Research Topics
| J SchwarzSummaryAffiliation: California Institute of Technology Country: USA Publications
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Detail Information
Publications
Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear declineJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
J Nucl Med 45:1694-7. 2004..Most follow-up studies have provided data best fitted by a linear decline of their outcome measure. However, in these studies, patients were repeatedly scanned during their first years after a diagnosis had been established...- Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signallingJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
J Neurochem 99:913-23. 2006..We conclude that uracil nucleotides exert specific P2 receptor-mediated effects on midbrain-derived human NPCs, and may be used to enhance both proliferation and dopaminergic differentiation... - Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiationJavorina Milosevic
Translational Centre for Regenerative Medicine Leipzig TRM Leipzig, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
Mol Neurodegener 4:25. 2009..In conclusion, a reduction of LRRK2 expression in hmNPCs severely impaired dopaminergic differentiation and/or survival of dopaminergic neurons most likely via preserving or reactivating the cell cycle... - Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson diseaseIoannis U Isaias
Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, Milano, Italy
BMC Neurol 11:88. 2011..Little is known however, about the functional state of the LC in patients with Parkinson disease (PD)... - Rationale for dopamine agonist use as monotherapy in Parkinson's diseaseJohannes Schwarz
Department of Neurology, University of Leipzig, Germany
Curr Opin Neurol 16:S27-33. 2003..Dopamine agonists also appear to reduce the loss of functional dopamine transporters when used early in the disease course, and these factors combine to build a case for the use of dopamine agonists in early-stage Parkinson's disease... - [Nuclear medicine imaging in patients with Parkinson's syndrome: an update]J Schwarz
Klinik und Poliklinik fur Neurologie, Universitat Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland
Nervenarzt 81:1160-7. 2010..More recently, molecular imaging has been directed towards understanding the pathophysiology of non-motor symptoms in this disorder... - Depression in Parkinson's diseaseJ Schwarz
Department of Neurology, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
J Neurol 258:S336-8. 2011..Data on specific diagnostic tools or treatment for depressive symptoms in PD patients are still sparse. Here we summarize an expert opinion based on available data and clinical experience... - Increased periodontal pathology in Parkinson's diseaseJohannes Schwarz
Dept of Neurology, University of Leipzig, Liebigstr 22a, 04103, Leipzig, Germany
J Neurol 253:608-11. 2006..We believe that problems in oral hygiene contribute to this increased periodontal pathology in patients with Parkinson's disease, which may further compromise the quality of life... - Developmental perspectives on human midbrain-derived neural stem cellsJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
Neurodegener Dis 3:45-9. 2006..Neural stem cells derived from human fetal midbrain tissue maintain a considerable capacity to self-renew and to differentiate into DA neurons. Therefore, these cells may be a promising source to generate functional human DA neurons... - Developmental perspectives on human midbrain-derived neural stem cellsJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
Parkinsonism Relat Disord 13:S466-8. 2007..Such cells allow for prior extensive in-vitro and in-vivo testing as well as "good manufacturing production" to reduce the risks in subsequent clinical applications... - [The status of imaging methods for the treatment of patients with Parkinson's syndrome]J Schwarz
Klinik und Poliklinik fur Neurologie, Universitat Leipzig
Dtsch Med Wochenschr 133:S8-10. 2008..The cost of these imaging procedures needs to be set against the cost of unnecessary medication... - Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: implications for a preclinical diagnosisJ Schwarz
Department of Neurology, University of Ulm, Germany
Arch Neurol 57:205-8. 2000..Specific binding to dopamine transporters may serve as a tool to detect early loss of nigrostriatal dopaminergic neurons in patients with Parkinson's disease... - Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomographyG D Borasio
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munchen, Germany
J Neurol Neurosurg Psychiatry 65:263-5. 1998..These data indicate that nigrostriatal dopaminergic neurons are subclinically affected in a subset of patients with sporadic ALS... - Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
J Neurochem 75:2259-69. 2000..These results provide further impetus to explore the neuroprotective potential of riluzole in Parkinson's disease... - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal levelA Kupsch
Ludwig Maximilians University, Klinikum Grosshadern, Department of Neurology, Munchen, Germany
Brain Res 741:185-96. 1996.... - Reduced striatal dopaminergic innervation shown by IPT and SPECT in patients under neuroleptic treatment: need for levodopa therapy?J Schwarz
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
