Alexander Panov

Summary

Affiliation: Carolinas Medical Center
Country: USA

Publications

  1. ncbi Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication
    Alexander Panov
    Carolinas Neuromuscular ALS MDA Center, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    J Biol Chem 280:42026-35. 2005
  2. ncbi Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice
    Alexander Panov
    Carolinas Neuromuscular ALS MDA Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    Am J Physiol Cell Physiol 292:C708-18. 2007
  3. ncbi The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria
    Alexander Panov
    Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Biol Chem 284:14448-56. 2009
  4. ncbi Effect of bovine serum albumin on mitochondrial respiration in the brain and liver of mice and rats
    A V Panov
    Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina, USA
    Bull Exp Biol Med 149:187-90. 2010
  5. ncbi Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Neurobiol Dis 44:53-62. 2011
  6. ncbi In vitro effects of cholesterol ?-D-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondria
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    J Membr Biol 237:71-7. 2010

Detail Information

Publications6

  1. ncbi Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication
    Alexander Panov
    Carolinas Neuromuscular ALS MDA Center, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    J Biol Chem 280:42026-35. 2005
    ..We suggest that the damage to Co-I and Co-II shifts O*2- generation from the CoQ10 sites to more proximal sites, such as flavines, and makes it independent of the RBM functional state...
  2. ncbi Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice
    Alexander Panov
    Carolinas Neuromuscular ALS MDA Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    Am J Physiol Cell Physiol 292:C708-18. 2007
    ..Thus the observed differences in the Ca(2+)-induced mPT and ROS generation may underlie both the organ-specific and species-specific variability in the animal models of neurodegenerative diseases...
  3. ncbi The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria
    Alexander Panov
    Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Biol Chem 284:14448-56. 2009
    ....
  4. ncbi Effect of bovine serum albumin on mitochondrial respiration in the brain and liver of mice and rats
    A V Panov
    Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina, USA
    Bull Exp Biol Med 149:187-90. 2010
    ..Our results confirm the hypothesis that inhibition of SDH in brain mitochondria is not the artifact. This process serves as a mechanism protecting neurons from free oxygen radicals during succinate oxidation...
  5. ncbi Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Neurobiol Dis 44:53-62. 2011
    ..Thus mitochondrial dysfunction is a key early element in pathogenesis of motor neuron degeneration in tgmSOD1 rats...
  6. ncbi In vitro effects of cholesterol ?-D-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondria
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    J Membr Biol 237:71-7. 2010
    ..Unlike heart mitochondria, in activated neurons mitochondria specifically increase ROS production associated with succinate oxidation (Panov et al., J Biol Chem 284:14448-14456, 2009)...