Gilbert M Rishton

Summary

Affiliation: California State University
Country: USA

Publications

  1. ncbi Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer's disease
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Curr Opin Drug Discov Devel 9:303-13. 2006
  2. ncbi Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
    Gilbert M Rishton
    Alzheimer s Initiative, Science Building 206, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Med Chem 1:519-27. 2005
  3. ncbi Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, CSUCI, Aliso Hall, Camarillo, CA 93012, USA
    Curr Opin Chem Biol 12:340-51. 2008
  4. ncbi Natural products as a robust source of new drugs and drug leads: past successes and present day issues
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University, Camarillo, CA 93012, USA
    Am J Cardiol 101:43D-49D. 2008
  5. ncbi Small molecules that promote neurogenesis in vitro
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Recent Pat CNS Drug Discov 3:200-8. 2008
  6. ncbi Nonleadlikeness and leadlikeness in biochemical screening
    Gilbert M Rishton
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Drug Discov Today 8:86-96. 2003
  7. ncbi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008

Detail Information

Publications7

  1. ncbi Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer's disease
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Curr Opin Drug Discov Devel 9:303-13. 2006
    ..The trends in logBB values and the associated physiochemical properties of these agents as they relate to the potential for BBB permeability are also discussed...
  2. ncbi Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
    Gilbert M Rishton
    Alzheimer s Initiative, Science Building 206, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Med Chem 1:519-27. 2005
    ..Consideration of these guiding principles will improve our chances of success in drug discovery, and increase our ability to address unmet medical need in the future...
  3. ncbi Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, CSUCI, Aliso Hall, Camarillo, CA 93012, USA
    Curr Opin Chem Biol 12:340-51. 2008
    ..Chemically stable low molecular weight 'minimalist' compounds (or fragments) with dense heteroatom substitution and variable conformational constraint are promoted as conceptually superior compounds for biochemical screening...
  4. ncbi Natural products as a robust source of new drugs and drug leads: past successes and present day issues
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University, Camarillo, CA 93012, USA
    Am J Cardiol 101:43D-49D. 2008
    ..Natural compounds can again become central players in the treatment of disease and in the understanding of disease mechanisms...
  5. ncbi Small molecules that promote neurogenesis in vitro
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Recent Pat CNS Drug Discov 3:200-8. 2008
    ..This relatively new area of research into small molecule modulators of neurogenesis is reviewed and recent patents claiming small molecule neurogenic compounds, potentially orally administered CNS regenerative therapies are summarized...
  6. ncbi Nonleadlikeness and leadlikeness in biochemical screening
    Gilbert M Rishton
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Drug Discov Today 8:86-96. 2003
    ..The physiochemical properties of leadlikeness and the surprising differences between those properties and the now classical definitions of druglikeness are becoming apparent...
  7. ncbi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008