Psychiatry Res 83:23-8. 1998..Imaging of dopamine transporters with SPECT and IPT or a related compound represents an attractive alternative to the more complex measurements of fluorodopa uptake with positron emission tomography (PET)... - Relative quantification of signal on T2-weighted images in the basal ganglia: limited value in differential diagnosis of patients with parkinsonismJ Schwarz
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Neuroradiology 41:124-8. 1999..However, this method does not exclude idiopathic parkinsonism in a given patient... - HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Germany
Neurochem Int 35:393-403. 1999..This cell system may serve as a screening system for endogenous and exogenous compounds with similar effects compared to MPP+ as well as protective agents... - Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controlsI Eisensehr
Department of Neurology, University of Munich, Germany
Brain 123:1155-60. 2000..This study demonstrates that [123I]IPT-SPECT is a useful diagnostic tool in RBD and that reduced striatal dopamine transporters may be a pathophysiological mechanism of idiopathic RBD. (Results are given as mean +/- standard deviation.).. - Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndromeS Hesse
Clinic for Nuclear Medicine, University Hospital, Leipzig, Germany
J Neural Transm 113:1177-90. 2006..5-year clinical follow-up. We conclude that dopamine SPECT may support establishing or refuting the clinical diagnosis and, therefore, help to make the decision for or against dopaminomimetic treatment in cases with PS... - 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
Brain Res 855:67-75. 2000..These results suggest that cell death induced by salsolinol is due to impairment of cellular energy supply, caused in particular by inhibition of mitochondrial complex II (succinate-Q reductase), but not complex I... - Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neuronsA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
Mol Pharmacol 57:589-94. 2000..These data demonstrate that COMT inhibition attenuates L-dopa toxicity toward DA neurons in vitro, but probably not by preventing 3-O-methyldopa production or cellular S-adenosyl-L-methionine depletion... - Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cellsA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
Exp Neurol 170:317-25. 2001.... - Profound midbrain atrophy in patients with Wilson's disease and neurological symptoms?K Strecker
Department of Neurology, University of Leipzig, Liebigstr 22a, 04103 Liebigstr, Germany
J Neurol 253:1024-9. 2006.... - Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degenerationA Storch
Department of Neurology, University of Ulm, Germany
J Neural Transm 111:1267-86. 2004..Taken together, there is large body of evidence from morphological, molecular biological and toxicological studies indicating that the DAT might be responsible for the selectivity of DA cell death in PD... - Improvement of motor fluctuations in patients with Parkinson's disease following treatment with high doses of pergolide and cessation of levodopaJ Schwarz
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Eur Neurol 37:236-8. 1997..These data show that in some patients oral treatment with high doses of a dopamine agonist may improve the severity of motor fluctuations and achieve a good control of parkinsonian signs without concomitant levodopa treatment... - Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cellsA Storch
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neural Transm 113:1895-901. 2006..Our results suggest that TaClo and related analogs are strong cytotoxins without selectivity towards dopaminergic cells... - Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signalingJavorina Milosevic
Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
J Neurosci 27:412-21. 2007..In conclusion, HIF-1alpha seems to be a transcription factor relevant to the development and survival of substantia nigra dopaminergic neurons involving VEGF signaling... - Midbrain-derived neural stem cells: from basic science to therapeutic approachesAlexander Storch
Department of Neurology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Cell Tissue Res 318:15-22. 2004..This review discusses new data concerning the cell biology and therapeutic potential of NSCs derived from the midbrain region of the central nervous system... - Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitroJavorina Milosevic
Translational Centre for Regenerative Medicine, Leipzig, 04103 Leipzig, Germany, Department of Neurology, University of Leipzig, 04103, Germany
Stem Cells Dev 16:625-35. 2007..Our data question the relevance of neuroregenerative effects of dopamine agonists for human predopaminergic cells as well as patients with Parkinson's disease... - Neural stem cells and Parkinson's diseaseAlexander Storch
Department of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 249:III/30-2. 2002..These cells will hopefully enable restorative treatment of patients with Parkinson's disease in the near future... - Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cellsAlexander Storch
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
J Chem Neuroanat 26:133-42. 2003.... - Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxinsMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Neurotoxicology 29:714-21. 2008..This cell system seems not suitable as a screening tool for selective dopaminergic toxicity... - Dexamethasone blocks astroglial differentiation from neural precursor cellsMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Neuroreport 17:1719-23. 2006.... - Increase of intracellular Ca2+ by adenine and uracil nucleotides in human midbrain-derived neuronal progenitor cellsPatrizia Rubini
