Research Topics
| Richard HansonSummaryAffiliation: Case Western Reserve University Country: USA Publications
Research Grants
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Detail Information
Publications
Glyceroneogenesis, the pathway that almost wasn'tRichard W Hanson
Department of Biochemistry, Case Western Reserve University School of Medicine Cleveland, Ohio 44106 4539
Biochem Mol Biol Educ 34:317-23. 2006..Others may view things differently, but this is our story as we remember it...- Born to run; the story of the PEPCK-Cmus mouseRichard W Hanson
Department of Biochemistry, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
Biochimie 90:838-42. 2008..The possible reasons for the profound alteration in activity and longevity caused the introduction of a simple metabolic enzyme into the skeletal muscle of the mice will be discussed... - Metabolism in the era of molecular biologyRichard W Hanson
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4935, USA
J Biol Chem 280:1705-15. 2005 - Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alphaJianqi Yang
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
J Biol Chem 280:38689-99. 2005..These findings demonstrate that C/EBPalpha is essential for the survival of animals during postnatal life and that its ablation leads to distinct biphasic change in metabolic processes... - The key role of anaplerosis and cataplerosis for citric acid cycle functionOliver E Owen
Department of Pediatrics, Case Western Reserve University School of Medicine, Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109, USA
J Biol Chem 277:30409-12. 2002 - A computer model of gluconeogenesis and lipid metabolism in the perfused liverElie Chalhoub
Dept of Chemical and Biomedical Engineering, Cleveland State Univ, 2121 Euclid Ave, Cleveland, OH 44115 2425, USA
Am J Physiol Endocrinol Metab 293:E1676-86. 2007..5-4 min) and the dynamic behavior of substrate and product fluxes. It is expected that this model will be a useful tool for analyzing the complex relationships between carbohydrate and fat metabolism... - Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-CKaushik Chakravarty
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4935, USA
Crit Rev Biochem Mol Biol 40:129-54. 2005..Because of its extraordinary importance in mammalian metabolism and its broad pattern of tissue-specific expression, the PEPCK-C gene has become a model for studying the biological basis of the control of gene transcription... - Metabolic and genomic response to dietary isocaloric protein restriction in the ratSatish C Kalhan
Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Biol Chem 286:5266-77. 2011..These may be related to high methylation demands placed on the organism and caused by possible changes in cellular osmolarity as a result of the efflux of the intracellular taurine... - Metabolic programming: fetal origins of obesity and metabolic syndrome in the adultFaramarz Ismail-Beigi
Dept of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Am J Physiol Endocrinol Metab 291:E439-40. 2006..Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented... - Querying metabolism under different physiological constraintsAli Cakmak
Department of Electrical Engineering and Computer Science, Case Western Reserve University, USA
J Bioinform Comput Biol 8:247-93. 2010..The query results of MQL are enriched with both textual and visual representations, and its query processing is completely tailored based on the underlying metabolic principles... - Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouseParvin Hakimi
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4935, USA
J Biol Chem 282:32844-55. 2007..5 years ran twice as fast as 6-12-month-old control animals. We conclude that overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity... - Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humansSatish C Kalhan
Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
Metabolism 57:305-12. 2008..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus... - Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infantsSatish C Kalhan
Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Department of Pedatrics and Biochemistry, CaseWestern Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
J Pediatr 146:642-7. 2005..To examine the effect of supplemental glutamine (0.6 g.kg -1 .d -1 ) on whole body protein/nitrogen and glutamine kinetics in low birth weight (LBW) infants receiving parenteral nutrition in the immediate neonatal period... - Reassessing triglyceride synthesis in adipose tissueColleen Nye
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 3549, USA
Trends Endocrinol Metab 19:356-61. 2008..Here, we review recent information on triglyceride synthesis and introduce the pathway of glyceroneogenesis as an important and highly regulated source of glyceride-glycerol in adipose tissue... - Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusionSrinivasan Dasarathy
Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland, USA
Am J Physiol Gastrointest Liver Physiol 297:G567-75. 2009..An increase in oxidative stress, induced by a higher rate of fatty acid oxidation in NASH, may have caused an increase in the contribution of serine to cystathionine to meet the higher demands for glutathione... - SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liverKaushik Chakravarty
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
J Biol Chem 279:15385-95. 2004..We propose that insulin represses transcription of the gene for PEPCK-C by inducing SREBP-1c production in the liver, which interferes with the stimulatory effect of Sp1 at -590 of the PEPCK-C gene promoter... - Glyceroneogenesis revisitedRichard W Hanson
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 3945, USA
Biochimie 85:1199-205. 2003.... - Amino acids, glutamine, and protein metabolism in very low birth weight infantsPrabhu S Parimi
Department of Pediatrics, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA
Pediatr Res 58:1259-64. 2005..These data show an acute increase in parenteral amino acid-suppressed proteolysis, however, such an effect was not seen when amino acids were infused for 20 h and resulted in an increase in glutamine synthesis... - Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infantsPrabhu S Parimi
Department of Pediatrics, Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109-1998, USA
Am J Physiol Endocrinol Metab 282:E618-25. 2002..The negative relationship between glutamine turnover and the irreversible oxidation of protein (urea synthesis) suggests an important role of glutamine as a nitrogen source for other synthetic processes and accretion of body proteins... - Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infantsPrabhu S Parimi
Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
Am J Clin Nutr 79:402-9. 2004..Although supplementation with glutamine has been suggested for growing infants, its effect on protein metabolism has not been examined... - Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alphaJianqi Yang
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
J Biol Chem 284:27042-53. 2009..However, SIRT1 deacetylation of other key regulatory proteins that control PEPCK-C gene transcription also likely contributed to the inhibitory effect... - Metabolism of methionine in the newborn infant: response to the parenteral and enteral administration of nutrientsBiju Thomas
Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
Pediatr Res 64:381-6. 2008.... - Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the ratColleen K Nye
Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 283:27565-74. 2008..Thus, glyceroneogenesis, in contrast to glucose, via glycolysis, is quantitatively the predominant source of triglyceride glycerol in adipose tissue, skeletal muscle, and liver of the rat during fasting and high sucrose feeding... - Effect of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat fetusPrabhu S Parimi
Robert Schwartz MD Center for Metabolism and Nutrition, Departments of Pediatrics and Biochemistry, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
Pediatr Res 53:325-32. 2003..IUGR, as a result of decreased fractional inspired oxygen concentration may also be the consequence of pH-mediated changes in uterine blood flow. However, these remain to be examined in this experimental model... - How I became a biochemistRichard W Hanson
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4935, USA
IUBMB Life 54:373-5. 2002 - Nanoparticles of compacted DNA transfect postmitotic cellsGe Liu
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Biol Chem 278:32578-86. 2003..A marked decrease in transgene expression was observed as the minor ellipsoidal diameter approached 25 nm. In summary, suitably sized DNA nanoparticles productively transfect growth arrested cells by traversing the nuclear membrane pore... - Glyceroneogenesis and the triglyceride/fatty acid cycleLea Reshef
Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
J Biol Chem 278:30413-6. 2003 - The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the geneHanoch Cassuto
Department of Developmental Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Gene 318:177-84. 2003..These two modulations, as well as the basal activity of the gene, require intact HNF-1 binding site in the gene promoter... - Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unitHanoch Cassuto
Department of Developmental Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
J Biol Chem 280:33873-84. 2005..This mutation inhibited the full response of hepatic PEPCK-C gene to diabetes by reducing PEPCK-C mRNA level by 3.5-fold and the level of circulating glucose by 25%... - Analysis of the adult human plasma metabolomeKay A Lawton
Metabolon, Inc, 800 Capitola Dr Suite 1, Durham, NC 27713, USA
Pharmacogenomics 9:383-97. 2008.... - Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1cKaushik Chakravarty
Department of Cardiovascular Medicine, Discovery Biology, Pfizer La Jolla, San Diego, California 92121, USA
Nutr Rev 65:S47-56. 2007..This review will focus on a specific transcription factor, sterol regulatory element-binding protein 1c (SREBP-1c), and its role in the control of PEPCK-C gene transcription... - Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activationYael Olswang
Department of Developmental Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel 91120, USA
J Biol Chem 278:12929-36. 2003..In contrast, the repression by mutant GR depended on the intact AF1 site in the gene promoter, whereby mutation of the AF1 element abolished the repression... - Sidney Weinhouse and the mechanism of ketone body synthesis from fatty acidsNicole Kresge
J Biol Chem 280:e20. 2005 - A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in miceYael Olswang
Department of Developmental Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 99:625-30. 2002....
Research Grants
- HORMONAL REGULATION OF ENZYME LEVELS IN MAMMALIAN TISSUERichard Hanson; Fiscal Year: 2004..Based on the results, he will attempt to establish a physiological model of much greater resolution to explain the complex pattern of hormonal regulation of PEPCK gene transcription in mammals. ..
- Metabolic Regulation of PEPCK IsozymesRichard Hanson; Fiscal Year: 2004..In addition, the role of PEPCK in tissue such as kidney, small intestine, brain, skeletal muscle and brown adipose tissue will be determined using genetically modified mice. ..
- Metabolic Regulation of PEPCK IsozymesRichard Hanson; Fiscal Year: 2007..The research proposed in this grant application aims to resolve many of the issues concerning the role of PEPCK in mammals, with the broad goal of relating its function with the control of triglyceride/fatty acid cycling in humans. ..
- HORMONAL REGULATION OF ENZYME LEVELS IN MAMMALIAN TISSUERichard Hanson; Fiscal Year: 2009..This research has special significance to diabetes and obesity, since PEPCK-C is a critical enzyme in both the control of hepatic glucose output and triglyceride deposition in adipose tissue. ..
- Metabolic Regulation of PEPCK IsozymesRichard Hanson; Fiscal Year: 2009..The research proposed in this grant application aims to resolve many of the issues concerning the role of PEPCK in mammals, with the broad goal of relating its function with the control of triglyceride/fatty acid cycling in humans. ..
- Metabolic Regulation of PEPCK IsozymesRichard Hanson; Fiscal Year: 2009..abstract_text> ..
- Metabolic Regulation of PEPCK IsozymesRichard W Hanson; Fiscal Year: 2010..The research proposed in this grant application aims to resolve many of the issues concerning the role of PEPCK in mammals, with the broad goal of relating its function with the control of triglyceride/fatty acid cycling in humans. ..
- HORMONAL REGULATION OF ENZYME LEVELS IN MAMMALIAN TISSUERichard Hanson; Fiscal Year: 1999..This research has clear implications for the understanding of the etiology of diabetes and the more basic processes which underlie the control of glucose homeostasis in mammals. ..
- HORMONAL REGULATION OF ENZYME LEVELS IN MAMMALIAN TISSUERichard Hanson; Fiscal Year: 1993....
- Metabolic Regulation of PEPCK IsozymesRichard W Hanson; Fiscal Year: 2010..The research proposed in this grant application aims to resolve many of the issues concerning the role of PEPCK in mammals, with the broad goal of relating its function with the control of triglyceride/fatty acid cycling in humans. ..