    ..Although not conventionally considered a biomarker, the technique has the potential to be exploited as a marker of intentional or unanticipated toxic biological effects in the preclinical development of drugs and chemicals...
  3. ncbi Spectral and color M-mode Doppler in genetically altered mice. Assessment of diastolic function
    B D Hoit
    Division of Cardiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106 5038, USA
    Minerva Cardioangiol 51:609-18. 2003
    ....
  4. ncbi Obstructive sleep apnea is a false-negative cause of flow velocity paradoxus in pericardial effusion: case report
    H Paydak
    Division of Cardiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5029, USA
    Echocardiography 18:685-8. 2001
    ....
  5. ncbi Murine physiology: measuring the phenotype
    Brian D Hoit
    Department of Medicine, Division of Cardiology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 37:377-87. 2004
    ..Such stringent conditions are crucial because it is phenotypic analysis that ultimately determines the utility of genetically altered and spontaneous mutant mice for biomedical research...
  6. ncbi Left ventricular diastolic function
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA
    Crit Care Med 35:S340-7. 2007
    ....
  7. ncbi Pericardial disease and pericardial tamponade
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA
    Crit Care Med 35:S355-64. 2007
    ..This article reviews the pathogenesis and diagnosis of pericardial heart disease, focusing on the diagnostic utility of echocardiography, with an emphasis on those areas of greatest interest to the intensivist...
  8. ncbi Remodeling of the left atrium in pacing-induced atrial cardiomyopathy
    Brian D Hoit
    University Hospitals of Cleveland and Case Western Reserve University, OH, USA
    Mol Cell Biochem 238:145-50. 2002
    ..Thus, rapid pacing-induced atrial failure is associated with differential changes in MMP activity, an unchanged number of calcium pumps, and compensatory changes in the level of phospholamban...
  9. ncbi Management of effusive and constrictive pericardial heart disease
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio, USA
    Circulation 105:2939-42. 2002
  10. ncbi Phenotype-driven genetic approaches in mice: high-throughput phenotyping for discovering new models of cardiovascular disease
    B D Hoit
    Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Trends Cardiovasc Med 11:82-9. 2001
    ..Insights into the genetic control of these diseases could lead to improved diagnosis and treatment as well as a deeper understanding of basic physiological processes...
  11. ncbi Influence of left ventricular dysfunction on the role of atrial contraction: an echocardiographic-hemodynamic study in dogs
    B D Hoit
    Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106, USA
    J Am Coll Cardiol 36:1713-9. 2000
    ..The purpose of this study was to understand the significance of an effective atrial systole and the interactions between atrial and ventricular function...
  12. ncbi Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution
    B D Hoit
    Division of Cardiology, University of Cincinnati Medical Center, Cincinnati 45267 0575, Ohio
    Am J Physiol Heart Circ Physiol 278:H958-63. 2000
    ..Furthermore, our data suggest a dissociation of processes within the SR that govern contraction and relaxation...
  13. ncbi beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals
    B D Hoit
    Division of Cardiology and the Departments of Medicine and Pharmacology, University of Cincinnati, Ohio, USA
    Am Heart J 139:537-42. 2000
    ..The Gly16 beta(2)-adrenergic receptor (beta(2)AR) polymorphism is a common variant of the beta(2)AR that displays depressed function caused by enhanced receptor downregulation in vitro compared with the Arg16 receptor...
  14. ncbi Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo
    J Zhai
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Biol Chem 275:10538-44. 2000
    ..Thus, pentameric phospholamban N27A mutant can act as a superinhibitor of the affinity of SERCA2a for Ca(2+) and of cardiac contractility in vivo...
  15. ncbi Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo
    G Chu
    Department of Pharmacology and Cell Biophysics, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Biol Chem 273:33674-80. 1998
    ..These findings suggest that pentameric assembly of phospholamban is necessary for optimal regulation of myocardial contractility in vivo...
  16. ncbi Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice
    V J Kadambi
    Department of Pharmacology, University of Cincinnati, College of Medicine, Ohio 45267, USA
    J Clin Invest 97:533-9. 1996
    ....
  17. ncbi Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure
    K Haghighi
    Department of Pharmacology and Cell Biophysics, Division of Cardiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 276:24145-52. 2001
    ..These results suggest a causal relationship between defective SR Ca(2+) cycling and cardiac remodeling leading to heart failure, with a gender-dependent influence on the time course of these alterations...