Rudolf Boehm Institute for Pharmacology und Toxicology, Haertelstrasse 16 18, University of Leipzig, D 04107 Leipzig, Germany
Cell Calcium 45:485-98. 2009..In conclusion, UTP may induce the release of ATP from hmNPCs via P2Y(2) receptor-activation and thereby causes [Ca(2+)](i) transients by stimulating a P2Y(1)-like receptor... - Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporterAlexander Storch
Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
Biochem Pharmacol 63:909-20. 2002.... - High doses of pergolide improve clinical global impression in advanced Parkinson's disease:- a preliminary open label studyGuy Arnold
Department of Neurology, Charite, University Hospital Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
Arch Gerontol Geriatr 41:239-53. 2005..A possible relationship to the study medication was assumed for two serious adverse events reporting psychosis. We conclude that high doses of pergolide are efficacious in advanced stages of PD if given in appropriate regimens... - Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatallySabine Orb
Department of Neurology, University of Leipzig, 04316 Leipzig, Germany
Physiol Genomics 18:299-307. 2004..This novel concept may be relevant to the pathophysiology of Parkinson disease... - Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's diseaseVera Lehmensiek
Department of Neurology, University of Ulm, Germany
Neurochem Int 48:329-40. 2006.... - Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disordersSwen Hesse
Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
Neurosci Biobehav Rev 28:547-63. 2004..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors... - The first evaluation of brain shift during functional neurosurgery by deformation field analysisD Winkler
Department of Neurosurgery, University of Leipzig, Leipzig, Germany
J Neurol Neurosurg Psychiatry 76:1161-3. 2005..This case report shows the need to reduce risk factors for intraoperative brain movement and demonstrates the ability of deformation field analysis to quantify this complication... - L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trialC Trenkwalder
Department of Neurology, University of Munich, Klinikum Grosshadern, Germany
Sleep 18:681-8. 1995..030) while the patients received L-dopa therapy. We conclude that L-dopa 100-200 mg proved to be effective in idiopathic RLS and for the first time under controlled conditions in uremic RLS without any severe side effects... - Monoamine transporter availability in Parkinson's disease patients with or without depressionSwen Hesse
Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
Eur J Nucl Med Mol Imaging 36:428-35. 2009..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT... - Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptakeAlexander Storch
Department of Neurology, University of Ulm, Ulm, Germany
J Neurochem 89:685-94. 2004..Our data suggest that DAT-mediated cellular uptake of 2[N]-methylated betaCs represents a potential mechanism for selective toxicity towards dopaminergic neurons and may be relevant for the pathogenesis of Parkinson's disease... - Labeling of human neural precursor cells using ferromagnetic nanoparticlesAlmut Focke
Department of Neurology, University of Leipzig, Leipzig, Germany
Magn Reson Med 60:1321-8. 2008..Our data indicate that hmNPCs can be labeled with VSOPs without impairment of viability, proliferation, or multipotency. Labeled, transplanted cells are detectable in vivo using 1.5T MRI... - Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitroFlorian Wegner
Department of Neurology, University of Leipzig, Leipzig, Germany
J Neurochem 111:204-16. 2009..These data suggest that NMDA receptors in differentiating human mesencephalic NPCs are important regulators of dopaminergic neurogenesis in vitro... - Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicityHeike Blessing
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
Neurochem Int 42:139-51. 2003..In addition, we demonstrate a second mechanism of L-DOPA toxicity in vitro mediated by a COMT- and glia-dependent pathway, which is blocked by COMT inhibitors, most likely due to enhanced glial uptake of L-DOPA... - Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's diseaseIlonka Eisensehr
Department of Neurology, University of Munich, Germany
Sleep 26:507-12. 2003.... - Non-viral gene transfer by nucleofection allows stable gene expression in human neural progenitor cellsMaja Theresa Dieterlen
Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Germany
J Neurosci Methods 178:15-23. 2009..These data provide a basis for future studies using hNPCs to investigate the neuronal differentiation in vivo after transplantation, the feasibility as a vector for gene (protein) therapy, and the induction of pluripotent stem cells... - Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neuronsJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
FASEB J 20:935-46. 2006..This produced increased L9'S mutant nAChR expression, which in turn led to nicotinic cholinergic excitotoxicity in dopaminergic neurons... - Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursorsJavorina Milosevic
Department of Neurology, University of Leipzig, Germany
