Charles E Ahlfors

Summary

Affiliation: California Pacific Medical Center
Country: USA

Publications

  1. ncbi Unbound bilirubin in a term newborn with kernicterus
    Charles E Ahlfors
    Department of Pediatrics, California Pacific Medical Center, San Francisco, California 94118, USA
    Pediatrics 111:1110-2. 2003
  2. ncbi Bilirubin-albumin binding and neonatal jaundice
    Charles E Ahlfors
    LW Ligand, LLC, Vashon, WA, USA
    Semin Perinatol 28:334-9. 2004
  3. ncbi A different view on bilirubin binding
    Richard P Wennberg
    Pediatrics 118:846-7. 2006
  4. ncbi Factors affecting the binding of bilirubin to serum albumins: validation and application of the peroxidase method
    Leslye Roca
    Centro Studi Fegato, Department of Biochima, Biofisica Chimica, Marcomolecole, Area Science Park, University of Trieste, 34012 Trieste, Italy
    Pediatr Res 60:724-8. 2006
  5. ncbi Effects of sample dilution, peroxidase concentration, and chloride ion on the measurement of unbound bilirubin in premature newborns
    Charles E Ahlfors
    PO Box 2904, Vashon, WA 98070, USA
    Clin Biochem 40:261-7. 2007
  6. ncbi Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population
    C E Ahlfors
    Division of Neonatology, Department of Pediatrics, California Pacific Medical Center, San Francisco, CA, USA
    J Perinatol 29:305-9. 2009
  7. ncbi Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice
    Charles E Ahlfors
    Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA
    Clin Chem 55:1288-99. 2009
  8. ncbi Predicting bilirubin neurotoxicity in jaundiced newborns
    Charles E Ahlfors
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California, USA
    Curr Opin Pediatr 22:129-33. 2010
  9. ncbi Bilirubin binding contributes to the increase in total bilirubin concentration in newborns with jaundice
    Charles E Ahlfors
    Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA
    Pediatrics 126:e639-43. 2010
  10. ncbi Unbound bilirubin concentration is associated with abnormal automated auditory brainstem response for jaundiced newborns
    Charles E Ahlfors
    Department of Pediatrics, Division of Neonatology, California Pacific Medical Center, San Francisco, California, USA
    Pediatrics 121:976-8. 2008

Collaborators

Detail Information

Publications17

  1. ncbi Unbound bilirubin in a term newborn with kernicterus
    Charles E Ahlfors
    Department of Pediatrics, California Pacific Medical Center, San Francisco, California 94118, USA
    Pediatrics 111:1110-2. 2003
  2. ncbi Bilirubin-albumin binding and neonatal jaundice
    Charles E Ahlfors
    LW Ligand, LLC, Vashon, WA, USA
    Semin Perinatol 28:334-9. 2004
    ....
  3. ncbi A different view on bilirubin binding
    Richard P Wennberg
    Pediatrics 118:846-7. 2006
  4. ncbi Factors affecting the binding of bilirubin to serum albumins: validation and application of the peroxidase method
    Leslye Roca
    Centro Studi Fegato, Department of Biochima, Biofisica Chimica, Marcomolecole, Area Science Park, University of Trieste, 34012 Trieste, Italy
    Pediatr Res 60:724-8. 2006
    ....
  5. ncbi Effects of sample dilution, peroxidase concentration, and chloride ion on the measurement of unbound bilirubin in premature newborns
    Charles E Ahlfors
    PO Box 2904, Vashon, WA 98070, USA
    Clin Biochem 40:261-7. 2007
    ....
  6. ncbi Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population
    C E Ahlfors
    Division of Neonatology, Department of Pediatrics, California Pacific Medical Center, San Francisco, CA, USA
    J Perinatol 29:305-9. 2009
    ....
  7. ncbi Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice
    Charles E Ahlfors
    Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA
    Clin Chem 55:1288-99. 2009
    ....
  8. ncbi Predicting bilirubin neurotoxicity in jaundiced newborns
    Charles E Ahlfors
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California, USA
    Curr Opin Pediatr 22:129-33. 2010
    ..The management of jaundice in the newborn infant is an area of clinical practice sorely lacking an evidence-based foundation, and neonatal bilirubin neurotoxicity (kernicterus) continues to occur worldwide...
  9. ncbi Bilirubin binding contributes to the increase in total bilirubin concentration in newborns with jaundice
    Charles E Ahlfors
    Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA
    Pediatrics 126:e639-43. 2010
    ..This study tests the hypothesis that the hourly rate of increase in plasma bilirubin concentration (DeltaBT) would increase significantly with increasing binding avidity...
  10. ncbi Unbound bilirubin concentration is associated with abnormal automated auditory brainstem response for jaundiced newborns
    Charles E Ahlfors
    Department of Pediatrics, Division of Neonatology, California Pacific Medical Center, San Francisco, California, USA
    Pediatrics 121:976-8. 2008
    ..This study was conducted to determine whether incidental jaundice affects automated auditory brainstem response results...
  11. ncbi Evaluation of a model for brain bilirubin uptake in jaundiced newborns
    Charles E Ahlfors
    California Pacific Medical Center, Department of Pediatrics, Division of Neonatology, San Francisco 94118, USA
    Pediatr Res 58:1175-9. 2005
    ..A mathematical model calculating BBU as a function of TBC and k1 could not be validated. BBU calculated from Bf is consistent with the observation that <1% of the miscible bilirubin pool is distributed in the brain...
  12. ncbi Measurement of unbound bilirubin by the peroxidase test using Zone Fluidics
    Charles E Ahlfors
    LW Ligand, LLC, PO Box 2904, Vashon, WA 98070, USA
    Clin Chim Acta 365:78-85. 2006
    ..We investigated improving the test by adapting it to Zone Fluidics, which is a system for automating reactant handling that requires small sample volumes and dilution...
  13. ncbi Effect of ibuprofen on bilirubin-albumin binding
    Charles E Ahlfors
    Division of Neonatology, California Pacific Medical Center, San Francisco, California, USA
    J Pediatr 144:386-8. 2004
    ..Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants...
  14. ncbi Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns
    Richard P Wennberg
    Division of Neonatology, Department of Pediatrics, University of Washington, Box 356320, Seattle, WA 98195, USA
    Pediatrics 117:474-85. 2006
    ....
  15. ncbi Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants >or=35 weeks gestation
    Vinod K Bhutani
    School of Medicine at Stanford University, Stanford, CA, USA
    Neonatology 94:63-7. 2008
    ..Translational research is needed to better understand the mechanisms of bilirubin neurotoxicity and potential therapeutic interventions...
  16. ncbi Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 127:62-70. 2011
    ..We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2)...
  17. ncbi Bilirubin-binding capacity in premature infants
    Sanjiv B Amin
    Pediatrics 121:872-3; author reply 873. 2008