  18. ncbi Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice
    Y Sato
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 273:28470-7. 1998
    ..These findings suggest that calsequestrin overexpression is associated with increases in SR Ca2+ capacity, but decreases in Ca2+-induced SR Ca2+ release, leading to depressed contractility in the mammalian heart...
  19. ncbi Effect of angiotensin type I-receptor blockade on left ventricular remodeling in pressure overload hypertrophy
    S Kiatchoosakun
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106-5038, USA
    J Card Fail 7:342-7. 2001
    ....
  20. ncbi In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency
    B D Hoit
    Division of Cardiology, University of Cincinnati, Ohio 45267 0542, USA
    Circ Res 77:632-7. 1995
    ..These findings indicate that assessment of LV function can be performed noninvasively in mice under varying physiological conditions and that PLB regulates basal LV function in vivo...
  21. ncbi Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106-5029, USA
    J Mol Cell Cardiol 33:1637-48. 2001
    ..In addition, the differential inhibition of p90RSK and BMK1 in hearts with congestive heart failure suggests the specific role of these two kinases to maintain cardiac function under chronic pressure-overload...
  22. ncbi Effects of tribromoethanol anesthesia on echocardiographic assessment of left ventricular function in mice
    S Kiatchoosakun
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-5038, USA
    Comp Med 51:26-9. 2001
    ..The effects to tribromoethanol anesthesia were similar among three commonly used mice strains...
  23. ncbi Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy
    H Wakasaki
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:9320-5. 1997
    ..These findings have firmly established that the activation of the PKCbeta2 isoform can cause specific cardiac cellular and functional changes leading to cardiomyopathy of diabetic or nondiabetic etiology...
  24. ncbi Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Cardiovasc Res 45:883-8. 2000
    ..Thus we examined whether protein kinase C activation and decreased Ca2+ cycling protein levels could be reversed by left ventricular assist device support...
  25. ncbi Naturally occurring variation in cardiovascular traits among inbred mouse strains
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, MS 5038, Cleveland, Ohio 44106 5038, USA
    Genomics 79:679-85. 2002
    ....
  26. ncbi Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations
    Joseph H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genome Res 13:2082-91. 2003
    ..These networks are therefore an important approach for defining and characterizing functional relations in complex biological systems in health and disease...
  27. ncbi Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol 99:1796-801. 2005
    ....
  28. ncbi Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload
    David J Chess
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    J Card Fail 14:82-8. 2008
    ..This study investigated the effects of a high-fat diet on the development of cardiac hypertrophy...
  29. ncbi Vascular reactivity in heart failure: role of myosin light chain phosphatase
    Syed M Karim
    Department of Physiology, Case Western Reserve Univerisity, Cleveland, Ohio 44106 4970, USA
    Circ Res 95:612-8. 2004
    ..The data suggest that the resistance to NO-mediated relaxation observed during CHF lies at least in part at the level of the smooth muscle and is a consequence of the decrease in the expression of the LZ+ MYPT1 isoform...
  30. ncbi Selective aldosterone blockade suppresses atrial tachyarrhythmias in heart failure
    Sunil C Shroff
    Department of Medicine/Cardiology, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 17:534-41. 2006
    ..Aldosterone blockade may be a promising new approach for atrial tachyarrhythmia prevention in CHF...
  31. ncbi Routine transesophageal echocardiography for the evaluation of cerebral emboli in elderly patients
    Sergey Vitebskiy
    University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106-5038, USA
    Echocardiography 22:770-4. 2005
    ..Until the benefits of specific therapies for these conditions are known, routine TEE in elderly patients with suspected embolic neurological events appears to be unwarranted...
  32. ncbi Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice
    Michael D Faulx
    Division of Cardiology, Dept. of Medicine, Univ. Hospitals of Cleveland and Case Western Reserve Univ, MS 5038, 11100 Euclid Ave, Cleveland, OH 44106-5038, USA
    Am J Physiol Heart Circ Physiol 289:H30-6. 2005
    ..Abnormalities in beta-adrenergic regulation may contribute to strain-related differences in the vulnerability to isoproterenol-induced cardiac changes...
  33. ncbi Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy
    Qiujing Song
    Department of Pharmacology and Cell Biophysics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Clin Invest 111:859-67. 2003
    ..Thus, PLN ablation normalized contractility in isolated myocytes, but failed to rescue the cardiomyopathic phenotype elicited by activation of the Galphaq pathway or MyBP-C mutations...