J Neurochem 92:718-29. 2005..Gene regulation governed by low oxygen tension may be relevant to the normal development and survival of midbrain neurons... - Is levodopa toxic?Thomas Muller
Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
J Neurol 251:VI/44-6. 2004..e. folic acid administration in the case of levodopa-associated homocysteine elevation... - Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitroVera Lehmensiek
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Neuroreport 13:1279-83. 2002..Our data suggest a new mechanism of MPP+-induced dopaminergic toxicity by an interaction between mutant alpha-synucleins and the DAT, which is independent of the function of the proteasome... - Transplantation of human neural precursor cells in the 6-OHDA lesioned rats: effect of immunosuppression with cyclosporine ASigrid C Schwarz
Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Saxony, Germany
Parkinsonism Relat Disord 12:302-8. 2006..There was no evidence for tumor formation. Immunosuppression of rats, xenotransplanted with human NPC did not improve graft survival or function... - Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson diseasePhilipp M Meyer
Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
Arch Gen Psychiatry 66:866-77. 2009..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)... - [Syncope. A diagnostic challenge]S Kimmel
Department für Innere Medizin, Universitat Leipzig, Johannisallee 32, 04103 Leipzig
Internist (Berl) 49:185-95, quiz 196-7. 2008..We provide an algorithm on how to proceed to determine the various reasons for syncope... - Characterization of voltage-gated potassium channels in human neural progenitor cellsGrit Schaarschmidt
Department of Neurology, University of Leipzig, Leipzig, Germany
PLoS ONE 4:e6168. 2009..We tested this hypothesis, using human neural progenitor cells (hNPCs) as a model system... - Translation of stem cell therapy for neurological diseasesSigrid C Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
Transl Res 156:155-60. 2010..Such cells allow for extensive in vitro and in vivo testing as well as "good manufacturing production," reducing the risks in clinical application... - Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulatorsMartina Maisel
Department of Neurology, Dresden University of Technology, Dresden, Germany
Exp Cell Res 316:2760-78. 2010.... - Initiation of dopaminergic differentiation of Nurr1(-) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathwaysMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Stem Cells 27:2009-21. 2009..Our results indicate that induction of terminal dopaminergic specification of Nurr1(-) mdNPCs by IL-1beta depends on activation of the ERK1/2 and p38 MAP kinase pathway... - A new culturing strategy improves functional neuronal development of human neural progenitor cellsGrit Schaarschmidt
Department of Neurology, University of Leipzig, Leipzig, Germany
J Neurochem 109:238-47. 2009..Thus, depolarizing followed by hyperpolarizing culture conditions enable developing human neural progenitor cells to adopt more mature functional qualities... - Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cellsJavorina Milosevic
Translational Centre for Regenerative Medicine Leipzig TRM Leipzig, University of Leipzig, Philipp Rosenthal Strasse 55, 04103, Leipzig, Germany
Neurotox Res 15:367-80. 2009..These findings suggest that several HIF stabilizing agents or conditions can rescue impaired neurons and promote neurogenesis in vitro... - Rostro-caudal gradual loss of cellular diversity within the periventricular regions of the ventricular systemAndreas Hermann
Department of Neurology, Dresden University of Technology, Dresden, Germany
Stem Cells 27:928-41. 2009..Our data provide the histological framework for future studies on orthotopic regenerative approaches in PD by recruiting endogenous predopaminergic progenitors from the midbrain PVR... - Parkinson's disease: emerging pharmacotherapyKarl Strecker
Department of Neurology, University of Leipzig, Movement Disorders Group, Liebigstrasse 22 a, 04103 Leipzig, Germany
Expert Opin Emerg Drugs 13:573-91. 2008..Here, we describe current therapies and possible future developments that we hope will contribute to sustaining quality of life in patients suffering from Parkinson's disease for many years... - Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-upSwen Hesse
Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
J Neurol 255:1059-66. 2008..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery... - High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesiasAlexander Storch
Department of Neurology, University of Ulm, Ulm, Germany
Parkinsonism Relat Disord 11:393-8. 2005..Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy... - Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET studyWolfgang H Oertel
Department of Neurology, Philipps University, Marburg, Germany
Mov Disord 21:343-53. 2006..In principle, both levodopa and a dopamine agonist such as pergolide seem to be suitable options as initial PD therapy. The choice remains with the treating physician based on the different efficacy and adverse event profiles... - Neurorestoration in Parkinson's disease by cell replacement and endogenous regenerationAndreas Hermann
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Expert Opin Biol Ther 4:131-43. 2004..However, one major problem is the control of growth and differentiation of these cells. This review discusses new data on stem cell technology in cell replacement strategies in PD as well as endogenous dopaminergic regeneration... - Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neuronsAndreas Hermann
