Research Topics
Genomes and GenesSpecies | R GongSummaryAffiliation: Brown University Country: USA Publications
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Detail Information
Publications
The renaissance of corticotropin therapy in proteinuric nephropathiesRujun Gong
Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
Nat Rev Nephrol 8:122-8. 2012....- Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cellsRujun Gong
Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Provindence, Rhode Island 02903, USA
J Biol Chem 283:7401-10. 2008.... - Multi-target anti-inflammatory action of hepatocyte growth factorRujun Gong
Brown University School of Medicine, Department of Medicine, Providence, RI 02903, USA
Curr Opin Investig Drugs 9:1163-70. 2008..Thus, HGF might represent a novel integrated multiple-target approach to suppress inflammation and to lower the risk of complications from inflammatory injury... - Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endotheliumRujun Gong
Division of Renal Diseases, Department of Medicine, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
J Am Soc Nephrol 17:2464-73. 2006..These findings suggest that HGF has potent and direct anti-inflammatory effects on the basis of suppression of NF-kappaB activation and downstream endothelial inflammation... - Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectinR Gong
Department of Medicine, Division of Renal Diseases, Brown University School of Medicine, Providence, Rhode Island 02903, USA
Kidney Int 69:1166-74. 2006..These findings suggest that HGF ameliorates acute renal inflammation in part by downregulating E-selectin mediated macrophage adhesion to the inflamed endothelium... - Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTESRujun Gong
Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
J Am Soc Nephrol 15:2868-81. 2004..These findings suggest that the beneficial effect of HGF in chronic renal disease is attributable, at least in part, to a direct anti-inflammatory action, likely via NF-kappaB, on tubular epithelial cells... - Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft diseaseR Gong
Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Providence, RI, USA
Am J Transplant 8:1852-63. 2008..Collectively, GSK3beta plays an important role in mediating proinflammatory NF-kappaB activation and renal inflammation. Suppression of GSK3beta activity might represent a novel therapeutic strategy to treat CRAD... - Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cellsRujun Gong
Division of Renal Diseases, Department of Medicine, Brown University Medical School, Providence, RI 02903, USA
Biochem Biophys Res Commun 330:27-33. 2005..These findings suggest that PI3K-Akt activation and subsequent inhibitory phosphorylation of GSK3beta are required for HGF-induced suppression of RANTES in HKC... - Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockadeShan Chen
Division of Kidney Disease and Hypertension, Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
Kidney Int 74:1128-38. 2008..There was, however, a dose-dependent improvement of renal redox homeostasis. Our study suggests that candesartan suppresses redox-sensitive NFkappaB-mediated renal inflammation by a direct antioxidant effect independent of AT1R blockade... - Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathwaysMurugavel Ponnusamy
Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA
Am J Physiol Renal Physiol 297:F1361-70. 2009..Therefore, we have identified TGase-1 as a novel survival factor in renal epithelial cells and it contributes to cell survival through activation of the AKT and STAT3 signaling pathways following oxidant injury... - Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injuryLance D Dworkin
Brown Medical School, and Rhode Island Hospital, Providence, Rhode Island 02903, USA
Kidney Int 65:409-19. 2004..Hepatocyte growth factor (HGF) has been reported to prevent injury in several models of renal disease; however, whether HGF can also retard progression of established renal disease is not known... - Long-term, high-dosage candesartan suppresses inflammation and injury in chronic kidney disease: nonhemodynamic renal protectionChen Yu
Division of Renal Disease, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
J Am Soc Nephrol 18:750-9. 2007..Renal protection with high-dosage therapy may depend on these nonhemodynamic effects... - Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal diseaseJin Si
Department of Medicine, Brown University School of Medicine, Providence, RI, USA
Lab Invest 90:448-58. 2010.... - Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3Zhu Zhang
Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA
J Biol Chem 284:3345-53. 2009..These results demonstrate that TGase-1 plays an important role in regulation of renal epithelial cell proliferation through the JAK2-Stat-3 signaling pathway... - Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cellsRujun Gong
Rhode Island Hospital, Division of Kidney Diseases and Hypertension, Brown Medical School, Providence, RI 02903, United States
Steroids 73:1187-96. 2008..Changes in 11beta-HSD1 with growth and during repair occurred at the transcription level. Thus, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth... - Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosisRujun Gong
Division of Renal Diseases, Department of Medicine, and Department of Pathology, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
J Am Soc Nephrol 14:3047-60. 2003..Collectively, these findings demonstrate that HGF ameliorates renal fibrosis by enhancing extracellular matrix catabolism via both MMP and the PA/plasmin proteolytic pathways... - Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration ratePurba Biswas
Diivsion of Renal Diseases, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
Am J Physiol Renal Physiol 288:F8-15. 2005..This finding was consistent with the observation in vivo of a decrease in ET-1 production in renal parenchyma of rats chronically treated with HGF. Our data suggest both a hemodynamic and biological role for HGF-mediated ET-1 regulation... - Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2Rujun Gong
Rhode Island Hospital Division of Kidney Diseases and Hypertension, Brown Medical School, Providence, R I, United States
Life Sci 82:631-7. 2008..Thus, normal human kidney contains active 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 co-localizes with COX-2 in proximal tubule cells...