  34. ncbi Intrafamilial variability of noncompaction of the ventricular myocardium
    Mark T Johnson
    Department of Genetics, Case University, Cleveland, OH, USA
    Am Heart J 151:1012.e7-14. 2006
    ..Evaluation of families with NVM requires careful assessment that uses a combination of imaging techniques and diagnostic criteria...
  35. ncbi High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction
    Julie H Rennison
    Dept of Physiology and Biophysics, School of Medicine E558, Case Western Reserve Univ, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 292:H1498-506. 2007
    ....
  36. ncbi Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats
    Kin M Choi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Heart Circ Physiol 283:H1398-408. 2002
    ..The increase in phospholamban, decrease in Na(+)/Ca(2+) exchanger, and unchanged L-type Ca(2+) channel activity in this model of diabetic cardiomyopathy are distinct from other types of cardiomyopathy...
  37. ncbi Bimodal cardiac dysfunction in an animal model of iron overload
    Tianen Yang
    Rammelkamp Center for Education and Research, MetroHealth Campus, 2500 MetroHealth Drive R301, Cleveland, OH 44109-1998, USA
    J Lab Clin Med 140:263-71. 2002
    ....
  38. ncbi Type 1 phosphatase, a negative regulator of cardiac function
    Andrew N Carr
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Cell Biol 22:4124-35. 2002
    ..Thus, PP1 is an important regulator of cardiac function, and inhibition of its activity may represent a novel therapeutic target in heart failure...
  39. ncbi Prevalence of unsuspected and significant mitral and aortic regurgitation
    Gregory Stefano
    Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5038, USA
    J Am Soc Echocardiogr 21:38-42. 2008
    ..We sought to determine the prevalence of unsuspected, pre-existing valvular regurgitation in a large, heterogeneous population of patients referred for an echocardiogram...
  40. ncbi Mouse strain-specific differences in cardiac metabolic enzyme activities observed in a model of isoproterenol-induced cardiac hypertrophy
    Michael D Faulx
    Department of Medicine, Division of Cardiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5038, USA
    Clin Exp Pharmacol Physiol 34:77-80. 2007
    ..The metabolic adaptations associated with ISO-induced hypertrophy differ from those reported with pressure overload hypertrophy...
  41. ncbi Images in cardiovascular medicine. Case of anomalous right superior vena cava
    Hesham Sadek
    Department of Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, Tex, USA
    Circulation 114:e532-3. 2006
  42. ncbi Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA
    Am J Physiol Heart Circ Physiol 290:H1899-904. 2006
    ..In conclusion, LV dysfunction and dilation are not worsened despite upregulation of the fatty acid metabolic pathway and LV hypertrophy or accumulation of myocardial triglyceride in the rat infarct model of HF...
  43. ncbi Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure
    Julie H Rennison
    Department of Physiology and Biophysics, School of Medicine E558, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    J Mol Cell Cardiol 46:883-90. 2009
    ..These studies support the concept that high fat feeding can modify multiple cellular pathways that differentially affect mitochondrial function under normal and pathological conditions...
  44. ncbi Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA
    Eur J Heart Fail 8:687-93. 2006
    ..In conclusion, reduced mRNA expression of PPAR/RXR regulated genes is not dependent on reduced PPAR/RXR protein expression...
  45. ncbi Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model
    Hiranmoy Das
    The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 4:e7325. 2009
    ..Therapeutic potential was evaluated in a rat model of myocardial infarction using nanofiber-expanded human cord blood derived hematopoietic stem cells (CD133+/CD34+) genetically modified with VEGF plus PDGF genes (VIP)...
  46. ncbi The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation
    Zhan Yin
    Department of Pharmacology and Cancer Center, University Hospitals of Cleveland, OH 44106 4965, USA
    Proc Natl Acad Sci U S A 99:10488-93. 2002
    ..These findings demonstrate that Cited2 is an indispensable regulatory gene during prenatal development...
  47. ncbi Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy
    Yasuchika Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Cardiovasc Res 53:131-7. 2002
    ..However, the abundance and activity of these kinases in human hearts are unknown...
  48. ncbi The myocardial performance index in patients with aortic stenosis
    Jude A Mugerwa
    Division of Cardiology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106-5038, USA
    Echocardiography 19:267-72. 2002
    ..CONCLUSIONS: Doppler-derived MPI reflects severity of global left ventricular dysfunction in patients with aortic stenosis and may be of clinical value in this patient population...
  49. ncbi The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure
    Jessica M Berthiaume
    Dept of Physiology and Biophysics, School of Medicine E521, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 299:H410-21. 2010
    ....
  50. ncbi Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload
    Monika K Duda
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Cardiovasc Res 76:303-10. 2007
    ..We assessed the effects of dietary supplementation with omega-3 PUFA from fish oil on the response of the left ventricle (LV) to arterial pressure overload...
  51. ncbi Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload
    David J Chess
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1853-60. 2007
    ....
  52. ncbi Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats
    Margaret P Chandler
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 293:H1609-16. 2007
    ..These results, demonstrating enhanced remodeling and LV dysfunction 8 wk postligation provide evidence of an accelerated progression of heart failure in T2D rats...
  53. ncbi High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Am J Hypertens 20:403-9. 2007
    ..We investigated the effects of consuming either a high complex carbohydrate diet, a high simple sugar diet, or a high fat diet on cardiac hypertrophy and mortality in hypertensive Dahl salt-sensitive (DSS) rats...
  54. ncbi Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet
    Isidore C Okere
    Department of Physiology, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Clin Exp Pharmacol Physiol 34:113-9. 2007
    ..5. Taken together, the data suggest that consuming a high-fat diet or inhibiting CPT-I do not result in cardiac hypertrophy or cardiac dysfunction in normal rats...
  55. ncbi Real time embolization of a mitral valve vegetation
    Hesham A Sadek
    Division of Cardiology, UT Southwestern, Dallas, Texas, USA
    Echocardiography 24:768-9. 2007
  56. ncbi High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat
    Isidore C Okere
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    Clin Exp Pharmacol Physiol 32:825-31. 2005
    ..It remains to be determined whether preventing cardiac hypertrophic adaptations would be deleterious to the heart if the hypertensive stress is maintained long term...
  57. ncbi Assessment of left ventricular mass in mice: comparison between two-dimensional and m-mode echocardiography
    Songsak Kiatchoosakun
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106-5038, USA
    Echocardiography 19:199-205. 2002
    ..CONCLUSIONS: The 2-D area-length method is an accurate method of LV mass determination in symmetrical ventricles and can be used as an alternative for in vivo measurement of LV mass in mice...
  58. ncbi Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure
    Julie H Rennison
    Department of Physiology and Biophysics, School of Medicine E553, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Cardiovasc Res 79:331-40. 2008
    ..The aim of the present study was to investigate possible mechanisms by which high fat feeding improved mitochondrial and contractile function in heart failure...
  59. ncbi Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction
    Monika K Duda
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Card Fail 14:327-35. 2008
    ..We hypothesized that a low-carbohydrate/high-fat diet prevents LV hypertrophy and dysfunction compared with high-carbohydrate diets...
  60. ncbi High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    J Hypertens 26:1402-10. 2008
    ..We investigated the effects of high-fructose or sucrose diets on ventricular function and mortality in hypertensive Dahl salt-sensitive rats...
  61. ncbi Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis
    Helen Kiriazis
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
    Cardiovasc Res 53:372-81. 2002
    ..To determine whether the hyperdynamic phospholamban-knockout hearts are capable of withstanding a chronic aortic stenosis...
  62. ncbi Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation
    Bridgette Christopher
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106, USA
    J Muscle Res Cell Motil 30:111-23. 2009
    ..These findings suggest that altered TnI function, due to changes in the distribution of phosphorylated sites, is an early contributor to reduced contractility of the heart...
  63. ncbi The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance
    Darryl Miller
    University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Am Soc Echocardiogr 17:443-7. 2004
    ....
  64. ncbi Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension
    Isidore C Okere
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA
    Hypertension 48:1116-23. 2006
    ..In conclusion, increased dietary lipid intake can reduce cardiac growth, left ventricular remodeling, contractile dysfunction, and alterations in gene expression in response to hypertension...
  65. ncbi Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western University, Univ. Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106-5038, USA
    Am J Physiol Heart Circ Physiol 287:H2049-53. 2004
    ..These findings support the use of WMSI and MPI as indexes of global LV function in the rat infarction model of heart failure...
  66. ncbi Detection of endothelial dysfunction with brachial artery ultrasound scanning
    Michael D Faulx
    Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-5038, USA
    Am Heart J 145:943-51. 2003
    ....
  67. ncbi Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin
    Isidore C Okere
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 291:H38-44. 2006
    ..In conclusion, dietary fatty acid composition affects cardiac ceramide accumulation, cardiomyocyte apoptosis, and expression of PPAR-regulated genes independent of cardiac mass or function...
  68. ncbi Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA
    Fundam Clin Pharmacol 20:503-5. 2006
    ..On the other hand, TMZ significantly reduced atrial natriuretic peptide mRNA levels compared with untreated rats...
  69. ncbi Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation
    Frank C Chen
    Division of Cardiovascular Diseases, Mayo Clinic, Guggenheim 9, 200 First Street, Southwest, Rochester, MN 55905, USA
    J Mol Cell Cardiol 41:488-95. 2006
    ..These data suggest that ACE inhibition, unique from pure afterload reduction, prevents MYPT1 isoform switching, which would preserve normal flow, or NO-mediated vasodilatation...
  70. ncbi Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer
    Michael J Cox
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Circulation 109:2123-8. 2004
    ..Although it is known that oxidative stress activates MMP and CIMP inhibits MMP, it is unclear whether CIMP administration attenuates oxidative stress and MMP-mediated cardiac dilatation...
  71. ncbi Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004
    ..In conclusion, increased local production of angiotensin II in the heart is not sufficient to induce ventricular hypertrophy or fibrosis. Instead, it leads to atrial morphological changes, cardiac arrhythmia, and sudden death...
  72. ncbi Evaluation of left ventricular diastolic function from spectral and color M-mode Doppler in genetically altered mice
    Albrecht G Schmidt
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, USA
    J Am Soc Echocardiogr 15:1065-73. 2002
    ....
  73. ncbi Matrix metalloproteinases and atrial structural remodeling
    Brian D Hoit
    J Am Coll Cardiol 42:345-7. 2003
  74. ncbi Assessing atrial mechanical remodeling and its consequences
    Brian D Hoit
    Circulation 112:304-6. 2005
  75. ncbi Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure
    Albrecht G Schmidt
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA
    Cardiovasc Res 56:248-59. 2002
    ..Furthermore, the hinge domain may play an important role in transmitting PLB's regulatory effects on SERCA...
  76. ncbi Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage
    Scott M Raidel
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 282:H1672-8. 2002
    ..Tat caused cardiac dysfunction in this TG and may impact on cardiomyopathy in acquired immunodeficiency syndrome...
  77. ncbi Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome
    Roy L Sutliff
    Department of Experimental Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Lab Invest 83:983-9. 2003
    ..Histopathologically, perivascular fibrosis and interstitial fibrosis were evident in cocaine-treated TG. Data suggest that additive cardiac insults (from AIDS and cocaine) result in combined deleterious effects...
  78. ncbi Excitation-contraction coupling in the MLP knockout mouse
    Brian D Hoit
    J Mol Cell Cardiol 40:335-8. 2006
  79. ncbi Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy
    Rajesh Dash
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, OH 45267-0575, USA
    Cardiovasc Res 57:704-14. 2003
    ..CONCLUSION: These findings suggest that norepinephrine-induced hypertrophy is linked closely with p38 MAP kinase activation, which can be endogenously modulated through estrogen-responsive regulation of MKP-1 expression...
  80. ncbi Relaxation... it's not getting any easier
    Brian D Hoit
    J Mol Cell Cardiol 34:1135-9. 2002
  81. ncbi Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure
    Matthew J Hunt
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Lung Cell Mol Physiol 283:L239-45. 2002
    ..In vitro, treatment of CIMP abrogated the DMP activity. The treatment with CIMP may prevent degradation of integrin and connexin and ameliorate heart failure...
  82. ncbi Role of echocardiography in congestive heart failure
    Songsak Kiatchoosakun
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Med Assoc Thai 86:37-45. 2003
    ..The objective of this review was to critically evaluate the clinical impact of conventional echocardiographic methods on the management of heart failure patients...
  83. ncbi Understanding the molecular regulation of T-wave alternans
    Brian D Hoit
    Transl Res 152:47-8. 2008
  84. ncbi Compensated hypertrophy of cardiac ventricles in aged transgenic FVB/N mice overexpressing calsequestrin
    Yoji Sato
    Division of Xenobiotics, Metabolism and Disposition, National Institute of Health Sciences, Setagaya, Tokyo, Japan
    Mol Cell Biochem 242:19-25. 2003
    ....
  85. ncbi Metalloproteinase in myocardial adaptation and maladaptation
    Suresh C Tyagi
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Cardiovasc Pharmacol Ther 7:241-6. 2002
    ..The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy...

Research Grants1

  1. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....