Department of Neurology, University of Ulm, Germany
Stem Cells 24:949-64. 2006..Here, we demonstrate the existence of adult tNSCs with functional neurogenic and dopaminergic potential, a prerequisite for future endogenous cell replacement strategies in Parkinson's disease... - Functional and molecular analysis of GABA receptors in human midbrain-derived neural progenitor cellsFlorian Wegner
Department of Neurology, University of Leipzig, Leipzig, Germany
J Neurochem 107:1056-69. 2008..These data indicate that NPCs derived from human fetal midbrain tissue acquire essential GABA(A) receptor properties during neuronal maturation in vitro... - Low extracellular calcium is sufficient for survival and proliferation of murine mesencephalic neural precursor cellsJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
Cell Tissue Res 324:377-84. 2006..0 mM) are not required, a concentration of 0.5 mM being adequate for cell maintenance... - Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocolsAndreas Hermann
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neurosci Res 83:1502-14. 2006..Analysis of marker gene expression for characterization of neural cells derived from MSCs has to take into account that several early and late neuroectodermal genes are already expressed in undifferentiated MSCs... - Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cellsAndreas Hermann
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neurochem 98:629-40. 2006..Our findings reinforce the emerging view that the differentiation capacity of adult hNPCs is critically influenced by non-neuronal mesodermal feeder cells... - Spontaneous apoptosis in murine free-floating neurospheresJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
Exp Cell Res 294:9-17. 2004..Pro-apoptotic proteins of the Bcl-2 family, Bax and Bak, exhibited conformational changes in neural precursors expanding in vitro. Key molecules such as executioner caspase-3 may be useful targets to reduce the amount of apoptosis... - Steele-Richardson-Olszewski-syndrome: reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: (123)IBZM SPECT and MRI studyGuy Arnold
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Mov Disord 17:557-62. 2002..010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected... - Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell stateMartina Maisel
Department of Neurology, Technical University of Dresden, Dresden, Germany
Stem Cells 25:1231-40. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Neural stem cells and neurodegenerationAlexander Storch
Department of Neurology, University of Ulm, Germany
Curr Opin Investig Drugs 3:774-81. 2002..These cells can be grown in vitro while retaining the potential to differentiate into nervous tissue. This review focuses on regenerative therapy in neurodegenerative diseases using NSC... - Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cellsAndreas Hermann
Department of Neurology, University of Ulm, Helmholtzstr. 8/1, 89081 Ulm, Germany
J Cell Sci 117:4411-22. 2004..Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases... - Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosisFlorian Then Bergh
Department of Neurology, University of Leipzig, Leipzig, Germany
Acta Haematol 116:207-10. 2006..While AZA is the probable cause for the chromosomal deletion and MDS, combined or sequential immunomodulatory therapies may permit clonal expansion of malignant hematopoietic progenitors... - Increase of frequency in deep brain stimulation relieves apraxia of eyelid opening in patients with Parkinson's disease: case reportKarl Strecker
Department of Neurology, University of Leipzig, Leipzig, Germany
Neurosurgery 63:E1204; discussion E1204. 2008..However, approximately 5% of patients might develop apraxia of eyelid opening after DBS of the subthalamic nucleus. We provide data on a new noninvasive treatment approach to this adverse event... - Levodopa-induced striatal activation in Parkinson's disease: a functional MRI studyEduard Kraft
Department of Neurology, University of Ulm, Ulm, Germany
Parkinsonism Relat Disord 15:558-63. 2009..To assess the effect of a single levodopa dose (200 mg levodopa, 50 mg carbidopa=sdLD) on cortical and subcortical motor-circuit activation during bimanual grip force in patients with Parkinson's disease (PD)... - D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathwaysAbraham Kovoor
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 25:2157-65. 2005..Thus, alterations in RGS9-2 may be a key factor in the pathway leading from D2DRs to the side effects associated with the treatment both of psychoses and Parkinson's disease... - Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitizationAndrew R Tapper
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Science 306:1029-32. 2004..These data indicate that activation of a4* receptors is sufficient for nicotine-induced reward, tolerance, and sensitization... - Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET studyAlexander Gerhard
MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
Neuroimage 24:591-5. 2005..Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration... - Role of DAT-SPECT in the diagnostic work up of parkinsonismChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 22:1229-38. 2007..This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression...